C fragment of lipotropin has a high affinity for brain opiate receptors
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The endogenous opiate system comprises three opioid receptor types (MOR, DOR, KOR) and their endogenous ligands endorphin, enkephalin, and dynorphin.
“This system is comprised of three types of opioid receptors: μ (MOR), δ (DOR), and κ (KOR); and their endogenous ligands, endorphin, enkephalin and dynorphin (Hughes et al 1975; Birdsall and Hulme 1976; Goldstein et al 1979; Evans et al 1992; Kieffer et al 1992; Chen et al 1993; Yasuda et al 1993).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Birdsall and Hulme 1976
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- Authors
- BRADBURY, A. F., SMYTH, D. G., SNELL, C. R., BIRDSALL, N. J. M., & HULME, E. C.
- Affiliations
- National Institute for Medical Research (GB)
- ORCID
- BIRDSALL, N. J. M.
- Venue
- Nature
- Published
- 1976-04
- Volume
- 260
- Issue
- 5554
- Pages
- 793-795
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2054951528
- Cited by
- 489
- References
- 15
- Citations by year
- 2024: 1 · 2022: 2 · 2021: 2 · 2020: 3 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 5 · 2012: 1
- FWCI
- 29.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- lipotropin, opioid receptor affinity, pituitary gland, trypsin digestion, peptide fragments, endogenous opioids
- MeSH terms
- Amino Acid Sequence, Binding, Competitive, Brain, beta-Lipotropin, Morphine Derivatives, Naloxone, Nerve Tissue Proteins, Opium, Peptides, Potassium, Receptors, Drug, Sodium, Structure-Activity Relationship
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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