The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index; none of the 20 sources its claims cite is checked for support yet.
From ideas to efficacy: The ORBIT model for developing behavioral treatments for chronic diseases
Open accessAbstract
OBJECTIVE: Given the critical role of behavior in preventing and treating chronic diseases, it is important to accelerate the development of behavioral treatments that can improve chronic disease prevention and outcomes. Findings from basic behavioral and social sciences research hold great promise for addressing behaviorally based clinical health problems, yet there is currently no established pathway for translating fundamental behavioral science discoveries into health-related treatments ready for Phase III efficacy testing. This article provides a systematic framework for developing behavioral treatments for preventing and treating chronic diseases. METHOD: The Obesity-Related Behavioral Intervention Trials (ORBIT) model for behavioral treatment development features a flexible and progressive process, prespecified clinically significant milestones for forward movement, and return to earlier stages for refinement and optimization. RESULTS: This article presents the background and rationale for the ORBIT model, a summary of key questions for each phase, a selection of study designs and methodologies well-suited to answering these questions, and prespecified milestones for forward or backward movement across phases. CONCLUSIONS: The ORBIT model provides a progressive, clinically relevant approach to increasing the number of evidence-based behavioral treatments available to prevent and treat chronic diseases. (PsycINFO Database Record
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Phase IIb data showing that a behavioral treatment produces a clinically significant signal on the behavioral risk factor in patients with the specified clinical problem, while the chosen control does not, supports moving to a Phase III efficacy trial.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > THE ORBIT MODEL FOR BEHAVIORAL TREATMENT DEVELOPMENT > Previous Efforts to Define a Process for Behavioral Intervention Development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“It is widely acknowledged that behavior plays a central role in the prevention and management of chronic disease.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > INTRODUCTION
What the sources say
- Not checked yetcites Mokdad, Marks, Stroup, & Gerberding, 2004
- Not checked yetcites Schroeder, 2007
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“While understanding the mechanisms through which an intervention produces its effects can be useful in developing better-targeted interventions, it is not critical to understand mechanisms of action in order to demonstrate an intervention’s effectiveness (Blumenthal, Babyak, Wei, O’Connor, Waugh, Eisenstein, Mark, Sherwood, et al., 2002).”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
What the sources say
- Not checked yetcites Blumenthal, Babyak, Wei, O’Connor, Waugh, Eisenstein, Mark, Sherwood, et al., 2002
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“a 5% weight loss as a biomedical target (Hamman, Wing, Edelstein, Lachin, Bray, Delahanty, Hoskin, Kriska, et al., 2006)”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > THE ORBIT MODEL FOR BEHAVIORAL TREATMENT DEVELOPMENT > Previous Efforts to Define a Process for Behavioral Intervention Development
What the sources say
- Not checked yetcites Hamman, Wing, Edelstein, Lachin, Bray, Delahanty, Hoskin, Kriska, et al., 2006
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“If the trial produces positive results, evidence specifically supporting each link of the chain strengthens the assertion that the observed effects were due to hypothesized pathways.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > THE ORBIT MODEL FOR BEHAVIORAL TREATMENT DEVELOPMENT > Previous Efforts to Define a Process for Behavioral Intervention Development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“Interventions that encourage healthy lifestyle behaviors, grounded in fundamental behavioral research and developed incrementally over time, have proven highly effective in reducing weight, blood pressure, cholesterol levels, and incidence of diabetes, among other clinically important outcomes (Appel, Clark, Yeh, Wang, Coughlin, Daumit, Miller, Dalcin et al., 2011; Appel, Champagne, Harsha, Cooper”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > INTRODUCTION
What the sources say
- Not checked yetcites Appel, Clark, Yeh, Wang, Coughlin, Daumit, Miller, Dalcin et al., 2011
- Not checked yetcites Appel, Champagne, Harsha, Cooper, Obarzanek, Elmer, Stevens, Vollmer, et al., 2003
- Not checked yetcites Knowler, Barrett-Connor, Fowler, Hamman, Lachin, Walker, Nathan, Diabetes Prevention Program Research Group, 2002
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Evidence collected for each link of the chain in negative trials can help determine whether null findings were due to a failure of the hypothesis that change in the behavioral risk factor is causally related to change in the biomedical outcome or a failure of the treatment to affect its targets.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > THE ORBIT MODEL FOR BEHAVIORAL TREATMENT DEVELOPMENT > Previous Efforts to Define a Process for Behavioral Intervention Development
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“a Phase Ia review of epidemiological studies and clinical trials provides empirical support for the clinical significance of a 30% reduction in diabetes over standard drug treatment (Hamman, Wing, Edelstein, Lachin, Bray, Delahanty, Hoskin, Kriska, et al., 2006)”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > THE ORBIT MODEL FOR BEHAVIORAL TREATMENT DEVELOPMENT > Previous Efforts to Define a Process for Behavioral Intervention Development
What the sources say
- Not checked yetcites Hamman, Wing, Edelstein, Lachin, Bray, Delahanty, Hoskin, Kriska, et al., 2006
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Without a consistent framework to support progression toward the behavioral efficacy trial, the ability of behavioral and social science researchers to provide the type of evidence that is meaningful to clinical gatekeepers and third-party payers is compromised.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
Tests✓ Asserted: passes? Checkable: unclear✓ Load-bearing: passes✓ Based: passesIn the paper
“Although a feasibility pilot study produces an unstable estimate of the effect size on the primary endpoint of the Phase III efficacy trial (Kraemer, Mintz, Noda & Tinklenberg, 2006), it should be considered along with accumulated effect sizes from similar past trials to determine the sample size needed for the efficacy trial.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > THE ORBIT MODEL FOR BEHAVIORAL TREATMENT DEVELOPMENT > Previous Efforts to Define a Process for Behavioral Intervention Development
What the sources say
- Not checked yetcites Kraemer, Mintz, Noda & Tinklenberg, 2006
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes
- Probably not a substantial claim. 17
- It may state two separate claims as one. 9
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Without a progressive approach to treatment development that embraces a variety of designs and methods, there is a risk that promising treatments will be abandoned prematurely because they fail tests that are too stringent for an evolving understanding of their fundamental elements.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
Tests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence.
In the paper
“Past models have emphasized the value of a systematic, phased approach to behavioral treatment development, and the recent emergence of evidence-based behavioral medicine (Davidson, Goldstein, Kaplan, Kaufmann, Knatterud, Orleans, Spring, Trudeau, & Whitlock, 2002) provides clear standards for rigor.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
What the sources say
- Not checked yetcites Davidson, Goldstein, Kaplan, Kaufmann, Knatterud, Orleans, Spring, Trudeau, & Whitlock, 2002
Strength:boosted· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The ORBIT model complements and extends these efforts in proposing a systematic, well-defined process by which the investigator can achieve these rigorous standards.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
Tests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Moreover, moderators (also called a priori subgroups in clinical trial methodology) can be studied in Phase Ib with the goal of adapting treatments so they are maximally powerful across all patients at risk.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Creating a robust evidence base for the value of behavioral treatments in clinical care has enormous potential to expand choices for patients, improve quality of care, prevent or delay disease and disability, and, most urgently, lower health care costs not only for individual patients but for society as a whole.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
Tests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✗ Based: failsProbably not a substantial claim. It may be too vague to check against evidence. The paper may give no reason why it holds. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Crosstalk between clinicians in medical practice and applied behavioral scientists can increase the significance of the questions posed and identify targets that have meaning in clinical practice.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
Tests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✗ Based: failsProbably not a substantial claim. It may be too vague to check against evidence. The paper may give no reason why it holds. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Without the early discovery and innovation that is characteristic of basic science, the potential for behavioral treatments to be robust enough to produce clinically significant results is undercut.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✗ Based: failsProbably not a substantial claim. The paper may give no reason why it holds.
In the paper
“both dietary changes (e.g., a 5% reduction in percent fat) and increases in physical activity (e.g., 150 minutes/week of moderately vigorous physical activity) as behavioral targets (Hamman, Wing, Edelstein, Lachin, Bray, Delahanty, Hoskin, Kriska, et al., 2006)”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > THE ORBIT MODEL FOR BEHAVIORAL TREATMENT DEVELOPMENT > Previous Efforts to Define a Process for Behavioral Intervention Development
What the sources say
- Not checked yetcites Hamman, Wing, Edelstein, Lachin, Bray, Delahanty, Hoskin, Kriska, et al., 2006
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In the ORBIT model, physiological mechanisms by which the behavioral risk factor translates into biomedical risk (referred to as biologic plausibility in epidemiology) can be focused on in early Phase Ia studies to help justify the choice of a behavioral risk factor and its cutpoint for clinical significance.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Such crosstalk can facilitate the evaluation of a behavioral treatment’s viability as an alternative or adjunctive treatment, its side effect profile and effects on quality of life, and its potential cost-effectiveness relative to existing treatments.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“It suggests that use of a progressive, transdisciplinary framework to facilitate the translation of basic behavioral science findings to clinical application will strengthen behavioral treatments, encourage their testing in rigorous efficacy and effectiveness trials, promote success, and foster dissemination into clinical practice.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
Tests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✗ Based: failsProbably not a substantial claim. It may be too vague to check against evidence. The paper may give no reason why it holds. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Crosstalk between basic and applied behavioral and social scientists can foster innovative approaches to common problems, leading to novel methods for motivating patients to stick with early changes, sustaining change by mobilizing social networks, or maximizing executive function as a way to minimize impulsivity.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
Tests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✗ Based: failsProbably not a substantial claim. It may be too vague to check against evidence. The paper may give no reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There is a strong rationale for such methods, but when used universally, particularly in the early phases of treatment development, their use can undercut creativity, impede discovery, and produce weak treatments.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
Tests✓ Asserted: passes? Checkable: unclear✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: Most behavioral treatments are currently tested using randomized designs with attention control groups, fixed protocols, and blinding to outcomes until follow-up is complete.
None of the sources cited for this claim have been checked yet.
In the paper
“This contrasts with the biomedical arena which benefits from industry support for early translational research and has a well-defined process for developing a new drug or device, starting with basic science research and progressing to the FDA-required Phase III efficacy trial.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > INTRODUCTION
What the sources say
- Not checked yetcites Friedman, Furburg, & DeMets, 1998
- Not checked yetcites Lipsky & Sharp, 2001
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Research using fMRI has shown that biofeedback can directly alter neural activity in specific brain regions and these changes can affect chronic clinical pain (deCharms, Maeda, Glover, Ludlow, Pauly, Soneji, Gabrieli, & Mackey, 2005).”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
What the sources say
- Not checked yetcites deCharms, Maeda, Glover, Ludlow, Pauly, Soneji, Gabrieli, & Mackey, 2005
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“All of the studies presented in this illustration could be conducted by a single investigator, by a single team of investigators, or by a group of investigators who are, at best, loosely connected.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > THE ORBIT MODEL FOR BEHAVIORAL TREATMENT DEVELOPMENT > Previous Efforts to Define a Process for Behavioral Intervention Development
Strength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Without input from clinical practice, treatments that are judged to be successful because they achieve statistical significance may produce results that are too small to be clinically meaningful.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✗ Based: failsProbably not a substantial claim. The paper may give no reason why it holds.
In the paper
“Clinical guidelines promote lifestyle change as the first step in treatment of insulin resistant patients (Handelsman, Mechanick, Blonde, Gruberger, Bloomgarden, Bray, Dagogo-Jack, Davidson, et al., 2011), but few validated lifestyle interventions are available.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > THE ORBIT MODEL FOR BEHAVIORAL TREATMENT DEVELOPMENT > Previous Efforts to Define a Process for Behavioral Intervention Development
What the sources say
- Not checked yetcites Handelsman, Mechanick, Blonde, Gruberger, Bloomgarden, Bray, Dagogo-Jack, Davidson, et al., 2011
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Coller (2008) has observed that one of the key skills necessary for a successful translational effort is the ability to articulate a health need or clinical question requiring a solution “with the precision of a basic science hypothesis.””
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > THE ORBIT MODEL FOR BEHAVIORAL TREATMENT DEVELOPMENT > Previous Efforts to Define a Process for Behavioral Intervention Development
What the sources say
- Not checked yetcites Coller (2008)
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“It begins with preclinical basic science studies in animal or in vitro models to understand the disease process. Phase I and II studies turn to humans and focus on small numbers of highly-selected subjects. Phase I “dose-finding” studies determine the maximally tolerated dose of a candidate drug, while Phase II studies determine the impact of this maximally tolerated dose on significant biologic”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > THE ORBIT MODEL FOR BEHAVIORAL TREATMENT DEVELOPMENT > The Process of Drug Development
What the sources say
- Not checked yetcites Friedman, Furburg, & DeMets, 1998
- Not checked yetcites Lipsky & Sharp, 2001
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, if they are conceptualized as crucial steps in a program of research that is directed toward efficacy and effectiveness trials to answer pressing clinical problems, their value becomes more apparent.”
§ From Ideas to Efficacy: The ORBIT Model for Developing Behavioral Treatments for Chronic Diseases > SUMMARY AND CONCLUSIONS
Tests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence.
- Rests on an assumption: Small early phase studies run the risk of being judged not very important.
The paper relies on this without support.
Applying bench findings to the bedside (Translation I research) is rare in behavioral science.
“Translation I research in which “bench” findings are applied to the “bedside” is uncommon in the behavioral arena.”
The paper relies on this without support.
Knowledge about fundamental human processes is not being optimally used for pressing behavioral health problems.
“Advances in understanding fundamental human processes such as motivation, emotion, cognition, self-regulation, decision-making, stress, and social networks are not being optimally applied to pressing behavioral health problems.”
The paper relies on this without support.
Promising behavioral treatments in development are often abandoned instead of refined when they fail early tests.
“Promising behavioral treatments “in the pipeline” are often abandoned, rather than refined, if they fail early tests.”
The paper relies on this without support.
Some treatments that succeed in early studies are not advanced to Phase III efficacy trials, while others enter Phase III prematurely without sufficient early-phase development.
“In some cases, treatments that achieve success in early studies are not pushed toward rigorous testing in Phase III efficacy trials, while others are tested in Phase III trials prematurely, without undergoing adequate development and refinement in early-phase studies.”
The paper relies on this without support.
Behavioral treatments for physical health outcomes lack governmental regulation and a widely accepted development process.
“Since the development of behavioral treatments that target physical health outcomes has not been regulated by any governmental agency, it has not been guided by any widely recognized and agreed-upon process.”
The paper relies on this without support.
No established pathway currently exists to translate basic behavioral science discoveries into treatments ready for Phase III efficacy testing.
“Findings from basic behavioral and social science research hold great promise for addressing behaviorally-based clinical health problems, yet there is currently no established pathway for translating fundamental behavioral science discoveries into health-related treatments ready for Phase III efficacy testing.”
The authors state this as an assumption.
Research efficiency and quality are enhanced when a collaborative team of investigators integrates diverse studies into a chain of evidence justifying a Phase III trial.
“An essential assumption of the ORBIT model is that research efficiency and quality are enhanced when a collaborative team of investigators works to integrate diverse studies into a chain of evidence that justifies a Phase III trial.”
The paper relies on this without support.
Few validated lifestyle interventions are available for insulin resistant patients.
“Clinical guidelines promote lifestyle change as the first step in treatment of insulin resistant patients (Handelsman, Mechanick, Blonde, Gruberger, Bloomgarden, Bray, Dagogo-Jack, Davidson, et al., 2011), but few validated lifestyle interventions are available.”
The paper relies on this without support.
All elements needed to go from ideas to an efficacy trial currently exist, but the pathway for doing so is not well-defined.
“Currently, all of the elements needed to go from ideas to the efficacy trial exist, but the pathway for doing so is not well-defined.”
The paper relies on this without support.
Most behavioral treatments are currently tested using randomized designs with attention control groups, fixed protocols, and blinding to outcomes until follow-up is complete.
“Currently, most behavioral treatments are tested in the same way using randomized designs with attention control groups, fixed protocols, and blinding to outcomes until follow-up is complete.”
The paper relies on this without support.
Demand is growing for primary and secondary prevention strategies that can reduce the burden of costly chronic diseases which primarily have behavioral causes.
“Currently, a window of opportunity exists in which demand is growing for primary and secondary prevention strategies that can reduce the burden of costly chronic diseases which primarily have behavioral causes.”
The paper relies on this without support.
Small early phase studies run the risk of being judged not very important.
“Small, early phase studies run the risk of being judged to be not very important.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“As a result we opted to rooted our analysis in behavioural science terminology as other work has suggested that this approach can help facilitate relevant understanding and application within the field of behavioural science [63].”
From Barriers and facilitators to diet, physical activity and lifestyle behavior intervention adherence: a qualitative systematic review of the literature (2023) · cites this paper as [63]
Experimental — accuracy not yet measuredIn the citing paper
“The ORBIT model was first introduced in 2015 and provides a progressive and iterative approach for developing and testing new interventions.”
From A nonrandomized pilot of a group, video-based telehealth intervention to reduce diabetes distress in parents of youth with type 1 diabetes mellitus (2022) · cites this paper as [13]
In the citing paper
“A key difference of the ORBIT model versus other approaches is its focus on using small, fluid, and cost-effective formative studies to develop and refine interventions ahead of launching expensive efficacy trials [13].”
From A nonrandomized pilot of a group, video-based telehealth intervention to reduce diabetes distress in parents of youth with type 1 diabetes mellitus (2022) · cites this paper as [13]
In the citing paper
“The ORBIT model defines four phases of treatment development.”
From A nonrandomized pilot of a group, video-based telehealth intervention to reduce diabetes distress in parents of youth with type 1 diabetes mellitus (2022) · cites this paper as [13]
In the citing paper
“Per the ORBIT model, evidence of achieving these milestones indicate a treatment may be appropriate for Phase 2 proof of concept or randomized pilot testing. [13]”
From A nonrandomized pilot of a group, video-based telehealth intervention to reduce diabetes distress in parents of youth with type 1 diabetes mellitus (2022) · cites this paper as [13]
In the citing paper
“Some potential strengths of this study include our use of the ORBIT model for behavioral intervention development to standardize study methods and help refine the intervention [13]”
From A nonrandomized pilot of a group, video-based telehealth intervention to reduce diabetes distress in parents of youth with type 1 diabetes mellitus (2022) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Intervention Mapping citation adds an author absent from the reference
MinorThe in-text citation includes Fernandez, but the matching 2011 reference lists only Bartholomew, Parcel, Kok, and Gottlieb.
“Intervention Mapping (Bartholomew, Parcel, Kok, Gottlieb & Fernandez, 2011)”
“4. Bartholomew L Parcel G Kok G Gottlieb G 2011 Planning health promotion programs: Intervention mapping San Francisco Jossey-Bass”
Davidson citation has conflicting years
MinorThe text cites this Davidson work as published in 2002, while the corresponding reference lists 2003.
“Davidson, Goldstein, Kaplan, Kaufmann, Knatterud, Orleans, Spring, Trudeau, & Whitlock, 2002”
“14. Davidson KW Goldstein M Kaplan RM Kaufmann PG Knatterud GL Orleans CT Spring B Trudeau KJ Whitlock EP 2003 Evidence-based behavioral medicine: what is it and how do we achieve it?”
ORBIT initiative citation has conflicting years
MinorThe in-text citation dates the Office of Behavioral and Social Sciences Research initiative to 2010, but its reference-list entry is dated 2011.
“Office of Behavioral and Social Sciences Research, 2010”
“37. Office of Behavioral and Social Sciences Research 2011 Available at http://grants.nih.gov/grants/guide/pa-files/PA-11-063.html”
Citations
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Ecological momentary assessment
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Actual causes of death in the United States
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Mokdad, A. H. (2004) · JAMA · doi:10.1001/jama.291.10.1238 · Cited by 5,211
2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults
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Single-Case Research Designs: Methods for Clinical and Applied Settings
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Planning health promotion programs an intervention mapping approach
Bartholomew, L. K., Parcel, G. S., Kok, G., & Gottlieb, N. (2006) · Cited by 2,038
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Research works printed but not linked: 2
- Friedman LM Furberg CD DeMets DL 1998 Fundamentals of Clinical Trials 3 New York Springer-Verlag
- Wansink B 2010 Designing Interventions that Stick: Behavioral Event Monitoring Presented at NIH Workshop on “Translating Ideas into Interventions: The Process of Developing Behavorial Interventions December 6–7, 2010 Bethesda, MD Available at http://www.nihorbit.org/ORBIT%20Content/Workshops%20and%20Conferences.aspx?PageView=Shared
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Items 401–500 of 1,176
Rethorst, C. D., Carmody, T. J., Argenbright, K. E., Mayes, T. L., Hamann, H. A., & Trivedi, M. H. (2023) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-023-01437-x · Cited by 11
Toivonen, K., Carlson, L. E., Rash, J. A., & Campbell, T. S. (2021) · Patient Preference and Adherence · doi:10.2147/ppa.s319087 · Cited by 12
“The Obesity-Related Behavioral Intervention Trials (ORBIT) model provides a useful framework for intervention development which could be applied to AET adherence, including targeting clinically meaningful processes based on thoroughly understanding the problem.(11) This utilizes a phasic and iterative approach, which…”
MethodManasse, S. M., Clark, K. E., Juarascio, A. S., & Forman, E. M. (2019) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-018-0632-9 · Cited by 14
Bolpagni, M., Pardini, S., & Gabrielli, S. (2024) · Internet Interventions · doi:10.1016/j.invent.2024.100775 · Cited by 13
“Human-centered design approaches involving all key stakeholders should be adopted in the design and pre-clinical research phases of DTx (Czajkowski et al., 2015) to ensure future adoption and effectiveness of these solutions, overcoming possible conflicts of perspectives among different…”
BackgroundMethodBurnette, C. B., Davies, A., & Mazzeo, S. E. (2021) · Eating Disorders · doi:10.1080/10640266.2021.1877886 · Cited by 13
“Few behavioral health interventions progress beyond initial implementation (Czajkowski et al., 2015); thus, pilot feasibility and acceptability data are vital for intervention refinement and progression.”
BackgroundOverview of the obesity intervention taxonomy and pooled analysis working group
Belle, S. H., Stevens, J., Cella, D. F., Foltz, J. L., Loria, C. M., Murray, D. M., Czajkowski, S. M., Arteaga, S. S., Thom, E. A., & PRATT, C. A. (2016) · Translational Behavioral Medicine · doi:10.1007/s13142-015-0365-5 · Cited by 10
Self-citation(2022) · doi:10.1037/cpp0000433 · Cited by 11
“To that end, we are using the ORBIT Model (Czajkowski et al., 2015) as a guide to intervention development, in which the extant literature is reviewed and preliminary data are collected to assess patients ’ experiences prior to development and pilot testing of an intervention and fully powered randomized controlled ef…”
Engaging primary care patients with existing online tools for weight loss: A pilot trial
McVay, M. A., Cooper, K. B., Donahue, M. L., Seoane, M. C., Shah, N. R., Webb, F. J., Perri, M. G., & Jake‐Schoffman, D. E. (2022) · Obesity Science & Practice · doi:10.1002/osp4.592 · Cited by 12
Pozzar, R. A., Enzinger, A. C., Poort, H., Furey, A., Donovan, H. S., Orechia, M., Thompson, E., Tavormina, A., Fenton, A., Jaung, T., et al. (2022) · Journal of Palliative Medicine · doi:10.1089/jpm.2021.0618 · Cited by 13
Caccavale, L. J., LaRose, J. G., Mazzeo, S. E., & Bean, M. K. (2022) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsac084 · Cited by 10
Soelling, S. J., Rubio-Chavez, A., Ingram, Z., Baird, L., Brindle, M. E., Cooper, Z. R., Vranceanu, A., Ritchie, C. S., & Cauley, C. E. (2025) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2025.101963 · Cited by 12
Mindful Eating, General Mindful Awareness, and Acceptance as Predictors of Weight Loss
Tronieri, J. S., Wadden, T. A., Pearl, R. L., Berkowitz, R. I., Alamuddin, N., & Chao, A. M. (2020) · Mindfulness · doi:10.1007/s12671-020-01493-5 · Cited by 11
“Investigators might use an iterative approach, such as the Obesity-Related Behavioral Intervention Trials (ORBIT) model of intervention development, to first identify the aspects of mindfulness most relevant to weight loss and refine an intervention protocol to maximize its effect on those components prior to testingw…”
MethodWoolf-King, S. E., Firkey, M., Foley, J. D., Bricker, J., Hahn, J. A., Asiago-Reddy, E., Wikier, J., Moskal, D., Sheinfil, A. Z., Ramos, J., et al. (2022) · AIDS and Behavior · doi:10.1007/s10461-022-03649-x · Cited by 10
“Consistent with this movement, models such as ORBIT Model for Behavioral Treatments [53] and the Stage Model of Behavioral Therapies Research [68–70] have been developed to standardize and operationalize the behavioral treatment development process, from early phase developmental studies (Phases I-II) to efficacy (Pha…”
MethodOffodile, A. C., Delgado, D. A., Lin, Y.-L., Geyen, D., Miller, C. J., Jain, S., Finder, J. P., Shete, S. S., Fossella, F. V., Overman, M. J., et al. (2023) · JCO Oncology Practice · doi:10.1200/op.22.00676 · Cited by 12
“Consistent with published work and the ORBIT framework of behavioral treatment development guidelines, we attempted to recruit a sample (n5 25) that included at least three racial minorities, three patients older than 70 years, and an even gender distribution.(18,19) A digital health navigator (DHN) screened the clini…”
MethodPeterson, R. K., Longo, C. A., Cunningham, T., Janzen, L. A., Guger, S., Monteiro, L., Rapson, R., Bartels, U. K., Bouffet, É., Solomon, T., et al. (2022) · Child Neuropsychology · doi:10.1080/09297049.2022.2061933 · Cited by 12
“We conducted a Phase IIb feasibility pilot randomized, open-label, parallel arm, controlled clinical trial (Figure 1) (ClinicalTrials.gov, NCT02573441) using the ORBIT framework (Czajkowski et al., 2015).”
MethodAn Innovation to Expand the Reach of Peer Support: A Feasibility and Acceptability Study
Goldstein, K. M., Voils, C. I., Bastian, L. A., Heisler, M., Olsen, M. K., Woolson, S., White‐Clark, C., Zervakis, J., & Oddone, E. Ž. (2022) · Military Medicine · doi:10.1093/milmed/usac295 · Cited by 11
Autonomy-Supportive Interventions
Reeve, J., & Cheon, S. H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.035 · Cited by 13
Maheu‐Cadotte, M., Dubé, V., & Lavoie, P. (2022) · CIN Computers Informatics Nursing · doi:10.1097/cin.0000000000000966 · Cited by 11
“This study is part of the first phase of the development of a new SG, where a first prototype is designed and refined before moving on to a pilot evaluation phase.(18)”
Czajkowski, S. M. (2016) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2016.02.009 · Cited by 11
Self-citationAppetitive Needs and Addiction
Sussman, S. Y., & Pakdaman, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.004 · Cited by 12
Beets, M. W., Pfledderer, C. D., von Klinggraeff, L., Burkart, S. A., & Armstrong, B. (2022) · Pilot and Feasibility Studies · doi:10.1186/s40814-022-01179-w · Cited by 10
“Developing innovative behavioral interventions requires conducting multiple iterations of an intervention to refine, modify, and/or adapt its content to identify the maximally potent prevention or treatment package [4, 15].”
Oswald, L. B., Fox, R. S., Murphy, K. M., Salsman, J. M., Sanford, S. D., McDade, T. W., & Victorson, D. E. (2022) · International Journal of Behavioral Medicine · doi:10.1007/s12529-021-10050-w · Cited by 12
“Based on published guidelines for feasibility studies, the cutoff for feasibility was ≥ 70% [39, 40].”
MethodIntegrating Acupuncture Within a Wellness Intervention for Women With Multiple Sclerosis
Becker, H., Stuifbergen, A. M., Schnyer, R. N., Morrison, J. D., & Henneghan, A. M. (2016) · Journal of Holistic Nursing · doi:10.1177/0898010116644833 · Cited by 11
Vickerman, K. A., Carpenter, K., Miles, L. N., Hsu, J. M., Watt, K. A., Brandon, T. H., Hart, J. T., Javitz, H. S., & Wagener, T. L. (2021) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2021.100845 · Cited by 10
“Prior to conducting the randomized pilot trial, we conducted a Phase IIa proof-of-concept study [31] with 10 participants to determine whether updates were needed to the developed treatment or study procedures.”
MethodIllustrating the Multi-Faceted Dimensions of Group Therapy and Support for Cancer Patients
Giese‐Davis, J., Brandelli, Y. N., Kronenwetter, C., Golant, M., Cordova, M. J., Twirbutt, S., Chang, V. Y., KRAEMER, H. C., & Spiegel, D. (2016) · Healthcare · doi:10.3390/healthcare4030048 · Cited by 16
Physical Activity Among Rural Men: Barriers and Preferences
Gallagher, J. B., Bayman, E. O., Cadmus‐Bertram, L., Jenkins, N. D. M., Pearlman, A. M., Whitaker, K. M., & Carr, L. J. (2023) · Preventing Chronic Disease · doi:10.5888/pcd20.230046 · Cited by 10
“Previous interventions in rural communities have not been tailored to rural men (10,11).”
Arigo, D., Schumacher, L. M., Baga, K., & Mogle, J. A. (2024) · Annals of Behavioral Medicine · doi:10.1093/abm/kaae058 · Cited by 13
“In line with this goal, the present study was an initial short-term, proof-of-concept test of digital, social micro-interventions in the natural environment among midlife adults with elevated risk for CVD (i.e., NIH Stage 1 [29]; ORBIT Phase 2 [30]).”
Mancinelli, E., Magnolini, S., Gabrielli, S., & Salcuni, S. (2024) · JMIR Formative Research · doi:10.2196/58653 · Cited by 21
“The Obesity-Related Behavioral Intervention Trials (ORBIT) model [12] is instrumental to this end.”
BackgroundMethodInfluentialLamothe, M., Rondeau, É., Duval, M., McDuff, P., Pastore, Y. D., & Sultan, S. (2020) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2020.101249 · Cited by 10
Lim, K., Chi, C., Chan, S., Lim, S. L., Ang, S. M., Yoong, J. S., Tsai, C., Wong, S. R., Yew, T. W., Tai, E. S., et al. (2019) · BMC Public Health · doi:10.1186/s12889-019-7691-3 · Cited by 9
Ibrahim, A. H., Beaumont, C. T., & Strohacker, K. A. (2024) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-024-09645-2 · Cited by 11
“Following established guidelines for designing and refining behavioral interventions and strategies (Czajkowski et al., 2015), qualitative research designs represent key pre-efficacy approaches that yield richer descriptions of the target phenomena that should inform continued optimization of…”
InfluentialThe Grow parenting program: demonstrating proof of concept
Chesnut, R. P., DiNallo, J. M., Czymoniewicz‐Klippel, M. T., & Perkins, D. F. (2018) · Health Education · doi:10.1108/he-01-2018-0005 · Cited by 10
Dorfman, C. S., Shelby, R. A., Stalls, J. M., Somers, T. J., Keefe, F. J., Vilardaga, J. P., Winger, J. G., Mitchell, K., Ehren, C., & Oeffinger, K. C. (2023) · Journal of Adolescent and Young Adult Oncology · doi:10.1089/jayao.2022.0100 · Cited by 10
Parmet, T., Yusufov, M., Braun, I. M., Pirl, W. F., Matlock, D. D., & Sannes, T. S. (2023) · Translational Behavioral Medicine · doi:10.1093/tbm/ibac121 · Cited by 10
Applying P-Technique Factor Analysis to Explore Person-Specific Models of Readiness-to-Exercise
Strohacker, K. A., Keegan, R. J., Beaumont, C. T., & Zakrajsek, R. A. (2021) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2021.685813 · Cited by 9
“Systematic research efforts toward defining and testing key intervention components—in our case personspecific models of readiness-to-exercise—via experimental and qualitative designs are strongly promoted by experts in health psychology to more efficiently develop and refine promising, evidence-based behavioral treat…”
Naar, S., Hudgens, M. G., Brookmeyer, R., Carcone, A. I., Chapman, J. E., Chowdhury, S., Ciaranello, A. L., Comulada, W. S., Ghosh, S., Horvath, K. J., et al. (2019) · AIDS Patient Care and STDs · doi:10.1089/apc.2019.0095 · Cited by 10
“Relatively little attention has been paid to designs, methods, and analytic techniques for early-phase (T1) behavioral translational research.(15) More attention has been focused on the development of study designs and methods for later-phase (T2, T3, and T4) behavioral research; however, here too there is a need to i…”
BackgroundOccupational Outcomes of a Physical Activity Intervention for Post-Secondary Student Mental Health
Nesbitt, A. E., Collins, K. J., Nalder, E. J., & Sabiston, C. M. (2021) · Canadian Journal of Occupational Therapy · doi:10.1177/00084174211021708 · Cited by 12
Norweg, A. M., Wu, Y., Troxel, A. B., Whiteson, J. H., Collins, E. G., Haas, F., Skamai, A., Goldring, R. M., Jean‐Louis, G., Reibman, J., et al. (2023) · Journal of Integrative and Complementary Medicine · doi:10.1089/jicm.2022.0552 · Cited by 13
“17 A limitation of the study was high study dropout rates and missing re-evaluation data.”
Susinski, S., Bouchard, K., Stragapede, E., Dozois, S., Sterling, E., & Tulloch, H. E. (2024) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2023-0416 · Cited by 10
Powell, L. H., Kaufmann, P. G., & Freedland, K. E. (2021) · Springer eBooks · doi:10.1007/978-3-030-39330-4_7 · Cited by 12
Self-citationMarier-Tétrault, E., Bebawi, E., Béchard, S., Brouillard, P., Zuchinali, P., Rémillard, É., Carrier, Z., Jean-Charles, L., Nguyen, J., Lehoux, P., et al. (2024) · JMIR Formative Research · doi:10.2196/53444 · Cited by 11
“…Behavioral Intervention Trials model for developing behavioral treatments for chronic diseases helped us to design and structure this pilot study [6] with behavior change techniques being incorporated into the app development [18,19] (eg, information about HF and self-care tools) [20].”
Basic behavioral science research priorities in minority health and health disparities
Halbert, C. H., & Allen, C. G. (2021) · Translational Behavioral Medicine · doi:10.1093/tbm/ibab143 · Cited by 9
“Related Behavioral Intervention Trials (ORBIT) is to identify treatment targets and test and pilot test interventions [65].”
The development of a social norms adherence intervention for adolescents with epilepsy
Modi, A. C., Patel, A. D., Gutierrez‐Colina, A. M., Wetter, S. E., Heckaman, L. M., Debs, A., Mara, C. A., Wentzel, E., Schmidt, M., & Stevens, J. H. (2020) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2020.107628 · Cited by 8
“The ORBIT Model for Behavioral Treatment outlines a flexible and progressive process to develop behavioral interventions [37].”
MethodBehavioral Medicine in the COVID-19 Era: Dawn of the Golden Age
(2020) · doi:10.1093/abm/kaaa057 · Cited by 9
“We must incorporate lessons from past infectious disease events to identify those most likely to be affected first in order to stem transmission early before broader community spread [6].”
BackgroundHuffman, J. C., Millstein, R. A., Celano, C. M., Healy, B. C., Park, E. R., & Collins, L. M. (2019) · Annals of Behavioral Medicine · doi:10.1093/abm/kaz035 · Cited by 11
“Recently, more complex and iterative multiphase trial designs have been used for Type I translational research, such as in the National Institutes of Health (NIH) Obesity-Related Behavioral Intervention Trials (ORBIT) initiative [2] to develop obesity prevention and reduction strategies.”
Backgroundvon Klinggraeff, L., Ramey, K. T., Pfledderer, C. D., Burkart, S. A., Armstrong, B., Weaver, R. G., & Beets, M. W. (2023) · Pilot and Feasibility Studies · doi:10.1186/s40814-023-01345-8 · Cited by 9
“Conclusion Preliminary studies play a key role in the development of behavioral interventions by providing information about the practicality, execution, and resources needed to execute a larger iteration of the same or similar study [31, 32].”
BackgroundStevens, C. J., Gillman, A. S., Giordano, G., & Bryan, A. D. (2020) · Health Psychology · doi:10.1037/hea0001023 · Cited by 9
Watkins, J. M., Goss, J. M., Major, M. G., Kwaiser, M. M., Medellin, A. M., Hobson, J. M., Kercher, V. M. M., & Kercher, K. A. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21070913 · Cited by 10
“Moreover, analyzing a study’s feasibility helps ensure that interventions have effective designs with the ability to scale up [31].”
BackgroundImplementation Science and Translation in Behavior Change
Łuszczyńska, A., Łobczowska, K., & Horodyska, K. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.023 · Cited by 10
Menezes, M., Burroughs, C., Pappagianopoulos, J., Sadikova, E., Fuhrmann, E., Bohac, G., Cross, R., Witte, L., Brinkmann, G., Lemley, R., et al. (2024) · Autism · doi:10.1177/13623613241252470 · Cited by 9
“The sequential progression from pilot study to efficacy trial is aligned with established frameworks for development and testing of behavioral interventions (Craig et al., 2008; Czajkowski et al., 2015; Onken et al., 2014).”
Soltero, E. G., Lopez, C., Musaad, S. M. A., O’Connor, T. M., & Thompson, D. I. (2023) · Contemporary Clinical Trials · doi:10.1016/j.cct.2023.107117 · Cited by 7
Pratscher, S. D., Sibille, K. T., & Fillingim, R. B. (2023) · Pilot and Feasibility Studies · doi:10.1186/s40814-023-01247-9 · Cited by 9
“Consistent with models and recommendations for developing theoretically informed interventions [61, 62], several lines of evidence support the premise that CCBR will be helpful for individuals with chronic pain.”
Arpin, V., Brassard, A., Amiri, S. E., & Péloquin, K. (2019) · Journal of Sex & Marital Therapy · doi:10.1080/0092623x.2018.1526836 · Cited by 9
“Due to the small sample size, statistically significant effects were examined, although we primarily sought clinical, rather than statistical benefit (Czajkowski et al., 2015).”
BackgroundMethodInfluentialVickery, K. D., Ford, B. R., Gelberg, L., Bonilla, Z. E., Strother, E., Gust, S., Adair, E., Montori, V. M., Linzer, M., Evans, M. D., et al. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1225777 · Cited by 9
Evaluation of Behavior Change Interventions
Matthews, L., & Simpson, S. A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.022 · Cited by 8
A Pilot Randomized Trial of an Obesity Prevention Program for High-Risk Infants in Primary Care
Rybak, T. M., Modi, A. C., Mara, C. A., Herbst, R. B., Lauer, B. A., Burkhardt, M. C., & Stark, L. J. (2022) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsac075 · Cited by 9
Bissonnette, J., Pierre, S., Duong, A. T. J., Pinard, A.-M., Rainville, P., & Ogez, D. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.926584 · Cited by 9
Sweeney, A. M., Wilson, D. K., Zarrett, N. R., Horn, M. L. V., & Resnicow, K. (2020) · Health Promotion Practice · doi:10.1177/1524839920939572 · Cited by 11
“Consistent with the ORBIt model, which highlights the importance of refining interventions during Phase-1 development (Czajkowski et al., 2015), the formative process evaluation provided key insights into strengths and areas for improvement.”
ResultSwartz, M. C., Robertson, M. C., Christopherson, U., Wells, S. J., Lewis, Z. H., Bai, J., Swartz, M. D., Silva, H. C., Martínez, E., & Lyons, E. (2023) · Life · doi:10.3390/life13020574 · Cited by 8
“We conducted a phase II feasibility pilot study [33].”
MethodContractor, A. A., Caldas, S. V., Dolan, M., Banducci, A. N., & Jin, L. (2019) · Counselling and Psychotherapy Research · doi:10.1002/capr.12267 · Cited by 9
Murray, H. B., Weeks, I., Thurler, A. H., Calabrese, S., Lapinel, M. K., Madva, E. N., Staller, K. D., Keefer, L., & Kuo, B. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14526 · Cited by 9
Xie, E. B., Simpson, K. M., Reynolds, K., Giuliano, R. J., Protudjer, J. L. P., Söderström, M., Sauer-Zavala, S. E., Giesbrecht, G. F., Lebel, C. A., MacKinnon, A., et al. (2022) · Trials · doi:10.1186/s13063-022-06512-5 · Cited by 10
Self-citationBreiner, C. E., Miller, M. L., & Hormes, J. M. (2024) · International Journal of Eating Disorders · doi:10.1002/eat.24269 · Cited by 9
Sauvé, G., Buck, G., Lepage, M., & Corbière, M. (2021) · Journal of occupational rehabilitation · doi:10.1007/s10926-021-09995-2 · Cited by 9
Greenberg, J., Lin, A. C., Popok, P., Kulich, R. J., Edwards, R. R., & Vranceanu, A. (2021) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-020-09758-w · Cited by 7
Driving Pressure: The Road Ahead
Sahetya, S. K., & Fan, E. (2019) · Respiratory Care · doi:10.4187/respcare.07226 · Cited by 8
Jeske, S., Brawley, L. R., & Arbour‐Nicitopoulos, K. P. (2020) · Adapted Physical Activity Quarterly · doi:10.1123/apaq.2019-0103 · Cited by 7
Bradley, S. S., de Holanda, L. J., Chau, T. T., & Wright, F. V. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1398459 · Cited by 7
Ferrara, P.-M. M., Zakrajsek, R. A., Eckenrod, M. R., Beaumont, C. T., & Strohacker, K. A. (2021) · Journal of Applied Sport Psychology · doi:10.1080/10413200.2021.1996482 · Cited by 11
“The rationale for the design of this study lies in the Obesity-Related Behavioral Intervention Trials (ORBIT) Model—guidelines designed for the development of long-term health behavior interventions (Czajkowski et al., 2015).”
BackgroundMethodInfluentialStrengthening behavioral clinical trials with online qualitative research methods
Bouchard, K., & Tulloch, H. E. (2019) · Journal of Health Psychology · doi:10.1177/1359105319855120 · Cited by 8
“More recently, the Obesity-Related Behavioral Intervention Trials (ORBIT) model (Czajkowski et al., 2015), which was created to guide the development of clinically relevant behavioral treatments that address chronic disease, cites that qualitative research methods can help to build an evidence base…”
BackgroundTeo, A. R., Hooker, E. R., Call, A. A., Dobscha, S. K., Gamble, S., Cross, W. F., & Rodgers, C. S. (2023) · Suicide and Life-Threatening Behavior · doi:10.1111/sltb.13028 · Cited by 8
Ma, J., Lewis, M. A., & Smyth, J. M. (2018) · Translational Behavioral Medicine · doi:10.1093/tbm/ibx032 · Cited by 8
“Intervention Trials (ORBIT) model [11] and the”
Meaney, P. A., Hokororo, A., Masenge, T. J., Mwanga, J. R., Kalabamu, F. S., Berg, M., Rozenfeld, B., Smith, Z. H., Chami, N., Mkopi, N. P., et al. (2023) · Digital Health · doi:10.1177/20552076231180471 · Cited by 6
Kariuki, J. K., Sereika, S. M., Erickson, K. I., Burke, L. E., Kriska, A. M., Cheng, J. S.-C., Milton, H., Hirshfield, S., Ogutu, D., & Gibbs, B. B. (2023) · Contemporary Clinical Trials · doi:10.1016/j.cct.2023.107318 · Cited by 9
Hohl, S. D., Knerr, S. A., & Thompson, B. (2019) · Research Evaluation · doi:10.1093/reseval/rvz012 · Cited by 8
Franco‐Arellano, B., Brown, J. M., Daggett, Q., Lockhart, C., Kapralos, B., LeSage, A., & Arcand, J. (2023) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2023-0214 · Cited by 9
Palfai, T. P., Saitz, R., Kratzer, M. P. L., Taylor, J. L., Otis, J. D., & Bernstein, J. (2020) · AIDS Care · doi:10.1080/09540121.2020.1776825 · Cited by 8
The S.P.A.C.E Hypothesis: Physical Activity as Medium — Not Medicine — for Public Health Impact
Bustamante, E. E., Ramer, J. D., Santiago-Rodríguez, M. E., Mehta, T. G., Bustamante, A. S., Márquez, D. X., & Frazier, S. L. (2021) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000248 · Cited by 8
(2020) · doi:10.1080/09540121.2020.1810617 · Cited by 8
“The Model provides a framework for behavioral interventions explicating the trajectory from the generation of ideas to testing for intervention efficacy with the goal of focusing on meaningful and important clinical outcomes for patients with chronic illnesses (Czajkowski et al., 2015).”
BackgroundMethodInfluentialProcessing of Positive Memories Technique
Banducci, A. N., Fondren, A. H., Bocanegra, A., Crespo, M., & Contractor, A. A. (2022) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000001599 · Cited by 8
Millstein, R. A., Thorndike, A. N., Kim, S., Park, E. R., & Huffman, J. C. (2020) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2020.100626 · Cited by 9
Proeschold‐Bell, R. J., Eagle, D. E., Tice, L. C., Yao, J., Rash, J. A., Choi, J. Y., Stringfield, B., & Labrecque, S. M. (2023) · Journal of Religion and Health · doi:10.1007/s10943-023-01848-x · Cited by 15
“Following best practices for developing behavioral treatments (Czajkowski et al., 2015), we conducted Phase-II preliminary testing of four potentially stressreducing interventions to: 1) evaluate the feasibility and acceptability of the trial protocols; 2) inform intervention modifications; and 3) provide initial esti…”
MethodDigital Twins in the Future Design of Digital Therapeutics
Gabrielli, S., Piras, E. M., & Mayora, O. (2023) · doi:10.1145/3594739.3611325 · Cited by 7
“…evidence-based behavioral treatments for prevention and care have been provided, such as the ORBIT model (Fig.1) in the field of chronic diseases [8], there is still room for improving and optimizing the methodologies leading to an effective design and preliminary testing of DTx (Phase I and…”
MethodStern, M., Rancourt, D., Lozano, S. S., Buro, A. W., Gray, H. L., Rodriguez, C., Bailey, R., & Redwine, L. S. (2023) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsad049 · Cited by 8
de Ridder, D. T. D., Gillebaart, M., & Friese, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.040 · Cited by 9
Butryn, M. L., Hagerman, C. J., Crane, N. T., Ehmann, M. M., Forman, E. M., Milliron, B., & Simone, N. L. (2023) · Cancer Control · doi:10.1177/10732748231214122 · Cited by 8
Ninot, G., & Carbonnel, F. (2016) · HEGEL - HEpato-GastroEntérologie Libérale · doi:10.4267/2042/61405 · Cited by 9
Sangalli, L., Manning, E., Miller, C. S., Fricton, J., Lok, B. C. L., & Boggero, I. A. (2025) · Journal of Dental Education · doi:10.1002/jdd.13928 · Cited by 9
Sawicki, G. S., Goodman, A. S., Bacon, C., Collins, L., Greenberg, J., Duncan, C. L., Frederick, C., Luebbert, S., Mazuera, S., Polineni, D., et al. (2023) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2023.04.015 · Cited by 8
Zheng, D. J., Rose, L., Borgundvaag, B., et al. (2024) · Trials · doi:10.1186/s13063-024-08250-2 · Cited by 8
“The current protocol is part of a program of research following the Obesity-Related Behavioral Interventional Trials (ORBIT) model whereby complex behavioral interventions are systematically refined to prevent premature evaluation, similar to the development of pharmaceuticals [11].”
MethodAramideh, J., Ogez, D., Rondeau, É., Duval, M., & Sultan, S. (2022) · British Journal of Pain · doi:10.1177/20494637221103170 · Cited by 9
“Participants’ feedback is crucial when developing new non-pharmacological interventions.(31) The focus group showed that nurses were satisfied with the training and that it was adequate for training pediatric nurses.”
BackgroundOgez, D., Péloquin, K., Bertout, L., Bourque, C.-J., Curnier, D., Drouin, S., Laverdière, C., Marcil, V., Aramideh, J., Ribeiro, R., et al. (2021) · Cogent Medicine · doi:10.1080/2331205x.2021.1944476 · Cited by 8
“The definition of the intervention program is an important and integral part of the intervention development stages (Czajkowski et al., 2015).”
BackgroundMethodInfluentialPfledderer, C. D., von Klinggraeff, L., Burkart, S. A., Bandeira, A. D. S., Armstrong, B., Weaver, R. G., Adams, E. L., & Beets, M. W. (2023) · Pilot and Feasibility Studies · doi:10.1186/s40814-023-01389-w · Cited by 9
“…frameworks, including the National Institutes of Health Stage Model [36] and the Obesity-Related Behavioral Intervention Trials (ORBIT) model [37], outline the sequential and iterative processes for developing large-scale interventions, and specific attention is devoted to preliminary…”
MethodMassierer, D., Sapir‐Pichhadze, R., Bouchard, V., Dasgupta, K., Fernández, N., Costa, D. D., Ahmed, S., Fortin, M., Langevin, R., Mayo, N. E., et al. (2019) · JMIR Research Protocols · doi:10.2196/13420 · Cited by 7
“We will use the Obesity-Related Behavioral Intervention Trials (ORBIT) model for developing behavioral treatments for chronic diseases [22] to guide the proposed project and develop our Web-based guide, the GETONTRAK.”
Dewez, S., Laurin, C., Ogez, D., Bourque, C. J., Curnier, D. Y., Laverdière, C., Lévesque, A., Marcil, V., Sinnett, D., & Sultan, S. (2021) · Health Psychology and Behavioral Medicine · doi:10.1080/21642850.2021.1903326 · Cited by 6
“In line with recommendations on program development (Czajkowski et al., 2015), we defined and refined the design of the training Motivation Cafés, a manualized training program aimed to enhance MC competencies in healthcare professionals working in pediatric oncology.”
MethodInfluentialFeig, E. H., Harnedy, L. E., Thorndike, A. N., Psaros, C., Healy, B. C., & Huffman, J. C. (2022) · JMIR Research Protocols · doi:10.2196/39856 · Cited by 7
“The GOALS intervention and study protocol were developed and refined in accordance with the Obesity-Related Behavioral Intervention Trials (ORBIT) model [40].”
MethodLang, M., Dort, J. C., Stephen, J. E., Lamont, L., & Giese‐Davis, J. (2020) · Journal of Adolescent and Young Adult Oncology · doi:10.1089/jayao.2020.0030 · Cited by 7
“To leverage video-based narratives, peer connections, and technology-facilitated interventions for AYAs, we modified the existing OSG + E model and developed a phase II, randomized proof-of-concept trial.(10) This trial explores a new narrative-informed emotion-focused model using video as a discussion stimulus for ch…”
Method
Metadata
- Authors
- Czajkowski, S. M., Powell, L. H., Adler, N., Naar-King, S., Reynolds, K. D., Hunter, C. M., Laraia, B., Olster, D. H., Perna, F. M., Peterson, J. C., Epel, E., Boyington, J. E., & Charlson, M. E.
- Affiliations
- National Institutes of Health (US)
- Rush University Medical Center (US)
- University of California, San Francisco (US)
- Claremont Graduate University (US)
- University of California, Berkeley (US)
- Weill Cornell Medicine (US)
- ORCID
- Venue
- Health Psychology
- Published
- 2015-10
- Volume
- 34
- Issue
- 10
- Pages
- 971-982
- ISSN
- 0278-6133 (ISSN-L)
- 1930-7810
- PMC
- PMC4522392
- OpenAlex
- W1985326609
- Cited by
- 1,161
- References
- 54
- Citations by year
- 2026: 118 · 2025: 152 · 2024: 158 · 2023: 142 · 2022: 116 · 2021: 119 · 2020: 191 · 2019: 69 · 2018: 48 · 2017: 20 · 2016: 21 · 2015: 4
- FWCI
- 50.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Health Psychology (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Scholarship @ Claremont (The Claremont Colleges) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging
- American Federation for Aging Research
- John A. Hartford Foundation
- Atlantic Philanthropies (K23AG042869)
- Topics
- Social Sciences › Psychology › Applied Psychology › Behavioral Health and Interventions
- Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
- Social Sciences › Psychology › Developmental and Educational Psychology › Behavioral and Psychological Studies
- Keywords
- ORBIT model, chronic disease prevention, chronic disease treatment
- MeSH terms
- Behavior Therapy, Chronic Disease, Humans, Biomedical Research
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-06, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-06 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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