Cited by 87Origins and Evolution of LifeEvolution and Genetic DynamicsRNA and protein synthesis mechanisms

Host–parasite oscillation dynamics and evolution in a compartmentalized RNA replication system

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Bansho, Yohsuke, Furubayashi, Taro, Ichihashi, Norikazu, Yomo, Tetsuya·2016·Proceedings of the National Academy of Sciences

Abstract

Significance: We reconstituted a simple in vitro molecular ecosystem using two self-replicating RNA molecules. The host RNA species produces an RNA-dependent RNA polymerase for their replication, and the parasitic RNA relies on the same enzyme for its replication as well. We found that only when compartmentalized into microscale droplets did the ecosystem show a typical host–parasite oscillatory dynamics. Furthermore, after a long cultivation, the ecosystem evolved to allow the coexistence of the two species. These results demonstrate that cell-size compartmentalization is essential for the ecological dynamics and evolution of host and parasite species.

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Crossref · 10.1073/pnas.1524404113

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32 of 32 references verified0 citation errors · 0 not checkable

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  • Experimentally, even transient compartmentalization is sufficient to prevent extinction caused by parasites.

    “Experimentally, even transient compartmentalization is sufficient to prevent extinction caused by parasites (Bansho et al. 2016;Matsumura et al. 2016).”

    From Protocells and RNA Self-Replication (2018) · cites this paper as Bansho et al. 2016

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Authors
Bansho, Y., Furubayashi, T., Ichihashi, N., & Yomo, T.
Affiliations
  • Japan Society for the Promotion of Science (JP)
  • The University of Osaka (JP)
  • Japan Science and Technology Agency (JP)
Venue
Proceedings of the National Academy of Sciences
Published
2016-03-28
Volume
113
Issue
15
Pages
4045-4050
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2320164531
Cited by
87
References
33
Citations by year
2026: 5 · 2025: 2 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 13 · 2020: 11 · 2019: 10 · 2018: 13 · 2017: 5 · 2016: 1
FWCI
4.62
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (15H04407, 15H01534, 15KT0080)
Topics
  • Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords
host-parasite coevolution, RNA self-replication, compartmentalization, oscillatory dynamics, population dynamics, in vitro reconstitution, origin of life
MeSH terms
Animals, Biological Evolution, Host-Parasite Interactions, Parasites, RNA

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