The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Cloning of Genomic and Complementary DNA from Shaker , a Putative Potassium Channel Gene from Drosophila
Abstract
On the basis of electrophysiological analysis of Shaker mutants, the Shaker locus of Drosophila melanogaster has been proposed to encode a structural component of a voltage-dependent potassium channel, the A channel. Unlike sodium channels, acetylcholine receptors, and calcium channels, K + channels have not been purified biochemically. To facilitate biochemical studies of a K + channel, genomic DNA from the Shaker locus has been cloned. Rearrangements in five Shaker mutants have been mapped to a 60-kilobase segment of the genome. Four complementary DNA clones have been analyzed. These clones indicate that the Shaker gene contains multiple exons distributed over at least 65 kilobases of genomic DNA in the region where the mutations mapped. Furthermore, the gene may produce several classes of alternatively spliced transcripts. Two of the complementary DNA clones have been sequenced and their sequences support the hypothesis that Shaker encodes a component of a K + channel.
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Cites
The isolation of structural genes from libraries of eucaryotic DNA
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Sequence of a Probable Potassium Channel Component Encoded at Shaker Locus of Drosophila
Tempel, B. L., Papazian, D. M., Schwarz, T. L., Jan, Y. N., & Jan, L. Y. (1987) · Science · doi:10.1126/science.2441471 · Cited by 652
Self-citationSerotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones
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Cited by
Molecular Diversity of K+ Channels
COETZEE, W. A., AMARILLO, Y., CHIU, J., CHOW, A., LAU, D., McCORMACK, T., MORENA, H., NADAL, M. S., OZAITA, A., POUNTNEY, D., et al. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11293.x · Cited by 1,095
Hay, B., Jan, L. Y., & Jan, Y. N. (1988) · Cell · doi:10.1016/0092-8674(88)90216-4 · Cited by 616
Self-citationThe Drosophila learning and memory gene rutabaga encodes a - adenylyl cyclase
Levin, L. R., Han, P.-L., Hwang, P. M., Feinstein, P. G., Davis, R. L., & Reed, R. R. (1992) · Cell · doi:10.1016/0092-8674(92)90185-f · Cited by 517
An essential ‘set’ of K+ channels conserved in flies, mice and humans
Salkoff, L., Baker, K., Butler, A., Covarrubias, M., Pak, M. D., & Wei, A. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90165-5 · Cited by 306
Recanatini, M., Poluzzi, E., Masetti, M., Cavalli, A., & De Ponti, F. (2005) · Medicinal Research Reviews · doi:10.1002/med.20019 · Cited by 285
Metadata
- Authors
- Papazian, D. M., Schwarz, T. L., Tempel, B. L., Jan, Y. N., & Jan, L. Y.
- Venue
- Science
- Published
- 1987-08-14
- Volume
- 237
- Issue
- 4816
- Pages
- 749-753
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1972882396
- Cited by
- 721
- References
- 27
- FWCI
- 14.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Papazian, D. M., Schwarz, T. L., Tempel, B. L., Jan, Y. N., & Jan, L. Y. (1987). Cloning of Genomic and Complementary DNA from Shaker , a Putative Potassium Channel Gene from Drosophila. Science. https://doi.org/10.1126/science.2441470
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