Cited by 14Neuroscience and Neuropharmacology ResearchNicotinic Acetylcholine Receptors StudyNeurotransmitter Receptor Influence on Behavior

The dendritically targeted protein Dendrin is induced by acute nicotine in cortical regions of adolescent rat brain

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Schochet, Terri L., Bremer, Quentin Z., Brownfield, Mark S., Kelley, Ann E., Landry, Charles F.·2008·European Journal of Neuroscience

Abstract

The response of the brain to addictive substances such as nicotine includes the rapid induction of genes that influence synaptic events. This response is different in adolescent brain, which continues to undergo synaptic remodeling in regions that include reward-associated corticolimbic areas. We report here that acute nicotine (0.4 mg/kg), but not cocaine or exposure to a novel environment, induces the expression of the dendritically targeted, corticolimbic mRNA Dendrin in specific regions of adolescent brain. Acute nicotine resulted in an increase in Dendrin mRNA levels in the adolescent prefrontal cortex that was not evident in adult animals. The induction in Dendrin mRNA was a rapid, short-lived transcriptional event that resulted in changes in Dendrin protein. For example, an increase in Dendrin protein levels following nicotine treatment paralleled enhanced Dendrin immunoreactivity in the dendrites of pyramidal neurons of somatosensory cortex. As Dendrin is an important component of cytoskeletal modifications at the synapse, these results suggest that nicotine influences unique plasticity-related changes in the adolescent forebrain that differ from the adult.

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Crossref · 10.1111/j.1460-9568.2008.06483.x

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  • Dendrin can produce unique plasticity changes in adolescent PFC.

    “therefore can lead to unique plasticity changes in the adolescent PFC (Schochet et al. 2008).”

    From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Schochet et al. 2008

    In “Dendrin expression may underscore plastic events at the synapse,” the paper links nicotine-induced Dendrin in adolescent brain regions to possible unique structural plasticity events. Its Conclusion says Dendrin induction in adolescent prefrontal regions may reflect nicotine’s influence on plasticity mechanisms. It does not establish that Dendrin itself produces those changes, and the claim omits the nicotine-exposure condition. (LLM, conf=0.87)

    Experimental — accuracy not yet measured
  • Dendrin is an important component of synaptic cytoskeletal modifications.

    “Dendrin is an important component of cytoskeletal modifications at the synapse”

    From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Schochet et al. 2008

    In “Dendrin expression may underscore plastic events at the synapse” (page not supplied), the paper links Dendrin to synaptic plasticity and notes its association with a synaptic cytoskeletal protein. It also says Dendrin’s precise role is less well understood, so the body text does not establish that it is an important component of cytoskeletal modifications. (LLM, conf=0.84)

    Experimental — accuracy not yet measured
  • Acute nicotine increases dendrin mRNA expression in PFC of adolescent but not adult animals.

    “Acute nicotine induces increases in the expression of the dendritically targeted dendrin mRNA in PFC of adolescent but not adult animals.”

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Research works printed but not linked: 1

  1. Paxinos, G. & Watson, C. (1998) The rat brain in stereotaxic coordinates. Academic Press, New York.

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Authors
Schochet, T. L., Bremer, Q. Z., Brownfield, M. S., Kelley, A. E., & Landry, C. F.
Affiliations
University of Wisconsin–Madison (US)
Venue
European Journal of Neuroscience
Publisher
Wiley
Published
2008-11
Volume
28
Issue
10
Pages
1967-1979
ISSN
  • 0953-816X (ISSN-L)
  • 1460-9568
OpenAlex
W2079518649
Cited by
14
References
86
Citations by year
2023: 1 · 2021: 2 · 2020: 1 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 2
FWCI
0.29
Type
journal article
Language
en
Open access
Locations
  • European Journal of Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (1 R24 MH 67346-01, R24MH067346)
  • National Institute on Drug Abuse (DA19153, R01DA019153, DA00003, F31DA014464, DA14464)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
adolescent brain, prefrontal cortex, somatosensory cortex, dendritic cytoskeleton, synaptic plasticity, gene induction, corticolimbic system, pyramidal neurons, nicotine dependence, cocaine, novel environment
MeSH terms
Age Factors, Aging, Animals, Cerebral Cortex, Cytoskeleton, Dendrites, Disease Models, Animal, Environment, Controlled, Exploratory Behavior, Male, Nerve Tissue Proteins, Neuronal Plasticity, Nicotine, Tobacco Use Disorder, Rats, Sprague-Dawley, Nicotinic Agonists, Rats

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