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Combined dieting and stress evoke exaggerated responses to opioids in binge-eating rats.
Abstract
The authors developed an animal model of binge eating where history of caloric restriction with footshock stress (R + S) causes rats to consume twice the normal amount of palatable food. The authors tested the hypothesis that binge eating is mediated by changes in opioid control of feeding by comparing rats' anorectic and orexigenic responses to naloxone and butorphanol, respectively, and by testing the ability of butorphanol to elicit binge eating of chow when palatable food was absent. Mu/kappa opioid-receptor blockade and activation had exaggerated responses in the R + S rats with naloxone suppressing binge eating to control levels, and although butorphanol did not trigger chow binge eating, it enhanced binge eating of palatable food. These responses in sated normal-weight rats strengthen evidence that reward, over metabolic need, drives binge eating.
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“For nonsweet palatable foods (typically high-fat foods), there is less convincing evidence for development of dependence ([21](#B21), [31](#B31)), although intermittent access to corn oil can stimulate dopamine release in the nucleus accumbens ([106](#B106)).”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [21]
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Metadata
- Authors
- Boggiano, M. M., Chandler, P. C., Viana, J. B., Oswald, K. D., Maldonado, C. R., & Wauford, P. K.
- Affiliations
- University of Alabama at Birmingham (US)
- ORCID
- Boggiano, Mary M.
- Venue
- Behavioral Neuroscience
- Published
- 2005-10
- Volume
- 119
- Issue
- 5
- Pages
- 1207-1214
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2172116958
- Cited by
- 131
- References
- 48
- Citations by year
- 2025: 7 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 14 · 2014: 12 · 2013: 8 · 2012: 16
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioral Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (R03-066007)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- binge eating, caloric restriction, footshock stress, naloxone, butorphanol, mu-opioid receptor, kappa opioid receptor, palatable food
- MeSH terms
- Analgesics, Opioid, Analysis of Variance, Animals, Behavior, Animal, Body Weight, Bulimia, Butorphanol, Energy Intake, Disease Models, Animal, Electroshock, Feeding Behavior, Female, Food Preferences, Naloxone, Narcotic Antagonists, Narcotics, Time Factors, Rats, Sprague-Dawley, Caloric Restriction, Rats
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