The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Adolescent male rats exposed to social defeat exhibit altered anxiety behavior and limbic monoamines as adults.
Open accessAbstract
Social stress in adolescence is correlated with emergence of psychopathologies during early adulthood. In this study, the authors investigated the impact of social defeat stress during mid-adolescence on adult male brain and behavior. Adolescent male Sprague-Dawley rats were exposed to repeated social defeat for 5 days while controls were placed in a novel empty cage. When exposed to defeat-associated cues as adults, previously defeated rats showed increased risk assessment and behavioral inhibition, demonstrating long-term memory for the defeat context. However, previously defeated rats exhibited increased locomotion in both elevated plus-maze and open field tests, suggesting heightened novelty-induced behavior. Adolescent defeat also affected adult monoamine levels in stress-responsive limbic regions, causing decreased medial prefrontal cortex dopamine, increased norepinephrine and serotonin in the ventral dentate gyrus, and decreased norepinephrine in the dorsal raphe. Our results suggest that adolescent social defeat produces both deficits in anxiety responses and altered monoaminergic function in adulthood. This model offers potential for identifying specific mechanisms induced by severe adolescent social stress that may contribute to increased adult male vulnerability to psychopathology.
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Cites
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“…can result in negative psychological maladjustments that include increased incidences of anxiety, depression, substance abuse and suicidal tendencies (Hawker & Boulton, 2000; Kaltiala-Heino, Rimpela, Rantanen, & Rimpela, 2000; Brunstein Klomek, Marrocco, Kleinman, Schonfeld, & Gould, 2007).”
BackgroundTrajectories of brain development: point of vulnerability or window of opportunity?
Andersen, S. L. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(03)00005-8 · Cited by 1,503
Periadolescence: age-dependent behavior and psychopharmacological responsivity in rats
Spear, L. P., & Brake, S. C. (1983) · Developmental Psychobiology · doi:10.1002/dev.420160203 · Cited by 539 · cited 2×
“It remains uncertain if repeated social defeat experienced during the peak of adolescent neural re-organization (P28 to P42, Spear, 2000; Andersen, 2003) affects adult monoamine levels and the expression of stress-induced and anxiety-like behaviors.”
BackgroundVentral hippocampal lesions affect anxiety but not spatial learning
Bannerman, D. M., Grubb, M., Deacon, R. M. J., Yee, B. K., Feldon, J., & Rawlins, J. N. P. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00268-1 · Cited by 530
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Degree of neuronal activation following FG-7142 changes across regions during development
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Cited by
Moore, S. E., Norman, R. E., Suetani, S., Thomas, H. J., Sly, P. D., & Scott, J. G. (2017) · World Journal of Psychiatry · doi:10.5498/wjp.v7.i1.60 · Cited by 1,320
Russo, S. J., Murrough, J. W., Han, M.-H., Charney, D. S., & Nestler, E. J. (2012) · Nature Neuroscience · doi:10.1038/nn.3234 · Cited by 1,206
Puberty and adolescence as a time of vulnerability to stressors that alter neurobehavioral processes
Holder, M. K., & Blaustein, J. D. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.10.004 · Cited by 279
Social defeat stress induces a depression-like phenotype in adolescent male c57BL/6 mice
Iñiguez, S. D., Riggs, L. M., Nieto, S. J., Dayrit, G., Zamora, N. N., Shawhan, K. L., Cruz, B., & Warren, B. L. (2014) · Stress · doi:10.3109/10253890.2014.910650 · Cited by 269
“Although few investigations have examined the effects of early-life social defeat stress on mood-eliciting behavioral tasks in adulthood (Buwalda et al., 2013; Ver Hoeve et al., 2013; Watt et al., 2009), the social defeat model has not been thoroughly examined as a potential model of stress-induced depression within t…”
BackgroundTests of unconditioned anxiety — Pitfalls and disappointments
Ennaceur, A. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.05.032 · Cited by 259
Metadata
- Authors
- Watt, M. J., Burke, A. R., Renner, K. J., & Forster, G. L.
- Venue
- Behavioral Neuroscience
- Published
- 2009
- Volume
- 123
- Issue
- 3
- Pages
- 564-576
- ISSN
- 0735-7044 (ISSN-L)
- 1939-0084
- OpenAlex
- W2032997620
- Cited by
- 179
- References
- 9
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- green
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