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Segmental distribution of bithorax complex proteins during Drosophila development
Abstract
The Ubx and bxd transcription units comprise a single functional domain in the bithorax complex of Drosophila melanogaster. The segmental distributions and nuclear localization of proteins encoded by the Ubx unit have been determined by immunofluorescence staining with antibodies raised against a fusion protein containing Ubx coding sequences. Wild-type and mutant distributions are consistent with a model in which the protein-coding functions of the domain derive from the Ubx unit and are regulated by the bxd unit.
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“In particular, microexons (Beachy et al., 1985; Coleman et al., 1987), defined here as 3-27 nucleotide (nt)-long exons, have been largely missed by genome annotations and transcriptome profiling studies (Volfovsky et al., 2003; Wu et al., 2013; Wu and Watanabe, 2005). This is especially true for microexons shorter than 15 nts.”
From A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains (2014) · cites this paper as Beachy et al., 1985
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A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains
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“In particular, microexons (Beachy et al., 1985; Coleman et al., 1987), defined here as 3–27 nucleotide (nt)-long exons, have been largely missed by genome annotations and transcriptome profiling studies (Volfovsky et al., 2003; Wu et al., 2013; Wu and Watanabe, 2005).”
Background
Metadata
- Authors
- Beachy, P. A., Helfand, S. L., & Hogness, D. S.
- Affiliations
- Stanford Medicine (US)
- ORCID
- Beachy, Philip A.
- Venue
- Nature
- Published
- 1985-02
- Volume
- 313
- Issue
- 6003
- Pages
- 545-551
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2041519679
- Cited by
- 413
- References
- 51
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2023: 14 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 5 · 2014: 5 · 2013: 4
- FWCI
- 23.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- bithorax complex, Ubx, Drosophila melanogaster, developmental gene expression, nuclear localization, homeotic genes, transcriptional regulation, segmental distribution
- MeSH terms
- Animals, Antibodies, Base Sequence, Cell Nucleus, Drosophila melanogaster, Fluorescent Antibody Technique, Gene Expression Regulation, Larva, Models, Genetic, Morphogenesis, Transcription Factors, Transcription, Genetic
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