Mechanism of Testosterone Action in Erythropoiesis
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Administration of graded doses of testosterone to healthy young and older men, whose endogenous testosterone production was suppressed, dose dependently increased hemoglobin and hematocrit but did not change EPO levels consistently after 20 weeks even at supraphysiologic doses.
“For example, administration of graded doses of testosterone to healthy young and older men, whose endogenous testosterone production was suppressed by administration of a long-acting gonadotropin releasing hormone agonist, dose dependently increased hemoglobin and hematocrit but did not change EPO levels consistently after 20 weeks even at supraphysiologic doses of testosterone (4).”
From Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point (2014) · cites this paper as [4]
Older men experience greater increments in hemoglobin and hematocrit in response to testosterone administration than young men.
“especially in older men, who experience greater increments in hemoglobin and hematocrit in response to testosterone administration than young men (4).”
From Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point (2014) · cites this paper as [4]
In testosterone therapy or supplementation, the new EPO/hemoglobin set point appears to become established after 3 months of treatment.
“In the case of testosterone therapy or supplementation, this new set point appears become established after 3 months of treatment (4,10).”
From Testosterone induces erythrocytosis via increased erythropoietin and suppressed hepcidin: evidence for a new erythropoietin/hemoglobin set point (2014) · cites this paper as [4]
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“4,7 Bachman et al. proposed a multifactorial mechanism in which testosterone induces erythropoiesis by stimulating EPO and recalibrating the set point of EPO in relation to hemoglobin, along with increasing iron utilization for erythropoiesis.”
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“An increase of PCV is an indication of enhanced erythropoiesis (Mirand et al., 1965) due to increased secretion of gonadotropins and testosterone.”
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- Authors
- MIRAND, E. A., GORDON, A. S., & WENIG, J.
- Affiliations
- Roswell Park Comprehensive Cancer Center (US)
- New York University (US)
- Venue
- Nature
- Published
- 1965-04
- Volume
- 206
- Issue
- 4981
- Pages
- 270-272
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2095110446
- Cited by
- 145
- References
- 27
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 1 · 2021: 1 · 2020: 7 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 1 · 2013: 2 · 2012: 3
- FWCI
- 15.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Keywords
- testosterone, erythropoiesis, erythropoietin, androgen action
- MeSH terms
- Animals, Blood, Erythropoiesis, Iron, Iron Isotopes, Rabbits, Rodentia, Testosterone, Mice, Rats, In Vitro Techniques
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