The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Corticosterone Increases Depression-Like Behavior, With Some Effects on Predator Odor-Induced Defensive Behavior, in Male and Female Rats.
Abstract
This experiment examined the effect of repeated corticosterone injections on anxiety and depression-like behavior in male and female rats. Rats received either corticosterone or vehicle injections for 21 consecutive days prior to behavioral testing in the forced swim, open-field, and predator odor tests. The corticosterone injections significantly increased depression-like behavior in the forced swim test in both male and female rats but had no significant effect on anxiety in the open-field test. In the predator odor test, the corticosterone injections significantly increased a subset of defensive behaviors in the male rats. These results suggest that repeated exposure to corticosterone increases depression-like behavior, with some effects on anxiety, and that male rats may be more affected than female rats by this manipulation.
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Cites
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“, restraint stress, repeated CORT injections, CORT pellets) produces clear neural changes within the hippocampus, such as cell loss, decreased neurogenesis, increased dendritic atrophy, and disrupted serotonergic functioning (Karten et al., 1999; Magarinos & McEwen, 1995; Pham et al., 2003; Sapolsky, 2000; Sousa et al…”
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Cited by
Postpartum depression: Etiology, treatment and consequences for maternal care
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The Rodent Forced Swim Test Measures Stress-Coping Strategy, Not Depression-like Behavior
Commons, K. G., Cholanians, A. B., Babb, J. A., & Ehlinger, D. G. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00042 · Cited by 525
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Self-citationMetabolic disturbances connecting obesity and depression
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The future of rodent models in depression research
Gururajan, A., Reif, A., Cryan, J. F., & Slattery, D. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0221-6 · Cited by 269
Metadata
- Authors
- Kalynchuk, L. E., Gregus, A., Boudreau, D., & Perrot-Sinal, T. S.
- Venue
- Behavioral Neuroscience
- Published
- 2004
- Volume
- 118
- Issue
- 6
- Pages
- 1365-1377
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2003164705
- Cited by
- 189
- References
- 14
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kalynchuk, L. E., Gregus, A., Boudreau, D., & Perrot-Sinal, T. S. (2004). Corticosterone Increases Depression-Like Behavior, With Some Effects on Predator Odor-Induced Defensive Behavior, in Male and Female Rats. Behavioral Neuroscience. https://doi.org/10.1037/0735-7044.118.6.1365
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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