Intense cocaine self-administration after episodic social defeat stress, but not after aggressive behavior: dissociation from corticosterone activation
Abstract
Rationale An intense stress response characterizes both the dominant and submissive individuals during an aggressive confrontation, and these stress responses have enduring neural and behavioral consequences. Objectives In spite of similar glucocorticoid and corticolimbic dopamine activation, dominant and defeated individuals appear to diverge in terms of their drug taking. Do rats that are intermittently subjected to defeat stress become more sensitized to cocaine taking relative to rats that engage in aggressive bouts? Methods Separate groups of male Long-Evans rats were investigated after an initial 10-day period with four brief episodes of social defeat (intruders) or aggressive behavior (residents): (1) the corticosterone responses to the very first and the last confrontations were measured; (2) the locomotor response to an amphetamine (1 mg/kg) challenge 10 days after the last stress exposure served as an index of behavioral sensitization; (3) intravenous self-administration sessions assessed the reinforcing effects of 0.75 mg/kg/infusion cocaine when available after every fifth response (fixed ratio), when delivered after completing progressively more demanding response requirements (progressive ratio; 0.3 mg/kg/infusion), and when available during a 24-h binge of continuous access (0.3 mg/kg/infusion). Results Both social defeat of the intruder rat and attack behavior by the resident rat rapidly increased plasma levels of corticosterone after the first and last aggres…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A unique aspect of social defeat stress that distinguishes it from other environmental stressors is its ability to continuously activate the pituitary-adrenal axis over repeated social confrontations.
“A unique aspect of social defeat stress that distinguishes it from other environmental stressors is its ability to continuously activate the pituitary-adrenal axis over repeated social confrontations9,18,19.”
From A standardized protocol for repeated social defeat stress in mice (2011) · cites this paper as [19]
Cites
How does stress increase risk of drug abuse and relapse?
Sinha, R. (2001) · Psychopharmacology · doi:10.1007/s002130100917 · Cited by 1,505 · see citing works
Activation of memory circuits during cue-elicited cocaine craving.
Grant, S., London, E. D., Newlin, D. B., Villemagne, V. L., Liu, X., Contoreggi, C., Phillips, R. L., Kimes, A. S., & Margolin, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.12040 · Cited by 936 · see citing works
Animal models of social stress: Effects on behavior and brain neurochemical systems
Blanchard, R. J., McKittrick, C. R., & Blanchard, D. C. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00449-8 · Cited by 595 · see citing works
Neurobiological evidence for hedonic allostasis associated with escalating cocaine use
Ahmed, S. H., Kenny, P. J., Koob, G. F., & Markou, A. (2002) · Nature Neuroscience · doi:10.1038/nn872 · Cited by 389 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A standardized protocol for repeated social defeat stress in mice
Golden, S. A., Covington, H. E., Berton, O., & Russo, S. J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.361 · Cited by 1,581 · see citing works
Self-citationDrug addiction: updating actions to habits to compulsions ten years on
Everitt, B. J., & Robbins, T. W. (2016) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033457 · Cited by 1,225 · see citing works
Animal Models of Depression: Molecular Perspectives
Krishnan, V., & Nestler, E. J. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2010_108 · Cited by 528 · see citing works
Natural rewards, neuroplasticity, and non-drug addictions
Olsen, C. M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.010 · Cited by 339 · see citing works
IκB Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity
Christoffel, D. J., Golden, S. A., Dumitriu, D., Robison, A. J., Janssen, W. G., Ahn, H. F., Krishnan, V., Reyes, C. M., Han, M.-H., Ables, J. L., et al. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4763-10.2011 · Cited by 267 · see citing works
Burke, A. R., McCormick, C. M., Pellis, S. M., & Lukkes, J. L. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.018 · Cited by 225 · see citing works
McCormick, C. M., & Mathews, I. Z. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.09.019 · Cited by 230 · see citing works
Defeat stress in rodents: from behavior to molecules
Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J.-P., Lesch, K.-P., Daskalakis, N. P., Steinbusch, H. W. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.006 · Cited by 230 · see citing works
Stress in adolescence and drugs of abuse in rodent models: role of dopamine, CRF, and HPA axis
Burke, A. R., & Miczek, K. A. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3369-1 · Cited by 207 · see citing works
Self-citationInoculation stress hypothesis of environmental enrichment.
Crofton, E. J., Zhang, Y., & Green, T. A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.11.017 · Cited by 206 · see citing works
Individual Differences and Social Influences on the Neurobehavioral Pharmacology of Abused Drugs
Bardo, M. T., Neisewander, J. L., & Kelly, T. H. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005124 · Cited by 167 · see citing works
Miczek, K. A., Nikulina, E. M., Shimamoto, A., & Covington, H. E. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0637-11.2011 · Cited by 162 · see citing works
Self-citationIñiguez, S. D., Vialou, V., Warren, B. L., Cao, J.-L., Alcantara, L. F., Davis, L. C., Manojlovic, Z., Neve, R. L., Russo, S. J., Han, M.-H., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0951-10.2010 · Cited by 103 · see citing works
Holly, E. N., Shimamoto, A., DeBold, J. F., & Miczek, K. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2846-2 · Cited by 98 · see citing works
Self-citationNeisewander, J. L., Peartree, N. A., & Pentkowski, N. S. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2853-3 · Cited by 87 · see citing works
Yap, J. J., Chartoff, E. H., Holly, E. N., Potter, D. N., Carlezon, W. A., & Miczek, K. A. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3796-7 · Cited by 55 · see citing works
Self-citationMontagud-Romero, S., Reguilon, M. D., Roger-Sanchez, C., Pascual, M., Aguilar, M. A., Guerri, C., Miñarro, J., & Rodríguez-Arias, M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.07.008 · Cited by 31 · see citing works
Stress-induced cross-sensitization to amphetamine is related to changes in the dopaminergic system
Cruz, F. C., Marin, M. T., Leão, R. M., & Planeta, C. S. (2012) · Journal of Neural Transmission · doi:10.1007/s00702-011-0720-8 · Cited by 31 · see citing works
mGluR5 Facilitates Long-Term Synaptic Depression in a Stress-Induced Depressive Mouse Model
Jiang, X., Lin, W., Cheng, Y., & Wang, D. (2020) · The Canadian Journal of Psychiatry · doi:10.1177/0706743719874162 · Cited by 18 · see citing works
- Authors
- Covington, H. E., & Miczek, K. A.
- Affiliations
- Tufts University (US)
- Corresponding author
- Miczek, Klaus A.
- Venue
- Psychopharmacology
- Published
- 2005-10-26
- Volume
- 183
- Issue
- 3
- Pages
- 331-340
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1990650114
- Cited by
- 169
- References
- 4
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 7 · 2021: 12 · 2020: 6 · 2019: 10 · 2018: 11 · 2017: 8 · 2016: 9 · 2015: 13 · 2014: 9 · 2013: 12 · 2012: 8
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- National Institute on Drug Abuse (DA-02632, R01DA002632)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- cocaine self-administration, social defeat stress, aggression, corticosterone, stress habituation, amphetamine challenge, locomotor sensitization, domination and subordination, social stress, cocaine reinforcement
- MeSH terms
- Aggression, Animals, Cocaine, Corticosterone, Dominance-Subordination, Male, Self Administration, Stress, Psychological, Rats, Long-Evans, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
