The DOI matches its Crossref record.
The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning.
Abstract
Five groups of rats were given Pavlovian fear conditioning. Four groups were then given extinction training. Prior to extinction these groups received an injection of either the noncompetitive NMDA antagonist MK-801 (0.025, 0.05, or 0.1 mg/kg) or saline. The 5th group received saline but no extinction. During testing, the extinction groups given saline or 0.025 mg/kg of MK-801 showed reduced fear, but the groups that had received the higher doses exhibited as much conditioned fear as the saline group, which had not received extinction. This study showed that MK-801 blocked extinction in a dose-dependent manner. The design of the study ruled out the possibility that the effect was due to state-dependency or to MK-801 interfering with the processing of the conditioned stimulus.
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“the consolidation of extinction memories depends on NMDAR-mediated changes in synaptic plasticity (Baker and Azorlosa, 1996; Lee et al., 2006a).”
From Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between (2020) · cites this paper as Baker and Azorlosa, 1996
In the citing paper
“but is in postweaning and adult rats (Baker and Azorlosa, 1996;Langton et al, 2007;Langton and Richardson, 2008).”
From Impaired Extinction Retention in Adolescent Rats: Effects of D-Cycloserine (2010) · cites this paper as Baker and Azorlosa, 1996
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Neural Mechanisms of Extinction Learning and Retrieval
Quirk, G. J., & Mueller, D. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301555 · Cited by 1,645
Optimizing inhibitory learning during exposure therapy
Craske, M. G., Kircanski, K., Zelikowsky, M., Mystkowski, J., Chowdhury, N., & Baker, A. (2008) · Behaviour Research and Therapy · doi:10.1016/j.brat.2007.10.003 · Cited by 1,607
Myers, K. M., & Davis, M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001939 · Cited by 1,277
Pape, H.-C., & Pare, D. (2010) · Physiological Reviews · doi:10.1152/physrev.00037.2009 · Cited by 994
Behavioral and Neural Analysis of Extinction
Myers, K. M., & Davis, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)01064-4 · Cited by 918
Metadata
- Authors
- Baker, J. D., & Azorlosa, J. L.
- Affiliations
- Southeastern Louisiana University (US)
- Venue
- Behavioral Neuroscience
- Published
- 1996-06
- Volume
- 110
- Issue
- 3
- Pages
- 618-620
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2007266319
- Cited by
- 179
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 10 · 2017: 12 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 6 · 2012: 8
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- MK-801, NMDA receptor antagonists, fear conditioning, fear extinction, dose-dependent effects, state dependence
- MeSH terms
- Animals, Avoidance Learning, Conditioning, Classical, Extinction, Psychological, Fear, Male, N-Methylaspartate, Dizocilpine Maleate, Rats, Sprague-Dawley, Rats
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