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GM-CSF induces human neutrophil IgA-mediated phagocytosis by an IgA Fc receptor activation mechanism
Abstract
Immunoglobulin A is the primary immunoglobulin isotype in tears, saliva, breast milk and other mucosal secretions, constituting between 6% and 15% of the total serum immunoglobulins. Human peripheral blood neutrophils have IgA receptors, but these cells do not normally participate in IgA-mediated phagocytosis. The haematopoietic factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) prime neutrophils to be more responsive to a variety of stimuli. We therefore studied their effect on IgA-mediated phagocytosis. GM-CSF and G-CSF both induce a change from low to high-affinity neutrophil IgA Fc crystallizable fragment receptors within 30 min; a change which is associated with the development of IgA-mediated phagocytosis. Human IL-3, which does not affect neutrophil function, is inactive in this system. These results define a new mechanism for CSF-augmented host defence whereby neutrophil function can be modulated by CSF-mediated IgA Fc receptor activation.
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“Short-term in vitro exposure to GM-CSF, so-called priming, favors functional responses of neutrophils [30,57–59], while long-term stimulation with GM-CSF alters the transcriptional profile of neutrophils [28,38].”
From Nascent RHOH acts as a molecular brake on actomyosin-mediated effector functions of inflammatory neutrophils (2022) · cites this paper as [58]
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Research works printed but not linked: 15
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Cited by
Wodnar-Filipowicz, A., Heusser, C. H., & Moroni, C. (1989) · Nature · doi:10.1038/339150a0 · Cited by 480
Fetissov, S. O., Hamze Sinno, M., Coëffier, M., Bole-Feysot, C., Ducrotté, P., Hökfelt, T., & Déchelotte, P. (2008) · Nutrition · doi:10.1016/j.nut.2007.12.006 · Cited by 175
Peng, S., Stojkov, D., Gao, J., Oberson, K., Latzin, P., Casaulta, C., Yousefi, S., & Simon, H.-U. (2022) · PLOS Biology · doi:10.1371/journal.pbio.3001794 · Cited by 15
Metadata
- Authors
- Weisbart, R. H., Kacena, A., Schuh, A., & Golde, D. W.
- Venue
- Nature
- Published
- 1988-04
- Volume
- 332
- Issue
- 6165
- Pages
- 647-648
- ISSN
- 0028-0836
- 1476-4687
- Cited by
- 160
- References
- 0
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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- CoChat. (2026). Citation check: GM-CSF induces human neutrophil IgA-mediated phagocytosis by an IgA Fc receptor activation mechanism. https://app.cochat.ai/papers/10.1038/332647a0
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- Weisbart, R. H., Kacena, A., Schuh, A., & Golde, D. W. (1988). GM-CSF induces human neutrophil IgA-mediated phagocytosis by an IgA Fc receptor activation mechanism. Nature. https://doi.org/10.1038/332647a0
