Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats
Abstract
The contribution to fear and fear learning of amygdala Group II metabotropic glutamate receptors was examined in rats. Pretest intra-amygdala infusions of the Group II receptor agonist LY354740 (0.3 or 1.0 microg/side) significantly disrupted fear-potentiated startle. The same rats were unimpaired when later tested without drug. The Group II receptor agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (3.0 microg/side) mimicked the effect of LY354740, and coadministration of the Group II receptor antagonist LY341495 (0.3 microg/side) prevented it. Pretraining LY354740 (0.3 microg/side) infusions also blocked learning. The effects on learning and performance were significantly less pronounced in rats with misplaced cannulas. Thus, Group II metabotropic receptors within or very near the amygdala regulate fear and fear learning and are a potential target for anxiolytic compounds.
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Agonism of Group II metabotropic receptors disrupts the fear-potentiated startle response in mice, suggesting that these receptors regulate the learning of fearful experiences.
“Agonism of Group II metabotropic receptors disrupts the fear-potentiated startle response in mice, suggesting that these receptors regulate the learning of fearful experiences (Walker et al., 2002).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Walker et al., 2002
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Barker, I., CleaWarburton, E., Robinson, J., & Collingridge, G. L. (2011)
- Authors
- Walker, D. L., Rattiner, L. M., & Davis, M.
- Affiliations
- Emory University (US)
- ORCID
- Walker, David L.
- Venue
- Behavioral Neuroscience
- Published
- 2002
- Volume
- 116
- Issue
- 6
- Pages
- 1075-1083
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2037270039
- Cited by
- 53
- References
- 40
- Citations by year
- 2023: 2 · 2022: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH59906, MH-57250, R01MH057250, P50MH052384, R01MH059906, P50MH058922, MH58922, MH 47840, MH-52384)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- group II metabotropic glutamate receptors, amygdala, fear, fear-potentiated startle, fear learning, LY354740, LY341495, anxiolytics, intracerebral infusion
- MeSH terms
- Amygdala, Animals, Avoidance Learning, Bridged Bicyclo Compounds, Fear, Male, Reflex, Startle, Stereoisomerism, Anti-Anxiety Agents, Rats, Sprague-Dawley, Receptors, Metabotropic Glutamate, Rats
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