Structure and ligand of a histone acetyltransferase bromodomain

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Items 601–700 of 1,001

1. Saccharomyces cerevisiae Set1p is a methyltransferase specific for lysine 4 of histone H3 and is required for efficient gene expression
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2. General mechanism of JQ1 in inhibiting various types of cancer
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3. Effects of Lysine Acetylation in a β-Hairpin Peptide: Comparison of an Amide−π and a Cation−π Interaction
   Robert M. Hughes, Marcey L. Waters · 2006 · Journal of the American Chemical Society
4. Epigenetic Information in Chromatin: the Code of Entry for DNA Repair
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5. PWWP domains and their modes of sensing DNA and histone methylated lysines
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6. Latent nuclear antigen of Kaposi’s sarcoma herpesvirus/human herpesvirus-8 induces and relocates RING3 to nuclear heterochromatin regions
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7. Hyperacetylated Chromatin Domains: Lessons from Heterochromatin
   Michael Bulger · 2005 · Journal of Biological Chemistry
8. Transcription factors: global and detailed views
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9. Pair of Unusual GCN5 Histone Acetyltransferases and ADA2 Homologues in the Protozoan Parasite Toxoplasma gondii
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10. BET bromodomains as novel epigenetic targets for brain health and disease
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11. Bromodomain-containing proteins BRD1, BRD2, and BRD13 are core subunits of SWI/SNF complexes and vital for their genomic targeting in Arabidopsis
    Yaoguang Yu, Wei Fu, Jianqu Xu, Yawen Lei, Xin Song, Zhenwei Liang, Tao Zhu, Yuhui Liang, Yuanhao Hao, Liangbing Yuan et al. · 2021 · Molecular Plant
12. Brd2 is a TBP-associated protein and recruits TBP into E2F-1 transcriptional complex in response to serum stimulation
    Peng Jinhong, Wei Dong, Lü Chen, Tingting Zou, Yipeng Qi, Yingle Liu · 2006 · Molecular and Cellular Biochemistry
13. Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4
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14. Targeting bromodomain and extraterminal proteins in breast cancer
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15. Dynamic Regulation of Histone H3 Methylated at Lysine 79 within a Tissue-specific Chromatin Domain
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16. A mechanism for epigenetic control of DNA replication
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17. Live imaging of transcription sites using an elongating RNA polymerase II–specific probe
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18. Acetyllysine-binding and function of bromodomain-containing proteins in chromatin
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19. Activation-induced nuclear translocation of RING3
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20. Selectivity On-Target of Bromodomain Chemical Probes by Structure-Guided Medicinal Chemistry and Chemical Biology
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21. Childhood Medulloblastoma: Current Therapies, Emerging Molecular Landscape and Newer Therapeutic Insights
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22. Complex functions of Gcn5 and Pcaf in development and disease
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23. Functional Roles of Bromodomain Proteins in Cancer
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24. YEATS Domains as Novel Epigenetic Readers: Structures, Functions, and Inhibitor Development
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25. Bromodomain coactivators in cancer, obesity, type 2 diabetes, and inflammation.
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26. The Arabidopsis BET Bromodomain Factor GTE4 Is Involved in Maintenance of the Mitotic Cell Cycle during Plant Development
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27. Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations
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28. CREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation
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29. Proteasomal degradation of BRAHMA promotes Boron tolerance in Arabidopsis
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30. Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7
    Julia G. Kzhyshkowska, André Rusch, Hans J. Wolf, Thomas Dobner · 2003 · Biochemical Journal
31. Histone acetylation and chromatin remodeling: which comes first?
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32. BRD4 (Bromodomain-Containing Protein 4) Interacts with GATA4 (GATA Binding Protein 4) to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes
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33. Mechanisms of DNA methylation and histone modifications
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34. Molecular Rotors as Simple Models to Study Amide NH−Aromatic Interactions and Their Role in the Folding of Peptide-like Structures
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35. A new, highly conserved domain in Swi2/Snf2 is required for SWI/SNF remodeling
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36. Bromodomains: Translating the words of lysine acetylation into myelin injury and repair
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37. Inhibition of BRD4 suppresses tumor growth and enhances iodine uptake in thyroid cancer
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38. BRD7: a novel tumor suppressor gene in different cancers.
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39. Distinct patterns of histone acetyltransferase and Mediator deployment at yeast protein-coding genes
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40. Regulating Chromatin by Histone Acetylation
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41. A Nucleosome Interaction Module Is Required for Normal Function of Arabidopsis thaliana BRAHMA
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42. Brpf1, a subunit of the MOZ histone acetyl transferase complex, maintains expression of anterior and posterior Hox genes for proper patterning of craniofacial and caudal skeletons
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43. Epigenetic Regulation of Memory by Acetylation and Methylation of Chromatin: Implications in Neurological Disorders, Aging, and Addiction
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44. A New Quinoline BRD4 Inhibitor Targets a Distinct Latent HIV-1 Reservoir for Reactivation from Other “Shock” Drugs
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45. BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors
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46. Telomeres, histone code, and DNA damage response
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47. Polybromo-1-bromodomains bind histone H3 at specific acetyl-lysine positions
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48. Lessons from Yeast on Emerging Roles of the ATAD2 Protein Family in Gene Regulation and Genome Organization
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49. The Role of Histone Modifications and Variants in Regulating Gene Expression in Breast Cancer
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50. The Activity of HDAC8 Depends on Local and Distal Sequences of Its Peptide Substrates
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51. Ellagic acid inhibits adipocyte differentiation through coactivator-associated arginine methyltransferase 1-mediated chromatin modification
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52. Bromodomain and Extraterminal Protein Inhibition Blocks Growth of Triple-negative Breast Cancers through the Suppression of Aurora Kinases
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53. Modifying Chromatin by Histone Tail Clipping
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54. Design, synthesis and biological evaluation of novel indole derivatives as potential HDAC/BRD4 dual inhibitors and anti-leukemia agents
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55. Chromatin higher order structure: Opening up chromatin for transcription
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56. Targeted Recruitment of Rpd3 Histone Deacetylase Represses Transcription by Inhibiting Recruitment of Swi/Snf, SAGA, and TATA Binding Protein
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57. Bioinformatic Analysis and Post-Translational Modification Crosstalk Prediction of Lysine Acetylation
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58. A viral histone H4 encoded by Cotesia plutellae bracovirus inhibits haemocyte-spreading behaviour of the diamondback moth, Plutella xylostella
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59. Targeting of epigenetic regulators in neuroblastoma
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60. Reading More than Histones: The Prevalence of Nucleic Acid Binding among Reader Domains
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61. Induction-independent Recruitment of CREB-binding Protein to the c-fos Serum Response Element through Interactions between the Bromodomain and Elk-1
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62. Role of BET Proteins in Inflammation and CNS Diseases
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63. Bromodomain proteins GTE9 and GTE11 are essential for specific BT2-mediated sugar and ABA responses in Arabidopsis thaliana
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64. Signal transduction pathways and the modification of chromatin structure
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65. The BAH domain, polybromo and the RSC chromatin remodelling complex
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66. GCN5 and ADA Adaptor Proteins Regulate Triiodothyronine/GRIP1 and SRC-1 Coactivator-Dependent Gene Activation by the Human Thyroid Hormone Receptor
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67. Autoimmune disease: a view of epigenetics and therapeutic targeting
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68. Structural Insights into Acetylated-Histone H4 Recognition by the Bromodomain-PHD Finger Module of Human Transcriptional Coactivator CBP
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69. New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition
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70. Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain
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72. Acetyltransferase machinery conserved in p300/CBP-family proteins
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73. The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect development and gene expression in Caenorhabditis elegans
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74. Mammalian histone acetyltransferases and their complexes
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75. Remodelling chromatin on a global scale: a novel protective function of p53
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76. The Histone Modification Circus
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77. The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis
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78. A Comprehensive Review of BET Protein Biochemistry, Physiology, and Pathological Roles
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79. Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington’s disease
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80. Structural basis for the recognition of sulfur in phosphorothioated DNA
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81. Pharmacologic Induction of BRCAness in BRCA-Proficient Cancers: Expanding PARP Inhibitor Use
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82. Protein lysine acetyltransferase CBP/p300: A promising target for small molecules in cancer treatment
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83. Structured Water Molecules in the Binding Site of Bromodomains Can Be Displaced by Cosolvent
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84. The role of chromatin modifiers in normal and malignant hematopoiesis
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85. A Role for CARM1-Mediated Histone H3 Arginine Methylation in Protecting Histone Acetylation by Releasing Corepressors from Chromatin
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86. Interplay of bromodomain and histone acetylation in the regulation of p300-dependent genes
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87. Advancements in the Development of non‐BET Bromodomain Chemical Probes
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88. Next Generation Therapeutics for the Treatment of Myelofibrosis
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89. Nuclear Receptor Recruitment of Histone-Modifying Enzymes to Target Gene Promoters
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90. Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain
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91. Nucleosome Dancing at the Tempo of Histone Tail Acetylation
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92. Chromatin Configuration as a Battlefield in Plant-Bacteria Interactions
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93. Gatekeepers of chromatin: Small metabolites elicit big changes in gene expression
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94. Targeting EHMT2/ G9a for cancer therapy: Progress and perspective
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95. Structure and Function of the TFIID Complex
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96. Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies
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97. BRD4: New hope in the battle against glioblastoma
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98. PHDs govern plant development
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99. Machine-assisted synthesis of modulators of the histone reader BRD9 using flow methods of chemistry and frontal affinity chromatography
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100. YEATS domain: Linking histone crotonylation to gene regulation
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