The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Open accessAbstract
Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“M. tuberculosis genome appears to contain several cell wall hydrolases.36”
From ChiZ levels modulate cell division process in mycobacteria (2011) · cites this paper as [36]
In the citing paper
“which were first discovered almost 20 years ago during in silico analyses of the genome sequence and the proteome of Mycobacterium tuberculosis H37Rv (17,18).”
From ESX/Type VII Secretion Systems—An Important Way Out for Mycobacterial Proteins (2019) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
Improved tools for biological sequence comparison.
Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227
tRNAscan-SE: A Program for Improved Detection of Transfer RNA Genes in Genomic Sequence
Lowe, T. M., & Eddy, S. R. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.5.955 · Cited by 11,200
The complete genome sequence of Escherichia coli K-12.
Blattner, F., Plunkett, G., Bloch, C., Perna, N., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C., Mayhew, G., et al. (1997) · Science · doi:10.1126/science.277.5331.1453 · Cited by 7,996
The complete genome sequence of the gram-positive bacterium Bacillus subtilis.
Kunst, F., Ogasawara, N., Moszer, I., Albertini, A. M., Alloni, G., Azevedo, V., Bertero, M. G., Bessières, P., Bolotin, A., Borchert, S., et al. (1997) · Nature · doi:10.1038/36786 · Cited by 3,679
Theory and Applications of Correspondence Analysis.
Jolliffe, I. T., & Greenacre, M. J. (1986) · Biometrics · doi:10.2307/2531266 · Cited by 3,026
The PROSITE database, its status in 1995
Bairoch, A., Bücher, P., & Hofmann, K. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.1.189 · Cited by 1,916
Escherichia coli and Salmonella.
Neidhart, F. C. (1996) · Cited by 1,577
inhA , a Gene Encoding a Target for Isoniazid and Ethionamide in Mycobacterium tuberculosis
Banerjee, A., Dubnau, E., Quemard, A., Balasubramanian, V., Um, K. S., Wilson, T., Collins, D., de Lisle, G., & Jacobs, W. R. (1994) · Science · doi:10.1126/science.8284673 · Cited by 1,389
Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis
Marahiel, M. A., Stachelhaus, T., & Mootz, H. D. (1997) · Chemical Reviews · doi:10.1021/cr960029e · Cited by 1,128
Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis
Mahairas, G. G., Sabo, P. J., Hickey, M. J., Singh, D. C., & Stover, C. K. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.5.1274-1282.1996 · Cited by 1,103
Sreevatsan, S., Pan, X., Stockbauer, K. E., Connell, N. D., Kreiswirth, B. N., Whittam, T. S., & Musser, J. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9869 · Cited by 1,035
A new DNA sequence assembly program
Bonfield, J., Smith, K. F., & Staden, R. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.4992 · Cited by 978
Tuberculosis: Pathogenesis, Protection and Control
(1996) · Nature Medicine · doi:10.1038/nm0296-244b · Cited by 977
Levitskaya, J., Coram, M., Levitsky, V., Imreh, S., Steigerwald-Mullen, P. M., Klein, G., Kurilla, M. G., & Masucci, M. G. (1995) · Nature · doi:10.1038/375685a0 · Cited by 823
Flynn, J. L., Goldstein, M. M., Triebold, K. J., Koller, B. H., & Bloom, B. R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.12013 · Cited by 793
Molecular basis of symbiosis between Rhizobium and legumes
Freiberg, C., Fellay, R., Bairoch, A., Broughton, W. J., Rosenthal, A., & Perret, X. (1997) · Nature · doi:10.1038/387394a0 · Cited by 764
Role of the Major Antigen of Mycobacterium tuberculosis in Cell Wall Biogenesis
Belisle, J. T., Vissa, V. D., Sievert, T., Takayama, K., Brennan, P. J., & Besra, G. S. (1997) · Science · doi:10.1126/science.276.5317.1420 · Cited by 734
Genetic Contributions to Understanding Polyketide Synthases
Hopwood, D. A. (1997) · Chemical Reviews · doi:10.1021/cr960034i · Cited by 711
(1992) · International Journal of Biochemistry · doi:10.1016/0020-711x(92)90281-5 · Cited by 673
Sørensen, A. L., Nagai, S., Houen, G., Andersen, P., & Andersen, A. B. (1995) · Infection and Immunity · doi:10.1128/iai.63.5.1710-1717.1995 · Cited by 586
Levitskaya, J., Sharipo, A., Leonchiks, A., Ciechanover, A. J., & Masucci, M. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12616 · Cited by 563
Tuberculosis: Pathogenesis, protection, and control
Cock, K. M. D. (1995) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(95)90122-1 · Cited by 416
Inhibition of a Mycobacterium tuberculosis β-Ketoacyl ACP Synthase by Isoniazid
Mdluli, K. E., Slayden, R. A., Zhu, Y.-Q., Ramaswamy, S. V., Pan, X., Mead, D., Crane, D. D., Musser, J. M., & Barry, C. E. (1998) · Science · doi:10.1126/science.280.5369.1607 · Cited by 398
Self-citationCloning of an M. tuberculosis DNA fragment associated with entry and survival inside cells
Arruda, S. M., Bomfim, G. F., Knights, R. W., Huima-Byron, T., & Riley, L. W. (1993) · Science · doi:10.1126/science.8367727 · Cited by 385
A hidden Markov model that finds genes inE.coliDNA
Krogh, A., Mian, S. I., & Haussler, D. H. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.22.4768 · Cited by 315
Self-citation(1998) · Revista Panamericana de Salud Pública · doi:10.1590/s1020-49891998000900018 · Cited by 295
Bardarov, S., Kriakov, J., Carrière, C., Yu, S., Vaamonde, C., McAdam, R. A., Bloom, B. R., Hatfull, G. F., & Jacobs, W. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10961 · Cited by 278
Philipp, W. J., Poulet, S., Eiglmeier, K., Pascopella, L., Balasubramanian, V., Heym, B., Bergh, S., Bloom, B. R., Jacobs, W. R., & Cole, S. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.3132 · Cited by 253
Self-citationThe Biology of the Mycobacteria
Ratledge, C., & Stanford, J. A. (1982) · Cited by 248
Salmonella typhimurium loci involved in survival within macrophages
Bäumler, A. J., Kusters, J. G., Stojiljković, I., & Heffron, F. (1994) · Infection and Immunity · doi:10.1128/iai.62.5.1623-1630.1994 · Cited by 244
Brosch, R., Gordon, S. V., Billault, A., Garnier, T., Eiglmeier, K., Soravito, C., Barrell, B. G., & Cole, S. T. (1998) · Infection and Immunity · doi:10.1128/iai.66.5.2221-2229.1998 · Cited by 228
Self-citationThe BCG Experience: Implications for Future Vaccines against Tuberculosis
Bloom, B. R., & Fine, P. (2014) · ASM Press eBooks · doi:10.1128/9781555818357.ch31 · Cited by 219
Gobin, J., Moore, C. H., Reeve, J. R., Wong, D. K., Gibson, B. W., & Horwitz, M. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.5189 · Cited by 179
Biochemistry and molecular genetics of cell‐wall lipid biosynthesis in mycobacteria
Kolattukudy, P. E., Fernandes, N. D., Azad, A. K., Fitzmaurice, A. M., & Sirakova, T. D. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.3361705.x · Cited by 177
Ishiguro, T., Saitoh, J., Yawata, H., Otsuka, M., Inoue, T., & SUGIURA, Y. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.24.4992 · Cited by 173
Drug resistance in Mycobacterium tuberculosis.
Cole, S. T., & Telenti, A. (1995) · PubMed · Cited by 170
Self-citationGenetic variation in pathogenic bacteria
Robertson, B. D., & Meyer, T. F. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90325-x · Cited by 160
Hermans, P. W. M., van Soolingen, D., & van Embden, J. D. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.12.4157-4165.1992 · Cited by 149
Poulet, S., & Cole, S. T. (1995) · Archives of Microbiology · doi:10.1007/bf00381781 · Cited by 122
Self-citationCole, S. T., & Girons, I. S. (1994) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1994.tb00084.x · Cited by 118
Self-citationAnalysis of the Genome of Mycobacterium tuberculosis H37Rv
Cole, S. T., & Barrell, B. G. (1998) · Novartis Foundation symposium · doi:10.1002/0470846526.ch12 · Cited by 107
Self-citationMetabolism ofMycobacterium tuberculosis
Wheeler, P. R., & Ratledge, C. (2014) · ASM Press eBooks · doi:10.1128/9781555818357.ch23 · Cited by 99
Genetic and immunological analysis of Mycobacterium tuberculosis fibronectin-binding proteins
Abou-Zeid, C., Garbe, T. R., Lathigra, R. B., Wiker, H. G., Harboe, M., Rook, G. A. W., & Young, D. B. (1991) · Infection and Immunity · doi:10.1128/iai.59.8.2712-2718.1991 · Cited by 92
Short-Insert Libraries as a Method of Problem Solving in Genome SequencingPreprint
McMurray, A. A., Sulston, J., & Quail, M. A. (1998) · Genome Research · doi:10.1101/gr.8.5.562 · Cited by 63
Self-citationUltrastructure ofMycobacterium tuberculosis
Brennan, P. J., & Draper, P. (2014) · Tuberculosis · doi:10.1128/9781555818357.ch19 · Cited by 39
Multiplex Sequencing of 1.5 Mb of the Mycobacterium leprae GenomePreprint
Smith, D. R., Richterich, P., Rubenfield, M., Rice, P. W., Butler, C., Lee, H.-M., Kirst, S., Gundersen, K., Abendschan, K., Xu, Q., et al. (1997) · Genome Research · doi:10.1101/gr.7.8.802 · Cited by 34
Self-citationIn search of tuberculosis virulence genes
Collins, D. M. (1996) · Trends in Microbiology · doi:10.1016/0966-842x(96)10066-4 · Cited by 32
Sequence and immunological characterization of a serine-rich antigen from Mycobacterium leprae
Vega‐López, F., Brooks, L., Dockrell, H. M., Smet, K. A. D., Thompson, J. K., Hussain, R., & Stoker, N. G. (1993) · Infection and Immunity · doi:10.1128/iai.61.5.2145-2153.1993 · Cited by 24
Components of Eukaryotic-like Protein Signaling Pathways in Mycobacterium tuberculosis
Av‐Gay, Y., & DAVIES, J. E. (1997) · Microbial & Comparative Genomics · doi:10.1089/omi.1.1997.2.63 · Cited by 24
Recovery from Pneumocystis carinii pneumonia in dexamethasone-treated Wistar rats
Sukura, A., Konttinen, Y., Sepper, R., & Lindberg, L. (1995) · European Respiratory Journal · doi:10.1183/09031936.95.08050701 · Cited by 21
Bothamley, G. H. (1998) · Thorax · doi:10.1136/thx.53.12.1094a · Cited by 18
Flagged first, then by citations
1 of the 53 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Minnikin, D. E. in The Biology of the Mycobacteria (eds Ratledge, C. & Stanford, J.) 95–184 (Academic, London, (1982).
- Barry, C. E. IIet al . Mycolic acids: structure, biosynthesis, and phsyiological functions. Prog. Lipid Res.(in the press).
Cited by
Sorted by citations
A Greedy Algorithm for Aligning DNA Sequences
Zhang, Z., Schwartz, S., Wagner, L., & Miller, W. (2000) · Journal of Computational Biology · doi:10.1089/10665270050081478 · Cited by 5,459
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
Stover, C. K., Pham, X. Q., Erwin, A. L., Mizoguchi, S., Warrener, P., Hickey, M. J., Brinkman, F. S. L., HUFNAGLE, W. O., Kowalik, D., Mj, L., et al. (2000) · Nature · doi:10.1038/35023079 · Cited by 4,544
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
Bentley, S. D., Chater, K. F., Cerdeño-Tárraga, A. M., Challis, G. L., Thomson, N. R., James, K., Harris, D. E., Quail, M. A., Kieser, H. M., Harper, D., et al. (2002) · Nature · doi:10.1038/417141a · Cited by 3,226
Self-citationGenes required for mycobacterial growth defined by high density mutagenesis
Sassetti, C. M., Boyd, D. H., & Rubin, E. J. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03425.x · Cited by 2,544
Besemer, J., Lomsadze, A., & Borodovsky, M. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.12.2607 · Cited by 2,343
Metadata
- Authors
- Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., Tekaia, F., Badcock, K., Basham, D., Brown, D., Chillingworth, T., Connor, R., Davies, R., Devlin, K., Feltwell, T., Gentles, S., Hamlin, N., Holroyd, S., Hornsby, T., Jagels, K., Krogh, A., McLean, J., Moule, S., Murphy, L., Oliver, K., Osborne, J., Quail, M. A., Rajandream, M.-A., Rogers, J., Rutter, S., Seeger, K., Skelton, J., Squares, R., Squares, S., Sulston, J. E., Taylor, K., Whitehead, S., & Barrell, B. G.
- Affiliations
- Institut Pasteur (FR)
- Wellcome Sanger Institute (GB)
- National Institutes of Health (US)
- Technical University of Denmark (DK)
- Corresponding author
- Barrell, B. G.
- ORCID
- Venue
- Nature
- Published
- 1998-06
- Volume
- 393
- Issue
- 6685
- Pages
- 537-544
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2158023121
- Cited by
- 7,847
- References
- 53
- Citations by year
- 2026: 124 · 2025: 173 · 2024: 157 · 2023: 209 · 2022: 188 · 2021: 233 · 2020: 220 · 2019: 235 · 2018: 259 · 2017: 257 · 2016: 259 · 2015: 312 · 2014: 385 · 2013: 340 · 2012: 318
- FWCI
- 249.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- American Heart Association
- Wellcome Trust
- Medical Research Council Canada
- National Institutes of Health
- Medical Research Council
- National Institute of Allergy and Infectious Diseases (Z01AI000783)
- Brookhaven National Laboratory
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Keywords
- Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv, complete genome sequence, genome analysis, GC content, amino acid composition, lipogenesis, lipolysis, glycine-rich proteins, antigenic variation, tuberculosis pathogenesis, tuberculosis treatment
- MeSH terms
- Chromosome Mapping, Chromosomes, Bacterial, Drug Resistance, Microbial, Humans, Molecular Sequence Data, Mycobacterium tuberculosis, Tuberculosis, Genome, Bacterial, Sequence Analysis, DNA, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
