Cited by 1,182Advanced Drug Delivery SystemsHydrogels: synthesis, properties, applicationsNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 12 of the 13 references it cites were found in a registry or an index.

Polymers for the sustained release of proteins and other macromolecules

LANGER, ROBERT, FOLKMAN, JUDAH·1976·Nature

DOI 10.1038/263797a0

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1038/263797a0

Cites

12 of 12 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
A modified uronic acid carbazole reaction
Bitter, T., & Muir, H. M. (1962) · Analytical Biochemistry · doi:10.1016/0003-2697(62)90095-7 · Cited by 6,259
Critical Variables in the Radioimmunoassay of Serum Insulin Using the Double Antibody Technic
Soeldner, J. S., & Slone, D. (1965) · Diabetes · doi:10.2337/diab.14.12.771 · Cited by 714
Proceedings: Tumor angiogenesis factor.
Folkman, J. (1974) · PubMed · Cited by 460
Self-citation
The use of silicone rubber as a carrier for prolonged drug therapy
Folkman, J., & Long, D. M. (1964) · Journal of Surgical Research · doi:10.1016/s0022-4804(64)80040-8 · Cited by 368
Self-citation
An evaluation of the role of leukocytes in the pathogenesis of experimentally induced corneal vascularization.
Fromer, C., & Klintworth, G. K. (1975) · PubMed · Cited by 119
Radial diffusion in gel for micro determination of enzymes
Schumacher, G., & Schill, W. (1972) · Analytical Biochemistry · doi:10.1016/0003-2697(72)90165-0 · Cited by 113
Diffusion in Polymer Gel Implants
Davis, B. K. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.8.3120 · Cited by 112
Radial diffusion in gel for micro determination of enzymes
Schill, W., & Schumacher, G. (1972) · Analytical Biochemistry · doi:10.1016/0003-2697(72)90324-7 · Cited by 94
Control of diabetes with polyacrylamide implants containing insulin
Davis, B. K. (1972) · Cellular and Molecular Life Sciences · doi:10.1007/bf01928732 · Cited by 72

Flagged first, then by citations

Show all 13 references

1 of the 13 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

Gimbrone, M. A., Jr, Cotran, R. S., Leapman, S. B., and Folkman, J., J. natn. Cancer Inst., 42, 314–427 (1974).
Fromer, C. H., and Klintworth, G. K., Am. J. Path., 79, 537–554 (1975).
Folkman, J., Cancer Res., 34, 2109–2113 (1974).

Sorted by citations

Items 401–500 of 1,000

Nanotechnology based devices and applications in medicine: An overview
Martis, E. A. F., Badve, R., & Degwekar, M. (2012) · Chronicles of young scientists · doi:10.4103/2229-5186.94320 · Cited by 54
Corneal (Lymph)angiogenesis—From Bedside to Bench and Back: A Tribute to Judah Folkman
Regenfuß, B., Bock, F., Parthasarathy, A., & Cursiefen, C. (2008) · Lymphatic Research and Biology · doi:10.1089/lrb.2008.6348 · Cited by 51
Angiogenesis — Retrospect and outlook
Folkman, J. (1992) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-0348-7001-6_2 · Cited by 50
Self-citation
Controlled release of plasmid DNA
Jong, Y. S., Jacob, J. S., Yip, K., Gardner, G., Seitelman, E., Whitney, M., Montgomery, S., & Mathiowitz, E. (1997) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)01637-4 · Cited by 51
Local Versus Systemically Mediated Effects of Estrogen on Normal Mammary Epithelial Cell Deoxyribonucleic Acid Synthesis*
Haslam, S. Z. (1988) · Endocrinology · doi:10.1210/endo-122-3-860 · Cited by 51
Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective
Labouta, H. I., Langer, R., Cullis, P. R., Merkel, O. M., Prausnitz, M. R., Gomaa, Y. A., Nogueira, S. S., & Kumeria, T. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01146-1 · Cited by 52
Self-citation
Local antitumor effects of intratumoral delivery of rlL-2 loaded sustained-release dextran/PLGA–PLA core/shell microspheres
Zhao, H., Wu, F., Cai, Y., Chen, Y., Wei, L., Liu, Z., & Yuan, W. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.04.051 · Cited by 50
Historical development of drug delivery systems: From conventional macroscale to controlled, targeted, and responsive nanoscale systems
Abu-Thabit, N. Y., & Hamdy, A. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-08-101997-9.00001-1 · Cited by 54
Polymeric Nanomaterials
Raja, M. M., Lim, P. Q., Wong, Y. S., Xiong, G. M., Zhang, Y., Venkatraman, S. S., & Huang, Y. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814033-8.00018-7 · Cited by 51
Approaches to preclinical screening of antiangiogenic agents
Kruger, E. A., Duray, P. H., Price, D. K., Pluda, J. M., & Figg, W. D. (2001) · Seminars in Oncology · doi:10.1016/s0093-7754(01)90026-0 · Cited by 50
A new vitreal drug delivery system using an implantable biodegradable polymeric device.
Kimura, H., Ogura, Y., Hashizoe, M., Nishiwaki, H., Honda, Y., & Ikada, Y. (1994) · PubMed · Cited by 50
A Detailed Review on Synthesis, Functionalization, Application, Challenges, and Current Status of Magnetic Nanoparticles in the Field of Drug Delivery and Gene Delivery System
Ghosal, K., Chatterjee, S., Thomas, S., & Roy, P. (2022) · AAPS PharmSciTech · doi:10.1208/s12249-022-02485-5 · Cited by 50
mRNA therapy at the convergence of genetics and nanomedicine
Conde, J., Langer, R., & Rueff, J. (2023) · Nature Nanotechnology · doi:10.1038/s41565-023-01347-w · Cited by 49
Self-citation
Nanotechnology Applications in Transplantation Medicine
Yao, C. G., & Martins, P. N. A. (2019) · Transplantation · doi:10.1097/tp.0000000000003032 · Cited by 50
Gene expression and mucosal immune responses after vaginal DNA immunization in mice using a controlled delivery matrix
Shen, H. Y., Goldberg, E., & Saltzman, W. M. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00354-1 · Cited by 49
Organogenesis and angiogenin
Vallée, B. L., & Riordan, J. F. (1997) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050101 · Cited by 49
The Role of Heparin in Angiogenesis
Folkman, J., Taylor, S., & Spillberg, C. (1983) · Novartis Foundation symposium · doi:10.1002/9780470720813.ch9 · Cited by 50
Self-citation
Angiogenic activity of rat mammary carcinomas induced by 7, 12-dimethylbenz[a]anthracene and its inhibition by medroxyprogesterone acetate: possible involvement of antiangiogenic action of medroxyprogesterone acetate in its tumor growth inhibition
Oikawa, T., Hiragun, A., Yoshida, Y., Ashino-Fuse, H., Tominaga, T., & Iwaguchi, T. (1988) · Cancer Letters · doi:10.1016/0304-3835(88)90218-2 · Cited by 49
Thermoresponsive block copolymers containing reactive azlactone groups and their bioconjugation with lysozyme
Ho, H. T., Levere, M. E., Pascual, S., Montembault, V., Casse, N., Caruso, A., & Fontaine, L. (2012) · Polymer Chemistry · doi:10.1039/c2py20714a · Cited by 48
Vaginal rings with exposed cores for sustained delivery of the HIV CCR5 inhibitor 5P12-RANTES
McBride, J. W., Boyd, P., Dias, N., Cameron, D., Offord, R. E., Hartley, O., Kett, V. L., & Malcolm, K. R. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.02.003 · Cited by 48
Binding of basic fibroblast growth factor to normal and neovascularized rabbit cornea.
Soubrane, G., Jerdan, J. A., Karpouzas, I., Fayein, N. A., Glaser, B. M., COSCAS, G. J., Courtois, Y., & Jeanny, J. (1990) · PubMed · Cited by 48
Ethylene-Vinyl Acetate Copolymer Microspheres for Controlled Release of Macromolecules
Sefton, M. V., Brown, L. R., & Langer, R. (1984) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.2600731258 · Cited by 48
Self-citation
Proteoglycans in the microvascular. II. Histochemical localization in proliferating capillaries of the rabbit cornea.
Ausprunk, D. H., Boudreau, C. L., & Nelson, D. A. (1981) · PubMed Central · Cited by 48
Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury
Mehrotra, P., Jablonski, J., Toftegaard, J., Zhang, Y., Shahini, S., Wang, J., Hung, C. W., Ellis, R., Kayal, G., Rajabian, N., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53276-4 · Cited by 53
More than a delivery system: the evolving role of lipid-based nanoparticles
Karmaker, S., Rosales, P. D., Tirumuruhan, B., Viravalli, A., & Boehnke, N. (2025) · Nanoscale · doi:10.1039/d4nr04508d · Cited by 56
Release of macromolecules and daunomycin from hydrophilic gels containing enzymatically degradable bonds
Šubr, V., Duncan, R., & Kopec̆ek, J. (1989) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856289x00145 · Cited by 47
Local Delivery of Minocycline and Systemic BCNU have Synergistic Activity in the Treatment of Intracranial Glioma
Frazier, J. L., Wang, P. P., Case, D., Tyler, B., Pradilla, G., WEINGART, J. D., & Brem, H. (2003) · Journal of Neuro-Oncology · doi:10.1023/a:1025695423097 · Cited by 48
Morphological changes of ethylene/vinyl acetate-based controlled delivery systems during release of water-soluble solutes
Miller, E. S., Peppas, N. A., & Winslow, D. N. (1983) · Journal of Membrane Science · doi:10.1016/s0376-7388(00)81375-7 · Cited by 47
TRANSPORT STUDIES ON MACROMOLECULES USED AS DRUG CARRIERS
Kulkarni, P. V., Rajur, S. B., Antich, P. P., Aminabhavi, T. M., & Aralaguppi, M. I. (1990) · Journal of macromolecular science. Part C, Reviews in macromolecular chemistry and physics/Journal of macromolecular science. Reviews in macromolecular chemistry and physics · doi:10.1080/07366579008050915 · Cited by 46
The Role of BCNU Polymer Wafers (Gliadel) in the Treatment of Malignant Glioma
Nagpal, S. (2012) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2012.01.004 · Cited by 46
Nanocarriers for Tracking and Treating Diseases
Marrache, S., Pathak, R., Darley, K., Choi, J. J., Zaver, D., Kolishetti, N., & Dhar, S. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320280007 · Cited by 46
Controlled release technology for anti-angiogenesis treatment of posterior eye diseases: Current status and challenges
Lau, C. M. L., Yu, Y., Jahanmir, G., & Chau, Y. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.03.013 · Cited by 46
Biomaterials for Drug Delivery and Tissue Engineering
Langer, R. (2006) · MRS Bulletin · doi:10.1557/mrs2006.122 · Cited by 47
Self-citation
12(R)-hydroxyeicosatrienoic acid, a potent chemotactic and angiogenic factor produced by the cornea
Masferrer, J. L., Rimarachin, J. A., Gerritsen, M. E., Falck, J. R., YADAGIRI, P., Dunn, M. W., & Schwartzman, M. L. (1991) · Experimental Eye Research · doi:10.1016/0014-4835(91)90037-f · Cited by 46
Nanomaterials in diagnostics, imaging and delivery: Applications from COVID-19 to cancer
Bardhan, N. M. (2022) · MRS Communications · doi:10.1557/s43579-022-00257-7 · Cited by 48
From micro to nano: evolution and impact of drug delivery in treating disease
Hrkach, J., & Langer, R. (2020) · Drug Delivery and Translational Research · doi:10.1007/s13346-020-00769-6 · Cited by 45
Self-citation
Controling the rate of protein release from polyelectrolyte complexes
Kamiya, N., & Klibanov, A. M. (2003) · Biotechnology and Bioengineering · doi:10.1002/bit.10606 · Cited by 45
A Mathematical Model for the Diffusion of Tumour Angiogenesis Factor into the Surrounding Host Tissue
Chaplain, M. A. J., & Stuart, A. M. (1991) · Mathematical Medicine and Biology A Journal of the IMA · doi:10.1093/imammb/8.3.191 · Cited by 45
A Tunable Hydrogel for Encapsulation and Controlled Release of Bioactive Proteins
Delgado, M., Spanka, C., Kerwin, L., Paul Wentworth, & Janda, K. D. (2001) · Biomacromolecules · doi:10.1021/bm010147y · Cited by 45
Clinical applications of musculoskeletal tissue engineering
Roberts, S. J., Howard, D. J., Buttery, L. D. K., & Shakesheff, K. M. (2008) · British Medical Bulletin · doi:10.1093/bmb/ldn016 · Cited by 45
Origins and development of biomedical engineering within chemical engineering
Peppas, N. A., & Langer, R. (2004) · AIChE Journal · doi:10.1002/aic.10048 · Cited by 45
Self-citation
STIMULI-SENSITIVE PARTICLES FOR DRUG DELIVERY
Grainger, S. J., & ElSayed, M. E. H. (2010) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814295680_0008 · Cited by 45
Biodegradable carriers for the sustained release of polypeptides
Hutchinson, F., & Furr, B. J. A. (1987) · Trends in biotechnology · doi:10.1016/0167-7799(87)90028-x · Cited by 45
Angiogenesis in arteries: Review
Eisenstein, R. (1991) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(91)90019-i · Cited by 45
Tumor angiogenesis and anti-angiogenic therapy
Guo, Z., Xu, J., Sun, X., Sun, S., Yang, Y., & Cao, Y. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003231 · Cited by 48
O-Hexadecyl-Dextran Entrapped Berberine Nanoparticles Abrogate High Glucose Stress Induced Apoptosis in Primary Rat Hepatocytes
Kapoor, R., Singh, S., Tripathi, M., Bhatnagar, P., Kakkar, P., & Gupta, K. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089124 · Cited by 44
Recent Progress in Phthalocyanine-Polymeric Nanoparticle Delivery Systems for Cancer Photodynamic Therapy
Borzęcka, W., Domiński, A., & Kowalczuk, M. M. (2021) · Nanomaterials · doi:10.3390/nano11092426 · Cited by 45
Engineering the tissue which encapsulates subcutaneous implants. III. Effective tissue response times
Sharkawy, A. A., Klitzman, B. M., Truskey, G. A., & Reichert, W. M. (1998) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(19980615)40:4 · Cited by 110
Inhibition of Tumor Angiogenesisa
Sipos, E. P., Tamargo, R. J., WEINGART, J. D., & Brem, H. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb24741.x · Cited by 44
A review on nanoparticles categorization, characterization and applications in drug delivery systems
Wani, S. U. D., Ali, M., Masoodi, M. H., Khan, N. A., Zargar, M. I., Mir, R. H., Mir, S. A., Gautam, S. P., Gangadharappa, H. V., & Osmani, R. A. M. (2022) · Vibrational Spectroscopy · doi:10.1016/j.vibspec.2022.103407 · Cited by 43
Partitioning of spherical particles into fibrous matrices
Fanti, L. A., & Glandt, E. D. (1990) · Journal of Colloid and Interface Science · doi:10.1016/0021-9797(90)90008-c · Cited by 43
Systemic Amiloride Inhibits Experimentally Induced Neovascularization
Avery, R. L. (1990) · Archives of Ophthalmology · doi:10.1001/archopht.1990.01070120122041 · Cited by 43
Radiation‐grafted polymers for biomaterial applications. I. 2‐hydroxyethyl methacrylate: Ethyl methacrylate grafting onto low density polyethylene films
Cohn, D., Hoffman, A. S., & Ratner, B. D. (1984) · Journal of Applied Polymer Science · doi:10.1002/app.1984.070290819 · Cited by 43
A ribonuclease inhibitor expresses anti-angiogenic properties and leads to reduced tumor growth in mice.
Polakowski, I. J., Lewis, M., Muthukkaruppan, V., Erdman, B., Kubai, L., & Auerbach, R. (1993) · PubMed Central · Cited by 43
Prevention and Reversal of Experimental Posthemorrhagic Vasospasm by the Periadventitial Administration of Nitric Oxide from a Controlled-release Polymer
Tierney, T. S., Clatterbuck, R. E., Lawson, C., Thai, Q.-A., Rhines, L. D., & Tamargo, R. J. (2001) · Neurosurgery · doi:10.1097/00006123-200110000-00028 · Cited by 43
Ambiguities in the preclinical quality assessment of microparticulate vaccines
Johansen, P. (2000) · Trends in biotechnology · doi:10.1016/s0167-7799(00)01437-2 · Cited by 43
Evaluation of pH-sensitive polyurethane/2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
Pardini, F. M., Faccia, P. A., & Amalvy, J. I. (2015) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2015.10.016 · Cited by 42
Porosity effects of natural latex (Hevea brasiliensis) on release of compounds for biomedical applications
Miranda, M. C. R., Prezotti, F. G., Borges, F. A., de Barros, N. R., Cury, B. S. F., Herculano, R. D., & Cilli, E. M. (2017) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2017.1377024 · Cited by 42
Polymeric Nanoparticles
Jarai, B. M., Kolewe, E. L., Stillman, Z. S., Raman, N., & Fromen, C. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816662-8.00018-7 · Cited by 44
Targeted Nanoparticles for the Delivery of Novel Bioactive Molecules to Pancreatic Cancer Cells
Sanna, V., Nurra, S., Pala, N., Marceddu, S., Pathania, D., Neamati, N., & Sechi, M. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01571 · Cited by 42
Oral Insulin – a Perspective
Raj, N. K. K., & Sharma, C. P. (2003) · Journal of Biomaterials Applications · doi:10.1177/0885328203017003567 · Cited by 42
Inhibition of angiogenesis by the antineoplastic agents mitoxantrone and bisantrene
Polverini, P. J., & NOVAK, R. F. (1986) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(86)90720-5 · Cited by 42
Biodegradable Delivery System for a Birth Control Vaccine: Immunogenicity Studies in Rats and Monkeys
Singh, M., Singh, O., & Talwar, G. P. (1995) · Pharmaceutical Research · doi:10.1023/a:1016294512292 · Cited by 42
Smart responsive materials for antibacterial therapy: Progress, opportunities, and challenges
Fu, J., Wang, C., Liu, X., Zhu, S., Zheng, Y., Li, Z., Cui, Z., Zhang, Y., Jiang, H., Cao, Y., et al. (2025) · Progress in Materials Science · doi:10.1016/j.pmatsci.2025.101532 · Cited by 43
Efficacy of Novel Collagen/Gelatin Scaffold With Sustained Release of Basic Fibroblast Growth Factor for Dermis-like Tissue Regeneration
Kanda, N., Morimoto, N., Takemoto, S., Ayvazyan, A. A., Kawai, K., Sakamoto, Y., Taira, T., & Suzuki, S. (2011) · Annals of Plastic Surgery · doi:10.1097/sap.0b013e318222832f · Cited by 41
Extended release of adenovirus from polymer microspheres: potential use in gene therapy for brain tumors
Beer, S. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00022-7 · Cited by 42
Angiogenesis Factor(s)
Gullino, P. M. (1981) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-67986-5_15 · Cited by 41
Effective charge of ionic microgel particles in the swollen and collapsed states: The role of the steric microgel-ion repulsion
Moncho-Jordá, A. (2013) · The Journal of Chemical Physics · doi:10.1063/1.4817852 · Cited by 39
Technological approaches to streamline vaccination schedules, progressing towards single-dose vaccines
Lofano, G., Mallett, C. P., Bertholet, S., & O’Hagan, D. T. (2020) · npj Vaccines · doi:10.1038/s41541-020-00238-8 · Cited by 41
Local delivery of antineoplastic agents by controlled-release polymers for the treatment of malignant brain tumours
Raza, S. M., Pradilla, G., Legnani, F. G., Thai, Q. A., Olivi, A., WEINGART, J. D., & Brem, H. (2005) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.5.4.477 · Cited by 39
Diclofenac Potassium Transdermal Patches Using Natural Rubber Latex Biomembranes as Carrier
de Barros, N. R., Chagas, P. A. M., Borges, F. A., Gemeinder, J. L. P., Miranda, M. C. R., Garms, B. C., & Herculano, R. D. (2015) · Journal of Materials · doi:10.1155/2015/807948 · Cited by 40
In vitro release of vascular endothelial growth factor from gadolinium‐doped biodegradable microspheres
Faranesh, A. Z., Nastley, M. T., de la Cruz, C. P., Haller, M. F., Laquerrière, P., Leong, K. W., & McVeigh, E. R. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20092 · Cited by 40
Controlled release of transforming growth factor-β from lipid-based microcylinders
Spargo, B. J., Cliff, R. O., Rollwagen, F. M., & Rudolph, A. S. (1995) · Journal of Microencapsulation · doi:10.3109/02652049509010293 · Cited by 40
Drug delivery to tumors of the central nervous system
Lesniak, M. S., Langer, R., & Brem, H. (2001) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-001-0020-z · Cited by 40
Self-citation
Gangliosides, copper ions and angiogenic capacity of adult tissues
Gullino, P. M., Ziche, M., & Alessandri, G. (1990) · Cancer and Metastasis Reviews · doi:10.1007/bf00046363 · Cited by 40
Xanthohumol—A Miracle Molecule with Biological Activities: A Review of Biodegradable Polymeric Carriers and Naturally Derived Compounds for Its Delivery
Olędzka, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063398 · Cited by 41
Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications
Jansen, J., Boerakker, M. J., Heuts, J., Feijén, J., & Grijpma, D. W. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.06.031 · Cited by 39
In‐vivostudies on intraperitoneally administrated poly(vinyl alcohol)
Jiang, Y., Schädlich, A., Amado, E., Weis, C., Odermatt, E. K., Mäder, K., & Kreßler, J. (2010) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.31585 · Cited by 39
Poly(lactic- co -glycolic acid) (PLGA) matrix implants
Sequeira, J. A. D., Paiva‐Santos, A. C., Serra, J. P., Veiga, F., & Ribeiro, A. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813665-2.00010-7 · Cited by 43
Silk fibroin-based hydrogels as a protective matrix for stabilization of enzymes against pH denaturation
Han, Y., Yu, S., Liu, L., Zhao, S., Yang, T., Yang, Y., Fang, Y., & Lv, S. (2018) · Molecular Catalysis · doi:10.1016/j.mcat.2018.07.009 · Cited by 39
Drug release using nanoparticles in the cancer cells on 2-D materials in order to target drug delivery: A numerical simulation via molecular dynamics method
Aldosari, S., Banawas, S., Ghafour, H. S., Tlili, I., & Le, Q. H. (2022) · Engineering Analysis with Boundary Elements · doi:10.1016/j.enganabound.2022.12.020 · Cited by 38
Advances toward transformative therapies for tendon diseases
Freedman, B. R., Mooney, D. J., & Weber, E. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abl8814 · Cited by 38
Effects of Echistatin and an RGD Peptide on Orthodontic Tooth Movement
Dolce, C., Vakani, A., Archer, L., Morris-Wiman, J. A., & Holliday, L. S. (2003) · Journal of Dental Research · doi:10.1177/154405910308200905 · Cited by 38
Postsynaptic inositol 1,4,5-trisphosphate signaling maintains presynaptic function of parallel fiber–Purkinje cell synapses via BDNF
Furutani, K., Okubo, Y., Kakizawa, S., & Iino, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600497103 · Cited by 39
Retention of Micronutrients by Polymer Coatings Used to Fortify Rice
PEIL, A., BARRETT, F., Rha, C., & Langer, R. (1982) · Journal of Food Science · doi:10.1111/j.1365-2621.1982.tb11073.x · Cited by 38
Self-citation
Extracellular matrix of newly forming vessels—An immunohistochemical study
Jerdan, J. A., Michels, R. G., & Glaser, B. M. (1991) · Microvascular Research · doi:10.1016/0026-2862(91)90060-o · Cited by 38
Mitoxantrone-loaded zeolite beta nanoparticles: Preparation, physico-chemical characterization and biological evaluation
Grund, S., Doussineau, T., Fischer, D., & Mohr, G. J. (2011) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2011.09.003 · Cited by 37
Functionalized linear poly(amidoamine)s are efficient vectors for intracellular protein delivery
Coué, G. M. J. P. C., & Engbersen, J. F. J. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.01.023 · Cited by 37
Microfabrication Methods for Biodegradable Polymeric Carriers for Drug Delivery System Applications: A Review
Cho, D., & Yoo, H. J. (2014) · Journal of Microelectromechanical Systems · doi:10.1109/jmems.2014.2368071 · Cited by 37
Nano Meets Micro-Translational Nanotechnology in Medicine: Nano-Based Applications for Early Tumor Detection and Therapy
Siemer, S., Gül, D., Khamis, A., Lü, Q., Scherberich, A., Filippi, M., Krafft, M. P., Hagemann, J., Weiß, C., Ding, G., et al. (2020) · Nanomaterials · doi:10.3390/nano10020383 · Cited by 37
Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies
Butowska, K., Woziwodzka, A., Borowik, A., & Piosik, J. (2021) · Materials · doi:10.3390/ma14092135 · Cited by 37
Strength of hollow hydroxyapatite microspheres prepared by a glass conversion process
Huang, W., Rahaman, M. N., Day, D. E., & Miller, B. A. (2008) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-008-3554-7 · Cited by 37
What Makes Subcortical Barrels?
Henderson, T. A., & Jacquin, M. F. (1995) · Cerebral cortex · doi:10.1007/978-1-4757-9616-2_3 · Cited by 37
Stromal vascularization prevents corneal ulceration.
Conn, H., Berman, M., Kenyon, K. R., Langer, R., & Gage, J. (1980) · PubMed · Cited by 37
Self-citation
Nanohybridization of Low-Dimensional Nanomaterials: Synthesis, Classification, and Application
Amarnath, C. A., Nanda, S. S., Papaefthymiou, G. C., Yi, D. K., & Paik, U. (2013) · Critical reviews in solid state and materials sciences/CRC critical reviews in solid state and materials sciences · doi:10.1080/10408436.2012.732545 · Cited by 37
How the field of controlled-release technology began, and its central role in the development of angiogenesis research
Folkman, J. (1990) · Biomaterials · doi:10.1016/0142-9612(90)90017-k · Cited by 36
Self-citation
Biodegradable implants for the delivery of veterinary vaccines: design, manufacture and antibody responses in sheep
Walduck, A. K., Opdebeeck, J. P., Benson, H. A., & Prankerd, R. J. (1998) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00180-6 · Cited by 36
A comparative study on the effects of tumor necrosis factor‐α (TNF‐α), human angiogenic factor (h‐AF) and basic fibroblast growth factor (bFGF) on the chorioallantoic membrane of the chick embryo
Olivo, M., Bhardwaj, R. S., Schulze‐Osthoff, K., Sorg, C., Jacob, H. J., & Flamme, I. (1992) · The Anatomical Record · doi:10.1002/ar.1092340112 · Cited by 36
Angiogenesis inhibitors and their delivery systems
Langer, R., & Murray, J. B. (1983) · Applied Biochemistry and Biotechnology · doi:10.1007/bf02798344 · Cited by 36
Self-citation
Lessons in simplicity that should shape the future of drug delivery
Raemdonck, K., & Smedt, S. C. D. (2015) · Nature Biotechnology · doi:10.1038/nbt.3366 · Cited by 36

Authors: LANGER, R., & FOLKMAN, J.
Affiliations: Boston Children's Hospital (US)
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1976-10-28
Volume: 263
Issue: 5580
Pages: 797-800
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/263797a0
OpenAlex: W2052580681
Cited by: 1,182
References: 13
Citations by year: 2026: 23 · 2025: 33 · 2024: 37 · 2023: 47 · 2022: 44 · 2021: 68 · 2020: 35 · 2019: 28 · 2018: 47 · 2017: 30 · 2016: 32 · 2015: 25 · 2014: 41 · 2013: 33 · 2012: 31
FWCI: 7.81
Type: journal article
Language: en
Update notices: correction (1976-11-18)
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: sustained drug release, protein delivery, macromolecule delivery, biodegradable polymers, silicone rubber, controlled drug release
MeSH terms: Alkaline Phosphatase, Animals, Catalase, Delayed-Action Preparations, Inflammation, Molecular Weight, Muramidase, Polymers, Rabbits, Structure-Activity Relationship, Trypsin Inhibitors, Angiogenesis Inducing Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Polymers for the sustained release of proteins and other macromolecules

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks