Cited by 107Cannabis and Cannabinoid ResearchPain Management and Placebo EffectPsychedelics and Drug Studies

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Effectiveness of a marijuana expectancy manipulation: Piloting the balanced-placebo design for marijuana

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Metrik, Jane, Rohsenow, Damaris J., Monti, Peter M., McGeary, John, Cook, Travis A. R., de Wit, Harriet, Haney, Margaret, Kahler, Christopher W.·2009·Experimental and Clinical Psychopharmacology

DOI 10.1037/a0016502PMC PMC2810847

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Abstract

Although alcohol and nicotine administration studies have demonstrated that manipulating subjects' expectancies regarding drug content affects drug response, research with marijuana has not adequately studied drug expectancy effects. The present pilot study was the first to evaluate the credibility and effect of expectancy manipulation on subjective measures and smoking patterns using a marijuana administration balanced-placebo design (BPD). In a 2 x 2 instructional set (told delta-9-tetrahydrocannabinol [THC] vs. told no THC) by drug (smoked marijuana with 2.8% THC vs. placebo) between-subjects design, the authors examined the effect of marijuana expectancy manipulation and the pharmacologic effect on affective and physiologic measures, cigarette ratings, and smoking behavior with 20 marijuana smokers (mean age = 20 years; 25% female). Large main effects of expectancy were found on ratings of cigarette potency, strength, taste, smell, and satisfaction, and observed smoking behavior. Pharmacologic effects were particularly evident for self-reported physical reactions to marijuana and cigarette potency and satisfaction ratings. This study demonstrated the feasibility of the BPD research with marijuana and yielded promising results for future studies examining the independent and combined effects of marijuana pharmacology and expectancies.

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Authors: Metrik, J., Rohsenow, D. J., Monti, P. M., McGeary, J., Cook, T. A. R., de Wit, H., Haney, M., & Kahler, C. W.
Affiliations: Brown University (US)
New York State Psychiatric Institute (US)
ORCID: Metrik, Jane
Rohsenow, Damaris J.
Monti, Peter M.
McGeary, John
de Wit, Harriet
Haney, Margaret
Kahler, Christopher W.
Venue: Experimental and Clinical Psychopharmacology
Publisher: American Psychological Association (APA)
Published: 2009-08
Volume: 17
Issue: 4
Pages: 217-225
ISSN: 1064-1297 (ISSN-L)
1936-2293
DOI: 10.1037/a0016502
PMC: PMC2810847
OpenAlex: W2054068506
Cited by: 107
References: 61
Citations by year: 2026: 3 · 2025: 4 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 12 · 2019: 10 · 2018: 1 · 2017: 9 · 2016: 6 · 2015: 3 · 2014: 10 · 2013: 8 · 2012: 9
FWCI: 3.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Experimental and Clinical Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Brown University
National Institute on Drug Abuse (R01 DA021403)
US Department of Veterans Affairs
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Keywords: cannabis, delta-9-tetrahydrocannabinol, smoking behavior, smoking satisfaction
MeSH terms: Adolescent, Adult, Affect, Attitude, Female, Humans, Male, Marijuana Smoking, Pilot Projects, Placebos, Dronabinol

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Effectiveness of a marijuana expectancy manipulation: Piloting the balanced-placebo design for marijuana

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