Tyro-3 family receptors are essential regulators of mammalian spermatogenesis

Lu, Qingxian, Gore, Martin, Zhang, Qing, Camenisch, Todd, Boast, Sharon, Casagranda, Franca, Lai, Cary, Skinner, Michael K. +5 more·1999·Nature

DOI 10.1038/19554

Cited by (509)

Items 101–200 of 509

Inhibition of vascular endothelial growth factor receptor 2–mediated endothelial cell activation by Axl tyrosine kinase receptor
Margherita Gallicchio, Stefania Maria Filomena Mitola, Donatella Valdembri, Roberto Fantozzi, Brian C. Varnum, Gian Carlo Avanzi, Federico Bussolino · 2004 · Blood
Sertoli Cell-Initiated Testicular Innate Immune Response through Toll-Like Receptor-3 Activation Is Negatively Regulated by Tyro3, Axl, and Mer Receptors
Bing Sun, Nan Qi, Tao Shang, Hui Wu, Tingting Deng, Daishu Han · 2010 · Endocrinology
Growth arrest‐specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway
Tateo Sawabu, Hiroshi Seno, Tomoko Kawashima, Akihisa Fukuda, Yoshito Uenoyama, Mayumi Kawada, Naoki Kanda, Akira M Sekikawa, Hirokazu Fukui, Motoko Yanagita et al. · 2006 · Molecular Carcinogenesis
Chromosomal variants among 1790 infertile men
Yoshihiro Nakamura, Masaya Kitamura, Kenji Nishimura, Minoru Koga, Nobuyuki Kondoh, Masami Takeyama, Kiyomi Matsumiya, Äkïhïko Okuyama · 2001 · International Journal of Urology
Regulation of granulosa and theca cell transcriptomes during ovarian antral follicle development
Michael K. Skinner, Michelle A. Schmidt, Marina I. Savenkova, Ingrid Sadler‐Riggleman, Eric E. Nilsson · 2008 · Molecular Reproduction and Development
Inhibition of the receptor tyrosine kinase Axl impedes activation of the FLT3 internal tandem duplication in human acute myeloid leukemia: implications for Axl as a potential therapeutic target
Il‐Kyoo Park, Anjali Mishra, Jason Claud Chandler, Susan P. Whitman, Guido Marcucci, Michael A. Caligiuri · 2013 · Blood
Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies
Mihalis S. Kariolis, Yu Rebecca Miao, Anh N. Diep, Shannon E. Nash, Monica M. Olcina, Dadi Jiang, Douglas S. Jones, Shiven Kapur, Irimpan I. Mathews, Albert C. Koong et al. · 2016 · Journal of Clinical Investigation
Gas6 Anti-apoptotic Signaling Requires NF-κB Activation
Francesca Demarchi, Roberto Verardo, Brian C. Varnum, Claudio Brancolini, Claudio Schneider · 2001 · Journal of Biological Chemistry
Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization
Judith M.E.M. Cosemans, Roger van Kruchten, Servé Olieslagers, Leon J. Schurgers, Fons Verheyen, Imke C.A. Munnix, Johannes L. Waltenberger, Anne Angelillo‐Scherrer, Marc Hoylaerts, Peter Carmeliet et al. · 2010 · Journal of Thrombosis and Haemostasis
TAM Receptors Affect Adult Brain Neurogenesis by Negative Regulation of Microglial Cell Activation
Rui Ji, Shifu Tian, Helen J. Lu, Qingjun Lu, Yan Zheng, Xiaomin Wang, Jixiang Ding, Qingxian Lu, Qingxian Lu · 2013 · The Journal of Immunology
The Role of TAM Family Receptors in Immune Cell Function: Implications for Cancer Therapy
Magdalena Paolino, Josef Martin Penninger · 2016 · Cancers
An SH2 Domain-dependent, Phosphotyrosine-independent Interaction between Vav1 and the Mer Receptor Tyrosine Kinase
Nupam P. Mahajan, Henry Shelton Earp · 2003 · Journal of Biological Chemistry
Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy
Marka R. Crittenden, Jason R. Baird, David J. Friedman, Talicia Savage, Lauren Uhde, Alejandro F. Alice, Benjamin Cottam, Kristina Hoot Young, Pippa Newell, Cynthia Nguyen et al. · 2016 · Oncotarget
Gas6/Axl Signaling Activates the Phosphatidylinositol 3-Kinase/Akt1 Survival Pathway to Protect Oligodendrocytes from Tumor Necrosis Factorα-Induced Apoptosis
Sai Latha Shankar, Kathleen O’Guin, Mimi Kim, Brian C. Varnum, Greg Lemke, Celia F. Brosnan, Bridget Shafit‐Zagardo · 2006 · Journal of Neuroscience
TAM receptors, Phosphatidylserine, inflammation, and Cancer
Tal Burstyn‐Cohen, Avi Maimon · 2019 · Cell Communication and Signaling
Large-scale death of retinal astrocytes during normal development is non-apoptotic and implemented by microglia
Vanessa M. Puñal, Caitlin E. Paisley, Federica S. Brecha, Monica A. Lee, Robin M. Perelli, Jingjing Wang, Emily G. O’Koren, Caroline R. Ackley, Daniel R. Saban, Benjamin E. Reese et al. · 2019 · PLoS Biology
MERTK in cancer therapy: Targeting the receptor tyrosine kinase in tumor cells and the immune system
Justus M. Huelse, Diana M. Fridlyand, Shelton H. Earp, Deborah DeRyckere, Douglas K. Graham · 2020 · Pharmacology & Therapeutics
Growth Arrest-Specific Gene 6 (gas6) and Vascular Hemostasis
Sandrine Laurance, Catherine A. Lemarié, Mark D. Blostein · 2012 · Advances in Nutrition
Impact of genetic engineering on the understanding of spermatogenesis
Denise Escalier · 2001 · Human Reproduction Update
Sertoli Cell Immune Regulation: A Double-Edged Sword
Rachel L. Washburn, Taylor Hibler, Gurvinder Kaur, Jannette M. Dufour · 2022 · Frontiers in Immunology
Toll-Like Receptor-Initiated Testicular Innate Immune Responses in Mouse Leydig Cells
Tao Shang, Xiaoyan Zhang, Tao Wang, Bing Sun, Tingting Deng, Daishu Han · 2011 · Endocrinology
Role of Gas6 in erythropoiesis and anemia in mice
Anne Angelillo‐Scherrer, Laurent Burnier, Diether Lambrechts, Richard J. Fish, Marc Tjwa, Stéphane Plaisance, Rocco Sugamele, Maria DeMol, Eduardo Martínez-Soria, Patrick Henry Maxwell et al. · 2008 · Journal of Clinical Investigation
Overexpression of MERTK Receptor Tyrosine Kinase in Epithelial Cancer Cells Drives Efferocytosis in a Gain-of-Function Capacity
Khanh-Quynh N. Nguyen, Wen‐I Tsou, Daniel A. Calarese, Stanley Gititu Kimani, Sukhwinder Singh, Shelly Hsieh, Yongzhang Liu, Bin Lü, Yi Wu, S. Garforth et al. · 2014 · Journal of Biological Chemistry
MERTK as negative regulator of human T cell activation
Raquel Cabezón, Eugenio Antonio Carrera Silva, Georgina Flórez‐Grau, Andrea Emilse Errasti, Elisabeth Calderón‐Gómez, Juan José Lozano, Carolina Espan a, Elena Ricart, Julián Panés, Carla Vanina Rothlin et al. · 2015 · Journal of Leukocyte Biology
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction
Matthew DeBerge, Kristofor E. Glinton, Manikandan Subramanian, Lisa D. Wilsbacher, Carla Vanina Rothlin, Ira A. Tabas, Edward Benjamin Thorp · 2021 · Journal of Clinical Investigation
Gas6 and the Tyro 3 receptor tyrosine kinase subfamily regulate the phagocytic function of Sertoli cells
Weipeng Xiong, Yongmei Chen, Huizhen Wang, Haikun Wang, Hui Wu, Qingxian Lu, Daishu Han · 2007 · Reproduction
The role of γ-carboxylation in the anti-apoptotic function of gas6
Ines Hasanbasic, Isabelle Rajotte, Mark D. Blostein · 2005 · Journal of Thrombosis and Haemostasis
Hydrogen Peroxide Activates the Gas6-Axl Pathway in Vascular Smooth Muscle Cells
Atsushi Konishi, Toru Aizawa, Amy M. Mohan, Vyacheslav A. Korshunov, Bradford C. Berk · 2004 · Journal of Biological Chemistry
AXL signaling in cancer: from molecular insights to targeted therapies
Monika Yadav, Akansha Sharma, Ketki Patne, Saba Tabasum, Jyoti Suryavanshi, Laxminarayan Rawat, Marc Machaalani, Marc Eid, Rana P. Singh, Toni K. Choueiri et al. · 2025 · Signal Transduction and Targeted Therapy
A genomic screen identifies TYRO3 as a MITF regulator in melanoma
Shoutian Zhu, Heiko Wurdak, Yan Wang, Anna Galkin, Haiyan Tao, Jie Li, Costas Andreas Lyssiotis, Feng Yan, Buu P. Tu, Loren J. Miraglia et al. · 2009 · Proceedings of the National Academy of Sciences
Disruption of Spermatogenic Cell Adhesion and Male Infertility in Mice Lacking TSLC1/IGSF4, an Immunoglobulin Superfamily Cell Adhesion Molecule
Daisuke Yamada, Midori Yoshida, Yuko N. Williams, Takeshi Fukami, Shinji Kikuchi, Mari Masuda, Tomoko Maruyama, Tsutomu Ohta, Dai Nakae, Akihiko Maekawa et al. · 2006 · Molecular and Cellular Biology
Therapeutic Targeting of the Gas6/Axl Signaling Pathway in Cancer
Mai Tanaka, Dietmar W. Siemann · 2021 · International Journal of Molecular Sciences
Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1/3, and NF-κB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury
Ye-Ji Lee, Ji‐Young Han, Jiyeon Byun, Hyun-Jeong Park, Eun‐Mi Park, Young Hae Chong, Min-Sun Cho, Jihee Lee Kang · 2012 · Journal of Leukocyte Biology
Growth arrest-specific gene 6 (GAS6)
Laura Fernández-Fernández, Lola Bellido‐Martín, Pablo Garcı́a de Frutos · 2008 · Thrombosis and Haemostasis
Outer Segment Phagocytosis by Cultured Retinal Pigment Epithelial Cells Requires Gas6
Michael O. Hall, Anne L. Prieto, Martin S. Obin, Toshka A. Abrams, Barry L. Burgess, Mary Jo Heeb, Brian J Agnew · 2001 · Experimental Eye Research
The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity
Pamela Y. Chan, Eugenio Antonio Carrera Silva, Dimitri A. de Kouchkovsky, Leonel D. Joannas, Liming Hao, Donglei Hu, Scott Huntsman, Celeste S. Eng, Paula Licona-Limón, Jason S. Weinstein et al. · 2016 · Science
Requirement of Gamma-Carboxyglutamic Acid Modification and Phosphatidylserine Binding for the Activation of Tyro3, Axl, and Mertk Receptors by Growth Arrest-Specific 6
Ke Geng, Sushil Kumar, Stanley Gititu Kimani, Vladyslav V. Kholodovych, Canan Kasikara, Kensaku Mizuno, Oleta A. Sandiford, Pranela Rameshwar, Sergei V. Kotenko, Raymond B. Birge · 2017 · Frontiers in Immunology
Identification of Gas6, a putative ligand for Sky and Axl receptor tyrosine kinases, as a novel neurotrophic factor for hippocampal neurons
Hiroshi Funakoshi, Tomoko Yonemasu, Toru Nakano, Kunio Matumoto, Toshikazu Nakamura · 2002 · Journal of Neuroscience Research
Impaired Apoptotic Cell Clearance in the Germinal Center by Mer-Deficient Tingible Body Macrophages Leads to Enhanced Antibody-Forming Cell and Germinal Center Responses
Ziaur S. M. Rahman, Wen-Hai Shao, Tahsin N. Khan, Yuxuan Zhen, Philip L. Cohen · 2010 · The Journal of Immunology
Emerging Microbes & Infections
Kwok‐Yung Yuen · 2016
Vitamin K–Dependent Protein S: Beyond the Protein C Pathway
Björn Dahlbäck · 2017 · Seminars in Thrombosis and Hemostasis
Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt
Sam M. Janes, Tyler A. Ofstad, Douglas H. Campbell, Fiona M. Watt, David M. Prowse · 2004 · Journal of Cell Science
Crystal Structure of a C-terminal Fragment of Growth Arrest-specific Protein Gas6
Takako Sasaki, Pjotr G. Knyazev, Yu. V. Cheburkin, Walter Göhring, Dominic Tisi, Axel Ullrich, Rupert Timpl, Erhard Hohenester · 2002 · Journal of Biological Chemistry
Apoptosis, subcellular particles, and autoimmunity
Amy M. Cline, Marko Z. Radic · 2004 · Clinical Immunology
The role of TAM family receptors and ligands in the nervous system: From development to pathobiology
Bridget Shafit‐Zagardo, Ross C. Gruber, Juwen C. DuBois · 2018 · Pharmacology & Therapeutics
Immuno-oncological Efficacy of RXDX-106, a Novel TAM (TYRO3, AXL, MER) Family Small-Molecule Kinase Inhibitor
Yumi Yokoyama, Erin Denise Lew, Ruth Seelige, Elizabeth A. Tindall, Colin T. Walsh, Patrick C. Fagan, Jack Y. Lee, Robin Nevarez, Joanne Oh, Kathleen D. Tucker et al. · 2019 · Cancer Research
TAM Receptor Pathways at the Crossroads of Neuroinflammation and Neurodegeneration
Giacomo Tondo, Daniela Perani, Cristoforo Comi · 2019 · Disease Markers
The Emerging Role of TYRO3 as a Therapeutic Target in Cancer
Sherri K. Smart, Eleana Vasileiadi, Xiaodong Wang, Deborah DeRyckere, Douglas K. Graham · 2018 · Cancers
Ligand Recognition and Homophilic Interactions in Tyro3
Christoph Heiring, Björn Dahlbäck, Yves A. Muller · 2004 · Journal of Biological Chemistry
Signal Pathways in Up-regulation of Chemokines by Tyrosine Kinase MER/NYK in Prostate Cancer Cells
Yi-Mi Wu, Dan R. Robinson, Hsing-Jien Kung · 2004 · Cancer Research
The many ways tissue phagocytes respond to dying cells
Blander, J. Magarian · 2017 · Immunological Reviews
Therapeutic targeting of the functionally elusive TAM receptor family
Yu Rebecca Miao, Erinn B. Rankin, Amato J. Giaccia · 2023 · Nature Reviews Drug Discovery
RETRACTED ARTICLE: Soluble Axl Is Generated by ADAM10-Dependent Cleavage and Associates with Gas6 in Mouse Serum
Vadim Budagian, Elena Bulanova, Zane Orinska, Erwin H. Duitman, Katja Brandt, Andreas Ludwig, Dieter Hartmann, Greg Lemke, Paul Säftig, Silvia Bulfone‐Paus · 2005 · Molecular and Cellular Biology · Retracted
Mer Receptor Tyrosine Kinase Signaling
Katherine L. Guttridge, J. Christopher Luft, Thomas Larry Dawson, Ewa Kozłowska, Nupam P. Mahajan, Brian C. Varnum, Henry Shelton Earp · 2002 · Journal of Biological Chemistry
Origins, Lineage-Specific Expansions, and Multiple Losses of Tyrosine Kinases in Eukaryotes
Shin‐Han Shiu, Wen‐Hsiung Li · 2004 · Molecular Biology and Evolution
Axl and Tyro3 Modulate Female Reproduction by Influencing Gonadotropin-Releasing Hormone Neuron Survival and Migration
Angela M. Pierce, Brian Bliesner, Mei Xu, Sheila M. Nielsen‐Preiss, Greg Lemke, Stuart A. Tobet, Margaret E. Wierman · 2008 · Molecular Endocrinology
AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity
Edward T. Schmid, Iris K. Pang, Eugenio Antonio Carrera Silva, Lidia Bosurgi, Jonathan J. Miner, Michael Diamond, Akiko Iwasaki, Carla Vanina Rothlin · 2016 · eLife
MerTK-mediated engulfment of pyrenocytes by central macrophages in erythroblastic islands
Toda, Satoshi, Segawa, Katsumori, Nagata, Shigekazu · 2014 · Blood
Deciphering Genetic Disease in the Genomic Era: The Model of GnRH Deficiency
Gerasimos P. Sykiotis, Nelly Pitteloud, Stephanie Beth Seminara, Ursula B. Kaiser, William F. Crowley · 2010 · Science Translational Medicine
Axl/Phosphatidylinositol 3-Kinase Signaling Inhibits Mineral Deposition by Vascular Smooth Muscle Cells
Georgina D.M. Collett, Andrew P. Sage, John Paul Kirton, M. Yvonne Alexander, Andrew P. Gilmore, Ann E. Canfield · 2007 · Circulation Research
AXL Receptor Tyrosine Kinase as a Promising Therapeutic Target Directing Multiple Aspects of Cancer Progression and Metastasis
Marie-Anne Goyette, Jean‐François Côté · 2022 · Cancers
Epithelial cell-directed efferocytosis in the post-partum mammary gland is necessary for tissue homeostasis and future lactation
Melissa A. Sandahl, Debra M. Hunter, Karen E. Strunk, Henry Shelton Earp, Rebecca S. Cook · 2010 · BMC Developmental Biology
After cell death: the molecular machinery of efferocytosis
Moon, Byeongjin, Yang, Susumin, Moon, Hyunji, Lee, Juyeon, Park, Daeho · 2023 · Experimental & Molecular Medicine
Maternal effect genes: Findings and effects on mouse embryo development
Kyeoung‐Hwa Kim, Kyung‐Ah Lee · 2014 · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine
Analysis of Seminal Plasma from Patients with Non-obstructive Azoospermia and Identification of Candidate Biomarkers of Male Infertility
Ihor Batruch, Christopher R. Smith, Brendan M. Mullen, Ethan D. Grober, Kirk C. Lo, Eleftherios P. Diamandis, Keith Allen Jarvi · 2011 · Journal of Proteome Research
Gas6 Induces Growth, β-Catenin Stabilization, and T-Cell Factor Transcriptional Activation in Contact-Inhibited C57 Mammary Cells
Sandro Goruppi, Cristina Chiaruttini, Maria Elisabetta Ruaro, Brian C. Varnum, Claudio Schneider · 2001 · Molecular and Cellular Biology
Functions of TAM RTKs in regulating spermatogenesis and male fertility in mice
Yongmei Chen, Huizhen Wang, Nan Qi, Hui Wu, Weipeng Xiong, Jing Ma, Qingxian Lu, Daishu Han · 2009 · Reproduction
A promiscuous liaison between IL‐15 receptor and Axl receptor tyrosine kinase in cell death control
Vadim Budagian, Elena Bulanova, Zane Orinska, Lutz Thon, Uwe Mamat, Paola Bellosta, Claudio Basilico, Dieter Adam, Ralf Paus, Silvia Bulfone‐Paus · 2005 · The EMBO Journal · Retracted
Toll‐like receptor‐mediated inhibition of Gas6 and ProS expression facilitates inflammatory cytokine production in mouse macrophages
Tingting Deng, Yue Zhang, Qiaoyuan Chen, Keqin Yan, Daishu Han · 2011 · Immunology
The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development
Il‐Kyoo Park, Chiara Giovenzana, Tiffany L. Hughes, Jianhua Yu, Rossana Trotta, Michael A. Caligiuri · 2008 · Blood
Axl Phosphorylates Elmo Scaffold Proteins To Promote Rac Activation and Cell Invasion
Afnan Abu-Thuraia, Rosemarie Gauthier, Rony Chidiac, Yoshinori Fukui, Robert A. Screaton, Jean‐Philippe Gratton, Jean‐François Côté · 2014 · Molecular and Cellular Biology
Vitamin K‐Dependent Actions of Gas6
Lola Bellido‐Martín, Pablo Garcı́a de Frutos · 2008 · Vitamins and hormones
Acidification Prevents Endothelial Cell Apoptosis by Axl Activation
Daniela D’Arcangelo, Carlo Gaetano, Maurizio Colognesi Capogrossi · 2002 · Circulation Research
Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models
Claire E. J. Waterborg, Silke Beermann, Mathijs G A Broeren, Miranda B. Bennink, Marije I. Koenders, Peter L. E. M. van Lent, Wim B. van den Berg, Peter M. van der Kraan, Fons A. J. van de Loo · 2018 · Frontiers in Immunology
Macrophage-Stimulating Protein, the Ligand for the Stem Cell-Derived Tyrosine Kinase/RON Receptor Tyrosine Kinase, Inhibits IL-12 Production by Primary Peritoneal Macrophages Stimulated with IFN-γ and Lipopolysaccharide
Amy C Morrison, Caleph B. Wilson, Manujendra Ray, Pamela H. Correll · 2004 · The Journal of Immunology
TAM receptor tyrosine kinases: Expression, disease and oncogenesis in the central nervous system
Angela M. Pierce, Amy K. Keating · 2013 · Brain Research
Immunoexpression of Tyro 3 Family Receptors—Tyro 3, Axl, and Mer—and Their Ligand Gas6 in Postnatal Developing Mouse Testis
Huizhen Wang, Yongmei Chen, Yehua Ge, Pengpeng Ma, Quanhong Ma, Jing Ma, Haikun Wang, Shepu Xue, Daishu Han · 2005 · Journal of Histochemistry & Cytochemistry
Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic Response
Viralkumar Davra, Stanley Gititu Kimani, David C. Calianese, Raymond B. Birge · 2016 · Cancers
The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase
K.S. Gajiwala, Neil B. Grodsky, Ben Bolaños, Junli Feng, Rose Ann Ferre, Sergei L. Timofeevski, Meirong Xu, Brion William Murray, Ted W. Johnson, Albert Stewart · 2017 · Journal of Biological Chemistry
GnRH neuronal development: insights into hypogonadotrophic hypogonadism
Gavin MacColl, Richard Quinton, Pierre Marc Bouloux · 2002 · Trends in Endocrinology and Metabolism
Localization and signaling of the receptor protein tyrosine kinase Tyro3 in cortical and hippocampal neurons
Anne L. Prieto, S. O’Dell, Brian C. Varnum, Cary Lai · 2007 · Neuroscience
The Dual Role of TAM Receptors in Autoimmune Diseases and Cancer: An Overview
Martha Wium, Juliano D. Paccez, Luiz Fernando Zerbini · 2018 · Cells
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
Meriem Belabed, Matthew D. Park, Cédric M. Blouin, Sreekumar Balan, Chang Yoon Moon, Grace S. Freed, Miguel Quijada‐Álamo, Ante Peros, Raphaël Mattiuz, Amanda M. Reid et al. · 2025 · Nature Immunology
Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels
Marie-Anne Goyette, Islam E. Elkholi, Chloé Apcher, Hellen Kuasne, Carla Vanina Rothlin, William J. Muller, Darren E. Richard, Morag Park, Jean‐Philippe Gratton, Jean‐François Côté · 2021 · Proceedings of the National Academy of Sciences
Microarray‐based understanding of normal and malignant plasma cells
John De Vos, Dirk Hose, Thierry X. Reme, Karin Tarte, Jérôme Moreaux, Karène Mahtouk, Michel Jourdan, Hartmut Goldschmidt, Jean‐François Rossi, Friedrich W. Cremer et al. · 2006 · Immunological Reviews
Protein S Protects Neurons from Excitotoxic Injury by Activating the TAM Receptor Tyro3–Phosphatidylinositol 3-Kinase–Akt Pathway through Its Sex Hormone-Binding Globulin-Like Region
Zhihui Zhong, Yaoming Wang, Huang Guo, Abhay P. Sagare, José A. Fernández, Robert D. Bell, Theresa M. Barrett, John H. Griffin, Robert S. Freeman, Berislav V. Zloković · 2010 · Journal of Neuroscience
TAM Receptors Support Neural Stem Cell Survival, Proliferation and Neuronal Differentiation
Rui Ji, Lingbin Meng, Xin Mei Jiang, Naresh Kumar CVM, Jixiang Ding, Qiutang Li, Qingxian Lu · 2014 · PLoS ONE
Transforming activity of receptor tyrosine kinase Tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway
Zhengdao Lan, Huiyun Wu, Wenqing Li, Shechao Wu, Luo Lu, Ming Xu, Wei Dai · 2000 · Blood
MerTK inhibition is a novel therapeutic approach for glioblastoma multiforme
Kristina H. Knubel, B. M. Pernu, Alexandra Sufit, Sarah Nelson, Angela M. Pierce, Amy K. Keating · 2014 · Oncotarget
Coexpression of growth arrest-specific gene 6 and receptor tyrosine kinases Axl and Sky in human uterine endometrial cancers
Wen-Shu Sun, Jiro Fujimoto, T Tamaya · 2003 · Annals of Oncology
Clearance of Apoptotic Cells by Tissue Epithelia: A Putative Role for Hepatocytes in Liver Efferocytosis
Scott P Davies, Gary M. Reynolds, Zania Stamataki · 2018 · Frontiers in Immunology
Gas 6 promotes Axl-mediated survival in pulmonary endothelial cells
Aileen M. Healy, John J. Schwartz, Xiahui Zhu, Brian Herrick, Brian C. Varnum, Harrison W. Farber · 2001 · American Journal of Physiology-Lung Cellular and Molecular Physiology
TAM receptors in cardiovascular disease
Lucy McShane, Ira A. Tabas, Greg Lemke, Mariola Kurowska‐Stolarska, Pasquale Maffia · 2019 · Cardiovascular Research
Adhesion-Related Kinase Induction of Migration Requires Phosphatidylinositol-3-Kinase and Ras Stimulation of Rac Activity in Immortalized Gonadotropin-Releasing Hormone Neuronal Cells
Sheila M. Nielsen‐Preiss, Melissa P. Allen, Mei Xu, Daniel A. Linseman, John E. Pawlowski, Ron J. Bouchard, Brian C. Varnum, Kim A. Heidenreich, Margaret E. Wierman · 2007 · Endocrinology
Male Reproductive Defects Caused by Puromycin-Sensitive Aminopeptidase Deficiency in Mice
Tomoharu Osada, Gen Watanabe, Shunzo Kondo, Masashi Toyoda, Yoshiyuki Sakaki, Takashi Takeuchi · 2001 · Molecular Endocrinology
Aging of the Hematopoietic Stem Cell Niche: New Tools to Answer an Old Question
Francesca Matteini, Medhanie Assmelash Mulaw, Maria Carolina Florian · 2021 · Frontiers in Immunology
TAM receptors in phagocytosis: Beyond the mere internalization of particles
Tal Burstyn‐Cohen, Roberta Fresia · 2023 · Immunological Reviews
GAS6/TAM Pathway Signaling in Hemostasis and Thrombosis
Luke A. Law, Douglas K. Graham, Jorge Di Paola, Brian R. Branchford · 2018 · Frontiers in Medicine
A chimerical phagocytosis model reveals the recruitment by Sertoli cells of autophagy for the degradation of ingested illegitimate substrates
Marina Yéfimova, Nadia Messaddeq, Thomas Harnois, Annie-Claire Meunier, Jonathan A. Clarhaut, Anaïs Noblanc, Jean‐Luc Weickert, Anne Cantereau, M. Philippe, Nicolas Bourmeyster et al. · 2013 · Autophagy
Rethinking Phagocytes: Clues from the Retina and Testes
Kristen K. Penberthy, Jeffrey J. Lysiak, Kodi S. Ravichandran · 2018 · Trends in Cell Biology