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Cited by 67Neurotransmitter Receptor Influence on BehaviorNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

Alcohol and violence: neuropeptidergic modulation of monoamine systems

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Miczek, Klaus A., DeBold, Joseph F., Hwa, Lara S., Newman, Emily L., de Almeida, Rosa M. M.·2015·Annals of the New York Academy of Sciences
DOI 10.1111/nyas.12862PMC PMC4564371
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Abstract

Neurobiological processes underlying the epidemiologically established link between alcohol and several types of social, aggressive, and violent behavior remain poorly understood. Acute low doses of alcohol, as well as withdrawal from long‐term alcohol use, may lead to escalated aggressive behavior in a subset of individuals. An urgent task will be to disentangle the host of interacting genetic and environmental risk factors in individuals who are predisposed to engage in escalated aggressive behavior. The modulation of 5‐hydroxytryptamine impulse flow by gamma‐aminobutyric acid (GABA) and glutamate, acting via distinct ionotropic and metabotropic receptor subtypes in the dorsal raphe nucleus during alcohol consumption, is of critical significance in the suppression and escalation of aggressive behavior. In anticipation and reaction to aggressive behavior, neuropeptides such as corticotropin‐releasing factor, neuropeptide Y, opioid peptides, and vasopressin interact with monoamines, GABA, and glutamate to attenuate and amplify aggressive behavior in alcohol‐consuming individuals. These neuromodulators represent novel molecular targets for intervention that await clinical validation. Intermittent episodes of brief social defeat during aggressive confrontations are sufficient to cause long‐lasting neuroadaptations that can lead to the escalation of alcohol consumption.

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  • Alcohol exerts chronic effects on aggression independent of its acute pharmacological actions and causes long-term neurobehavioral changes that increase aggressive tendencies even during abstinence.

    “alcohol also exerts chronic effects on aggression, independent of its acute pharmacological actions, and causes long-term neurobehavioral changes that increase aggressive tendencies even during periods of abstinence (Lipsey et al. 1997; White et al. 2009; Miczek et al. 2015; Robertson et al. 2020)”

    From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Miczek et al. 2015

    The Abstract and “Basic pharmacology of alcohol and aggression” section report heightened aggression during withdrawal from long-term alcohol use, including after two months of intermittent access in mice. This supports an effect beyond acute intoxication, but the paper does not establish persistently increased aggression throughout abstinence or attribute it to long-term neurobehavioral changes. Its discussion of long-lasting neuroadaptations concerns increased alcohol consumption after social defeat, not increased aggression. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Decades of findings delineated the conditions and neurobiological mechanisms by which alcohol facilitates aggression in a susceptible subpopulation of subjects.

    “Decades of findings delineated the conditions and neurobiological mechanisms by which alcohol facilitates aggression in a susceptible subpopulation of subjects (Miczek et al. 2015).”

    From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Miczek et al. 2015

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Authors
Miczek, K. A., DeBold, J. F., Hwa, L. S., Newman, E. L., & de Almeida, R. M. M.
Affiliations
  • Tufts University (US)
  • Department of Psychology LPNeC, Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil
Corresponding author
Miczek, Klaus A.
ORCID
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2015-08-18
Volume
1349
Issue
1
Pages
96-118
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1111/nyas.12862
PMC
PMC4564371
OpenAlex
W1818524920
Cited by
67
References
18
Citations by year
2026: 4 · 2025: 5 · 2023: 6 · 2022: 3 · 2021: 8 · 2020: 14 · 2019: 5 · 2018: 6 · 2017: 11 · 2016: 5
FWCI
0.87
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
NIAAA (AA013983)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
alcohol, aggression, violence, monoaminergic systems, neuropeptides, serotonin, GABA, glutamate, dorsal raphe nucleus, corticotropin-releasing factor, neuropeptide Y, opioid peptides, vasopressin, alcohol withdrawal, social defeat, neural adaptation, genetic and environmental risk factors
MeSH terms
Aggression, Alcohol Drinking, Ethanol, Animals, Brain, Crime, Humans, Neuropeptides, Stress, Psychological, Violence, Biogenic Monoamines

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