Structure and ligand of a histone acetyltransferase bromodomain
Dhalluin, Christophe, Carlson, Justin E., Zeng, Lei, He, Cheng, Aggarwal, Aneel K., Zhou, Ming-Ming, Zhou, Ming-Ming·1999·Nature
DOI 10.1038/20974
Cited by (1,001)
Items 101–200 of 1,001
- AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 MethylationYuanyuan Li, Hong Wen, Yuanxin Xi, Kaori Y. Tanaka, Haibo Wang, Danni Peng, Yong-Feng Ren, Qihuang Jin, Sharon Dent, Wei Li et al. · 2014 · Cell
- The ISWI Chromatin-Remodeling Protein Is Required for Gene Expression and the Maintenance of Higher Order Chromatin Structure In VivoRenate Deuring, Laura Fanti, Jennifer A Armstrong, Melinda Sarte, Ophelia Papoulas, Matthias Prestel, Gary Daubresse, Megan Verardo, Sarah L. Moseley, Maria Francesca Berloco et al. · 2000 · Molecular Cell
- The bromodomain interaction moduleP. Filippakopoulos, Stefan Knapp · 2012 · FEBS Letters
- Quantitative Proteomic Analysis of Histone ModificationsHe Huang, Shu Lin, Benjamin Aaron Garcia, Yingming Zhao · 2015 · Chemical Reviews
- The Double Bromodomain Proteins Brd2 and Brd3 Couple Histone Acetylation to TranscriptionGary LeRoy, Brenden Rickards, Sarah Jane Flint · 2008 · Molecular Cell
- Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS DomainLi, Yuanyuan, Sabari, Benjamin R., Panchenko, Tatyana, Wen, Hong, Zhao, Dan, Guan, Haipeng, Wan, Liling, Huang, He, Tang, Zhanyun, Zhao, Yingming et al. · 2016 · Molecular Cell
- Lysine Acetylation Goes Global: From Epigenetics to Metabolism and TherapeuticsIbraheem Ali, Ryan J. Conrad, Eric M. Verdin, Mélanie Ott · 2018 · Chemical Reviews
- Histone Acetyltransferase Complexes Stabilize SWI/SNF Binding to Promoter NucleosomesAhmed H. Hassan, Kristen E. Neely, Jerry L. Workman · 2001 · Cell
- Selective Recognition of Acetylated Histones by Bromodomain Proteins Visualized in Living CellsTomohiko Kanno, Yuka Kanno, Richard M. Siegel, Moon Kyoo Jang, Michael J. Lenardo, Keiko Ozato · 2004 · Molecular Cell
- Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du RenneFrido Welker, Mateja Hajdinjak, Sahra Talamo, Klervia Jaouen, Michael Dannemann, Francine David, Michèle Julien, Matthias Meyer, Janet F. Kelso, Ian Barnes et al. · 2016 · Proceedings of the National Academy of Sciences
- Lysine acetylation and the bromodomain: a new partnership for signalingXiang‐Jiao Yang · 2004 · BioEssays
- The Roles of Histone Deacetylases and Their Inhibitors in Cancer TherapyLi Guo, Yuan Tian, Wei‐Guo Zhu · 2020 · Frontiers in Cell and Developmental Biology
- Achieving clinical success with BET inhibitors as anti-cancer agentsTatiana Shorstova, William D. Foulkes, Michael Witcher · 2021 · British Journal of Cancer
- SIRT1 Deacetylation and Repression of p300 Involves Lysine Residues 1020/1024 within the Cell Cycle Regulatory Domain 1Toula Bouras, Maofu Fu, Anthony A. Sauve, Fang Wang, Andrew A. Quong, Neil D. Perkins, Ronald T. Hay, Wei Jun Gu, Richard G. Pestell · 2005 · Journal of Biological Chemistry
- Recent advances in understanding chromatin remodeling by Swi/Snf complexesJoseph A. Martens, Fred Winston · 2003 · Current Opinion in Genetics & Development
- Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent InteractionsAlexander J. Ruthenburg, Haitao Li, Thomas A. Milne, Scott B. Dewell, Robert K. McGinty, Melanie Ann Yuen, Beatrix M. Ueberheide, Yali Dou, Tom W. Muir, Dinshaw J. Patel et al. · 2011 · Cell
- Relationship between Histone H3 Lysine 9 Methylation, Transcription Repression, and Heterochromatin Protein 1 RecruitmentM. David Stewart, Jiwen Li, Jiemin Wong · 2005 · Molecular and Cellular Biology
- Four histone variants mark the boundaries of polycistronic transcription units in Trypanosoma bruceiT. Nicolai Siegel, Doeke R. Hekstra, Louise E. Kemp, Luísa M. Figueiredo, Joanna E. Lowell, David Fenyö, Xuning Wang, Scott B. Dewell, George Cross · 2009 · Genes & Development
- The Swi/Snf familyPriya Sudarsanam, Fred Winston · 2000 · Trends in Genetics
- Memory and flexibility of cytokine gene expression as separable properties of human TH1 and TH2 lymphocytesMara Messi, Isabella Giacchetto, Kinya Nagata, Antonio Lanzavecchia, Gioacchino Natoli, Federica Sallusto · 2002 · Nature Immunology
- Composition and functional specificity of SWI2/SNF2 class chromatin remodeling complexesLisette Mohrmann, C. Peter Verrijzer · 2004 · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
- Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modificationsDafna Nathan, Kristin Ingvarsdottir, David E. Sterner, Gwendolyn R. Bylebyl, Milos Dokmanovic, Jean A. Dorsey, Kelly A. Whelan, Mihajlo L. Krsmanovic, William S. Lane, Pamela B. Meluh et al. · 2006 · Genes & Development
- The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous ProteinsY. Taniguchi · 2016 · International Journal of Molecular Sciences
- BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid LeukemiaJae‐Seok Roe, Fatih Mercan, Keith D. Rivera, Darryl Pappin, Christopher R. Vakoc · 2015 · Molecular Cell
- Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expressionTom Latham, C. Logan Mackay, Duncan Sproul, Muhammed Karim, Jayne Culley, David James Harrison, Larry Hayward, Pat R. R. Langridge‐Smith, Nick Gilbert, Bernard H. Ramsahoye · 2012 · Nucleic Acids Research
- Epigenetic inheritance and the missing heritabilityTrerotola, Marco, Relli, Valeria, Simeone, Pasquale, Alberti, Saverio · 2015 · Human Genomics
- Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexesJeffrey A. Simon, John W. Tamkun · 2002 · Current Opinion in Genetics & Development
- Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and SpermatogenesisQian, Min-Xian, Pang, Ye, Liu, Cui Hua, Haratake, Kousuke, Du, Bo-Yu, Ji, Dan-Yang, Wang, Guang-Fei, Zhu, Qian-Qian, Song, Wei, Yu, Yadong et al. · 2013 · Cell
- MYCN and the epigenomeStanley He, Zhihui Liu, Doo‐Yi Oh, Carol J. Thiele · 2013 · Frontiers in Oncology
- Drug Discovery Targeting Bromodomain-Containing Protein 4Zhiqing Liu, Pingyuan Wang, Haiying Chen, Eric A. Wold, Bing Tian, Allan R. Brasier, Jia Zhou · 2017 · Journal of Medicinal Chemistry
- Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approachBao, Xiucong, Wang, Yi, Li, Xin, Li, Xiao-Meng, Liu, Zheng, Yang, Tangpo, Wong, Chi Fat, Zhang, Jiangwen, Hao, Quan, Li, Xiang David · 2014 · eLife
- Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3bLei Zeng, Qiang Zhang, SiDe Li, Alexander N. Plotnikov, Martin J. Walsh, Ming‐Ming Zhou · 2010 · Nature
- Epigenetics—An Epicenter of Gene Regulation: Histones and Histone‐Modifying EnzymesMarkus Biel, Veit Wascholowski, Athanassios Giannis · 2005 · Angewandte Chemie International Edition
- Structural Mechanism of the Bromodomain of the Coactivator CBP in p53 Transcriptional ActivationShiraz Mujtaba, Yan He, Lei Zeng, Sherry X. Yan, Olga V. Plotnikova, Sachchidanand, Roberto Sánchez, Nancy J. Zeleznik‐Le, Ze’ev A. Ronai, Ming‐Ming Zhou · 2004 · Molecular Cell
- Growth and Early Postimplantation Defects in Mice Deficient for the Bromodomain-Containing Protein Brd4Houzelstein, Denis, Bullock, Simon L., Lynch, Denise E., Grigorieva, Elena F., Wilson, Valerie A., Beddington, Rosa S. P. · 2002 · Molecular and Cellular Biology
- Readout of Epigenetic ModificationsDinshaw J. Patel, Zhanxin Wang · 2013 · Annual Review of Biochemistry
- Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibitionYujie Tang, Sharareh Gholamin, Simone Schubert, Minde I Willardson, Alex Gia Lee, Pratiti Bandopadhayay, Guillame Bergthold, Sabran J. Masoud, Brian Nguyen, Nujsaubnusi Cassandra Vue et al. · 2014 · Nature Medicine
- Functional consequences of histone modificationsMasayoshi Iizuka, M. Mitchell Smith · 2003 · Current Opinion in Genetics & Development
- The BET family in immunity and diseaseWang, Nian, Wu, Runliu, Tang, Daolin, Kang, Rui · 2021 · Signal Transduction and Targeted Therapy
- The KAP1 Corepressor Functions To Coordinate the Assembly of De Novo HP1-Demarcated Microenvironments of Heterochromatin Required for KRAB Zinc Finger Protein-Mediated Transcriptional RepressionSripathy, Smitha P., Stevens, Jessica, Schultz, David C. · 2006 · Molecular and Cellular Biology
- A Bromodomain Protein, MCAP, Associates with Mitotic Chromosomes and Affects G2-to-M TransitionAnup Dey, Jan Ellenberg, Andrea Farina, Allen Coleman, Tetsuo Maruyama, Selvaggia Sciortino, Jennifer Lippincott‐Schwartz, Keiko Ozato · 2000 · Molecular and Cellular Biology
- Re-SET-ting heterochromatin by histone methyltransferasesThomas Jenuwein · 2001 · Trends in Cell Biology
- Epigenetic silencing of RNA polymerase I transcriptionIngrid Grummt, Craig S. Pikaard · 2003 · Nature Reviews Molecular Cell Biology
- The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading partsKelly, Richard D.W., Cowley, Shaun M. · 2013 · Biochemical Society Transactions
- The role of human bromodomains in chromatin biology and gene transcription.Roberto Sánchez, Ming‐Ming Zhou · 2009 · PubMed
- Acetylation and chromosomal functionsWang L. Cheung, Scott D. Briggs, C. David Allis · 2000 · Current Opinion in Cell Biology
- The emerging field of dynamic lysine methylation of non-histone proteinsJing Li Huang, Shelley L. Berger · 2008 · Current Opinion in Genetics & Development
- Is there a code embedded in proteins that is based on post-translational modifications?Sims, Robert J., Reinberg, Danny · 2008 · Nature Reviews Molecular Cell Biology
- A Poised Chromatin Platform for TGF-β Access to Master RegulatorsQiaoran Xi, Zhanxin Wang, Alexia-Ileana Zaromytidou, Xiang H.-F. Zhang, Lai-Fong Chow-Tsang, Jing X. Liu, Hyesoo Kim, Afşar Barlas, Katia O Manova-Todorova, Vesa Kaartinen et al. · 2011 · Cell
- The Control of HIV Transcription: Keeping RNA Polymerase II on TrackMélanie Ott, Matthias Geyer, Qiang Zhou · 2011 · Cell Host & Microbe
- Genome-wide patterns of histone modifications in yeastCatherine B. Millar, Michael R. Grunstein · 2006 · Nature Reviews Molecular Cell Biology
- Acetylation-Dependent Chromatin Reorganization by BRDT, a Testis-Specific Bromodomain-Containing ProteinChristophe Pivôt-Pajot, Cécile Caron, Jérôme Govin, Alexandre Vion, Sophie Rousseaux, Saadi Khochbin · 2003 · Molecular and Cellular Biology
- Cellular machineries for chromosomal DNA repairCraig L. Peterson, Jacques Côté · 2004 · Genes & Development
- Regulation of distinct biological activities of the NF-?B transcription factor complex by acetylationLin‐Feng Chen, Warner C. Greene · 2003 · Journal of Molecular Medicine
- Acetylation of H2AZ Lys 14 is associated with genome-wide gene activity in yeastCatherine B. Millar, Feng Xu, Kangling Zhang, Michael R. Grunstein · 2006 · Genes & Development
- The first bromodomain of Brdt, a testis-specific member of the BET sub-family of double-bromodomain-containing proteins, is essential for male germ cell differentiationEnyuan Shang, Helen D. Nickerson, Duancheng Wen, Xiangyuan Wang, Debra J. Wolgemuth · 2007 · Development
- Chromatin and Transcription in YeastRando, Oliver J, Winston, Fred · 2012 · Genetics
- Histone Acetylation and Chromatin RemodelingPhilip D. Gregory, Klaus Wagner, Wolfram Hörz · 2001 · Experimental Cell Research
- Transcriptional adaptor and histone acetyltransferase proteins in Arabidopsis and their interactions with CBF1, a transcriptional activator involved in cold-regulated gene expressionEric J. Stockinger · 2001 · Nucleic Acids Research
- The bromodomain: a chromatin-targeting module?Fred Winston, C. David Allis · 1999 · Nature Structural Biology
- Combinatorial complexity in chromatin structure and function: revisiting the histone codeOliver J. Rando · 2012 · Current Opinion in Genetics & Development
- The human SWI/SNF-B chromatin-remodeling complex is related to yeast Rsc and localizes at kinetochores of mitotic chromosomesYutong Xue, Julie C. Canman, Cheol-Soon Lee, Zuqin Nie, Dafeng Yang, G. Tony Moreno, Mary K. Young, Edward D. Salmon, Weidong Wang · 2000 · Proceedings of the National Academy of Sciences
- Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor RegressionQin, Chong, Hu, Yang, Zhou, Bing, Fernandez-Salas, Ester, Yang, Chao-Yie, Liu, Liu, McEachern, Donna, Przybranowski, Sally, Wang, Mi, Stuckey, Jeanne et al. · 2018 · Journal of Medicinal Chemistry
- Chromatin remodeling enzymes: who's on first?Christopher J. Fry, Craig L. Peterson · 2001 · Current Biology
- Aging Hallmarks and Progression and Age-Related Diseases: A Landscape View of Research AdvancementTenchov, Rumiana, Sasso, Janet M., Wang, Xinmei, Zhou, Qiongqiong Angela · 2024 · ACS Chemical Neuroscience
- Pathogenesis of NUT Midline CarcinomaChristopher Alexander French · 2011 · Annual Review of Pathology Mechanisms of Disease
- The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding foldsChen Qiu, Ken Sawada, Xing Zhang, Xiaodong Cheng · 2002 · Nature Structural Biology
- PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)He, Ming, Cao, Chaoguo, Ni, Zhihao, Liu, Yongbo, Song, Peilu, Hao, Shuang, He, Yuna, Sun, Xiuyun, Rao, Yu · 2022 · Signal Transduction and Targeted Therapy
- CREB-binding protein and p300: molecular integrators of hematopoietic transcriptionGerd A. Blobel · 2000 · Blood
- Do protein motifs read the histone code?Xavier de la Cruz, Sergio Lois, Sara Sánchez-Molina, Marian A. Martínez‐Balbás · 2005 · BioEssays
- Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3.N. Macdonald, J. Welburn, M. Noble, Anhco Nguyen, M. Yaffe, D. Clynes, J. Moggs, G. Orphanides, S. Thomson, J. W. Edmunds et al. · 2005 · Molecules and Cells
- Chromatin dynamics: Interplay between remodeling enzymes and histone modificationsSarah G. Swygert, Craig L. Peterson · 2014 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- Functional Anthology of Intrinsic Disorder. 2. Cellular Components, Domains, Technical Terms, Developmental Processes, and Coding Sequence Diversities Correlated with Long Disordered RegionsSlobodan Vučetić, Hongbo Michael Xie, Lilia M. Iakoucheva, Christopher J. Oldfield, A. Keith Dunker, Zoran Obradovic A, Vladimir Nikolaevich Uversky · 2007 · Journal of Proteome Research
- The diversity of acetylated proteins.Bogdan V. Polevoda, Fred Sherman · 2002 · Genome biology
- PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET BromodomainsS. Picaud, David Da Costa, Angeliki Thanasopoulou, P. Filippakopoulos, Paul V. Fish, Martin Philpott, O. Fedorov, Paul E. Brennan, Mark E. Bunnage, Dafydd R. Owen et al. · 2013 · Cancer Research
- Bromodomain biology and drug discoveryNilesh Zaware, Ming‐Ming Zhou · 2019 · Nature Structural & Molecular Biology
- Epigenetic alterations in agingSusana Gonzalo · 2010 · Journal of Applied Physiology
- Histone H3 Lysine 4 Methylation Disrupts Binding of Nucleosome Remodeling and Deacetylase (NuRD) Repressor ComplexPhilip Zegerman, Benito Cañas, Darryl Pappin, Tony Kouzarides · 2002 · Journal of Biological Chemistry
- Bromodomain and Extra-Terminal Motif Inhibitors: a Review of Preclinical and Clinical Advances in Cancer TherapyAli Alqahtani, Khalil Choucair, Mushtaq Ashraf, Danae Hamouda, Abdurahman Alloghbi, Talal Ali Khan, Neil N. Senzer, John J. Nemunaitis · 2019 · Future Science OA
- Clinical trials for BET inhibitors run ahead of the scienceAndrieu, Guillaume, Belkina, Anna C., Denis, Gerald V. · 2016 · Drug Discovery Today: Technologies
- Histones: At the Crossroads of Peptide and Protein ChemistryMüller, Manuel M., Muir, Tom W. · 2015 · Chemical Reviews
- Association of Class II Histone Deacetylases with Heterochromatin Protein 1: Potential Role for Histone Methylation in Control of Muscle DifferentiationChun Li Zhang, Timothy A. McKinsey, Eric N. Olson · 2002 · Molecular and Cellular Biology
- Histone acetylation in gene regulationLoredana Verdone · 2006 · Briefings in Functional Genomics and Proteomics
- BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic TherapyMiguel F. Segura, Bárbara Fontanals-Cirera, Avital Gaziel‐Sovran, María V. Guijarro, Douglas Hanniford, Guangtao Zhang, Pilar González‐Gómez, Marta Morante, Luz Jubierre, Weijia Zhang et al. · 2013 · Cancer Research
- Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genesJanine M. Lamonica, Wulan Deng, Stephan Kadauke, Amy E. Campbell, Roland Gamsjaeger, Hongxin Wang, Yong Cheng, Andrew N. Billin, Ross C. Hardison, Joel P. Mackay et al. · 2011 · Proceedings of the National Academy of Sciences
- Epigenetics in cancer: Fundamentals and BeyondSubhankar Biswas, C. Mallikarjuna Rao · 2017 · Pharmacology & Therapeutics
- Bromodomains Mediate an Acetyl-Histone Encoded Antisilencing Function at Heterochromatin BoundariesAndreas G. Ladurner, Carla J. Inouye, Rajan Jain, Robert Tjian · 2003 · Molecular Cell
- Structural Basis of Lysine-Acetylated HIV-1 Tat Recognition by PCAF BromodomainShiraz Mujtaba, Yan He, Lei Zeng, Amjad Farooq, Justin E. Carlson, Mélanie Ott, Eric M. Verdin, Ming‐Ming Zhou · 2002 · Molecular Cell
- ATAD2 Is a Novel Cofactor for MYC, Overexpressed and Amplified in Aggressive TumorsMarco Cirò, Elena Prosperini, Micaela Quarto, Ursula Grazini, Julian Walfridsson, Fraser McBlane, Paolo Nucifero, Giovanni Pacchiana, Maria Cristina Capra, Jesper Frank Christensen et al. · 2009 · Cancer Research
- Functional Interaction between the Mouse Notch1 Intracellular Region and Histone Acetyltransferases PCAF and GCN5Hisanori Kurooka, Tasuku Honjo · 2000 · Journal of Biological Chemistry
- The epigenetic magic of histone lysine methylationThomas Jenuwein · 2006 · FEBS Journal
- The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathwayHe Huang, Di Zhang, Yejing Weng, Kyle Delaney, Zhanyun Tang, Cong Yan, Shankang Qi, Chao Peng, Philip A. Cole, Robert G. Roeder et al. · 2021 · Science Advances
- Activation of AML1‐mediated transcription by MOZ and inhibition by the MOZ–CBP fusion proteinIssay Kitabayashi, Yukiko Aikawa, Lan Anh Nguyen, Akihiko Yokoyama, Misao Ohki · 2001 · The EMBO Journal
- Surf the Post-translational Modification Network of p53 RegulationBo Gu, Wei‐Guo Zhu · 2012 · International Journal of Biological Sciences
- Bromodomains: Structure, function and pharmacology of inhibitionElena Ferri, Carlo Petosa, Charles E. McKenna · 2015 · Biochemical Pharmacology
- Biochemical Analysis of Distinct Activation Functions in p300 That Enhance Transcription Initiation with Chromatin TemplatesW. Lee Kraus, E. Tory Manning, James T. Kadonaga · 1999 · Molecular and Cellular Biology
- Acetylation & Co: an expanding repertoire of histone acylations regulates chromatin and transcriptionClaire E. Barnes, David M. English, Shaun M. Cowley · 2019 · Essays in Biochemistry
- Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant CancersPapillon, Julien P. N., Nakajima, Katsumasa, Adair, Christopher D., Hempel, Jonathan, Jouk, Andriana O., Karki, Rajeshri G., Mathieu, Simon, Möbitz, Henrik, Ntaganda, Rukundo, Smith, Troy et al. · 2018 · Journal of Medicinal Chemistry
- BRG-1 Is Recruited to Estrogen-Responsive Promoters and Cooperates with Factors Involved in Histone AcetylationJames DiRenzo, Yongfeng Shang, Michael L. Phelan, Saı̈d Sif, Molly Myers, Robert E. Kingston, Myles A Brown · 2000 · Molecular and Cellular Biology
- Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys14Margaret M. Kasten, Heather J. Szerlong, Hediye Erdjument‐Bromage, Paul Tempst, Michel Werner, Bradley Robert Cairns · 2004 · The EMBO Journal