Tyro-3 family receptors are essential regulators of mammalian spermatogenesis

Lu, Qingxian, Gore, Martin, Zhang, Qing, Camenisch, Todd, Boast, Sharon, Casagranda, Franca, Lai, Cary, Skinner, Michael K. +5 more·1999·Nature
DOI 10.1038/19554

Cited by (509)

Items 401–500 of 509

  1. Mertk deficiency alters expression of micrornas in the retinal pigment epithelium cells
    Tang, Yong, Lu, Qingjun, Wei, Yunrong, Han, Lixia, Ji, Rui, Li, Qiutang, Lu, Qingxian · 2015 · Metabolic Brain Disease
  2. AXL limits the mobilization of cholesterol to regulate dendritic cell maturation and the immunogenic response to cancer
    Meriem Belabed, Matthew D. Park, Cédric M. Blouin, Sreekumar Balan, Chang Yoon Moon, Jesse Boumelha, Ante Peros, Raphaël Mattiuz, Amanda M. Reid, Camillia S. Azimi et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  3. Autophagy mediated tubulobulbar complex components degradation is required for spermiation
    Liying Wang, Ruidan Zhang, Bingbing Wu, Yang Yu, Wei Li, Shiguo Li, Chao Liu · 2022 · Fundamental Research
  4. Absence of MerTK Disrupts Spermatogenesis in an Age-Dependent Manner
    Jie Ru Shi, Sheng Gao, Zhengru Chen, Zifeng Chen, Damin Yun, Xiaolong Wu, Fei Sun · 2022 · Molecular and Cellular Endocrinology
  5. Post-translational modifications of the ligands: Requirement for TAM receptor activation
    Ke Geng · 2020 · International review of cytology
  6. Expression of Rabbit Sex Hormone-Binding Globulin during Pregnancy and Prenatal Development and Identification of a Novel Isoform
    Kwong-Man Ng, Man-ting So, Will M. Lee · 2004 · Endocrinology
  7. ETK2 receptor tyrosine kinase promotes survival of factor-dependent FDC-P1 progenitor cells
    Christine Darby, Diane M. Giannola, Matthew S. Couzens, Stephen G. Emerson · 2000 · Experimental Hematology
  8. Efferocytosis in Homeostasis
    Christian Maueröder, Caitlin M. Gillis, Kodi S. Ravichandran · 2025 · Advances in experimental medicine and biology
  9. Identification and Characterisation of cis-Regulatory Elements Upstream of the Human Receptor Tyrosine Kinase Gene MERTK
    Alexander D. Walsh, Laura Johnson, Alexandra J. Harvey, Trevor John Kilpatrick, Michele D. Binder · 2020 · Brain Plasticity
  10. Axl deficiency promotes preeclampsia and vascular malformations in mice
    Chan Zhou, Yun-Qing Zhu, Liang Zhang, Miaomiao Zhao, Cong Zhang · 2024 · Molecular Therapy — Nucleic Acids
  11. Atlas of Genetics and Cytogenetics in Oncology and Haematology
    Éric Jeandidier, Nicole Dastugue, Francine Mugneret, Mårina Lafage‐Pochitaloff, Lucienne Michaux, C. Verellen‐Dumoulin, Pascaline Talmant, Pascale Cornillet‐Lefèbvre, Carole Barin, Marie‐Agnès Collonge‐Rame et al. · 2009
  12. Insights into the molecular roles of Zika virus in human reproductive complications and congenital neuropathologies
    Rajendra Gharbaran, Latchman Somenarain · 2017 · Pathology
  13. Transcriptomic investigation of the effects of TDCPP on PC12 and GC2 cells with experimental validation
    Xi Zhang, Qifu Zhang, Yaohui Shan, Jingsong Xiao, Jin Shiung Cheng, Ye Feng, Yan Sai · 2022 · Gene
  14. Phagocytic clearance of targeted cells with a synthetic ligand
    Yuki Yamato, Jun Suzuki · 2025 · Nature Biomedical Engineering
  15. Viral apoptotic mimicry and the role of phosphatidylserine receptors
    Melinda Ann Brindley, Michael A. Pisciotta · 2025 · mSphere
  16. Expression levels of tam receptors and ligands in the testes of rats exposed to short and middle‐term 2100 MHz radiofrequency radiation
    Ertan Katırcı, Esma Konuk, Aslı Okan, Enis Hidişoğlu, Alexandra Cernomorcenco, Piraye Yargıçoğlu, Şükrü Özen, Necdet Demır · 2024 · Bioelectromagnetics
  17. Mammalian Models Based on RCAS-TVA Technique
    Yidong Niu, Shu-long LIANG · 2008 · Zoological Research
  18. Decreased expression of airway epithelial Axl is associated with eosinophilic inflammation in severe asthma
    Koji Itakura, Naoya Fujino, Yosuke Kamide, Ikuo Saito, Mitsuhiro Yamada, Koji Okutomo, Yoko Tsukita, Takuya Saito, Tomohiro Ichikawa, Tadahisa Numakura et al. · 2022 · Allergology International
  19. The therapeutic effect of GAS6 in remyelination is dependent upon Tyro3
    Negar Asadian, Andrea Aprico, Moore Z. Chen, Daniel Yuen, Angus P. R. Johnston, Trevor John Kilpatrick, Michele D. Binder · 2024 · Glia
  20. Study of the Role of the Tyrosine Kinase Receptor MerTK in the Development of Kidney Ischemia-Reperfusion Injury in RCS Rats
    Thomas Pelé, Sébastien Giraud, Sandrine Joffrion, Virginie Ameteau, Adriana Delwail, Jean‐Michel Goujon, Laurent Macchi, Thierry Hauet, Fatima Dkhissi, Omar Benzakour · 2021 · International Journal of Molecular Sciences
  21. Gene knockouts that affect Sertoli cell function
    Wei Yan · 2014 · Elsevier eBooks
  22. Chromosome 7q11 controls sperm beat cross frequency (BCF) in mice
    Aniela Gołas, Paweł Grzmil, Christian Müller, Józefa Styrna · 2004 · Folia Biologica
  23. Targeted disruption of the mouse testis-enriched gene Znf230 does not affect spermatogenesis or fertility
    Yunqiang Liu, Dachang Tao, Yongjie Lu, Yuan Yang, Yongxin Ma, Sizhong Zhang · 2014 · Genetics and Molecular Biology
  24. Sertoli Cell function and Protein Secretion
    Michael D. Griswold, Derek J. McLean · 2005 · Elsevier eBooks
  25. Gas6 protein induces invasion and reduces inflammatory cytokines in oral squamous cell carcinoma
    Kelsey M. Hirschi, Steven Chapman, Parker D. Hall, Adam S. Ostergar, Duane R. Winden, Paul R. Reynolds, Juan Alberto Arroyo · 2018 · Journal of Oral Pathology and Medicine
  26. A MERry Response After Myocardial Infarction
    Sanja Arandjelovic, Kodi S. Ravichandran · 2013 · Circulation Research
  27. Nrf2/Bach1 axis regulates redox homeostasis and energy metabolism to optimize Sertoli cell-mediated efferocytosis
    Di Wu, Kejia Zhang, Jiachen Tan, Faheem Ahmed Khan, Chunjie Huang, Fei Sun · 2025 · Molecular and Cellular Endocrinology
  28. MiRNA-34c Regulates Bovine Sertoli Cell Proliferation, Gene Expression, and Apoptosis by Targeting the AXL Gene
    Hao Xuan Sun, Haibin Yu, Lixin Xia, Ping Jiang, Zitong Bai, Ming Gao, Zhihui Zhao, Runjun Yang, Xibi Fang · 2021 · Animals
  29. The TAM Receptor Family
    Greg Lemke · 2015 · Springer eBooks
  30. Tumor-Extrinsic Axl Expression Shapes an Inflammatory Microenvironment Independent of Tumor Cell Promoting Axl Signaling in Hepatocellular Carcinoma
    Kristina Breitenecker, Denise Heiden, Tobias Demmer, Gerhard Weber, Ana-Maria Primorac, Viola Hedrich, Gregor Ortmayr, Thomas Gruenberger, Patrick P. Starlinger, Dietmar Herndler‐Brandstetter et al. · 2024 · International Journal of Molecular Sciences
  31. Molecular cloning, expression and partial characterization of Xksy, Xenopus member of the Sky family of receptor tyrosine kinases
    Yuko Kishi, Hiroshi Funakoshi, Kunio Matsumoto, Toshikazu Nakamura · 2002 · Gene
  32. Roles of TYRO3 Family Receptors in Germ Cell Development During Mouse Testis Formation
    Zhenhua Ming, Stefan Bagheri‐Fam, Emily R. Frost, Janelle Ryan, Michele D. Binder, Vincent R. Harley · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Tyro3 deletion is protective in experimental autoimmune encephalomyelitis
    Michele D. Binder, Mohammad Asadian, Darnell Leepel, Gerry ZM, Andrea Aprico, Liz Barreto‐Arce, Trevor John Kilpatrick, Sarrabeth Stone · 2025 · Immunology and Cell Biology
  34. RTK AXL and its Isoforms: Regulation and Implications in Cancer
    Ilona Malikova, Aizhan Syzdykova, Nazia Islam, Marina Kriajevskaia, Eugene M. Tulchinsky · 2026 · Current Medicinal Chemistry
  35. Autoimmune Orchitis and Autoimmune Oophoritis
    Livia Lustig, Vanesa Anabella Guazzone, Kenneth S. K. Tung · 2019 · Elsevier eBooks
  36. Loss of Tyro3 causes anxiety-relevant behavioural changes in female mice
    U Thivisol, Michele D. Binder, Anthony John Hannan, Terence Y. Pang · 2023 · Brain Research
  37. Evaluation of methods and applications for behavioural profiling of transgenic mice
    Vootele Võikar · 2006 · Työväentutkimus Vuosikirja
  38. A Mechanistic Overview on Male Infertility and Germ Cell Cancers
    Pascale Crépieux, Charlotte Lécureuil, Sébastien Marion, Elodie Kara, Vincent Piketty, Nadine Martinat, Florian Guillou, Dominique Royère, Éric Reiter · 2004 · Current Pharmaceutical Design
  39. The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade During HER2-Positive Breast Cancer Progression
    Marie-Anne Goyette, Stéphanie Duhamel, Léo Aubert, Ariane Pelletier, Paul Savage, Marie-Pier Thibault, Radia Marie Johnson, Peter Carmeliet, Mark Basik, Louis Arthur Gaboury et al. · 2018 · SSRN Electronic Journal
  40. Structural organization of TAM receptor ectodomains
    C.A. Starbird, Y. Zuo, Kahlil Walker, Steven E. Stayrook, Kathryn M. Ferguson · 2026 · Biochemical Journal
  41. The Future Directions of Testicular Autoimmunity Investigation
    Masahiro Itoh · 2017 · Springer eBooks
  42. Testicular Autoimmunity by Alteration of the Immune System in Experimental Animals
    Masahiro Itoh · 2017 · Springer eBooks
  43. Studies of Murine Systemic Autoimmunity
    Philip L. Cohen · 2003 · Immunologic Research
  44. Une nouvelle fonction pour la transferrine exprimée par le testicule
    Betty Fumel, A. Sow, Sophie Fouchécourt, Florian Guillou · 2009 · Basic and Clinical Andrology
  45. Innate Immunity Signaling
    Tsuneya Ikezu · 2016 · Springer eBooks
  46. TAM family proteins and therapy resistance
    Nellie K. McDaniel, Samantha R. Fischbach, Olivia J. Ondracek, Noah B. Welke, Mari Iida, Deric L. Wheeler · 2020 · Elsevier eBooks
  47. Mouse Models of Receptor Tyrosine Kinases
    Martin Holcmann, Nicole Amberg, Barbara Drobits, Elisabeth Glitzner, Karin Komposch, Jonathan Robson, Fabio Savarese, Sriram Srivatsa, Gabriel Stulnig, Maria Chiara Sibilia · 2014 · Springer eBooks
  48. TYRO3 (TYRO3 protein tyrosine kinase)
    KM Jacobsen, Rachel M. A. Linger, DK Graham · 2011 · Atlas of Genetics and Cytogenetics in Oncology and Haematology
  49. Warfarin: Mechanisms for Durable Effects in Coronary Artery Disease
    Kim L. Askew, Reidar Wallin, David C. Sane · 2002 · Heart Drug
  50. In vitro und in vivo Studien zur Charakterisierung von Testican-2 und SMOC-1, zweier neuer Mitglieder der BM-40 Familie
    Detlef Heep · 2005 · Kölner Universitäts PublikationsServer (Universität zu Köln)
  51. Unveiling the Transcriptomic Landscape of Holstein Bull Testes Post-Sexual Maturation: Insights into Spermatogenesis-Associated MicroRNAs and mRNA Profiles
    Bahlibi Weldegebriall Sahlu, Huan Wang, Zhihui Hu, Jianfei Gong, Xueming Zhao, Haisheng Hao, Shanjiang Zhao, Huabin Zhu · 2023 · Preprints.org
  52. Unveiling the Transcriptomic Landscape of Holstein Bull Testes Post-Sexual Maturation: Insights into Spermatogenesis-Associated MicroRNAs and mRNA Profiles
    Bahlibi Weldegebriall Sahlu, Huan Wang, Zhihui Hu, Jianfei Gong, Xueming Zhao, Haisheng Hao, Shanjiang Zhao, Huabin Zhu · 2023 · Preprints.org
  53. Phosphatidylserine exposure by developing astrocytes initiates microglia-mediated developmental cell death
    Caitlin E. Paisley, Kristina Sakers, Leykashree Nagendren, Xi Chen, Francesca Mazzoni, Silvia C. Finnemann, Çağla Eroğlu, Jeremy N. Kay · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  54. Mouse Models to Study the Pituitary-Testis Interplay Leading to Regulated Gene Expression
    Emiliana Borrelli, T. Rajendra Kumar, Paolo Sassone‐Corsi · 2001 · Humana Press eBooks
  55. THE ROLE OF RECEPTOR TYROSINE KINASE AXL IN PANCREATIC DUCTAL ADENOCARCINOMA AND ITS REGULATION BY HEMATOPOIETIC PROGENITOR KINASE 1
    Xianzhou Song · 2011 · Digital Commons-TMC (Texas Medical Center)
  56. A veleszületett immunitás szabályozásának vizsgálata in vitro és in vivo rendszerekben
    András Szász · 2013
  57. Caracterització del gen GAS6 i associació amb malalties humanes
    Xavier Muñoz i Miralles · 2006 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
  58. The Soluble Form of the Axl Receptor Tyrosine Kinase
    Carl Johan Ekman · 2010 · Lund University Publications (Lund University)
  59. A multifaceted study of the receptor tyrosine kinase Axl with focus on Renal Cell Carcinoma
    Anna Gustafsson · 2009 · Lund University Publications (Lund University)
  60. Axl RTK and microRNAs in urogenital cancers
    H Fritz · 2015 · Lund University Publications (Lund University)
  61. Dynamic regulation of thrombus stability : focus on platelet receptors and downstream signaling
    Judith M.E.M. Cosemans · 2009
  62. Tyro-3, Axl and Mer: sperm support group
    Kirsten C. Sadler · 1999 · Trends in Cell Biology
  63. THE ROLE OF THE TAM FAMILY OF RECEPTOR PTKS IN RETINAL HOMEOSTASIS
    Dipti Prasad · 2006 · eScholarship (California Digital Library)
  64. Anchor or Accelerate – A Study on Cancer Cell Adhesion and Motility
    Karoliina Vuoriluoto · 2010 · UTUPub (University of Turku)
  65. The role of MerTK and BAFF in dendritic cell-B cell interactions
    Paul Reid Gohlke · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  66. Intrinsic mechanisms of regulation of anti-Sm B cell anergy
    Ramiro Diz · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  67. Study of Molecular Mechanisms of Sensitivity and Resistance to EGFR-Targeted Therapy in Lung Cancer
    Zhenfeng Zhang · 2010 · OhioLink ETD Center (Ohio Library and Information Network)
  68. The role of TAM receptors in brain tumour cell signalling and behaviour
    Mikaella Vouri · 2016
  69. The mechanisms by which apoptotic neurons are cleared in developing dorsal root ganglia
    Jami L. Scheib · 2012
  70. Evaluation of MERTK evolution and efferocytosis signalling
    Amanda Evans · 2016 · Scholarship@Western (Western University)
  71. Novel role for Gas6 as a positive regulator of myelination
    Salman Goudarzi · 2016
  72. Functional Analysis of the Anorexia Mouse Mutation
    Joanna Yu · 2013 · TSpace (University of Toronto)
  73. Molecular Genetic Analysis of the Mouse Anorexia Mutation
    Dennis S. Kim · 2012 · Library and Archives Canada (Government of Canada)
  74. Regulation of innate immune responses by Mertk
    Julie Clarke Williams · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  75. The Role of MERTK in Central Inflammatory Demyelination
    Chris Dwyer · 2020 · Minerva Access (University of Melbourne)
  76. ADAM17 inhibition effects on Mer shedding
    Livia Salmi, Filippo Patrucco, Luca Molinari, Mattia Bellan, Pier Paolo Sainaghi, Luigi Mario Castello · 2022 · Minerva Biotechnology and Biomolecular Research
  77. Protein Kinases
    Garima Gupta · 2005 · Springer eBooks
  78. AXL
    Matthew Brown, David James Pinato · 2017 · Springer eBooks
  79. Faculty Opinions recommendation of Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways.
    Edvard Ingjald Moser, David C Rowland · 2014 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  80. AXL
    Matthew Brown, David James Pinato · 2016 · Springer eBooks
  81. Defining novel physiological roles for cardiac-residen Macrophages
    José Ángel Nicolás Ávila · 2020
  82. 03 / Granulosa cells provide elimination of apoptotic oocytes through unconventional autophagy-assisted phagocytosis.
    Marina Yéfimova, Célia Ravel · 2018
  83. Data from AXL Is an Essential Factor and Therapeutic Target for Metastatic Ovarian Cancer
    Erinn B. Rankin, Katherine Cynthia Fuh, Tiffany E. Taylor, Adam J. Krieg, Margaret Musser, Jenny Yuan, Kevin Wei, Calvin Jay Kuo, Teri A. Longacre, Amato J. Giaccia · 2023
  84. ANP rescues the preeclamptic symptoms in Axl knockout mice by improving trophoblast function ANP rescues the preeclamptic symptoms
    Chan Zhou, Yun-Qing Zhu, Liang Zhang, Xuexiang Li, Jiatong Yao, Miaomiao Zhao, Zi‐Jiang Chen, Cong Zhang · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  85. Role of TAM Receptors in Antimalarial Humoral Immune Response
    Lijo John, Rahul Vijay · 2024 · Pathogens
  86. The transcription factors NR5A1 and JUNB cooperate to activate the Axl promoter in mouse Sertoli cell lines
    Mariama Diawara, Luc J. Martin · 2024 · Molecular Biology Reports
  87. Ovarian expression of MerTK and its ligand Pros1 in non-pregnant estrus and pregnant mice
    Esma Konuk, Alexandra Cernomorcenco, Ertan Katırcı · 2024 · Journal of Molecular Histology
  88. Axl inhibition on dendritic cells enhances STING anticancer therapy through type I interferon signaling
    Todd Anthony Aguilera, Isaac Gonzalez, Eslam A. Elghonaimy, Qiongwen Zhang, Isaac Montgomery, Peter Q. Leung, Arely Rodriguez, Sebastian Diegeler, Katy L. Swancutt, Rolf A. Brekken · 2025 · Research Square
  89. The role of Axl/Mertk/Tyro3 receptor tyrosine kinases in the clearance of apoptotic cells
    Heather Seitz · 2019 · Carolina Digital Repository (University of North Carolina at Chapel Hill)
  90. Additional file 1 of Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis
    Gao, Liang, He, Chao, Yang, Aizhen, Zhou, Haibin, Lu, Qingxian, Raymond B. Birge, Wu, Yi · 2024 · Figshare
  91. Additional file 2 of Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis
    Gao, Liang, He, Chao, Yang, Aizhen, Zhou, Haibin, Lu, Qingxian, Birge, Raymond B., Wu, Yi · 2023 · Figshare
  92. Rôles des récepteurs à l'hormone thyroïdienne, TRa1 et p43, dans le contrôle de la prolifération des cellules de Sertoli chez la souris
    Betty Fumel · 2011 · theses.fr (ABES)
  93. Identification de nouvelles voies de signalisation activées dans les léiomyosarcomes
    Hiba El Sayadi · 2009 · theses.fr (ABES)
  94. Identification et optimisation de nouvelles séries chimiques anti-kinases
    Clémence Feneyrolles · 2014 · theses.fr (ABES)
  95. Signalisation et ciblage thérapeutique du récepteur tyrosine kinase AXL dans les cancers
    Wilhem Leconet · 2014 · theses.fr (ABES)
  96. Étude des mécanismes extracellulaires régulant la fonction du récepteur MerTK au cours de la phagocytose rétinienne
    Célia Parinot · 2015 · theses.fr (ABES)
  97. Étude des effets potentiels du récepteur MerTK sur le développement des lésions liées à une ischémie/reperfusion rénale chez le rat
    Thomas Pelé · 2019 · theses.fr (ABES)
  98. Molecular and cellular basis of phosphatidylserine receptors mediated flavivirus infection
    Ophélie Dejarnac · 2017 · theses.fr (ABES)
  99. Régulation épigénétique de l’expression de FOXL2 et voies activées en aval de ce gène dans la gonade
    Clara Gobé · 2018 · theses.fr (ABES)
  100. Expression des récepteurs TAM dans les cellules immunitaires humaines et identification de MerTK comme cible thérapeutique dans le microenvironnement tumoral
    P Giroud · 2020 · theses.fr (ABES)