Brosch, Roland

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence

Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature

Tuberculosis Research and EpidemiologyGenomics and Phylogenetic Studies

Cited by 7,847

Benzothiazinones Kill Mycobacterium tuberculosis by Blocking Arabinan Synthesis

Makarov, V., Manina, G., Mikusova, K., Möllmann, U., Ryabova, O., Saint-Joanis, B., Dhar, N., Pasca, M. R., Buroni, S., Lucarelli, A. P., et al. (2009) · Science

Tuberculosis Research and EpidemiologyPhenothiazines and Benzothiazines Synthesis and Activities

Cited by 740

Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti

Pym, A. S., Brodin, P., Brosch, R., Huerre, M., & Cole, S. T. (2002) · Molecular Microbiology

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosis

Cited by 729

Ancient Origin and Gene Mosaicism of the Progenitor of Mycobacterium tuberculosis

Gutierrez, M. C., Brisse, S., Brosch, R., Fabre, M., Omaïs, B., Marmiesse, M., Supply, P., & Vincent, V. (2005) · PLoS Pathogens

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosis

Cited by 646

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis

Pym, A. S., Brodin, P., Majlessi, L., Brosch, R., Demangel, C., Williams, A., Griffiths, K. E., Marchal, G., Leclerc, C., & Cole, S. T. (2003) · Nature Medicine

Tuberculosis Research and EpidemiologyImmune responses and vaccinations

Cited by 644

Genome plasticity of BCG and impact on vaccine efficacy

Brosch, R., Gordon, S. V., Garnier, T., Eiglmeier, K., Frigui, W., Valenti, P., Dos Santos, S., Duthoy, S., Lacroix, C., Garcia-Pelayo, C., et al. (2007) · Proceedings of the National Academy of Sciences

Tuberculosis Research and EpidemiologyBacterial Genetics and Biotechnology

Cited by 574

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

Stinear, T. P., Seemann, T., Harrison, P. F., Jenkin, G. A., Davies, J. K., Johnson, P. D. R., Abdellah, Z., Arrowsmith, C., Chillingworth, T., Churcher, C., et al. (2008) · Genome Research

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosis

Cited by 570

Phagosomal Rupture by Mycobacterium tuberculosis Results in Toxicity and Host Cell Death

Simeone, R., Bobard, A., Lippmann, J., Bitter, W., Majlessi, L., Brosch, R., & Enninga, J. (2012) · PLoS Pathogens

Tuberculosis Research and EpidemiologyImmune responses and vaccinations

Cited by 561

ESX secretion systems: mycobacterial evolution to counter host immunity

Gröschel, M. I., Sayes, F., Simeone, R., Majlessi, L., & Brosch, R. (2016) · Nature Reviews Microbiology

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosis

Cited by 382

ESAT-6 proteins: protective antigens and virulence factors?

Brodin, P., Rosenkrands, I., Andersen, P., Cole, S. T., & Brosch, R. (2004) · Trends in Microbiology

Tuberculosis Research and EpidemiologyInfectious Diseases and Tuberculosis

Cited by 312

Analysis of the proteome of Mycobacterium tuberculosis in silico

Tekaia, F., Gordon, S. V., Garnier, T., Brosch, R., Barrell, B. G., & Cole, S. T. (1999) · Tubercle and Lung Disease

Tuberculosis Research and EpidemiologyGenomics and Phylogenetic Studies

Cited by 311

Systematic Genetic Nomenclature for Type VII Secretion Systems

Bitter, W., Houben, E. N. G., Bottai, D., Brodin, P., Brown, E. J., Cox, J. S., Derbyshire, K., Fortune, S. M., Gao, L.-Y., Liu, J., et al. (2009) · PLoS Pathogens

Bacterial Genetics and BiotechnologyEscherichia coli research studies

Cited by 307

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis

Supply, P., Marceau, M., Mangenot, S., Roche, D., Rouanet, C., Khanna, V., Majlessi, L., Criscuolo, A., Tap, J., Pawlik, A., et al. (2013) · Nature Genetics

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosis

Cited by 305

p62 and NDP52 Proteins Target Intracytosolic Shigella and Listeria to Different Autophagy Pathways

Mostowy, S., Sancho-Shimizu, V., Hamon, M. A., Simeone, R., Brosch, R., Johansen, T., & Cossart, P. (2011) · Journal of Biological Chemistry

Autophagy in Disease and TherapyEscherichia coli research studies

Cited by 294

ESX-1 and phthiocerol dimycocerosates of Mycobacterium tuberculosis act in concert to cause phagosomal rupture and host cell apoptosis

Augenstreich, J., Arbues, A., Simeone, R., Haanappel, E., Wegener, A., Sayes, F., Le Chevalier, F., Chalut, C., Malaga, W., Guilhot, C., et al. (2017) · Cellular Microbiology

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosis

Cited by 240

Myths and misconceptions: the origin and evolution of Mycobacterium tuberculosis

Smith, N. H., Hewinson, R. G., Kremer, K., Brosch, R., & Gordon, S. V. (2009) · Nature Reviews Microbiology

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosis

Cited by 229

The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis

Queval, C. J., Brosch, R., & Simeone, R. (2017) · Frontiers in Microbiology

Tuberculosis Research and EpidemiologyImmune responses and vaccinations

Cited by 215

Disruption of the ESX‐5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation

Bottai, D., Di Luca, M., Majlessi, L., Frigui, W., Simeone, R., Sayes, F., Bitter, W., Brennan, M. J., Leclerc, C., Batoni, G., et al. (2012) · Molecular Microbiology

Tuberculosis Research and EpidemiologyBacterial Genetics and Biotechnology

Cited by 210

Cytosolic Access of Mycobacterium tuberculosis: Critical Impact of Phagosomal Acidification Control and Demonstration of Occurrence In Vivo

Simeone, R., Sayes, F., Song, O., Gröschel, M. I., Brodin, P., Brosch, R., & Majlessi, L. (2015) · PLOS Pathogens

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosis

Cited by 198

Genomic Analysis Reveals Variation between Mycobacterium tuberculosis H37Rv and the Attenuated M. tuberculosis H37Ra Strain

Brosch, R., Philipp, W. J., Stavropoulos, E., Colston, M. J., Cole, S. T., & Gordon, S. V. (1999) · Infection and Immunity

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosis

Cited by 150

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus

Laencina, L., Dubois, V., Le Moigne, V., Viljoen, A., Majlessi, L., Pritchard, J., Bernut, A., Piel, L., Roux, A.-L., Gaillard, J.-L., et al. (2018) · Proceedings of the National Academy of Sciences

Mycobacterium research and diagnosisTuberculosis Research and Epidemiology

Cited by 147

ESX-1-induced apoptosis is involved in cell-to-cell spread of Mycobacterium tuberculosis: M. tuberculosis kills host cells to spread cell-to-cell

Aguilo, J. I., Alonso, H., Uranga, S., Marinova, D., Arbués, A., de Martino, A., Anel, A., Monzon, M., Badiola, J., Pardo, J., et al. (2013) · Cellular Microbiology

Tuberculosis Research and EpidemiologyImmune responses and vaccinations

Cited by 140

Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection

Gröschel, M. I., Sayes, F., Shin, S. J., Frigui, W., Pawlik, A., Orgeur, M., Canetti, R., Honoré, N., Simeone, R., van der Werf, T. S., et al. (2017) · Cell Reports

Tuberculosis Research and EpidemiologyImmune responses and vaccinations

Cited by 125

Mycobacterial Pan-Genome Analysis Suggests Important Role of Plasmids in the Radiation of Type VII Secretion Systems

Dumas, E., Christina Boritsch, E., Vandenbogaert, M., Rodríguez de la Vega, R. C., Thiberge, J.-M., Caro, V., Gaillard, J.-L., Heym, B., Girard-Misguich, F., Brosch, R., et al. (2016) · Genome Biology and Evolution

Tuberculosis Research and EpidemiologyMycobacterium research and diagnosis

Cited by 112