Helfand, Stephen L.

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 1,868

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

Rogina, B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 1,361

L1 drives IFN in senescent cells and promotes age-associated inflammation

De Cecco, M., Ito, T., Petrashen, A. P., Elias, A. E., Skvir, N. J., Criscione, S. W., Caligiana, A., Brocculi, G., Adney, E. M., Boeke, J. D., et al. (2019) · Nature

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,255

LINE1 Derepression in aged wild-type and SIRT6-deficient mice drives inflammation

Simon, M., Van Meter, M., Ablaeva, J., Ke, Z., Gonzalez, R. S., Taguchi, T., De Cecco, M., Leonova, K. I., Kogan, V., Helfand, S. L., et al. (2019) · Cell Metabolism

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 498

The role of retrotransposable elements in ageing and age-associated diseases

Gorbunova, V., Seluanov, A., Mita, P., McKerrow, W., Fenyö, D., Boeke, J. D., Linker, S. B., Gage, F. H., Kreiling, J. A., Petrashen, A. P., et al. (2021) · Nature

Chromosomal and Genetic VariationsGenetics, Aging, and Longevity in Model Organisms

Cited by 446

Segmental distribution of bithorax complex proteins during Drosophila development

Beachy, P. A., Helfand, S. L., & Hogness, D. S. (1985) · Nature

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 413

An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster

Bauer, J. H., Goupil, S., Garber, G. B., & Helfand, S. L. (2004) · Proceedings of the National Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsNeurobiology and Insect Physiology Research

Cited by 234

Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila

Wood, J. G., Jones, B. C., Jiang, N., Chang, C., Hosier, S., Wickremesinghe, P., Garcia, M., Hartnett, D. A., Burhenn, L., Neretti, N., et al. (2016) · Proceedings of the National Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsChromosomal and Genetic Variations

Cited by 214

Chromatin remodeling in the aging genome of Drosophila

Wood, J. G., Hillenmeyer, S., Lawrence, C., Chang, C., Hosier, S., Lightfoot, W., Mukherjee, E., Jiang, N., Schorl, C., Brodsky, A. S., et al. (2010) · Aging Cell

Genomics and Chromatin DynamicsGenetics, Aging, and Longevity in Model Organisms

Cited by 192

Genetics of Aging in the Fruit Fly,Drosophila melanogaster

Helfand, S. L., & Rogina, B. (2003) · Annual Review of Genetics

Genetics, Aging, and Longevity in Model OrganismsNeurobiology and Insect Physiology Research

Cited by 152

A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan

Jones, B. C., Wood, J. G., Chang, C., Tam, A. D., Franklin, M. J., Siegel, E. R., & Helfand, S. L. (2016) · Nature Communications

Chromosomal and Genetic VariationsGenetics, Aging, and Longevity in Model Organisms

Cited by 130

Dietary restriction: standing up for sirtuins

Baur, J. A., Chen, D., Chini, E. N., Chua, K., Cohen, H. Y., Cabo, R. D., Deng, C., Dimmeler, S., Gius, D., Guarente, L. P., et al. (2010) · Science

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 76

Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging

Jiang, N., Du, G., Tobias, E., Wood, J. G., Whitaker, R., Neretti, N., & Helfand, S. L. (2013) · Aging

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 54