Longitudinal trajectories of everyday function by diagnostic status
Open accessAbstract
Generalized linear mixed models were used to examine longitudinal trajectories of everyday functional limitations by diagnostic stability/progression. Older adults (N = 384) were followed an average 3.6 years; participants were grouped by diagnosis at study baseline and last follow-up (normal cognition, Mild Cognitive Impairment, or dementia at each time point). At study baseline there were clear group differences; most notably among participants initially characterized as cognitively normal, those who developed Mild Cognitive Impairment or dementia over follow-up already demonstrated greater functional impairment compared with those who remained cognitively normal. Change in functional impairment progressed slowly in the early disease groups, but showed an accelerated worsening in those converting to dementia.
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Subtle functional changes are associated with an increased risk of conversion from normal aging to mild cognitive impairment and dementia.
“Subtle functional changes are associated with an increased risk of conversion from “normal aging” to mild cognitive impairment and dementia [5–7].”
From Primary outcome from the augmenting cognitive training in older adults study (ACT): A tDCS and cognitive training randomized clinical trial (2023) · cites this paper as [6]
The Discussion says subtle everyday-function changes were detectable in cognitively normal people who later developed MCI or dementia. The Results found worse baseline function among those who later developed dementia, but the difference for those who developed MCI was only a nonsignificant trend (p = .12). Thus the paper suggests, rather than firmly establishes, the claimed association for conversion to MCI. (LLM, conf=0.84)
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- Authors
- Farias, S. T., Chou, E., Harvey, D. J., Mungas, D., Reed, B., DeCarli, C., Park, L. Q., & Beckett, L.
- Affiliations
- University of California, Davis (US)
- ORCID
- Venue
- Psychology and Aging
- Published
- 2013-12
- Volume
- 28
- Issue
- 4
- Pages
- 1070-1075
- ISSN
- 0882-7974 (ISSN-L)
- 1939-1498
- PMC
- PMC4021720
- OpenAlex
- W2328119499
- Cited by
- 68
- References
- 0
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 2
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychology and Aging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (AG031252, AG010220, AG031563, AG10129, AG021028)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- longitudinal trajectories, mild cognitive impairment, dementia, cognitive decline, older adults, diagnostic stability, conversion to dementia
- MeSH terms
- Activities of Daily Living, Adult, Aged, Aged, 80 and over, Aging, California, Cognition, Cognition Disorders, Dementia, Female, Humans, Longitudinal Studies, Male, Neuropsychological Tests, Psychiatric Status Rating Scales, Geriatric Assessment, Linear Models, Disease Progression, Cognitive Dysfunction
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