Cited by 87Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and SignalingNeurotransmitter Receptor Influence on Behavior

Pathophysiology of “cholinoceptor supersensitivity” in affective disorders

Dilsaver, Steven C·1986·Biological Psychiatry

Abstract

Phenomenological and physiological variables demonstrate supersensitive changes to cholinergic challenge in affective disorder subjects. Theorists generally assume the primary defect is the postsynaptic muscarinic receptor. However, in addition to defectiveness or up-regulation of this receptor, the appearance of postsynaptic "cholinoceptor supersensitivity" can result from abnormal presynaptic mechanisms, membrane "pathology," derangement of intrasystolic mechanisms that amplify effects of receptor-agonist coupling, or aberrant cholinergic-monoaminergic interaction. This article discusses abnormalities of the postsynaptic receptor, regulation of postsynaptic receptor density, the presynaptic muscarinic receptor, and other mechanisms regulating the release of acetylcholine, membrane dynamics, and "cascade" mechanisms-specifically the phosphatidylinositol (PI) cycle, Ca2+ mobilization, and cyclic guanosine monophosphate (GMP) generation-as causes of cholinergic system "supersensitivity." It is suggested that an approach to the topic emphasizing site of abnormality will encourage greater clarity of thought in the study of the cholinergic component of the pathophysiology of affective illness.

Integrity signals

Registry

Crossref · 10.1016/0006-3223(86)90246-5

Cites

162 of 162 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Dilsaver, S. C.
Affiliations
University of Michigan (US)
Corresponding author
Dilsaver, Steven C
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1986-07
Volume
21
Issue
8-9
Pages
813-829
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2155322333
Cited by
87
References
162
Citations by year
2021: 2 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 3
FWCI
2.66
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (submittedVersion)
Funders
National Institute of Mental Health (SRC1K11 MH00553-01)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
cholinergic supersensitivity, mood disorders, muscarinic receptors, acetylcholine release, phosphatidylinositol cycle, calcium mobilization, cyclic GMP, membrane dynamics
MeSH terms
Affective Disorders, Psychotic, Biogenic Amines, Brain, Cell Membrane, Cyclic GMP, Humans, Synaptic Transmission, Terminology as Topic, Phosphatidylinositols, Receptors, Cholinergic, Receptors, Muscarinic, Synapses

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review