Metabolic disturbances connecting obesity and depression
Open accessAbstract
Obesity markedly increases the odds of developing depression. Depressed mood not only impairs motivation, quality of life and overall functioning but also increases the risks of obesity complications. Abdominal obesity is a better predictor of depression and anxiety risk than overall adipose mass. A growing amount of research suggests that metabolic abnormalities stemming from central obesity that lead to metabolic disease may also be responsible for the increased incidence of depression in obesity. As reviewed here, a higher mass of dysfunctional adipose tissue is associated with several metabolic disturbances that are either directly or indirectly implicated in the control of emotions and mood. To better comprehend the development of depression in obesity, this review pulls together select findings addressing the link between adiposity, diet and negative emotional states and discusses the evidence that alterations in glucocorticoids, adipose-derived hormones, insulin and inflammatory signaling that are characteristic of central obesity may be involved.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Increased cardio-metabolic dysfunction has been associated with worse mental and cognitive symptoms in people with schizophrenia, major depressive disorder, bipolar disorder and binge eating disorder.
“Moreover, increased cardio-metabolic dysfunction has been associated with worse mental and cognitive symptoms in those with schizophrenia [98], MDD [99], bipolar disorder [100] and binge eating disorder [101].”
From Exercise as Medicine for Mental and Substance Use Disorders: A Meta-review of the Benefits for Neuropsychiatric and Cognitive Outcomes (2020) · cites this paper as [99]
The Insulin section reports that, in patients with MDD and abdominal obesity or metabolic syndrome, reduced insulin resistance correlated with reduced depressive symptoms. This supports the association with mental symptoms for the MDD portion of the sentence, which cites this paper as [99]. The passages do not establish an association with worse cognitive symptoms in people with MDD; the other diagnoses have separate citations. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257 · see citing works
RetractedYaşlı Kadınlarda Üreme Sağlığı
Kokanalı, D., & Engin Üstün, Y. (n.d.) · DergiPark (Istanbul University) · Cited by 170,090 · see citing works
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856 · see citing works
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755 · see citing works
Colman (2022) · doi:10.1073/pnas · Cited by 4,370 · see citing works
Abdominal obesity and metabolic syndrome
Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354 · see citing works
Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies
Luppino, F. S., de Wit, L. M., Bouvy, P. F., Stijnen, T., Cuijpers, P., Penninx, B. W. J. H., & Zitman, F. G. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.2 · Cited by 4,322 · see citing works
The Prevalence of Comorbid Depression in Adults With Diabetes
Anderson, R. J., Freedland, K. E., Clouse, R. E., & Lustman, P. J. (2001) · Diabetes Care · doi:10.2337/diacare.24.6.1069 · Cited by 3,926 · see citing works
Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine · doi:10.1038/nm1195-1155 · Cited by 3,725 · see citing works
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889 · see citing works
Pathophysiology of human visceral obesity: an update
Tchernof, A., & Després, J.-P. (2013) · Physiological Reviews · doi:10.1152/physrev.00033.2011 · Cited by 2,583 · see citing works
Changes in diet and lifestyle and long-term weight gain in women and men
Mozaffarian, D., Hao, T., Rimm, E. B., Willett, W. C., & Hu, F. B. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1014296 · Cited by 2,527 · see citing works
The Corticosteroid Receptor Hypothesis of Depression
Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181 · see citing works
Obesity is associated with hypothalamic injury in rodents and humans.
Thaler, J. P., Yi, C.-X., Schur, E. A., Guyenet, S. J., Hwang, B. H., Dietrich, M. O., Zhao, X., Sarruf, D. A., Izgur, V., Maravilla, K. R., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59660 · Cited by 1,857 · see citing works
Stress, eating and the reward system
Adam, T. C., & Epel, E. S. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.011 · Cited by 1,732 · see citing works
Maeda, N., Takahashi, M., Funahashi, T., Kihara, S., Nishizawa, H., Kishida, K., Nagaretani, H., Matsuda, M., Komuro, R., Ouchi, N., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.9.2094 · Cited by 1,659 · see citing works
Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586 · see citing works
Cnop, M., Havel, P. J., Utzschneider, K. M., Carr, D. B., Sinha, M. K., Boyko, E. J., Retzlaff, B. M., Knopp, R. H., Brunzell, J. D., & Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-003-1074-z · Cited by 1,483 · see citing works
How emotions affect eating: a five-way model
Macht, M. (2008) · Appetite · doi:10.1016/j.appet.2007.07.002 · Cited by 1,396 · see citing works
Chronic stress and obesity: a new view of “comfort food”
Dallman, M. F., Pecoraro, N., Akana, S. F., la Fleur, S. E., Gomez, F., Houshyar, H., Bell, M. E., Bhatnagar, S., Laugero, K. D., & Manalo, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1934666100 · Cited by 1,369 · see citing works
Avena, N. M., Rada, P., & Hoebel, B. G. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.019 · Cited by 1,358 · see citing works
Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity
Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., & Cai, D. (2008) · Cell · doi:10.1016/j.cell.2008.07.043 · Cited by 1,350 · see citing works
Association between obesity and psychiatric disorders in the US adult population
Simon, G. E., Von Korff, M., Saunders, K., Miglioretti, D. L., Crane, P. K., van Belle, G., & Kessler, R. C. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.7.824 · Cited by 1,338 · see citing works
Raison, C. L., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1554 · Cited by 1,197 · see citing works
Immune system to brain signaling: Neuropsychopharmacological implications
Capuron, L., & Miller, A. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.014 · Cited by 1,195 · see citing works
De Souza, C. T., Araujo, E. P., Bordin, S., Ashimine, R., Zollner, R. L., Boschero, A. C., Saad, M. J. A., & Velloso, L. A. (2005) · Endocrinology · doi:10.1210/en.2004-1520 · Cited by 1,171 · see citing works
Stetler, C., & Miller, G. E. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820ad12b · Cited by 1,123 · see citing works
Paroxetine for the prevention of depression induced by high-dose interferon alfa.
Musselman, D. L., Lawson, D. H., Gumnick, J. F., Manatunga, A. K., Penna, S., Goodkin, R. S., Greiner, K., Nemeroff, C. B., & Miller, A. H. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103293441303 · Cited by 1,120 · see citing works
The endocannabinoid system and the brain.
Mechoulam, R., & Parker, L. A. (2013) · Annual Review of Psychology · doi:10.1146/annurev-psych-113011-143739 · Cited by 1,090 · see citing works
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Hommel, J. D., Trinko, R., Sears, R. M., Georgescu, D., Liu, Z.-W., Gao, X.-B., Thurmon, J. J., Marinelli, M., & DiLeone, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.023 · Cited by 902 · see citing works
IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862 · see citing works
Ye, J., Gao, Z., Yin, J., & He, Q. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00435.2007 · Cited by 840 · see citing works
Stress-induced obesity and the emotional nervous system
Dallman, M. F. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.10.004 · Cited by 814 · see citing works
Emotional influences on food choice: Sensory, physiological and psychological pathways
Gibson, E. L. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.01.024 · Cited by 783 · see citing works
Adiponectin as a Biomarker of the Metabolic Syndrome
Ryo, M., Nakamura, T., Kihara, S., Kumada, M., Shibazaki, S., Takahashi, M., Nagai, M., Matsuzawa, Y., & Funahashi, T. (2004) · Circulation Journal · doi:10.1253/circj.68.975 · Cited by 773 · see citing works
Goshen, I., Kreisel, T., Ben-Menachem-Zidon, O., Licht, T., Weidenfeld, J., Ben-Hur, T., & Yirmiya, R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002055 · Cited by 762 · see citing works
Intranasal insulin improves memory in humans
Benedict, C., Hallschmid, M., Hatke, A., Schultes, B., Fehm, H. L., Born, J., & Kern, W. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.04.003 · Cited by 699 · see citing works
Perceived Effects of Stress on Food Choice
Oliver, G. D., & WARDLE, J. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00322-9 · Cited by 684 · see citing works
Western diet consumption and cognitive impairment: Links to hippocampal dysfunction and obesity
Kanoski, S. E., & Davidson, T. L. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.12.003 · Cited by 674 · see citing works
Prospective association between obesity and depression: evidence from the Alameda County Study
Roberts, R. E., Deleger, S., Strawbridge, W. J., & Kaplan, G. A. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802204 · Cited by 674 · see citing works
Chronic stress and comfort foods: Self-medication and abdominal obesity
Dallman, M. F., Pecoraro, N. C., & la Fleur, S. E. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2004.11.004 · Cited by 656 · see citing works
Leptin Regulation of the Mesoaccumbens Dopamine Pathway
Fulton, S., Pissios, P., Manchon, R. P., Stiles, L., Frank, L., Pothos, E. N., Maratos-Flier, E., & Flier, J. S. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.006 · Cited by 644 · see citing works
Self-citationAdiponectin: mechanistic insights and clinical implications
Turer, A. T., & Scherer, P. E. (2012) · Diabetologia · doi:10.1007/s00125-012-2598-x · Cited by 636 · see citing works
Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior
Koo, J. W., Russo, S. J., Ferguson, D., Nestler, E. J., & Duman, R. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910658107 · Cited by 607 · see citing works
Association of depression with medical illness: Does cortisol play a role?
Brown, E. S., Varghese, F. P., & McEwen, B. S. (2004) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00473-6 · Cited by 578 · cited 1× · see citing works
“Excess systemic cortisol has been shown to result in a 2- to 5-fold increase in visceral adipose tissue (Brown et al., 2004), and as such FIGURE 1 | Metabolic signals and disturbances linking obesity and abdominal adiposity with depression.”
BackgroundDepletion of Omega-3 Fatty Acid Levels in Red Blood Cell Membranes of Depressive Patients
Peet, M., Murphy, B., Shay, J., & Horrobin, D. F. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00206-0 · Cited by 578 · see citing works
Pecoraro, N., Reyes, F., Gomez, F., Bhargava, A., & Dallman, M. F. (2004) · Endocrinology · doi:10.1210/en.2004-0305 · Cited by 574 · see citing works
Micha, R., & Mozaffarian, D. (2010) · Lipids · doi:10.1007/s11745-010-3393-4 · Cited by 543 · see citing works
The neurobiology of depression and antidepressant action
Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works
Elevated C-Reactive Protein Levels, Psychological Distress, and Depression in 73 131 Individuals
Wium-Andersen, M. K., Ørsted, D. D., Nielsen, S. F., & Nordestgaard, B. G. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.102 · Cited by 489 · see citing works
Kleinridders, A., Schenten, D., Könner, A. C., Belgardt, B. F., Mauer, J., Okamura, T., Wunderlich, F. T., Medzhitov, R., & Brüning, J. C. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.013 · Cited by 483 · see citing works
Lin, P.-Y., & Su, K.-P. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0712 · Cited by 481 · see citing works
Serum Resistin (FIZZ3) Protein Is Increased in Obese Humans
Degawa‐Yamauchi, M., Bovenkerk, J. E., Juliar, B. E., Watson, W., Kerr, K. A., Jones, R., Zhu, Q., & Considine, R. V. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021808 · Cited by 475 · see citing works
(2005) · PubMed · Cited by 470 · see citing works
Cytokines as mediators of depression: what can we learn from animal studies?
Dunn, A. J., Swiergiel, A. H., & Beaurepaire, R. D. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.023 · Cited by 459 · see citing works
Neuroendocrine aspects of hypercortisolism in major depression
Parker, K. J., Schatzberg, A. F., & Lyons, D. M. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(02)00016-8 · Cited by 455 · see citing works
Leptin: A potential novel antidepressant
Lu, X.-Y., Kim, C. S., Frazer, A., & Zhang, W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508901103 · Cited by 446 · see citing works
Stress hormones: physiological stress and regulation of metabolism
Kyrou, I., & Tsigos, C. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.08.007 · Cited by 440 · see citing works
Gregus, A., Wintink, A. J., Davis, A. C., & Kalynchuk, L. E. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.05.013 · Cited by 435 · see citing works
Stress, stress hormones, and adult neurogenesis
Schoenfeld, T. J., & Gould, E. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.01.008 · Cited by 425 · see citing works
Sharma, S., & Fulton, S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.48 · Cited by 424 · see citing works
Self-citationWay, J. M., Görgün, C. Z., Tong, Q., Uysal, K. T., Brown, K. K., Harrington, W. W., Oliver, W. R., Willson, T. M., Kliewer, S. A., & Hotamışlıgil, G. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100189200 · Cited by 414 · see citing works
Epigenetics of the depressed brain: role of histone acetylation and methylation
Sun, H., Kennedy, P. J., & Nestler, E. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.73 · Cited by 413 · see citing works
Heilig, M. A., S�derpalm, B., Engel, J. A., & Widerl�v, E. (1989) · Psychopharmacology · doi:10.1007/bf00441953 · Cited by 390 · see citing works
Boyle, M. P., Brewer, J. A., Funatsu, M., Wozniak, D. F., Tsien, J. Z., Izumi, Y., & Muglia, L. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406458102 · Cited by 378 · see citing works
Piazza, P. V., & Moal, M. L. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(97)00025-8 · Cited by 375 · see citing works
A Systematic Review and Meta-analysis of the Association Between Depression and Insulin Resistance
Kan, C., Silva, N., Golden, S. H., Rajala, U., Timonen, M., Stahl, D. R., & Ismail, K. (2013) · Diabetes Care · doi:10.2337/dc12-1442 · Cited by 363 · see citing works
Cerebrospinal Cytokine Levels in Patients with Acute Depression
Levine, J., Barak, Y., Chengappa, K. N. R., Rapoport, A., Rebey, M., & Barak, V. (1999) · Neuropsychobiology · doi:10.1159/000026615 · Cited by 354 · see citing works
Benoit, S. C., Kemp, C. J., Elias, C. F., Abplanalp, W., Herman, J. P., Migrenne, S., Lefevre, A.-L., Cruciani-Guglielmacci, C., Magnan, C., Yu, F., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36714 · Cited by 351 · see citing works
Stress and dietary practices in adolescents.
Cartwright, M., Wardle, J., Steggles, N., Simon, A. E., Croker, H. A., & Jarvis, M. J. (2003) · Health Psychology · doi:10.1037/0278-6133.22.4.362 · Cited by 327 · see citing works
Insulin resistance in the nervous system
Kim, B., & Feldman, E. L. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.12.004 · Cited by 321 · see citing works
Intranasal Treatment of Central Nervous System Dysfunction in Humans
Chapman, C. D., Frey, W. H., Craft, S., Danielyan, L., Hallschmid, M., Schiöth, H. B., & Benedict, C. (2013) · Pharmaceutical Research · doi:10.1007/s11095-012-0915-1 · Cited by 310 · see citing works
High Adiponectin Concentrations Are Associated with the Metabolically Healthy Obese Phenotype
Aguilar-Salinas, C. A., García, E. G., Robles, L., Barros, D. A. R., Ruiz-Gómez, D. G., García-Ulloa, A. C., Melgarejo-Hernández, M. A., Zamora, M., Guillén-Pineda, L. E., Mehta, R., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2724 · Cited by 303 · see citing works
Human resistin: found in translation from mouse to man
Schwartz, D. R., & Lazar, M. A. (2011) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.03.005 · Cited by 297 · see citing works
Trans fatty acids: effects on metabolic syndrome, heart disease and diabetes
Micha, R., & Mozaffarian, D. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.79 · Cited by 290 · see citing works
Avena, N. M., Bocarsly, M. E., Rada, P., Kim, A., & Hoebel, B. G. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.01.008 · Cited by 277 · see citing works
Dietary treatment of the metabolic syndrome — the optimal diet
Riccardi, G., & Rivellese, A. A. (2000) · British Journal of Nutrition · doi:10.1017/s0007114500001082 · Cited by 265 · see citing works
Bidirectional association between depression and obesity in middle–aged and older women
Pan, A., Sun, Q., Czernichow, S., Kivimaki, M., Okereke, O. I., Lucas, M., Manson, J. E., Ascherio, A., & Hu, F. B. (2012) · International Journal of Obesity · doi:10.1038/ijo.2011.111 · Cited by 264 · see citing works
TNFα Signaling in Depression and Anxiety: Behavioral Consequences of Individual Receptor Targeting
Simen, B. B., Duman, C. H., Simen, A. A., & Duman, R. S. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.013 · Cited by 249 · see citing works
Glucocorticoid receptor overexpression in forebrain: A mouse model of increased emotional lability
Wei, Q., Lu, X., Liu, L., Schafer, G. L., Shieh, K.-R., Burke, S., Robinson, T. E., Watson, S. J., Seasholtz, A. F., & Akil, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402208101 · Cited by 249 · see citing works
Impaired CNS Leptin Action Is Implicated in Depression Associated with Obesity
Yamada, N., Katsuura, G., Ochi, Y., Ebihara, K., Kusakabe, T., Hosoda, K., & Nakao, K. (2011) · Endocrinology · doi:10.1210/en.2011-0004 · Cited by 247 · see citing works
11β-Hydroxysteroid dehydrogenases and the brain: From zero to hero, a decade of progress
Wyrwoll, C. S., Holmes, M. C., & Seckl, J. R. (2011) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.12.001 · Cited by 244 · see citing works
Possible mechanisms for atrophy of the human hippocampus
McEwen, B. S. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000254 · Cited by 243 · see citing works
Marks, D. R., Tucker, K., Cavallin, M. A., Mast, T. G., & Fadool, D. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.1350-09.2009 · Cited by 242 · see citing works
Challenges and Opportunities of Defining Clinical Leptin Resistance
Myers, M. G., Heymsfield, S. B., Haft, C. R., Kahn, B. B., Laughlin, M. R., Leibel, R. L., Tschöp, M. H., & Yanovski, J. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.002 · Cited by 241 · see citing works
Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids
Labouèbe, G., Liu, S., Dias, C., Zou, H., Wong, J. C. Y., Karunakaran, S., Clee, S. M., Phillips, A. G., Boutrel, B., & Borgland, S. L. (2013) · Nature Neuroscience · doi:10.1038/nn.3321 · Cited by 239 · see citing works
Relationship of obesity to depression: a family-based study
Dong, C., Sanchez, L. E., & Price, R. A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802626 · Cited by 234 · see citing works
The stress-eating paradox: Multiple daily measurements in adult males and females
Stone, A. A., & Brownell, K. D. (1994) · Psychology and Health · doi:10.1080/08870449408407469 · Cited by 233 · see citing works
Sharma, S., Fernandes, M. F., & Fulton, S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.197 · Cited by 231 · cited 3× · see citing works
“…to a more moderate gain in weight (∼11% relative to low-fat diet controls) and without influencing basal corticosterone levels, produced sucrose anhedonia (reduced ability to experience pleasure/reward), anxiety-like behavior and heightened stress-induced HPA activation (Sharma et al., 2012).”
BackgroundPleasurable behaviors reduce stress via brain reward pathways
Ulrich-Lai, Y. M., Christiansen, A. M., Ostrander, M. M., Jones, A. A., Jones, K. R., Choi, D. C., Krause, E. G., Evanson, N. K., Furay, A. R., Davis, J. F., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007740107 · Cited by 231 · see citing works
Romaguera, D., Norat, T., Vergnaud, A., Mouw, T., May, A. M., Agudo, A., Buckland, G., Slimani, N., Rinaldi, S., Couto, E., et al. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29482 · Cited by 227 · see citing works
Dietary Patterns and Changes in Body Weight in Women
Schulze, M. B., Fung, T. T., Manson, J. E., Willett, W. C., & Hu, F. B. (2006) · Obesity · doi:10.1038/oby.2006.164 · Cited by 220 · see citing works
Hypercortisolemic Depression Is Associated With Increased Intra-Abdominal Fat
Weber-Hamann, B., Hentschel, F., Kniest, A., Deuschle, M., Colla, M., Lederbogen, F., & Heuser, I. (2002) · Psychosomatic Medicine · doi:10.1097/00006842-200203000-00010 · Cited by 219 · see citing works
Are Stress Eaters at Risk for the Metabolic Syndrome?
EPEL, E., JIMENEZ, S., BROWNELL, K., STROUD, L., STONEY, C., & NIAURA, R. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.022 · Cited by 219 · see citing works
Zhao, G., Ford, E. S., Li, C., Tsai, J., Dhingra, S., & Balluz, L. S. (2011) · BMC Psychiatry · doi:10.1186/1471-244x-11-130 · Cited by 214 · see citing works
Novick, J. S., Stewart, J. W., Wisniewski, S. R., Cook, I. A., Manev, R. M., Nierenberg, A. A., Rosenbaum, J. F., Shores‐Wilson, K., Balasubramani, G. K., Biggs, M. M., et al. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0807 · Cited by 211 · see citing works
Overweight and Obesity Affect Treatment Response in Major Depression
Kloiber, S., Ising, M., Reppermund, S., Horstmann, S., Dose, T., Majer, M., Zihl, J., Pfister, H., Unschuld, P. G., Holsboer, F., et al. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.001 · Cited by 208 · see citing works
Rozeboom, A. M., Akil, H., & Seasholtz, A. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606067104 · Cited by 206 · see citing works
Leptin and cholesterol levels are low in major depressive disorder, but high in schizophrenia
Jow, G., Yang, T., & Chen, C.-L. (2005) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.09.015 · Cited by 200 · see citing works
Resistin and Adiponectin Expression in Visceral Fat of Obese Rats: Effect of Weight Loss
Milan, G., Granzotto, M., Scarda, A., Calcagno, A., Pagano, C., Federspil, G., & Vettor, R. (2002) · Obesity Research · doi:10.1038/oby.2002.149 · Cited by 199 · see citing works
Glucocorticoids, chronic stress, and obesity
Dallman, M. F., Pecoraro, N. C., La Fleur, S. E., Warne, J. P., Ginsberg, A. B., Akana, S. F., Laugero, K. C., Houshyar, H., Strack, A. M., Bhatnagar, S., et al. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)53004-3 · Cited by 198 · see citing works
CRF system recruitment mediates dark side of compulsive eating
Cottone, P., Sabino, V., Roberto, M., Bajo, M., Pockros, L., Frihauf, J. B., Fekete, E. M., Steardo, L., Rice, K. C., Grigoriadis, D. E., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908789106 · Cited by 192 · see citing works
Liu, J., Guo, M., Zhang, D., Cheng, S.-Y., Liu, M., Ding, J., Scherer, P. E., Liu, F., & Lu, X. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202835109 · Cited by 191 · see citing works
Kalynchuk, L. E., Gregus, A., Boudreau, D., & Perrot-Sinal, T. S. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.6.1365 · Cited by 188 · see citing works
C-Reactive Protein Increases BBB Permeability: Implications for Obesity and Neuroinflammation
Hsuchou, H., Kastin, A. J., Mishra, P. K., & Pan, W. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000343302 · Cited by 188 · see citing works
Romaguera, D., Norat, T., Mouw, T., May, A. M., Bamia, C., Slimani, N., Travier, N., Besson, H., Luan, J., Wareham, N., et al. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.108902 · Cited by 183 · see citing works
Heilig, M. A. (1995) · Regulatory Peptides · doi:10.1016/0167-0115(95)00103-i · Cited by 182 · see citing works
Low Leptin Levels but Norma Body Mass Indices in Patients with Depression or Schizophrenia
Kraus, T., Haack, M., Schuld, A., et al. (2001) · Neuroendocrinology · doi:10.1159/000054641 · Cited by 181 · see citing works
Long chain omega-3 fatty acids intake, fish consumption and mental disorders in the SUN cohort study
Sánchez‐Villegas, A., Henríquez, P., Figueiras, A., Ortuño, F., Lahortiga‐Ramos, F., & Martínez‐González, M. Á. (2007) · European Journal of Nutrition · doi:10.1007/s00394-007-0671-x · Cited by 181 · see citing works
Neurobehavioral deficits in db/db diabetic mice
Sharma, A. N., Elased, K. M., Garrett, T. L., & Lucot, J. B. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.07.002 · Cited by 180 · see citing works
Heilig, M., Zachrisson, O., Thorsell, A., Ehnvall, A., Mottagui-Tabar, S., Sjögren, M., Åsberg, M., Ekman, R., Wahlestedt, C., & Ågren, H. (2004) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(03)00101-8 · Cited by 177 · see citing works
Metabolic Syndrome Predisposes to Depressive Symptoms
Koponen, H., Jokelainen, J. J., Keinanen-Kiukaanniemi, S. M., Kumpusalo, E. A., & Vanhala, M. J. (2008) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v69n0202 · Cited by 177 · see citing works
Maniam, J., & Morris, M. J. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.10.013 · Cited by 173 · see citing works
Boyle, M. P., Kolber, B. J., Vogt, S. K., Wozniak, D. F., & Muglia, L. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2173-05.2006 · Cited by 172 · see citing works
Huang, Q., Rivest, R., & Richard, D. (1998) · Endocrinology · doi:10.1210/endo.139.4.5889 · Cited by 166 · see citing works
Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine
Liu, J., Garza, J. C., Bronner, J., Kim, C. S., Zhang, W., & Lu, X. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1684-3 · Cited by 163 · see citing works
Bremner, J. D. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706778559309 · Cited by 163 · see citing works
High-fat diet selectively protects against the effects of chronic social stress in the mouse
Finger, B. C., Dinan, T. G., & Cryan, J. F. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.06.072 · Cited by 161 · see citing works
Ko, W. K. D., Li, Q., & Bézard, E. (2014) · INRIA a CCSD electronic archive server · doi:10.1016/j.neulet · Cited by 160 · see citing works
Fulton, S. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.003 · Cited by 158 · see citing works
Self-citationDiet, a new target to prevent depression?
Sánchez‐Villegas, A., & Martínez‐González, M. Á. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-3 · Cited by 156 · see citing works
Association Between Metabolic Syndrome and Depressive Symptoms in Middle-Aged Adults
Akbaraly, T. N., Mika Kivimaki, B., Brunner, E. J., Chandola, T., Marmot, M. G., Singh‐Manoux, A., & Ferrie, J. E. (2008) · Diabetes Care · doi:10.2337/dc08-1358 · Cited by 155 · see citing works
Clinical Correlates of Major Depression in Cushing’s Disease
Sonino, N., Fava, G. A., Raffi, A. R., Boscaro, M., & Fallo, F. (1998) · Psychopathology · doi:10.1159/000029054 · Cited by 150 · see citing works
Choice of Lard, But Not Total Lard Calories, Damps Adrenocorticotropin Responses to Restraint
la Fleur, S. E., Houshyar, H., Roy, M., & Dallman, M. F. (2005) · Endocrinology · doi:10.1210/en.2004-1603 · Cited by 148 · see citing works
Kraus, T., Haack, M., Schuld, A., Hinze-Selch, D., Koethe, D., & Pollmächer, T. (2002) · Pharmacopsychiatry · doi:10.1055/s-2002-36390 · Cited by 144 · see citing works
Tryon, M. S., DeCant, R., & Laugero, K. D. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.02.018 · Cited by 143 · see citing works
Collin, M., Ovesjö, M., Misane, I., Ögren, S. O., & Meister, B. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00167-4 · Cited by 132 · see citing works
Hanley, A. J., Bowden, D. W., Wagenknecht, L. E., Balasubramanyam, A., Langfeld, C., Saad, M. F., Rotter, J. I., Guo, X., Chen, Y. I., Bryer‐Ash, M., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2614 · Cited by 132 · see citing works
Hamer, M., Batty, G. D., & Kivimaki, M. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.30 · Cited by 132 · see citing works
A longitudinal hormonal profile of the genetically obese mouse.
Garthwaite, T., Martinson, D., Tseng, L.-F., Hagen, T. C., & Menahan, L. A. (1980) · Endocrinology · doi:10.1210/endo-107-3-671 · Cited by 129 · see citing works
The association between traumatic brain injury and ADHD in a Canadian adult sample
Ilie, G., Vingilis, E. R., Mann, R. E., Hamilton, H., Toplak, M., Adlaf, E. M., Kolla, N., Ialomiteanu, A., van der Mass, M., Asbridge, M., et al. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.08.004 · Cited by 128 · see citing works
Pasquali, R. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06569.x · Cited by 128 · see citing works
The impact of stress systems and lifestyle on dyslipidemia and obesity in anxiety and depression
Dortland, A. K. B. V. R., Vreeburg, S. A., Giltay, E. J., Licht, C. M. M., Vogelzangs, N., van Veen, T., de Geus, E. J. C., Penninx, B. W. J. H., & Zitman, F. G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.05.017 · Cited by 125 · see citing works
Plasma Leptin in Depressed Patients and Healthy Controls
Deuschle, M., Blum, W. F., Englaro, P., et al. (1996) · Hormone and Metabolic Research · doi:10.1055/s-2007-979885 · Cited by 124 · see citing works
Gorzalka, B. B., & Hill, M. N. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.021 · Cited by 118 · see citing works
Liu, J., Perez, S. M., Zhang, W., Lodge, D. J., & Lu, X.-Y. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.36 · Cited by 118 · see citing works
Lasikiewicz, N., Hendrickx, H., Talbot, D., & Dye, L. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.10.013 · Cited by 117 · see citing works
Moranis, A., Delpech, J.-C., Smedt, V. D., Aubert, A., Guesnet, P., Lavialle, M., Joffre, C., & Layé, S. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.11.001 · Cited by 110 · see citing works
Kemp, D. E., Ismail-Beigi, F., Ganocy, S. J., Conroy, C., Gao, K., Obral, S., Fein, E., Findling, R. L., & Calabrese, J. R. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.06.033 · Cited by 109 · see citing works
Association of Lifestyle Factors With Abdominal Subcutaneous and Visceral Adiposity
Molenaar, E. A., Massaro, J. M., Jacques, P. F., Pou, K. M., Ellison, R. C., Hoffmann, U., Pencina, K. M., Shadwick, S. D., Vasan, R. S., O’Donnell, C. J., et al. (2008) · Diabetes Care · doi:10.2337/dc08-1382 · Cited by 108 · see citing works
Distribution of the glucocorticoid receptor in the human amygdala; changes in mood disorder patients
Wang, Q., Verweij, E. W. E., Krugers, H. J., Joëls, M., Swaab, D. F., & Lucassen, P. J. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0589-4 · Cited by 107 · see citing works
Pulkki-Råbäck, L., Elovainio, M. J., Mika Kivimaki, B., Mattsson, N., Raitakari, O. T., Puttonen, S., Marniemi, J., Viikari, J. S. A., & Keltikangas‐Järvinen, L. (2009) · Health Psychology · doi:10.1037/a0012646 · Cited by 106 · see citing works
Serum adiponectin and resistin levels in major depressive disorder
Lehto, S. M., Huotari, A., NISKANEN, L. K., Tolmunen, T., Koivumaa-Honkanen, H. T., Honkalampi, K. M., Ruotsalainen, H. J., Herzig, K., Viinamäki, H. T., & Hintikka, J. J. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2009.01463.x · Cited by 103 · see citing works
Downregulation of hypothalamic insulin receptor expression elicits depressive-like behaviors in rats
Grillo, C. A., Piroli, G. G., Kaigler, K. F., Wilson, S. P., Wilson, M. A., & Reagan, L. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.03.052 · Cited by 103 · see citing works
Serum Ghrelin and Cholesterol Values in Suicide Attempters
Atmaca, M., Tezcan, E., Parmaksiz, S., Saribas, M., Özler, S., & Üstündağ, B. (2006) · Neuropsychobiology · doi:10.1159/000096039 · Cited by 102 · see citing works
Longitudinal Relationship of Depressive and Anxiety Symptoms With Dyslipidemia and Abdominal Obesity
Dortland, A. K. B. V. R., Giltay, E. J., van Veen, T., Zitman, F. G., & Penninx, B. W. J. H. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318274d30f · Cited by 101 · see citing works
Selective deletion of leptin receptors in adult hippocampus induces depression-related behaviours
Guo, M., Huang, T.-Y., Garza, J. C., Chua, S. C., & Lu, X. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145712000703 · Cited by 101 · see citing works
Nikisch, G., Ågren, H., Eap, C. B., Czernik, A., Baumann, P., & Mathé, A. A. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005158 · Cited by 98 · see citing works
Solomon, M. B., Furay, A. R., Jones, K., Packard, A. E. B., Packard, B. A., Wulsin, A. C., & Herman, J. P. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.014 · Cited by 96 · see citing works
Leptin, Abdominal Obesity, and Onset of Depression in Older Men and Women
Milaneschi, Y., Simonsick, E. M., Vogelzangs, N., Strotmeyer, E. S., Yaffe, K. S., Harris, T. B., Tolea, M. I., Ferrucci, L., Penninx, B. W. J. H., & Health, A. (2012) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.11m07552 · Cited by 93 · see citing works
Withdrawal from free-choice high-fat high-sugar diet induces craving only in obesity-prone animals
Pickering, C., Alsiö, J., Hulting, A., & Schiöth, H. B. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1474-y · Cited by 91 · see citing works
Serum Leptin and Cholesterol Values in Suicide Attempters
Atmaca, M., Kuloğlu, M., Tezcan, E., Üstündağ, B., Geçici, Ö., & Firidin, B. (2002) · Neuropsychobiology · doi:10.1159/000054950 · Cited by 91 · see citing works
Mitra, R., Ferguson, D., & Sapolsky, R. M. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.04.016 · Cited by 88 · see citing works
Dietary fats, cerebrovasculature integrity and Alzheimer’s disease risk
Takechi, R., Galloway, S., Pallebage‐Gamarallage, M. M., Lam, V., & Mamo, J. C. L. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.10.004 · Cited by 88 · see citing works
Almeida, O. P., Alan, J., Jamrozik, K. D., Hankey, G. J., & Flicker, L. A. (2009) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181b047e3 · Cited by 88 · see citing works
Eşel, E., Özsoy, S., Tutuş, A., Sofuoǧlu, S., Kartalcı, Ş., Bayram, F., Kokbudak, Z., & Kula, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.01.009 · Cited by 87 · see citing works
High serum leptin levels in depressive disorders with atypical features
Geçici, Ö., Kuloğlu, M., Atmaca, M., Tezcan, A. E., Tunckol, H., Emül, H. M., & Üstündağ, B. (2005) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2005.01445.x · Cited by 86 · see citing works
Some metabolic and behavioral effects of adrenalectomy on obese Zucker rats
Castonguay, T. W., Dallman, M. F., & Stern, J. S. (1986) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1986.251.5.r923 · Cited by 86 · see citing works
Therrien, F., Drapeau, V., Lalonde, J., LUPIEN, S. J., Beaulieu, S., Tremblay, A., & Richard, D. (2007) · Obesity · doi:10.1038/oby.2007.509 · Cited by 85 · see citing works
Guo, M., Lu, Y., Garza, J. C., Li, Y., Chua, S. C., Zhang, W., Lu, B., & Lu, X.-Y. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.9 · Cited by 83 · see citing works
Low CSF leptin in female suicide attempters with major depression
Westling, S., Åhrén, B., Träskman‐Bendz, L., & Westrin, Å. (2003) · Journal of Affective Disorders · doi:10.1016/j.jad.2003.07.002 · Cited by 83 · see citing works
Cannabinoids and emotionality: a neuroanatomical perspective
McLaughlin, R. J., & Gobbi, G. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.052 · Cited by 82 · see citing works
Doumatey (2012) · Journal of Endocrinology and Metabolism · doi:10.4021/jem95w · Cited by 82 · see citing works
Ahmed, A. A. E., Al‐Rasheed, N. M., & Al-Rasheed, N. M. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328331b9bf · Cited by 82 · see citing works
Iemolo, A., Valenza, M., Tozier, L., Knapp, C. M., Kornetsky, C. H., Steardo, L., Sabino, V., & Cottone, P. (2012) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328357697f · Cited by 80 · see citing works
Effects of Inhibitor of κB Kinase Activity in the Nucleus Accumbens on Emotional Behavior
Christoffel, D. J., Golden, S. A., Heshmati, M., Graham, A., Birnbaum, S., Neve, R. L., Hodes, G. E., & Russo, S. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.121 · Cited by 78 · see citing works
Weber-Hamann, B., Kratzsch, J., Kopf, D., et al. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2006.01.002 · Cited by 77 · see citing works
Finger, B. C., Dinan, T. G., & Cryan, J. F. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.06.015 · Cited by 75 · see citing works
Finger, B. C., Dinan, T. G., & Cryan, J. F. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1858-z · Cited by 74 · see citing works
Rubín, R. T., Rhodes, M. E., & Czambel, R. K. (2002) · Psychiatry Research · doi:10.1016/s0165-1781(02)00263-9 · Cited by 73 · see citing works
Ge, J., Qi, C., & Zhou, J. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.04.020 · Cited by 73 · see citing works
Arvaniti, K., Huang, Q., & Richard, D. (2001) · Neuroendocrinology · doi:10.1159/000054639 · Cited by 73 · see citing works
Enhancement of endocannabinoid signaling and the pharmacotherapy of depression
Mangieri, R. A., & Piomelli, D. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.09.003 · Cited by 71 · see citing works
Leptin treatment ameliorates anxiety in ob/ob obese mice
Asakawa, A., Inui, A., Inui, T., Katsuura, G., Fujino, M., & Kasuga, M. (2003) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(02)00185-x · Cited by 70 · see citing works
Serum leptin and cholesterol values in violent and non-violent suicide attempters
Atmaca, M., Kuloğlu, M., Tezcan, E., & Üstündağ, B. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2003.05.002 · Cited by 68 · see citing works
ΔFosB-Mediated Alterations in Dopamine Signaling Are Normalized by a Palatable High-Fat Diet
Teegarden, S. L., Nestler, E. J., & Bale, T. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.007 · Cited by 68 · see citing works
Superposição entre depressão atípica, doença afetiva sazonal e síndrome da fadiga crônica
Juruena, M. F., & Cleare, A. J. (2007) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462007000500005 · Cited by 67 · see citing works
Matheny, M. E., Shapiro, A. M., Tümer, N., & Scarpace, P. J. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.11.002 · Cited by 65 · see citing works
Associations between depressive symptoms and insulin resistance: The Hoorn Study
Adriaanse, M. C., Dekker, J. M., Nijpels, G., Heine, R. J., Snoek, F. J., & Pouwer, F. (2006) · Diabetologia · doi:10.1007/s00125-006-0500-4 · Cited by 65 · see citing works
Mente, A., Meyre, D., Lanktree, M. B., Heydarpour, M., Davis, A. D., Miller, R., Gerstein, H. C., Hegele, R. A., Yusuf, S., Anand, S. S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066808 · Cited by 64 · see citing works
Rimonabant Precipitates Anxiety in Rats Withdrawn from Palatable Food: Role of the Central Amygdala
Blasio, A., Iemolo, A., Sabino, V., Petrosino, S., Steardo, L., Rice, K. C., Orlando, P., Iannotti, F. A., Marzo, V. D., Zorrilla, E. P., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.153 · Cited by 62 · see citing works
Maebuchi, M., Machidori, M., Urade, R., Ogawa, T., & Moriyama, T. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(03)00279-0 · Cited by 61 · see citing works
Leptin Regulates Dopamine Responses to Sustained Stress in Humans
Burghardt, P. R., Love, T., Stohler, C. S., Hodgkinson, C. A., Shen, P., Enoch, M., Goldman, D. A., & Zubieta, J. K. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2521-12.2012 · Cited by 60 · see citing works
Leptin, adiponectin, leptin to adiponectin ratio and insulin resistance in depressive women.
Zeman, M., Jirák, R., Jáchymová, M., Vecka, M., TVRZICKÁ, E., & Žák, A. (2009) · PubMed · Cited by 58 · see citing works
The relationship of C‐reactive protein to obesity‐related depressive symptoms: A longitudinal study
Daly, M. (2013) · Obesity · doi:10.1002/oby.20051 · Cited by 57 · see citing works
Delporte, M.-L., El Mkadem, S. A., Quisquater, M., & Brichard, S. M. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2003 · Cited by 55 · see citing works
Mathé, A. A., Husum, H., Khoury, A. E., Jiménez-Vasquez, P. A., Gruber, S. H. M., Wörtwein, G., Nikisch, G., Baumann, P., Ågren, H., Andersson, W., et al. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.05.016 · Cited by 55 · see citing works
Nazare, J., Smith, J. D., Borel, A., Alméras, N., Tremblay, A., Bergeron, J., Poirier, P., & Després, J. (2013) · Journal of Nutrition · doi:10.3945/jn.113.175273 · Cited by 54 · see citing works
Park, Y., Moon, H.-J., & Kim, S. H. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.04.018 · Cited by 53 · see citing works
Dietary intake of omega-3 fatty acids and risk of depressive symptoms in adolescents
Oddy, W. H., Hickling, S., Smith, M., O’Sullivan, T. A., Robinson, M., de Klerk, N. H., Beilin, L. J., Mori, T. A., Syrette, J. A., Zubrick, S. R., et al. (2011) · Depression and Anxiety · doi:10.1002/da.20822 · Cited by 53 · see citing works
Arnett, M. G., Kolber, B. J., Boyle, M. P., & Muglia, L. J. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.11.011 · Cited by 53 · see citing works
Plasma adiponectin elevation in elderly individuals with subsyndromal depression
Jeong, H., Min, B. J., Lim, S. K., Kim, T. H., Lee, J. J., Park, J. H., Lee, S. B., Han, J. W., Choi, S. H., Park, Y. J., et al. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.11.002 · Cited by 51 · see citing works
Serum Adiponectin in Relation to Body Mass Index and Other Correlates in Black and White Women
Cohen, S. S., Gammon, M. D., Signorello, L. B., North, K. E., Lange, E. M., Fowke, J. H., Hargreaves, M. K., Cai, Q., Zheng, W., Blot, W. J., et al. (2010) · Annals of Epidemiology · doi:10.1016/j.annepidem.2010.10.011 · Cited by 51 · see citing works
Hautanen, A., Räikkönen, K., & CREUTZ, H. A. (1997) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1997.tb00002.x · Cited by 51 · see citing works
Awakening cortisol response in relation to psychosocial profiles and eating behaviors
Therrien, F., Drapeau, V., LUPIEN, S. J., Beaulieu, S., Doré, J., Tremblay, A., & Richard, D. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.08.019 · Cited by 49 · see citing works
Serum Resistin Concentrations are Higher in Human Obesity but Independent from Insulin Resistance
Owecki, M., Miczke, A., Nikisch, E., Pupek‐Musialik, D., & Sowiński, J. (2010) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0030-1263111 · Cited by 47 · see citing works
Mujica-Parodi, L. R., Renelique, R., & Taylor, M. K. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.218 · Cited by 47 · see citing works
Volpi, L., Ferreli, F., Karligkiotis, A., et al. (2012) · UnissResearch (Università degli Studi di Sassari) · doi:10.1001/2013 · Cited by 47 · see citing works
Kršek, M., Silha, J. V., Ježková, J., Hána, V., Marek, J., Weiss, V., Stepan, J. J., & Murphy, L. J. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2003.01987.x · Cited by 46 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Liu J. Garza J. C. Bronner J. Kim C. S. Zhang W. Lu X. Y. (2010b). Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine. Psychopharmacology (Berl.) 207, 535– 545 10.1007/s00213-009-1684-3 19823809 PMC4057895 · DOI
Cited by
Sorted by citations
Intermittent metabolic switching, neuroplasticity and brain health
Mattson, M. P., Moehl, K., Ghena, N., Schmaedick, M., & Cheng, A. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.156 · Cited by 624 · see citing works
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.12.008 · Cited by 536 · see citing works
The Rodent Forced Swim Test Measures Stress-Coping Strategy, Not Depression-like Behavior
Commons, K. G., Cholanians, A. B., Babb, J. A., & Ehlinger, D. G. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00042 · Cited by 525 · see citing works
Ashdown-Franks, G., Firth, J., Carney, R., Carvalho, A. F., Hallgren, M., Koyanagi, A., Rosenbaum, S., Schuch, F. B., Smith, L., Solmi, M., et al. (2020) · Sports Medicine · doi:10.1007/s40279-019-01187-6 · Cited by 446 · see citing works
De Luca, M., Angrisani, L., Himpens, J., Busetto, L., Scopinaro, N., Weiner, R., Sartori, A., Stier, C., Lakdawala, M., Bhasker, A. G., et al. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2271-4 · Cited by 296 · see citing works
Lam, R. W., McIntosh, D., Wang, J., Enns, M. W., Kolivakis, T., Michalak, E. E., Sareen, J., Song, W.-Y., Kennedy, S. H., MacQueen, G. M., et al. (2016) · The Canadian Journal of Psychiatry · doi:10.1177/0706743716659416 · Cited by 288 · see citing works
The interface of depression and obesity
Jantaratnotai, N., Mosikanon, K., Lee, Y., & McIntyre, R. S. (2017) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2016.07.003 · Cited by 282 · see citing works
Milaneschi, Y., Lamers, F., Bot, M., Drent, M. L., & Penninx, B. W. J. H. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.023 · Cited by 209 · see citing works
Role of Adiposity-Driven Inflammation in Depressive Morbidity
Capuron, L., Lasselin, J., & Castanon, N. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.123 · Cited by 182 · see citing works
Hryhorczuk, C., Florea, M., Rodaros, D., Poirier, I., Daneault, C., Des Rosiers, C., Arvanitogiannis, A., Alquier, T., & Fulton, S. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.207 · Cited by 119 · see citing works
Self-citationCellular senescence in aging and age-related diseases: Implications for neurodegenerative diseases
(2020) · International Review of Neurobiology · doi:10.1016/bs.irn.2020.03.019 · Cited by 114 · see citing works
Décarie-Spain, L., Sharma, S., Hryhorczuk, C., Issa-Garcia, V., Barker, P. A., Arbour, N., Alquier, T., & Fulton, S. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.01.018 · Cited by 107 · see citing works
Self-citationMarcos, J., Renau, N., Casals, G., Segura, J., Ventura, R., & Pozo, O. J. (2014) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.12.030 · Cited by 76 · see citing works
Nicolas, S., Debayle, D., Béchade, C., Maroteaux, L., Gay, A.-S., Bayer, P., Heurteaux, C., Guyon, A., & Chabry, J. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0210-y · Cited by 73 · see citing works
Liu, C., Carvalho, A., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130204031 · Cited by 61 · see citing works
Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats
Rebolledo-Solleiro, D., Roldán-Roldán, G., Díaz, D., Velasco, M., Larqué, C., Rico-Rosillo, G., Vega-Robledo, G. B., Zambrano, E., Hiriart, M., & Pérez de la Mora, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176554 · Cited by 64 · see citing works
Hryhorczuk, C., Décarie-Spain, L., Sharma, S., Daneault, C., Rosiers, C. D., Alquier, T., & Fulton, S. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.06.002 · Cited by 51 · see citing works
Demers, G., Roy, J., Machuca-Parra, A. I., Dashtehei pour, Z., Bairamian, D., Daneault, C., Rosiers, C. D., Ferreira, G., Alquier, T., Fulton, S., et al. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0623-6 · Cited by 53 · see citing works
Testosterone imbalance may link depression and increased body weight in premenopausal women
Stanikova, D., Zsido, R. G., Luck, T., Pabst, A., Enzenbach, C., Bae, Y. J., Thiery, J., Ceglarek, U., Engel, C., Wirkner, K., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0487-5 · Cited by 47 · see citing works
El Massry, M., Alaeddine, L. M., Ali, L., Saad, C., & Eid, A. A. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867327666200908114902 · Cited by 27 · see citing works
Kiyici, S., Koca, N., Sigirli, D., Aslan, B. B., Guclu, M., & Kisakol, G. (2020) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2019.0108 · Cited by 22 · see citing works
- Authors
- Hryhorczuk, C., Sharma, S., & Fulton, S. E.
- Affiliations
- Université de Montréal (CA)
- Corresponding author
- Fulton, Stephanie E.
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 177-177
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC3791387
- OpenAlex
- W2100391099
- Cited by
- 322
- References
- 225
- Citations by year
- 2026: 18 · 2025: 30 · 2024: 22 · 2023: 20 · 2022: 28 · 2021: 27 · 2020: 32 · 2019: 35 · 2018: 17 · 2017: 21 · 2016: 20 · 2015: 26 · 2014: 26
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- obesity, depression, abdominal obesity, metabolic disorders, glucocorticoids, adipokines, insulin resistance, inflammation, diet, mood regulation, anxiety
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
