Tyro-3 family receptors are essential regulators of mammalian spermatogenesis
Lu, Qingxian, Gore, Martin, Zhang, Qing, Camenisch, Todd, Boast, Sharon, Casagranda, Franca, Lai, Cary, Skinner, Michael K. +5 more·1999·Nature
DOI 10.1038/19554
Cited by (509)
Items 301–400 of 509
- Coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases, Axl and Sky, in human uterine endometrium and ovarian endometriosisWen-Shu Sun · 2002 · Molecular Human Reproduction
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- Microglial phagocytosis of single dying oligodendrocytes is mediated by CX3CR1 but not MERTKGenaro E. Olveda, Maryanne N. Barasa, Robert Hill · 2024 · Cell Reports
- Evaluation of testicular toxicology of doxorubicin based on microarray analysis of testicular specific gene expressionHikari Takahashi, Hitoshi Tainaka, Masakazu Umezawa, Ken Takeda, Hiromitsu Tanaka, Yoshitake Nishimune, Shigeru Oshio · 2011 · The Journal of Toxicological Sciences
- Hypothalamic but not pituitary or ovarian defects underlie the reproductive abnormalities in Axl/Tyro3 null miceAngela M. Pierce, Mei Xu, Brian Bliesner, Zhilin Liu, JoAnne S. Richards, Stuart A. Tobet, Margaret E. Wierman · 2011 · Molecular and Cellular Endocrinology
- Galectin-3 Stimulates Tyro3 Receptor Tyrosine Kinase and Erk Signalling, Cell Survival and Migration in Human Cancer CellsNour Al Kafri, Sassan Hafizi · 2020 · Biomolecules
- Having an Old Friend for Dinner: The Interplay between Apoptotic Cells and EfferocytesAustin Le Lam, Bryan Heit · 2021 · Cells
- Targeting AXL in NSCLCAubhishek Zaman, Trever Grant Bivona · 2021 · Lung Cancer Targets and Therapy
- Axl Tyrosine Kinase Protects against Tubulo-Interstitial Apoptosis and Progression of Renal Failure in a Murine Model of Chronic Kidney Disease and HyperphosphataemiaGareth D. Hyde, Rebecca F. Taylor, Nick Ashton, Samantha J. Borland, Hon Sing Geoffrey Wu, Andrew P. Gilmore, Ann E. Canfield · 2014 · PLoS ONE
- Gas6/TAM Axis in Sepsis: Time to Consider Its Potential Role as a Therapeutic TargetLivia Salmi, Francesco Gavelli, Filippo Patrucco, Marina Caputo, Gian Carlo Avanzi, Luigi Mario Castello · 2019 · Disease Markers
- Axl Deficiency Does Not Affect Adipogenesis or Adipose Tissue DevelopmentIlse Scroyen, Liesbeth Frederix, H. Roger LIJNEN · 2011 · Obesity
- The proximal cis‐acting elements Sp1, Sp3 and E2F regulate mouse mer gene transcription in Sertoli cellsConnie C. S. Wong, Will M. Lee · 2002 · European Journal of Biochemistry
- Phagocytosis by Sertoli Cells: Analysis of Main Phagocytosis Steps by Confocal and Electron MicroscopyMarina Yéfimova, Nadia Messaddeq, Annie-Claire Meunier, Anne Cantereau, Bernard Jégou, Nicolas Bourmeyster · 2018 · Methods in molecular biology
- TAM kinases as regulators of cell deathSean M. Post, Michael Andreeff, Courtney Denton Dinardo, Joseph David Khoury, Peter P. Ruvolo · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Axl and Mer Receptor Tyrosine Kinases: Distinct and Nonoverlapping Roles in Inflammation and Cancer?Ian Dransfield, Sarah L. Farnworth · 2016 · Advances in experimental medicine and biology
- Protein S Negatively Regulates Neural Stem Cell Self-Renewal through Bmi-1 SignalingKatya Zelentsova, Ziv Talmi, Ghada Abboud-Jarrous, Tal Capucha, Tamar Sapir, Tal Burstyn‐Cohen · 2017 · Frontiers in Molecular Neuroscience
- Sjogren’s Syndrome and TAM Receptors: A Possible Contribution to Disease OnsetRichard Witas, Ammon B. Peck, Julian L. Ambrus, Cuong Quoc Nguyen · 2019 · Journal of Immunology Research
- NGF-induced Tyro3 and Axl function as survival factors for differentiating PC12 cellsYan Zheng, Lijuan Zhang, Qingjun Lu, Xuan Wang, Fen Yu, Xiaomin Wang, Qingxian Lu · 2008 · Biochemical and Biophysical Research Communications
- Role of Axl in T-Lymphocyte Survival in Salt-Dependent HypertensionSri Nagarjun Batchu, Angie Hughson, Kristine M. Wadosky, Craig N. Morrell, Deborah J. Fowell, Vyacheslav A. Korshunov · 2016 · Arteriosclerosis Thrombosis and Vascular Biology
- Gas6‐induced tissue factor expression in endothelial cells is mediated through caveolin‐1–enriched microdomainsSandrine Laurance, Meghedi N. Aghourian, Z. Jiva Lila, Catherine A. Lemarié, Mark D. Blostein · 2013 · Journal of Thrombosis and Haemostasis
- Mechanism of Mer receptor tyrosine kinase inhibition of glomerular endothelial cell inflammationYuxuan Zhen, Fred D. Finkelman, Wen-Hai Shao · 2018 · Journal of Leukocyte Biology
- 2021 Jeffrey M. Hoeg Award Lecture: Defining the Role of Efferocytosis in Cardiovascular Disease: A Focus on the CD47 (Cluster of Differentiation 47) AxisKai-Uwe Jarr, Yoko Kojima, Irving L. Weissman, Nicholas James Leeper · 2022 · Arteriosclerosis Thrombosis and Vascular Biology
- Two-Front War on Cancer—Targeting TAM Receptors in Solid Tumour TherapyAgata Mikołajczyk, Filip Mituła, Delfina Popiel, Bozena Kaminska, Maciej Wieczorek, Jerzy Pieczykolan · 2022 · Cancers
- The TAM receptor tyrosine kinases Axl and Mer drive the maintenance of highly phagocytic macrophagesLidia Jiménez-García, Christopher Mayer, Patrick Burrola, Youtong Huang, Maxim Nikolaievich Shokhirev, Greg Lemke · 2022 · Frontiers in Immunology
- Early death in a mouse model of Alzheimer’s disease exacerbated by microglial loss of TAM receptor signalingYoutong Huang, Greg Lemke · 2022 · Proceedings of the National Academy of Sciences
- Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented EpitheliumGrażyna Palczewska, Akiko Maeda, Marcin Golczak, Eisuke Arai, Zhiqian Dong, Lindsay Perusek, Brian M. Kevany, Krzysztof Palczewski · 2016 · Journal of Biological Chemistry
- Augmentation of Human Monocyte Responses to Lipopolysaccharide by the Protein S and Mer/Tyro3 Receptor Tyrosine Kinase AxisNicole D. Barth, John A. Marwick, Mary Jo Heeb, Andrew J. Gale, Adriano Giorgio Rossi, Ian Dransfield · 2018 · The Journal of Immunology
- Low-dose warfarin functions as an immunomodulator to prevent cyclophosphamide-induced NOD diabetes.Midori Kurohara, Hisafumi Yasuda, Hiroaki Moriyama, Maki Nakayama, Muneaki Sakata, Katsumi Yamada, Reiko Kotani, Kenta Hara, Koichi Yokono, Masao Nagata · 2008 · PubMed
- Signal Transduction Mechanisms Regulating Sperm Acrosomal ExocytosisGregory S. Kopf · 2002 · Elsevier eBooks
- Regulation of brain endothelial cell physiology by the TAM receptor tyrosine kinase MerKaisa E. Happonen, Patrick Burrola, Greg Lemke · 2023 · Communications Biology
- From MASH to HCC: the role of Gas6/TAM receptorsDaria Apostolo, Luciana L. Ferreira, Federica Vincenzi, Nicole Vercellino, Rosalba Minisini, Federico Latini, Barbara Ferrari, Michela Emma Burlone, Mario Pirisi, Mattia Bellan · 2024 · Frontiers in Immunology
- Bemcentinib as monotherapy and in combination with low-dose cytarabine in acute myeloid leukemia patients unfit for intensive chemotherapy: a phase 1b/2a trialSonja Loges, Michael Heuser, Jörg Chromik, Grerk Sutamtewagul, Silke Kapp‐Schwoerer, Monica Crugnola, Nicola Di Renzo, Roberto Massimo Lemoli, Daniele Giovanni Mattei, Walter Fiedler et al. · 2025 · Nature Communications
- Defective Efferocytosis in a Murine Model of Sjögren’s Syndrome Is Mediated by Dysfunctional Mer Tyrosine Kinase ReceptorRichard Witas, Astrid Rasmussen, Robert Hal Scofield, Lida Radfar, Donald U. Stone, Kiely M. Grundahl, David Lewis, Kathy L. Moser Sivils, Christopher J. Lessard, Amy Darise Farris et al. · 2021 · International Journal of Molecular Sciences
- Smtnl2 regulates apoptotic germ cell clearance and lactate metabolism in mouse Sertoli cellsDi Wu, Kejia Zhang, Faheem Ahmed Khan, Nuruliarizki Shinta Pandupuspitasari, Wangzhang Liang, Chunjie Huang, Fei Sun · 2022 · Molecular and Cellular Endocrinology
- The role of macrophage TAM receptor family in the acute‐to‐chronic progression of liver disease: From friend to foe?Haitao Huang, Jingyu Jiang, Ruihan Chen, Yimou Lin, Hui Chen, Qi Ling · 2022 · Liver International
- TAM Receptor Knockout Mice Are Susceptible to Retinal Autoimmune InductionFei Ye, Qiutang Li, Ke Yan, Qingjun Lu, Lixia Han, Henry J. Kaplan, Hui Shao, Qingxian Lu · 2011 · Investigative Ophthalmology & Visual Science
- Infertility Caused by Inefficient Apoptotic Germ Cell Clearance in Xkr8 -Deficient Male MiceYahiro Yamashita, Chigure Suzuki, Yasuo Uchiyama, Shigekazu Nagata · 2019 · Molecular and Cellular Biology
- Physiological Roles of Apoptotic Cell Clearance: Beyond Immune FunctionsMinjoo Han, Gyoungah Ryu, Seong-Ah Shin, Jangeun An, Huiji Kim, Daeho Park, Dae-Hee Lee, Chang Sup Lee · 2021 · Life
- Antagonistic Coevolution of MER Tyrosine Kinase Expression and FunctionAmanda L. Evans, Jack W. D. Blackburn, Kyle Taruc, Angela Kipp, Brennan S. Dirk, Nina R. Hunt, Stephen Dominic Barr, Jimmy Dimitrios Dikeakos, Bryan Heit · 2017 · Molecular Biology and Evolution
- Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allograftsJian Lin Yin, Brett David Hambly, Shi S. Bao, Dorothy M. Painter, G. Alex Bishop, Josette Eris · 2003 · Transplant International
- TAM receptors are dispensable in the phagocytosis and killing of bacteriaBy Julie C. Williams, Robin R. Craven, Henry Shelton Earp, T. H. Kawula, Glenn K. Matsushima · 2009 · Cellular Immunology
- Analysis of Candidate Colitis Genes in the Gdac1 Locus of Mice Deficient in Glutathione Peroxidase-1 and -2Robert Steven Esworthy, Byung-Wook Kim, Guillermo E. Rivas, Thomas L. Leto, James H. Doroshow, Fong‐Fong Chu · 2012 · PLoS ONE
- Dual role of DMXL2 in olfactory information transmission and the first wave of spermatogenesisClara Gobé, Maëva Elzaïat, Nicolas Meunier, Marjolaine André, Eli Sellem, Patrice Congar, Luc Jouneau, Aurélie Allais‐Bonnet, Ikrame Naciri, Bruno Passet et al. · 2019 · PLoS Genetics
- Immuno-oncology: are TAM receptors in glioblastoma friends or foes?Yunxiang Zhou, Yali Wang, Hailong Chen, Yanyan Xu, Yi Luo, Yongchuan Deng, Jianmin Zhang, Anwen Shao · 2021 · Cell Communication and Signaling
- Gas6 Downregulation Impaired Cytoplasmic Maturation and Pronuclear Formation Independent to the MPF ActivityKyeoung‐Hwa Kim, Eun Young Kim, Yuna Kim, Eunju Kim, Hyun-Seo Lee, Sook‐Young Yoon, Kyung‐Ah Lee · 2011 · PLoS ONE
- Animal Models for Retinal DegenerationMarijana Samardzija, Stephan C. F. Neuhauss, Sandrine Joly, Malaika M. Kurz-Levin, Christian Grimm · 2009 · Neuromethods
- β-cell function is regulated by metabolic and epigenetic programming of islet-associated macrophages, involving Axl, Mertk, and TGFβ receptor signalingLe May Thai, Liam O’Reilly, Saskia Reibe, Nancy Sue, Holly Holliday, Lewin Small, Carsten Schmitz‐Peiffer, Rama Dhenni, Vicky Wang-Wei Tsai, Nicholas Norris et al. · 2023 · iScience
- Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritisLiang Gao, Chao He, Aizhen Yang, Haibin Zhou, Qingxian Lu, Raymond B. Birge, Yi Wu · 2023 · Cell Communication and Signaling
- Sertoli Cell Phagocytosis: An Essential Event for SpermatogenesisFei Wang, Daishu Han · 2019 · IntechOpen eBooks
- Fonctions nouvelles de Gas-6 et de la protéine SOmar Benzakour, Aurore Gély-Pernot, Romain Lara, Valérie Coronas · 2007 · médecine/sciences
- AXL/Gas6 signaling mechanisms in the hypothalamic-pituitary-gonadal axisPardis Mohammadzadeh, Gregory C. Amberg · 2023 · Frontiers in Endocrinology
- MERTK Inhibition as a Targeted Novel Cancer TherapyK.M. Tanim, Alisha Holtzhausen, Aashis Thapa, Justus M. Huelse, Douglas K. Graham, Henry Shelton Earp · 2024 · International Journal of Molecular Sciences
- Human sperm RNA in male infertilityRossella Cannarella, Andrea Crafa, Roberto Curto, Laura M. Mongioì, Vincenzo Garofalo, Vittorio Cannarella, Rosita Angela Condorelli, Sandro La Vignera, Aldo Eugenio Calogero · 2024 · Nature Reviews Urology
- High incidence of distal vaginal atresia in mice lacking Tyro3 RTK subfamilyHui Wu, Hongmei Tang, Yongmei Chen, Haikun Wang, Daishu Han · 2008 · Molecular Reproduction and Development
- Vitamin K-dependent proteins: Functions in blood coagulation and beyondOmar Benzakour · 2008 · Thrombosis and Haemostasis
- Transcriptomic analysis of overexpressed SOX4 and SOX8 in TM4 Sertoli cells with emphasis on cell-to-cell interactionsPauline Roumaud, Luc J. Martin · 2019 · Biochemical and Biophysical Research Communications
- CD11c ‐Expressing Microglia Are Transient, Driven by Interactions With Apoptotic CellsNathaniel Ghena, Sarah Anderson, Jacqueline M. Roberts, Emmalyn Irvin, Joon Schwakopf, Alejandra Bosco, Monica L. Vetter · 2025 · Glia
- Vitamin K-Dependent γ -Glutamyl Carboxylase in Sertoli Cells Is Essential for Male Fertility in MiceSachiko Shiba, Kazuhiro Ikeda, Kuniko Horie‐Inoue, Kotaro Azuma, Tomoka Hasegawa, Norio Amizuka, Tomoaki Tanaka, Toshihiko Takeiwa, Yasuaki Shibata, Takehiko Koji et al. · 2021 · Molecular and Cellular Biology
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- Retinoic acid tiers mitochondrial metabolism to Sertoli Cell-Mediated efferocytosis via a non-RAR-dependent mechanismDi Wu, Kejia Zhang, Kaifeng Guan, Jiachen Tan, Chunjie Huang, Fei Sun · 2024 · Biochemical Pharmacology
- An insight into the TAM system in Alzheimer’s diseaseShiqi Zhou, Yanyan Li, Zhao Zhang, Yu‐He Yuan · 2023 · International Immunopharmacology
- MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult miceHossam Hassan Shawki, Hisashi Oishi, Toshiaki Usui, Yu Kitadate, Walaa Abdelwahab Abdelghani Basha, Ahmed M. Abdellatif, Kazunori Hasegawa, Risa Okada, Keiji Mochida, Hany A. El‐Shemy et al. · 2018 · PLoS ONE
- Recent advancements in role of TAM receptors on efferocytosis, viral infection, autoimmunity, and tissue repairAnnika Ranta, Sushil Kumar · 2020 · International review of cytology
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- GENES AND GENETICS OF MURINE LUPUSDwight H. Kono, Roberto Baccalà, Argyrios N. Theofilopoulos · 2004 · Elsevier eBooks
- MerTK negatively regulates Staphylococcus aureus induced inflammatory response via Toll-like receptor signaling in the mammary glandArshad Zahoor, Yaping Yang, Chao Yang, Sher Bahadar Khan, Christine E. Broster Reix, Farhan Anwar, Mengyao Guo, Ganzhen Deng · 2020 · Molecular Immunology
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