The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
Abstract
Helicobacter pylori, one of the most common bacterial pathogens of humans, colonizes the gastric mucosa, where it appears to persist throughout the host's life unless the patient is treated. Colonization induces chronic gastric inflammation which can progress to a variety of diseases, ranging in severity from superficial gastritis and peptic ulcer to gastric cancer and mucosal-associated lymphoma. Strain-specific genetic diversity has been proposed to be involved in the organism's ability to cause different diseases or even be beneficial to the infected host and to participate in the lifelong chronicity of infection. Here we compare the complete genomic sequences of two unrelated H. pylori isolates. This is, to our knowledge, the first such genomic comparison. H. pylori was believed to exhibit a large degree of genomic and allelic diversity, but we find that the overall genomic organization, gene order and predicted proteomes (sets of proteins encoded by the genomes) of the two strains are quite similar. Between 6 to 7% of the genes are specific to each strain, with almost half of these genes being clustered in a single hypervariable region.
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“The complete genome sequences of two H. pylori strains, 26695 and J99 (1, 34), have been published elsewhere and demonstrate that this organism contains only two rRNA operons, increasing the likelihood that rRNA mutations could arise.”
From Mutations in the 16S rRNA Genes of Helicobacter pylori Mediate Resistance to Tetracycline (2002) · cites this paper as [1]
In the citing paper
“Analysis of the H. pylori genome sequences (1, 34) indicates that the smallest distances between rdxA and one of the 16S rRNA genes are 193 kb in strain 26695 and 205 kb in strain J99.”
From Mutations in the 16S rRNA Genes of Helicobacter pylori Mediate Resistance to Tetracycline (2002) · cites this paper as [1]
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Cites
The complete genome sequence of the gastric pathogen Helicobacter pylori
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Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging
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Self-citationAnalyses of the cag pathogenicity island of Helicobacter pylori
Akopyants, N. S., Clifton, S. W., Kersulyte, D., Crabtree, J. E., Youree, B. E., Reece, C. A., Bukanov, N. O., Drazek, E. S., Roe, B. A., & Berg, D. E. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00770.x · Cited by 716
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Helicobacter Pylori and Gastroduodenal Disease
Cover, T. L., & Blaser, M. J. (1992) · Annual Review of Medicine · doi:10.1146/annurev.me.43.020192.001031 · Cited by 265
PCR-based RFLP analysis of DNA sequence diversity in the gastric pathogenHelicobacter pylori
Akopyanz, N., Bukanov, N. O., Westblom, T. U., & Berg, D. E. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.23.6221 · Cited by 250
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IS-Linked Movement of a Restriction-Modification System
Takahashi, N., Ohashi, S., Sadykov, M. R., Mizutani-Ui, Y., & Kobayashi, I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016554 · Cited by 18
Proteomic studies of micronutrient deficiency and toxicity
Ali, A., Bhat, B. A., Rather, G. A., Malla, B. A., & Ganie, S. A. (2020) · Plant Micronutrients · doi:10.1007/978-3-030-49856-6_11 · Cited by 15
Greber (1999) · doi:10.1002/(sici)1522-2683(19990101)20:4/5
Metadata
- Authors
- Alm, R. A., Ling, L.-S. L., Moir, D. T., King, B. L., Brown, E. D., Doig, P. C., Smith, D. R., Noonan, B., Guild, B. C., deJonge, B. L., Carmel, G., Tummino, P. J., Caruso, A., Uria-Nickelsen, M., Mills, D. M., Ives, C., Gibson, R., Merberg, D., Mills, S. D., Jiang, Q., Taylor, D. E., Vovis, G. F., & Trust, T. J.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Alm, Richard A.
- ORCID
- Venue
- Nature
- Published
- 1999-01-14
- Volume
- 397
- Issue
- 6715
- Pages
- 176-180
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2016299826
- Cited by
- 1,893
- References
- 21
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 21 · 2023: 18 · 2022: 16 · 2021: 25 · 2020: 21 · 2019: 24 · 2018: 33 · 2017: 30 · 2016: 46 · 2015: 53 · 2014: 94 · 2013: 49 · 2012: 56
- FWCI
- 171.93
- Type
- journal article
- Language
- en
- Update notices
- erratum (1999-02-25)
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- Helicobacter pylori, comparative genomics, hypervariable region, gene order, proteome, gastric colonization, chronic gastritis, peptic ulcer, gastric cancer, bacterial genomics
- MeSH terms
- Duodenal Ulcer, Humans, Molecular Sequence Data, Species Specificity, Gene Expression Regulation, Bacterial, Sequence Alignment, Helicobacter pylori, Helicobacter Infections, Genome, Bacterial, Sequence Analysis, DNA
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