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The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning.

Baker, Jeffrey D., Azorlosa, Julian L.·1996·Behavioral Neuroscience

DOI 10.1037/0735-7044.110.3.618

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Abstract

Five groups of rats were given Pavlovian fear conditioning. Four groups were then given extinction training. Prior to extinction these groups received an injection of either the noncompetitive NMDA antagonist MK-801 (0.025, 0.05, or 0.1 mg/kg) or saline. The 5th group received saline but no extinction. During testing, the extinction groups given saline or 0.025 mg/kg of MK-801 showed reduced fear, but the groups that had received the higher doses exhibited as much conditioned fear as the saline group, which had not received extinction. This study showed that MK-801 blocked extinction in a dose-dependent manner. The design of the study ruled out the possibility that the effect was due to state-dependency or to MK-801 interfering with the processing of the conditioned stimulus.

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Authors: Baker, J. D., & Azorlosa, J. L.
Affiliations: Southeastern Louisiana University (US)
Venue: Behavioral Neuroscience
Publisher: American Psychological Association (APA)
Published: 1996-06
Volume: 110
Issue: 3
Pages: 618-620
ISSN: 0735-7044 (ISSN-L)
1939-0084
DOI: 10.1037/0735-7044.110.3.618
OpenAlex: W2007266319
Cited by: 179
References: 0
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 10 · 2017: 12 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 6 · 2012: 8
FWCI: 0.71
Type: journal article
Language: en
Open access: closed
Locations: Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: MK-801, NMDA receptor antagonists, fear conditioning, fear extinction, dose-dependent effects, state dependence
MeSH terms: Animals, Avoidance Learning, Conditioning, Classical, Extinction, Psychological, Fear, Male, N-Methylaspartate, Dizocilpine Maleate, Rats, Sprague-Dawley, Rats

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The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning.

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