The dendritically targeted protein Dendrin is induced by acute nicotine in cortical regions of adolescent rat brain
Open accessAbstract
The response of the brain to addictive substances such as nicotine includes the rapid induction of genes that influence synaptic events. This response is different in adolescent brain, which continues to undergo synaptic remodeling in regions that include reward-associated corticolimbic areas. We report here that acute nicotine (0.4 mg/kg), but not cocaine or exposure to a novel environment, induces the expression of the dendritically targeted, corticolimbic mRNA Dendrin in specific regions of adolescent brain. Acute nicotine resulted in an increase in Dendrin mRNA levels in the adolescent prefrontal cortex that was not evident in adult animals. The induction in Dendrin mRNA was a rapid, short-lived transcriptional event that resulted in changes in Dendrin protein. For example, an increase in Dendrin protein levels following nicotine treatment paralleled enhanced Dendrin immunoreactivity in the dendrites of pyramidal neurons of somatosensory cortex. As Dendrin is an important component of cytoskeletal modifications at the synapse, these results suggest that nicotine influences unique plasticity-related changes in the adolescent forebrain that differ from the adult.
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Dendrin can produce unique plasticity changes in adolescent PFC.
“therefore can lead to unique plasticity changes in the adolescent PFC (Schochet et al. 2008).”
From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Schochet et al. 2008
In “Dendrin expression may underscore plastic events at the synapse,” the paper links nicotine-induced Dendrin in adolescent brain regions to possible unique structural plasticity events. Its Conclusion says Dendrin induction in adolescent prefrontal regions may reflect nicotine’s influence on plasticity mechanisms. It does not establish that Dendrin itself produces those changes, and the claim omits the nicotine-exposure condition. (LLM, conf=0.87)
Experimental — accuracy not yet measuredDendrin is an important component of synaptic cytoskeletal modifications.
“Dendrin is an important component of cytoskeletal modifications at the synapse”
From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Schochet et al. 2008
In “Dendrin expression may underscore plastic events at the synapse” (page not supplied), the paper links Dendrin to synaptic plasticity and notes its association with a synaptic cytoskeletal protein. It also says Dendrin’s precise role is less well understood, so the body text does not establish that it is an important component of cytoskeletal modifications. (LLM, conf=0.84)
Experimental — accuracy not yet measuredAcute nicotine increases dendrin mRNA expression in PFC of adolescent but not adult animals.
“Acute nicotine induces increases in the expression of the dendritically targeted dendrin mRNA in PFC of adolescent but not adult animals.”
From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Schochet et al. 2008
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“Dendrin is an important component of cytoskeletal modifications at the synapse and therefore can lead to unique plasticity changes in the adolescent PFC (Schochet et al. 2008).”
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Multidimensional Intersection of Nicotine, Gene Expression, and Behavior
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- Authors
- Schochet, T. L., Bremer, Q. Z., Brownfield, M. S., Kelley, A. E., & Landry, C. F.
- Affiliations
- University of Wisconsin–Madison (US)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2008-11
- Volume
- 28
- Issue
- 10
- Pages
- 1967-1979
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2079518649
- Cited by
- 14
- References
- 86
- Citations by year
- 2023: 1 · 2021: 2 · 2020: 1 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (1 R24 MH 67346-01, R24MH067346)
- National Institute on Drug Abuse (DA19153, R01DA019153, DA00003, F31DA014464, DA14464)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- adolescent brain, prefrontal cortex, somatosensory cortex, dendritic cytoskeleton, synaptic plasticity, gene induction, corticolimbic system, pyramidal neurons, nicotine dependence, cocaine, novel environment
- MeSH terms
- Age Factors, Aging, Animals, Cerebral Cortex, Cytoskeleton, Dendrites, Disease Models, Animal, Environment, Controlled, Exploratory Behavior, Male, Nerve Tissue Proteins, Neuronal Plasticity, Nicotine, Tobacco Use Disorder, Rats, Sprague-Dawley, Nicotinic Agonists, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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