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Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle
Open accessAbstract
The recent development of techniques for recording currents through single ionic channels1 has led to the identification of a K+-specific channel that is activated by cytoplasmic Ca2+ (refs 2–12). The channel has complex properties, being activated by depolarizing voltages and having a voltage-sensitivity that is modulated by cytoplasmic Ca2+ levels. The conduction behaviour of the channel is also unusual, its high ionic selectivity being displayed simultaneously with a very high unitary conductance2,4,12. Very little is known about the biochemistry of this channel, largely due to the lack of a suitable ligand for use as a biochemical probe for the channel. We describe here a protein inhibitor of single Ca2+-activated K+ channels of mammalian skeletal muscle. This inhibitor, a minor component of the venom of the Israeli scorpion, Leiurus quinquestriatus, reversibly blocks the large Ca2+-activated K+ channel in a simple bimolecular reaction. We have partially purified the active component, a basic protein of relative molecular mass (Mr) ∼ 7,000.
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Citations
Cited by
Diversity and ubiquity of K channels
Rudy, B. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90033-4 · Cited by 1,312
Archer, S. L., Huang, J. M., Hampl, V, Nelson, D. P., Shultz, P. J., & Weir, E. K. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7583 · Cited by 819
Chapter 12 Potassium currents in hippocampal pyramidal cells
Storm, J. F. (1990) · Progress in Brain Research · doi:10.1016/s0079-6123(08)61248-0 · Cited by 743
Papazian, D. M., Schwarz, T. L., Tempel, B. L., Jan, Y. N., & Jan, L. Y. (1987) · Science · doi:10.1126/science.2441470 · Cited by 721
Ion channel expression by white matter glia: The O-2A glial progenitor cell
Barres, B. A., Koroshetz, W. J., Swartz, K. J., Chun, L. L. Y., & Corey, D. P. (1990) · Neuron · doi:10.1016/0896-6273(90)90109-s · Cited by 301
Metadata
- Authors
- Miller, C., Moczydlowski, E., Latorre, R., & Phillips, M.
- Venue
- Nature
- Published
- 1985-01
- Volume
- 313
- Issue
- 6000
- Pages
- 316-318
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2082304034
- Cited by
- 795
- References
- 0
- FWCI
- 10.21
- Type
- journal article
- Language
- en
- Open access
- green
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- Miller, C., Moczydlowski, E., Latorre, R., & Phillips, M. (1985). Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle. Nature. https://doi.org/10.1038/313316a0
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