Ventral hippocampal lesions affect anxiety but not spatial learning
Abstract
Rats with cytotoxic ventral hippocampal lesions which removed approximately 50% of the hippocampus (including dentate gyrus) starting from the temporal pole, displayed a reduction in freezing behaviour following the delivery of an unsignalled footshock in an operant chamber. This was more plausibly a result of reduced susceptibility to fear than a result of a lesion-induced increase in general motor activity. There was no consistent difference between sham and lesioned animals in spontaneous locomotor activity, or locomotion following acute or chronic treatment with amphetamine. In contrast, ventral hippocampal lesioned animals were quicker to pass from the black to the white box during a modified version of the light/dark exploration test, and were quicker to begin eating during tests of hyponeophagia. Furthermore, rats with ventral hippocampal lesions defecated less than their sham counterparts both during open field testing and in extinction sessions following contextual conditioning. In contrast to these clear lesion effects, there were no signs of any spatial learning impairment either in the watermaze or on the elevated T-maze. Taken together these results suggest that the ventral hippocampus may play a role in a brain system (or systems) associated with fear and/or anxiety, and provide further evidence for a distinct specialisation of function along the septotemporal axis of the hippocampus.
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The ventral hippocampus, in contrast to the dorsal hippocampus, is thought to contribute to anxiety-related phenotypes and not spatial memory, per se.
“these studies specifically target alterations in the ventral hippocampus, which in contrast to the dorsal hippocampus, is thought to contribute to anxiety-related phenotypes and not spatial memory, per se.”
From Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal (2013) · cites this paper as Bannerman et al, 2003
Bilateral lesions of the vHIP reduce anxiety-like behavior in rodents.
“bilateral lesions of this area have been shown to reduce anxiety-like behavior in rodents (13–15)”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [14]
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Ballesteros, C. I., de Oliveira Galvão, B., Maisonette, S., & Landeira-Fernandez, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083342 · Cited by 39 · see citing works
“However, lesion data suggest that destruction of the of the ventral hippocampus (VH) also decreases unconditioned defensive behaviors, such as in the elevated plus maze [17,18], elevated Tmaze [19], open field [17], defensive burying test [16], light/dark transition test [20], social interaction test [18], and uncondi…”
BackgroundBidirectional Influence of Limbic GIRK Channel Activation on Innate Avoidance Behavior
Vo, B. N., Marron Fernandez de Velasco, E., Rose, T. R., Oberle, H., Luo, H., Hopkins, C. R., & Wickman, K. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.2787-20.2021 · Cited by 33 · see citing works
Xu, T. J., & Reichelt, A. C. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.04.012 · Cited by 33 · see citing works
Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal
Turner, J. R., Wilkinson, D. S., Poole, R. L., Gould, T. J., Carlson, G. C., & Blendy, J. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.105 · Cited by 29 · see citing works
- Authors
- Bannerman, D. M., Grubb, M., Deacon, R. M. J., Yee, B. K., Feldon, J., & Rawlins, J. N. P.
- Affiliations
- University of Oxford (GB)
- ETH Zurich (CH)
- Corresponding author
- Bannerman, D.M
- Venue
- Behavioural Brain Research
- Publisher
- Elsevier BV
- Published
- 2003-02
- Volume
- 139
- Issue
- 1-2
- Pages
- 197-213
- ISSN
- 0166-4328 (ISSN-L)
- OpenAlex
- W2019858347
- Cited by
- 530
- References
- 75
- Citations by year
- 2026: 10 · 2025: 18 · 2024: 27 · 2023: 21 · 2022: 25 · 2021: 34 · 2020: 15 · 2019: 21 · 2018: 25 · 2017: 25 · 2016: 21 · 2015: 27 · 2014: 27 · 2013: 28 · 2012: 29
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- ventral hippocampus, hippocampal lesions, anxiety, fear, spatial learning, freezing behavior, footshock, defecation, contextual conditioning, amphetamine, locomotor activity, dentate gyrus, septotemporal axis, rats
- MeSH terms
- Amphetamine, Analysis of Variance, Animals, Anxiety, Discrimination Learning, Fear, Feeding Behavior, Hippocampus, Male, Motor Activity, Space Perception, Hypokinesia, Maze Learning, Rats
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