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Elevated novelty seeking and peculiar d-amphetamine sensitization in periadolescent mice compared with adult mice
Abstract
Novelty seeking as well as amphetamine sensitization were studied in adult (postnatal day "PND" > 60) and periadolescent (PND 3343) mice treated with saline or amphetamine (2 or 10 mg/kg once per day) for 3 days in a familiar environment. After a 48-hr wash-out period, mice were challenged with either saline or amphetamine (2 mg/kg) in the same environment. When given a choice, animals showed a preference for a novel environment, an effect more marked in periadolescents. Acute amphetamine strongly increased novelty seeking in adults, whereas it had an opposite effect in periadolescents. Adult mice in the chronic amphetamine 2 group showed a conditioned preference for the drug-paired compartment, whereas an aversion characterized adult mice in the amphetamine 10 group. Periadolescents in the latter group exhibited a greater sensitization of the locomotor response, but did not show the compulsive licking typical of adults. This appears to be a useful model to study psychobiological risk factors involved in vulnerability to addiction during human adolescence.
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“adolescent rodents exhibit increased reinforcing effects to drugs that influence DA release, such as alcohol, nicotine, amphetamines, and cocaine (Adriani, Chiarotti et al. 1998; Laviola, Adriani et al. 1999; Adriani and Laviola 2000; Badanich, Adler et al. 2006; Shram, Funk et al. 2006; Frantz, O'Dell et al. 2007; Mathews and McCormick 2007; Brenhouse and Andersen 2008; Varlinskaya and Spear 2010”
From Developmental imaging genetics: Linking dopamine function to adolescent behavior (2014) · cites this paper as Adriani, Chiarotti et al. 1998
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Metadata
- Authors
- Adriani, W., Chiarotti, F., & Laviola, G.
- Affiliations
- Istituto Superiore di Sanità (IT)
- Venue
- Behavioral Neuroscience
- Published
- 1998
- Volume
- 112
- Issue
- 5
- Pages
- 1152-1166
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W1993940093
- Cited by
- 247
- References
- 0
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 9 · 2018: 8 · 2017: 6 · 2016: 12 · 2015: 10 · 2014: 12 · 2013: 21 · 2012: 12
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- novelty seeking, amphetamine sensitization, periadolescence, adolescence, addiction vulnerability, locomotor sensitization, drug preference, drug aversion, novelty preference
- MeSH terms
- Aging, Central Nervous System Stimulants, Analysis of Variance, Animals, Body Weight, Corticosterone, Dextroamphetamine, Drug Tolerance, Exploratory Behavior, Grooming, Male, Motor Activity, Repression-Sensitization, Research Design, Multivariate Analysis, Mice
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