Distress tolerance and psychopathological symptoms and disorders: A review of the empirical literature among adults.
Open accessAbstract
We review theory and empirical study of distress tolerance, an emerging risk factor candidate for various forms of psychopathology. Despite the long-standing interest in and promise of work on distress tolerance for understanding adult psychopathology, there has not been a comprehensive review of the extant empirical literature focused on the construct. As a result, a comprehensive synthesis of theoretical and empirical scholarship on distress tolerance, including integration of extant research on the relations between distress tolerance and psychopathology, is lacking. Inspection of the scientific literature indicates that there are a number of promising ways to conceptualize and measure distress tolerance, as well as documented relations between distress tolerance factors and psychopathological symptoms and disorders. Although promising, there also is notable conceptual and operational heterogeneity across the distress tolerance literature. Moreover, a number of basic questions remain unanswered regarding the associations between distress tolerance and other risk and protective factors and processes, as well as its putative role(s) in vulnerability for and resilience to psychopathology. Thus, the current article provides a comprehensive review of past and contemporary theory and research and proposes key areas for future empirical study of this construct.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The ability to tolerate distress and negative emotional states has long been associated with the development and maintenance of psychopathology and with difficulties discontinuing or withdrawing from psychiatric medications and drugs of abuse.
“The ability to tolerate distress negative emotional states has long been associated with the development and maintenance of psychopathology [49–51] as well as difficulties discontinuing or withdrawing from psychiatric medications as well as drugs of abuse [49].”
From Unified protocol for the discontinuation of long-term serotonin reuptake inhibitors in obsessive compulsive disorder: Study protocol and methods (2018) · cites this paper as [49]
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredImproving distress tolerance is a central aim of CBT and ACT.
“Notably, increased emotional distress tolerance is a key goal of several behavioral therapies, including cognitive-behavioral therapy (CBT) and acceptance and commitment therapy (ACT; Hayes, Strosahl, & Wilson, 1999; Leyro, Zvolensky, & Bernstein, 2010).”
From Enhancing Inhibitory Learning: The Utility of Variability in Exposure (2019) · cites this paper as Leyro, Zvolensky, & Bernstein, 2010
The Abstract (page not available) says that many behavioral therapies target distress tolerance directly or indirectly and explicitly names ACT and mindfulness-based cognitive therapy. It does not establish that improving distress tolerance is a key goal of CBT generally; the listed cognitive therapy is a more specific approach. (LLM, conf=0.85)
Experimental — accuracy not yet measuredDistress tolerance is negatively correlated with anxiety and depression across diagnostic boundaries.
“DT is negatively correlated with anxiety and depression across diagnostic boundaries (Leyro et al., 2010; Yoon et al., 2018).”
From Distress tolerance as a mediator of mindfulness-based intervention for anxiety and depression: Evidence from two randomized controlled trials (2024) · cites this paper as Leyro et al., 2010
The section on distress tolerance for negative emotional states (page unavailable) reports that lower distress tolerance was associated with more depressive symptoms among HIV-positive patients under higher life stress. The review also discusses anxiety-related constructs and possible transdiagnostic relevance, but its 'Specific versus common risk marker and factor?' section (page unavailable) treats that breadth as an open research question. It does not establish a general negative correlation with both anxiety and depression across diagnostic boundaries. (LLM, conf=0.84)
Experimental — accuracy not yet measuredThrough practicing mindfulness and other MIED exercises, individuals may become less likely to appraise uncomfortable emotions as unacceptable and better equipped to tolerate distressing experiences, thereby reducing emotional distress in the long run.
“This suggests that through practicing mindfulness and engaging in other exercises within the MIED program, individuals may become less likely to appraise uncomfortable emotions as unacceptable and better equipped to tolerate distressing experiences (e.g., Lotan et al., 2013), thereby reducing emotional distress in the long run (Leyro et al., 2010; Li et al., 2023b).”
From Distress tolerance as a mediator of mindfulness-based intervention for anxiety and depression: Evidence from two randomized controlled trials (2024) · cites this paper as Leyro et al., 2010
Split into 2 atoms — 0 confirmed, 2 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measuredLow distress tolerance has been proposed as a transdiagnostic factor that plays a key role in the maintenance of many psychopathological disorders, including obsessive-compulsive and related disorders.
“Low DT has been proposed as a transdiagnostic factor that plays a key role in the maintenance of many psychopathological disorders, including obsessive-compulsive and related disorders (Barton et al., 2021;Leyro et al., 2010;Yap et al., 2018).”
From A naturalistic study of emotion regulation-enhanced cognitive-behavioral group therapy for hoarding disorder in a community setting (2022) · cites this paper as Leyro et al., 2010
The introduction proposes distress tolerance as a maintenance factor across several forms of psychopathology, and the “Specific versus common risk marker and factor?” section discusses its possible transdiagnostic relevance (pages unavailable in our copy). The “Intolerance of uncertainty” section reports associations with obsessive-compulsive disorder, but does not establish that low distress tolerance plays a key role in maintaining OCD or other related disorders. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Distress tolerance is importantly involved in depression and anxiety.
“Distress tolerance, defined as the ability to withstand aversive emotions, plays a significant role in depression and anxiety [3].”
From Lower distress tolerance is associated with greater anxiety and depression symptoms among patients after acute coronary syndrome (2021) · cites this paper as [3]
Distress tolerance is central to the theoretical basis of numerous therapeutic approaches.
“Thus, it is not surprising that distress tolerance is central to the theoretical basis of numerous therapeutic approaches [49].”
From Unified protocol for the discontinuation of long-term serotonin reuptake inhibitors in obsessive compulsive disorder: Study protocol and methods (2018) · cites this paper as [49]
Various forms of distress may matter more for different psychological problems.
“different types of distress may be more relevant for distinct psychological issues”
From The Effect of a Brief Mindfulness Training on Distress Tolerance and Stress Reactivity. (2019) · cites this paper as Leyro et al., 2010
This brings into question both the validity of self-report methodology and the taxonomy of aversive internal experiences.
“This brings into question both the validity of self-report methodology and the taxonomy of aversive internal experiences (see also Leyro, et al., 2010).”
From Emotion and internal experience in Obsessive Compulsive Disorder: Reviewing the role of alexithymia, anxiety sensitivity and distress tolerance (2014) · cites this paper as Leyro, et al., 2010
Deficits in one's ability to tolerate negative affect (low DT) contribute to engagement in maladaptive behaviours that function to alleviate psychological discomfort associated with aversive emotional states, thereby strengthening a negative feedback loop through which such behaviours are maintained.
“It has been theorised that deficits in one's ability to tolerate negative affect (i.e., low DT) contributes to engagement in maladaptive behaviours that function to alleviate psychological discomfort associated with aversive emotional states, thereby strenghtening a negative feedback loop through which such behaviours are maintained (Leyro et al., 2010;Zvolensky and Hogan, 2013).”
From Distress tolerance across substance use, eating, and borderline personality disorders: A meta-analysis (2022) · cites this paper as Leyro et al., 2010
Search terms were replicated from Leyro et al. (2010) to assure adequate breadth of DT terminology.
“We replicated the DT search terms used in the widely cited narrative review of DT and psychopathology by Leyro et al. (2010) to assure adequate breadth of DT terminology.”
From Distress tolerance across substance use, eating, and borderline personality disorders: A meta-analysis (2022) · cites this paper as Leyro et al. (2010)
Distress tolerance is viewed as an important transdiagnostic factor underlying psychopathology, including emotional disorders in childhood.
“Recently, with the emergence of transdiagnostic approaches, distress tolerance is viewed as an important transdiagnostic factor underlying psychopathology; namely, emotional disorders (e.g., [8,69]), including in childhood [25,50].”
From The Factorial Structure, Psychometric Properties and Sensitivity to Change of the Distress Tolerance Scale for Children with Emotional Disorders. (2024) · cites this paper as [69]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 188 · Cited by 868
Research works printed but not linked: 7
- Frenkel-Brunswik E Morton L Meaning of psychoanalytic concepts and confirmation of psychoanalytic theories Readings in psychoanalytic psychology 1959 East Norwalk, CT Appleton-Century-Crofts 29 42 doi:10.1037/11306-003 · DOI
- Hedayati M Dugas MJ Buhr K Francis K The relationship between intolerance of uncertainty and the interpretation of ambiguous and unambiguous information Poster presented at the annual conference for the Association for Advancement of Behavior Therapy 2003 November Boston, MA 20 23
- Hines EA Brown GE A standard stimulus for measuring vasomotor reactions: Its application in the study of hypertension Mayo Clinic Proceedings 1932 7 332 335 Available from http://mayo.iii.com/
- Hoffeditz EL Guilford JP The factors present in the fluctuations of fifteen ambiguous phenonema Psychological Bulletin 1935 32 726 727 Retrieved from http://psycnet.apa.org/journals/bul/32/9/637.pdf
- Kose S A Psychobiological Model of Temperament and Character: TCI Yeni Symposium: psikiyatri, nöroloji ve davranis bilimleri dergisi 2003 41 86 97 Retrieved from http://www.yenisymposium.net/fulltext/2003(2/ys2003_41_2_6.pdf)
- Schmidt NB Mitchell MA Keough ME Riccardi CJ Bernstein A Zvolensky MJ Vujanovic AA Distress tolerance in anxiety and its disorders Distress Tolerance New York Guilford Press (in press)
- Zvolensky MJ Bernstein A Vujanovic AA Distress Tolerance New York, NY Guilford Press (in press)
- Authors
- Leyro, T. M., Zvolensky, M. J., & Bernstein, A.
- Affiliations
- University of Vermont (US)
- University of Haifa (IL)
- Venue
- Psychological Bulletin
- Published
- 2010-07
- Volume
- 136
- Issue
- 4
- Pages
- 576-600
- ISSN
- 0033-2909 (ISSN-L)
- 1939-1455
- PMC
- PMC2891552
- OpenAlex
- W2078108520
- Cited by
- 868
- References
- 188
- Citations by year
- 2026: 48 · 2025: 57 · 2024: 59 · 2023: 54 · 2022: 61 · 2021: 76 · 2020: 55 · 2019: 76 · 2018: 75 · 2017: 73 · 2016: 64 · 2015: 44 · 2014: 29 · 2013: 41 · 2012: 30
- FWCI
- 33.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychological Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (1 R01 MH076629-01; 1 R01 DA018734-01A1; R03 DA16307-01)
- National Research Service Award (1F31 DA024919-01)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- distress tolerance, psychopathology, risk factors, protective factors, resilience, psychiatric symptoms, conceptual heterogeneity, adults
- MeSH terms
- Adaptation, Psychological, Adult, Affect, Mental Disorders, Humans, Stress, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review