Cited by 868Resilience and Mental HealthPersonality Disorders and PsychopathologyAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Distress tolerance and psychopathological symptoms and disorders: A review of the empirical literature among adults.

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Leyro, Teresa M., Zvolensky, Michael J., Bernstein, Amit·2010·Psychological Bulletin

Abstract

We review theory and empirical study of distress tolerance, an emerging risk factor candidate for various forms of psychopathology. Despite the long-standing interest in and promise of work on distress tolerance for understanding adult psychopathology, there has not been a comprehensive review of the extant empirical literature focused on the construct. As a result, a comprehensive synthesis of theoretical and empirical scholarship on distress tolerance, including integration of extant research on the relations between distress tolerance and psychopathology, is lacking. Inspection of the scientific literature indicates that there are a number of promising ways to conceptualize and measure distress tolerance, as well as documented relations between distress tolerance factors and psychopathological symptoms and disorders. Although promising, there also is notable conceptual and operational heterogeneity across the distress tolerance literature. Moreover, a number of basic questions remain unanswered regarding the associations between distress tolerance and other risk and protective factors and processes, as well as its putative role(s) in vulnerability for and resilience to psychopathology. Thus, the current article provides a comprehensive review of past and contemporary theory and research and proposes key areas for future empirical study of this construct.

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  • The ability to tolerate distress and negative emotional states has long been associated with the development and maintenance of psychopathology and with difficulties discontinuing or withdrawing from psychiatric medications and drugs of abuse.

    “The ability to tolerate distress negative emotional states has long been associated with the development and maintenance of psychopathology [49–51] as well as difficulties discontinuing or withdrawing from psychiatric medications as well as drugs of abuse [49].”

    From Unified protocol for the discontinuation of long-term serotonin reuptake inhibitors in obsessive compulsive disorder: Study protocol and methods (2018) · cites this paper as [49]

    Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.

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  • Improving distress tolerance is a central aim of CBT and ACT.

    “Notably, increased emotional distress tolerance is a key goal of several behavioral therapies, including cognitive-behavioral therapy (CBT) and acceptance and commitment therapy (ACT; Hayes, Strosahl, & Wilson, 1999; Leyro, Zvolensky, & Bernstein, 2010).”

    From Enhancing Inhibitory Learning: The Utility of Variability in Exposure (2019) · cites this paper as Leyro, Zvolensky, & Bernstein, 2010

    The Abstract (page not available) says that many behavioral therapies target distress tolerance directly or indirectly and explicitly names ACT and mindfulness-based cognitive therapy. It does not establish that improving distress tolerance is a key goal of CBT generally; the listed cognitive therapy is a more specific approach. (LLM, conf=0.85)

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  • Distress tolerance is negatively correlated with anxiety and depression across diagnostic boundaries.

    “DT is negatively correlated with anxiety and depression across diagnostic boundaries (Leyro et al., 2010; Yoon et al., 2018).”

    From Distress tolerance as a mediator of mindfulness-based intervention for anxiety and depression: Evidence from two randomized controlled trials (2024) · cites this paper as Leyro et al., 2010

    The section on distress tolerance for negative emotional states (page unavailable) reports that lower distress tolerance was associated with more depressive symptoms among HIV-positive patients under higher life stress. The review also discusses anxiety-related constructs and possible transdiagnostic relevance, but its 'Specific versus common risk marker and factor?' section (page unavailable) treats that breadth as an open research question. It does not establish a general negative correlation with both anxiety and depression across diagnostic boundaries. (LLM, conf=0.84)

    Experimental — accuracy not yet measured
  • Through practicing mindfulness and other MIED exercises, individuals may become less likely to appraise uncomfortable emotions as unacceptable and better equipped to tolerate distressing experiences, thereby reducing emotional distress in the long run.

    “This suggests that through practicing mindfulness and engaging in other exercises within the MIED program, individuals may become less likely to appraise uncomfortable emotions as unacceptable and better equipped to tolerate distressing experiences (e.g., Lotan et al., 2013), thereby reducing emotional distress in the long run (Leyro et al., 2010; Li et al., 2023b).”

    From Distress tolerance as a mediator of mindfulness-based intervention for anxiety and depression: Evidence from two randomized controlled trials (2024) · cites this paper as Leyro et al., 2010

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  • Low distress tolerance has been proposed as a transdiagnostic factor that plays a key role in the maintenance of many psychopathological disorders, including obsessive-compulsive and related disorders.

    “Low DT has been proposed as a transdiagnostic factor that plays a key role in the maintenance of many psychopathological disorders, including obsessive-compulsive and related disorders (Barton et al., 2021;Leyro et al., 2010;Yap et al., 2018).”

    From A naturalistic study of emotion regulation-enhanced cognitive-behavioral group therapy for hoarding disorder in a community setting (2022) · cites this paper as Leyro et al., 2010

    The introduction proposes distress tolerance as a maintenance factor across several forms of psychopathology, and the “Specific versus common risk marker and factor?” section discusses its possible transdiagnostic relevance (pages unavailable in our copy). The “Intolerance of uncertainty” section reports associations with obsessive-compulsive disorder, but does not establish that low distress tolerance plays a key role in maintaining OCD or other related disorders. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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References 188 · Cited by 868

Research works printed but not linked: 7

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Authors
Leyro, T. M., Zvolensky, M. J., & Bernstein, A.
Affiliations
  • University of Vermont (US)
  • University of Haifa (IL)
Venue
Psychological Bulletin
Published
2010-07
Volume
136
Issue
4
Pages
576-600
ISSN
  • 0033-2909 (ISSN-L)
  • 1939-1455
OpenAlex
W2078108520
Cited by
868
References
188
Citations by year
2026: 48 · 2025: 57 · 2024: 59 · 2023: 54 · 2022: 61 · 2021: 76 · 2020: 55 · 2019: 76 · 2018: 75 · 2017: 73 · 2016: 64 · 2015: 44 · 2014: 29 · 2013: 41 · 2012: 30
FWCI
33.82
Type
journal article
Language
en
Open access
Locations
  • Psychological Bulletin (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Drug Abuse (1 R01 MH076629-01; 1 R01 DA018734-01A1; R03 DA16307-01)
  • National Research Service Award (1F31 DA024919-01)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
distress tolerance, psychopathology, risk factors, protective factors, resilience, psychiatric symptoms, conceptual heterogeneity, adults
MeSH terms
Adaptation, Psychological, Adult, Affect, Mental Disorders, Humans, Stress, Psychological

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