Do general anaesthetics act by competitive binding to specific receptors?
Franks, N. P., Lieb, W. R.·1984·Nature
DOI 10.1038/310599a0
Cited by (574)
Items 101–200 of 574
- Mechanistic aspects on chemical induction of spindle disturbances and abnormal chromosome numbersAgneta Önfelt · 1986 · Mutation Research/Reviews in Genetic Toxicology
- Antagonists of alcohol inhibition of cell adhesionMichael F. Wilkemeyer, Anita B. Sebastian, Sherri A. Smith, Michael E. Charness · 2000 · Proceedings of the National Academy of Sciences
- Volatile anesthetics compete for common binding sites on bovine serum albumin: a 19F-NMR study.Brian W. Dubois, Sebastian F. Cherian, Alex S. Evers · 1993 · Proceedings of the National Academy of Sciences
- Actions and interactions of high pressure and general anaestheticsKenneth T. Wann · 1988 · Progress in Neurobiology
- A hypothesis on the origin and evolution of the response to inhaled anestheticsSonner, James M. · 2008 · Anesthesia & Analgesia
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- Inhalational Anesthetics Stereochemistry: Optical Resolution of Halothane, Enflurane, and IsofluraneJerrold Meinwald, W. R. Thompson, D. L. Pearson, W. A. König, Torsten M. Runge, Wittko Francke · 1991 · Science
- Anesthesia, consciousness and hydrophobic pockets–a unitary quantum hypothesis of anesthetic actionHameroff, Stuart · 1998 · Toxicology Letters
- Effects of Temperature and Volatile Anesthetics on GABAAReceptorsAndrew Jenkins, Nicholas P. Franks, W.R. Lieb · 1999 · Anesthesiology
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- Channel Gating of the Glycine Receptor Changes Accessibility to Residues Implicated in Receptor Potentiation by Alcohols and AnestheticsIngrid A. Lobo, Maria Paola Mascia, James R. Trudell, Robert Adron Harris · 2004 · Journal of Biological Chemistry
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- Potentiation by sevoflurane of the γ‐aminobutyric acid‐induced chloride current in acutely dissociated CA1 pyramidal neurones from rat hippocampusJie Wu, Nobutoshi C. Harata, Norio Akaike · 1996 · British Journal of Pharmacology
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- Alcohol action on membrane ion channels gated by extracellular ATP (P2X receptors)Forrest F. Weight, Chaoying Li, Robert W. Peoples · 1999 · Neurochemistry International
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- MEMBRANE BURDENS OF CHLORINATED BENZENES LOWER THE MAIN PHASE TRANSITION TEMPERATURE IN DIPALMITOYL-PHOSPHATIDYLCHOLINE VESICLES: IMPLICATIONS FOR TOXICITY BY NARCOTIC CHEMICALSAnnemarie P. van Wezel, Gerard Cornelissen, J. Cees van Miltenburg, Antoon Opperhuizen · 1996 · Environmental Toxicology and Chemistry
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- Thermodynamics of anesthetic/protein interactions. Temperature studies on firefly luciferaseRobert Dickinson, Nicholas P. Franks, W.R. Lieb · 1993 · Biophysical Journal
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- The Quest for a Unified Model of Anesthetic Action: A Century in Claude Bernard's ShadowPerouansky, Misha · 2012 · Anesthesiology
- Membrane Structural Perturbations Caused by Anesthetics and Nonimmobilizers: A Molecular Dynamics InvestigationLaure Koubi, Mounir Tarek, Sanjoy Bandyopadhyay, Michael Lawrence Klein, Daphna Scharf · 2001 · Biophysical Journal
- Inhaled Anesthetic Binding Sites in Human Serum AlbuminRoderic G. Eckenhoff, Charles E. Petersen, Chung‐Eun Ha, Nadhipuram V. Bhagavan · 2000 · Journal of Biological Chemistry
- Molecular modelling of specific and non-specific anaesthetic interactionsJames R. Trudell, Edward J. Bertaccini · 2002 · British Journal of Anaesthesia
- EFFECTS OF ANAESTHETICS ON UPTAKE, SYNTHESIS AND RELEASE OF TRANSMITTERSR. GRIFFITHS, Robert I. Norman · 1993 · British Journal of Anaesthesia
- n-Alcohols Inhibit Voltage-Gated Na+ Channels Expressed in Xenopus OocytesTakafumi Horishita, Robert Adron Harris · 2008 · Journal of Pharmacology and Experimental Therapeutics
- Anesthetic inhibition of firefly luciferase, a protein model for general anesthesia, does not exhibit pressure reversalGuy W. J. Moss, W.R. Lieb, Nicholas P. Franks · 1991 · Biophysical Journal
- Is There a Specific Receptor for Anesthetics? Contrary Effects of Alcohols and Fatty Acids on Phase Transition and Bioluminescence of Firefly LuciferaseIssaku Ueda, Atsuya Suzuki · 1998 · Biophysical Journal
- Molecular Determinants of General Anesthetic Action: Role of GABAA Receptor StructureLie‐Huey Lin, Paul John Whiting, ROSALYN A. HARRIS · 1993 · Journal of Neurochemistry
- 19F nuclear magnetic resonance investigation of stereoselective binding of isoflurane to bovine serum albuminYan Xu, Pei Song Tang, Leonard L. Firestone, T.T. Zhang · 1996 · Biophysical Journal
- Modulation of the general anesthetic sensitivity of a protein: a transition between two forms of firefly luciferase.Guy W. J. Moss, Nicholas P. Franks, W.R. Lieb · 1991 · Proceedings of the National Academy of Sciences
- Effects of general anesthetics on the bacterial luciferase enzyme from Vibrio harveyi: an anesthetic target site with differential sensitivityStephen Curry, W.R. Lieb, Nicholas P. Franks · 1990 · Biochemistry
- Monod–Wyman–Changeux allosteric mechanisms of action and the pharmacology of etomidateStuart A. Forman · 2012 · Current Opinion in Anaesthesiology
- Moving in extreme environments: inert gas narcosis and underwater activitiesJames Clark · 2015 · Extreme Physiology & Medicine
- Clinical PharmacologyLeigh A. Lamont, Kurt A. Grimm · 2014
- Volatile anesthetics bind rat synaptic snare proteinsNagele, Peter, Mendel, J Brett, Placzek, William J., Scott, Barbara A., d'Avignon, D André, Crowder, C Michael · 2005 · Anesthesiology
- High pressure effects in anaesthesia and narcosisAgnieszka Włodarczyk, P. Mc Millan, Susan A. Greenfield · 2006 · Chemical Society Reviews
- Actions of general anaesthetics on a neuronal nicotinic acetylcholine receptor in isolated identified neurones of Lymnaea stagnalisD. McKenzie, Nicholas P. Franks, W.R. Lieb · 1995 · British Journal of Pharmacology
- Inhibition of Firefly Luciferase by General Anesthetics: Effect on In Vitro and In Vivo Bioluminescence ImagingMarleen Keyaerts, Isabel Remory, Vicky Caveliers, Karine Breckpot, Tomas Jan Bos, Jan Poelaert, Axel M. Bossuyt, Tony Lahoutte · 2012 · PLoS ONE
- Antagonism of Inhalant and Volatile Anesthetic Enhancement of Glycine Receptor FunctionMichael J. Beckstead, Rachel Phelan, S. John Mihic · 2001 · Journal of Biological Chemistry
- Bound Volatile General Anesthetics Alter Both Local Protein Dynamics and Global Protein StabilityJonas S. Johansson, Helen Y. Zou, Jonathan W. Tanner · 1999 · Anesthesiology
- Vascular effects of halothane and isoflurane: cGMP dependent and independent actionsMing Xia Jing, Jayne L. Hart, Eiji Masaki, Russell A. Van Dyke, Saiid Bina, Sheila M. Muldoon · 1994 · Life Sciences
- Dynamics of Firefly Luciferase Inhibition by General Anesthetics: Gaussian and Anisotropic Network AnalysesAgnieszka Szarecka, Yan Xu, Pei Song Tang · 2007 · Biophysical Journal
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- An overview of the use of quantitative structure-activity relationships for ranking and prioritizing large chemical inventories for environmental risk assessmentsChristine L. Russom, Roger L. Breton, John D. Walker, Steven P. Bradbury · 2003 · Environmental Toxicology and Chemistry
- Recent neurochemical basis of inert gas narcosis and pressure effects.J. C. Rostain, Norbert Balon · 2006 · PubMed
- The impact of drugs used in anaesthesia on bacteriaIstván Zoárd Bátai, Mónika Kerényi, M Tekeres · 1999 · European Journal of Anaesthesiology
- Do Specific or Nonspecific Interactions with Proteins Underlie Inhalational Anesthetic Action?Roderic G. Eckenhoff · 1998 · Molecular Pharmacology
- Effect of solvation on the structure conformation of human serum albumin in aqueous–alcohol mixed solventsPablo Taboada, Sílvia Barbosa, Emilio da Maia de Castro, Manuel Gutiérrez-Pichel, Vı́ctor Mosquera · 2007 · Chemical Physics
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- Interaction between Artificial Membranes and Enflurane, a General Volatile Anesthetic: DPPC-Enflurane InteractionNathalie Hauet, Franck Artzner, François Boucher, Cécile Grabielle-Madelmont, Isabelle Cloutier, G. Keller, P. Lesieur, DURAND Dominique Christiane, Maı̈té Paternostre · 2003 · Biophysical Journal
- Genetic differences affecting the potency of stereoisomers of halothane.Margaret M. Sedensky, HELMUT F. CASCORBI, Jerrold Meinwald, Peter Radford, Philip G. Morgan · 1994 · Proceedings of the National Academy of Sciences
- The mitochondrial division inhibitor Mdivi-1 rescues mammalian neurons from anesthetic-induced cytotoxicityFenglian Xu, Ryden Armstrong, Daniela Urrego, Munir Qazzaz, Mario Pehar, John N. Armstrong, Timothy E. Shutt, Naweed I. Syed · 2016 · Molecular Brain
- Sigmoidal compression rate-dependence of inert gas narcotic potency in rats: implication for lipid vs. protein theories of inert gas action in the central nervous systemJacques H. Abraini, Jean‐Claude Rostain, Badreddine Kriem · 1998 · Brain Research
- Anesthetics and control of breathingLuc J. Teppema, Santhosh Mukadiyil Baby · 2011 · Respiratory Physiology & Neurobiology
- Anesthetic and Nonanesthetic Halogenated Volatile Compounds Have Dissimilar Activities on Nicotinic Acetylcholine Receptor Desensitization KineticsDouglas E. Raines · 1996 · Anesthesiology
- Anaesthesia with diethyl ether impairs jasmonate signalling in the carnivorous plant Venus flytrap (Dionaea muscipula)Andrej Pavlovič, Michaela Libiaková, Boris Bokor, Jana Jakšová, Ivan Petřík, Ondřej Novák, František Baluška · 2019 · Annals of Botany
- Design, Synthesis, and Evaluation of Analogues of 3,3,3-Trifluoro-2-Hydroxy-2-Phenyl-Propionamide as Orally Available General AnestheticsIndrani Choudhury-Mukherjee, Hilary A. Schenck, Sylvia Cechova, Thomas N. Pajewski, Jaideep Kapur, Jeffrey Ellena, David S. Cafiso, Milton L. Brown · 2003 · Journal of Medicinal Chemistry
- The solubility of volatile anaesthetics in water at 25.0°C using 19F NMR spectroscopyTomoyoshi Seto, Takashi Mashimo, Ikuto Yoshiya, Masaru Kanashiro, Yoshihiro Taniguchi · 1992 · Journal of Pharmaceutical and Biomedical Analysis
- Saturation Transfer Difference Nuclear Magnetic Resonance Spectroscopy As a Method for Screening Proteins for Anesthetic BindingJohn H. Streiff, Nenad Juranić, Slobodan I Macura, David O. Warner, Keith A. Jones, William J. Perkins · 2004 · Molecular Pharmacology
- Computational Studies on the Interactions of Inhalational Anesthetics with ProteinsSatyavani Vemparala, Cármen Domene, Michael Lawrence Klein · 2009 · Accounts of Chemical Research
- Human Neuronal Nicotinic Acetylcholine Receptors Expressed in Xenopus Oocytes Predict Efficacy of Halogenated Compounds That Disobey the Meyer-Overton RuleRita A. Cardoso, Tomohiro Yamakura, Susan J. Brozowski, Laura E. Chavez-Noriega, Robert Adron Harris · 1999 · Anesthesiology
- Two States of Water Found in Hydrophobic Clefts: Their Possible Contribution to Mechanisms of Cation Pumps and Other EnzymesPhilippa M. Wiggins, Bera A.E. MacClement · 1987 · International review of cytology
- Catalytic Facilitation and Membrane BioenergeticsDouglas Bruce Kell, Hans Victor Westerhoff · 1985 · Elsevier eBooks
- Effects of halothane on high affinity agonist binding and guanine nucleotide sensitivity of muscarinic acetylcholine receptors from brainstem of ratRobert L. Dennison, Betty L. Anthony, T.K. Narayanan, Robert S. Aronstam · 1987 · Neuropharmacology
- A Double-Edged Sword: Volatile Anesthetic Effects on the Neonatal BrainSunny S. Chiao, Zhiyi Zuo · 2014 · Brain Sciences
- Living systems approached from physical principlesMatthias F. Schneider · 2020 · Progress in Biophysics and Molecular Biology
- Alcohol and benzodiazepines: recent mechanistic studies1Supported by funds from the NIH (NIAAA) and the Department of Veterans Affairs.1R. Adron Harris, S. John Mihic, Carlos Fernando Valenzuela · 1998 · Drug and Alcohol Dependence
- Cellular Mechanisms of AnesthesiaaKrešimir Krnjević · 1991 · Annals of the New York Academy of Sciences
- Halothane effects on muscarinic acetylcholine receptor complexes in rat brainRobert S. Aronstam, Betty L. Anthony, Robert L. Dennison · 1986 · Biochemical Pharmacology
- Synaptic PDZ domain-mediated protein interactions are disrupted by inhalational anestheticsFang, Ming, Tao, Yuan-Xiang, He, Fahu, Zhang, Mingjie, Levine, Claire F., Mao, Peizhong, Tao, Feng, Chou, Chih-Ling, Sadegh-Nasseri, Scheherazade, Johns, Roger A. · 2003 · Journal of Biological Chemistry
- Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer propertiesKarl F. Herold, R. Lea Sanford, William Lee, Margaret F. Schultz, Helgi I. Ingólfsson, Olaf Sparre Andersen, Hugh C. Hemmings · 2014 · The Journal of General Physiology
- Halothane, an inhalational anesthetic agent, increases folding stability of serum albuminJonathan W. Tanner, Roderic G. Eckenhoff, Paul A. Liebman · 1999 · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
- Ethanol-induced reduction of neuronal calcium currents inAplysia: An examination of possible mechanismsPatricia Camacho‐Nasi, Steven N. Treistman · 1987 · Cellular and Molecular Neurobiology
- Executive Functions of Divers Are Selectively Impaired at 20-Meter Water DepthFabian Steinberg, Michael M. Doppelmayr · 2017 · Frontiers in Psychology
- Alcohol effects on lipid bilayer permeability to protons and potassium: relation to the action of general anestheticsGail L. Barchfeld, David W. Deamer · 1988 · Biochimica et Biophysica Acta (BBA) - Biomembranes
- n-Alkanols and halothane inhibit red cell anion transport and increase band 3 conformational change rateStuart A. Forman, A. S. Verkman, James A. Dix, A. K. Solomon · 1985 · Biochemistry
- Irreversible phase transition of firefly luciferase: contrasting effects of volatile anesthetics and myristic acidIssaku Ueda, Atsuya Suzuki · 1998 · Biochimica et Biophysica Acta (BBA) - General Subjects
- Volatile anesthetics inhibit NMDA-stimulated45Ca uptake by rat brain microvesiclesRobert S. Aronstam, Dan C. Martin, Robert L. Dennison · 1994 · Neurochemical Research
- Chirality and anaesthetic drugs: A review and an updateSukanya Mitra, Puneet Chopra · 2011 · Indian Journal of Anaesthesia
- Relationship Between Lipophilicity of C6–10 Hydrocarbon Solvents and their ROS-Inducing Potency in Rat Cerebellar Granule CellsAnne Dreiem, Oddvar Myhre, Frode Fonnum · 2002 · NeuroToxicology
- Inhibitory Ligand-Gated Ion Channels as Substrates for General Anesthetic ActionsAnja Zeller, Rachel Jurd, Sachar Lambert, Margarete Arras, Berthold Drexler, Carsten Grashoff, Bożena Antkowiak, Uwe Rudolph · 2008 · Springer eBooks
- General anesthetics can competitively interfere with sensitive membrane proteins.Piet W.L. Tas, Hans Georg Kress, Klaus Koschel · 1987 · Proceedings of the National Academy of Sciences
- Direct and Specific Effect of Sevoflurane Anesthesia on rat Per2 Expression in the Suprachiasmatic NucleusMegumi Anzai, Norio Iijima, Shimpei Higo, Ken Takumi, Izumi Matsuo, Keisuke Mori, 裕美子 大江, Kana Kadota, Toshio Akimoto, Atsuhiro Sakamoto et al. · 2013 · PLoS ONE
- Binding Site and Affinity Prediction of General Anesthetics to Protein Targets Using DockingRenyu Liu, Jose Manuel Perez‐Aguilar, David Liang, Jeffery G. Saven · 2012 · Anesthesia & Analgesia
- Polar Narcosis in Aquatic OrganismsSP Bradbury, R.W. Carlson, T J Henry · 1989
- Halothane-induced changes in acetylcholine receptor channel kinetics are attenuated by cholesterolJames Donald Lechleiter, Michael A. Wells, Raphael Gruener · 1986 · Biochimica et Biophysica Acta (BBA) - Biomembranes
- General Anesthetic and Specific Effects of Ethanol on Acetylcholine ReceptorsaKeith W. Miller, Leonard L. Firestone, Stuart A. Forman · 1987 · Annals of the New York Academy of Sciences
- The cellular uptake of pharmaceutical drugs is mainly carrier-mediated and is thus an issue not so much of biophysics but of systems biologyDouglas Bruce Kell, Paul D. Dobson · 2009
- A review of recent neurochemical data on inert gas narcosis.J. C. Rostain, Cécile Lavoûte, Jean‐Jacques Risso, Nicolas Vallée, Michel Weiss · 2011 · PubMed
- Scientific Principles for Evaluating the Potential for Adverse Effects from Chlorinated Organic Chemicals in the EnvironmentR.F. Willes, Earle R. Nestmann, P.A. Miller, Joan C. Orr, Ian C. Munro · 1993 · Regulatory Toxicology and Pharmacology
- Small-angle neutron scattering study of the n-decane effect on the bilayer thickness in extruded unilamellar dioleoylphosphatidylcholine liposomesDaniela Uhrı́ková, Pavol Balgavý, Norbert Kučerka, Akhmed Kh. Islamov, Valentin Gordeliy, Alexander I. Kuklin · 2000 · Biophysical Chemistry
- Desflurane and the Nonimmobilizer 1,2-Dichlorohexafluorocyclobutane Suppress Learning by a Mechanism Independent of the Level of Unconditioned StimulationJames M. Sonner, Joana Li, Edmond I. Eger · 1998 · Anesthesia & Analgesia
- Ethanol effects on voltage-dependent membrane conductances: comparative sensitivity of channel populations inAplysia neuronsPatricia Camacho‐Nasi, Steven N. Treistman · 1986 · Cellular and Molecular Neurobiology
- Saturable binding of halothane to rat brain synaptosomes.Essam A. El-Maghrabi, Roderic G. Eckenhoff, Henry Shuman · 1992 · Proceedings of the National Academy of Sciences