Cited by 320Health disparities and outcomesTryptophan and brain disordersStress Responses and Cortisol

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Social support, social integration, and inflammatory cytokines: a meta-analysis

Uchino, Bert N., Trettevik, Ryan, Kent de Grey, Robert G., Cronan, Sierra, Hogan, Jasara, Baucom, Brian R. W.·2018·Health Psychology

DOI 10.1037/hea0000594

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Abstract

OBJECTIVE: Social support and social integration have been linked to lower rates of morbidity and mortality. However, the biological mechanisms responsible for such links need greater attention to advance theory and unique intervention opportunities. The main aim of this article was to conduct a meta-analytic review of the association between social support-social integration and inflammatory cytokines (e.g., interleukin-6, C-reactive protein) and test several proposed moderators from prior qualitative reviews. METHOD: . The review identified 41 studies with a total of 73,037 participants. RESULTS: The omnibus meta-analysis showed that social support-social integration were significantly related to lower levels of inflammation (Zr = -.073). These results were not moderated by the operationalization of social relationships or the type of population, cytokine, and design. CONCLUSIONS: These data suggest that inflammation is at least one important biological mechanism linking social support and social integration to the development and course of disease. Future work should continue to build on this review and address next-generation questions regarding antecedent processes, mechanisms, and other potential moderators. (PsycINFO Database Record

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Authors: Uchino, B. N., Trettevik, R., Kent de Grey, R. G., Cronan, S., Hogan, J., & Baucom, B. R. W.
ORCID: Uchino, Bert N.
Hogan, Jasara
Baucom, Brian R. W.
Venue: Health Psychology
Publisher: American Psychological Association (APA)
Published: 2018-05
Volume: 37
Issue: 5
Pages: 462-471
ISSN: 0278-6133 (ISSN-L)
1930-7810
DOI: 10.1037/hea0000594
OpenAlex: W2792810717
Semantic Scholar: 7d168fbdd00e3ec2efcb8e68133c1428db3bbd0f
Cited by: 320
References: 81
Citations by year: 2026: 37 · 2025: 45 · 2024: 48 · 2023: 46 · 2022: 43 · 2021: 47 · 2020: 24 · 2019: 26 · 2018: 3
FWCI: 26.66
Type: journal article
Language: en
Open access: closed
Locations: Health Psychology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Health › Health disparities and outcomes
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: social support, social integration, inflammatory cytokines, inflammation, interleukin-6, C-reactive protein, biological mechanisms, interpersonal relationships, health outcomes
MeSH terms: Humans, Inflammation, Social Support, Cytokines

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Social support, social integration, and inflammatory cytokines: a meta-analysis

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