Testosterone has rewarding affective properties in male rats: implications for the biological basis of sexual motivation
Abstract
Evidence from mammalian species, including humans, suggests that testosterone (T) enhances motivational aspects of sexual behavior, although the mechanism by which T exerts this effect is unknown. The hypothesis that increases in plasma T have rewarding affective properties was examined. Acute elevations of plasma T were induced in intact male rats by systemic administration of a recently developed testosterone-hydroxypropyl-beta-cyclodextrin inclusion complex that mimics pulsatile release of the hormone. In a conditioned-place-preference paradigm, rats displayed a preference for an environment previously paired with T administration (800 micrograms/kg and 1,200 micrograms/kg) as opposed to an environment paired with saline administration, indicating that T has rewarding affective properties. The findings suggest that T may enhance motivational aspects of mammalian sexual behavior by facilitating acquisition or expression of learned associations between environmental stimuli and sexual activity.
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Hormone-related changes sensitize the adolescent brain to reward.
“It is thought that these hormone-related changes sensitize the adolescent brain to reward (Forbes and Dahl, 2010, Peper and Dahl, 2013), as appears to be the case in animal studies (Alexander et al., 1994, Clark et al., 1996, Miele et al., 1988).”
From The dual systems model: Review, reappraisal, and reaffirmation (2016) · cites this paper as Alexander et al., 1994
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Dehydroepiandrosterone Alleviates Copulatory Disorder Induced by Social Stress in Male Rats
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Circulating androgens enhance sensitivity to testosterone self-administration in male hamsters
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Aggressive experience alters place preference in green anole lizards, Anolis carolinensis
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A testosterone metabolite is rewarding to ovariectomized female rats.
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Gonadal steroid hormones’ influence on reward and decision-making processes
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Sexual Behavior and Synaptic Plasticity
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Neural correlates of babyish adult face processing in men
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- Authors
- Alexander, G. M., Packard, M. G., & Hines, M.
- Affiliations
- University of California, Los Angeles (US)
- Venue
- Behavioral Neuroscience
- Published
- 1994
- Volume
- 108
- Issue
- 2
- Pages
- 424-428
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W1974892244
- Cited by
- 156
- References
- 34
- Citations by year
- 2024: 1 · 2023: 3 · 2022: 3 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 11 · 2014: 1 · 2013: 11 · 2012: 8
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1f32hd007596-01)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD07596, R01HD024542, HD 24542)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- testosterone, sexual motivation, reward, conditioned place preference, male rats, pulsatile hormone secretion, learned associations, sexual behavior
- MeSH terms
- Affect, Animals, Association Learning, Conditioning, Classical, Male, Motivation, Sexual Behavior, Animal, Social Environment, Testosterone, Rats, Sprague-Dawley, Rats
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