Hypercycles and the origin of life
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A selfish parasite can spread and channel away catalytic aid, leading to collapse of hypercycle.
“If this parasite receives strong enough catalysis, then it can spread and channel away catalytic aid, leading to the collapse of the hypercycle”
From Ecology and Evolution in the RNA World Dynamics and Stability of Prebiotic Replicator Systems (2017) · cites this paper as [71]
A shortcut parasite reduces hypercycle to fewer members, representing evolution to shorter hypercycles and loss of information.
“Such a shortcut parasite reduces the hypercycle to one that consists of fewer members than the original (i.e., reduces overall diversity). A shorter hypercycle having shared members with a longer hypercycle can spread in expense of the longer one. This represents evolution to shorter and shorter hypercycles. Information is lost with each loss of a member.”
From Ecology and Evolution in the RNA World Dynamics and Stability of Prebiotic Replicator Systems (2017) · cites this paper as [71]
Cited by
Sorted by citations
Prebiotic Systems Chemistry: New Perspectives for the Origins of Life
Ruiz-Mirazo, K., Briones, C., & de la Escosura, A. (2014) · Chemical Reviews · doi:10.1021/cr2004844 · Cited by 930 · see citing works
Group selection of early replicators and the origin of life
Szathmáry, E., & Demeter, L. (1987) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(87)80191-1 · Cited by 407 · see citing works
Spontaneous network formation among cooperative RNA replicators
Vaidya, N., Manapat, M. L., Chen, I. A., Xulvi-Brunet, R., Hayden, E. J., & Lehman, N. (2012) · Nature · doi:10.1038/nature11549 · Cited by 383 · see citing works
Wolf, Y. I., & Koonin, E. V. (2007) · Biology Direct · doi:10.1186/1745-6150-2-14 · Cited by 235 · see citing works
“At the same time, the existing level of replication fidelity limits the amount of information that can be encoded in the genome [3,6,7].”
BackgroundSub-exponential growth and coexistence of non-enzymatically replicating templates
Szathmáry, E., & Gladkih, I. (1989) · Journal of Theoretical Biology · doi:10.1016/s0022-5193(89)80177-8 · Cited by 165 · see citing works
Real ribozymes suggest a relaxed error threshold
Kun, Á., Santos, M., & Szathmáry, E. (2005) · Nature Genetics · doi:10.1038/ng1621 · Cited by 151 · see citing works
Multilevel Selection in Models of Prebiotic Evolution: Compartments and Spatial Self-organization
Hogeweg, P., & Takeuchi, N. (2003) · Origins of life and evolution of the biosphere · doi:10.1023/a:1025754907141 · Cited by 110 · see citing works
Host–parasite oscillation dynamics and evolution in a compartmentalized RNA replication system
Bansho, Y., Furubayashi, T., Ichihashi, N., & Yomo, T. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524404113 · Cited by 87 · see citing works
“Living” under the challenge of information decay: the stochastic corrector model vs. hypercycles
ZINTZARAS, E., SANTOS, M., & SZATHMÁRY, E. (2002) · Journal of Theoretical Biology · doi:10.1006/jtbi.2002.3026 · Cited by 69 · see citing works
Ecology and Evolution in the RNA World Dynamics and Stability of Prebiotic Replicator Systems
Szilágyi, A., Zachar, I., Scheuring, I., Kun, Á., Könnyű, B., & Czárán, T. (2017) · Life · doi:10.3390/life7040048 · Cited by 44 · see citing works
“The problem with the TGM is precisely what Maynard Smith recognized: a trait group, due to global mixing, does not form a true unit of selection but simply realizes kin selection (for example, by locally reproducing organisms forming a kin).”
BackgroundKönnyű, B., & Czárán, T. (2013) · BMC Evolutionary Biology · doi:10.1186/1471-2148-13-204 · Cited by 25 · see citing works
Hickinbotham, S. J., Stepney, S., & Hogeweg, P. (2021) · Royal Society Open Science · doi:10.1098/rsos.210441 · Cited by 14 · see citing works
Fluctuation in the physical environment as a mechanism for reinforcing evolutionary transitions
Boyle, R. A., & Lenton, T. M. (2006) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2006.05.003 · Cited by 12 · see citing works
- Authors
- Smith, J. M.
- Affiliations
- University of Sussex (GB)
- Corresponding author
- Smith, John Maynard
- Venue
- Nature
- Published
- 1979-08-01
- Volume
- 280
- Issue
- 5722
- Pages
- 445-446
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2058513344
- Cited by
- 240
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 7 · 2022: 20 · 2021: 7 · 2020: 9 · 2019: 9 · 2018: 7 · 2017: 8 · 2016: 14 · 2015: 9 · 2014: 4 · 2013: 8 · 2012: 7
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Update notices
- erratum (1979-08-01)
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
- Keywords
- hypercycles, origin of life, RNA world, CRISPR, genome editing, evolutionary biology, Kolmogorov scale, turbulent coherent structures
- MeSH terms
- Origin of Life, Mutation, RNA
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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