Cited by 1,025Evolution and Genetic DynamicsBacterial Genetics and BiotechnologyPhilosophy of Biology and Scientific Explanation

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The origin of mutants

Cairns, John, Overbaugh, Julie, Miller, Stephan·1988·Nature

DOI 10.1038/335142a0

Open this paper in CoChat — free account

Abstract

Nucleic acids are replicated with conspicuous fidelity. Infrequently, however, they undergo changes in sequence, and this process of change (mutation) generates the variability that allows evolution. As the result of studies of bacterial variation, it is now widely believed that mutations arise continuously and without any consideration for their utility. In this paper, we briefly review the source of this idea and then describe some experiments suggesting that cells may have mechanisms for choosing which mutations will occur.

Integrity signals

Registry

Crossref · 10.1038/335142a0

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The distribution of the numbers of mutants in bacterial populations
Lea, D. E., & Coulson, C. A. (1949) · Journal of Genetics · doi:10.1007/bf02986080 · Cited by 1,450

Flagged first, then by citations

Show all 0 references

Research works printed but not linked: 15

Luria, S. E. & Delbrück, M. Genetics 28, 491–511 (1943). · DOI · Paper page
Lederberg, J. & Lederberg, E. M. J. Bact. 63, 399–406 (1952). · DOI
Cavalli-Sforza, L. L. & Lederberg, J. Genetics 41, 367–381 (1956). · DOI
Hayes, W. The Genetics of Bacteria (Blackwell, Oxford, 1964).
Armitage, P. J. R. statist. Soc. B. 14, 1–40 (1952). · DOI · Paper page
Mandelbrot, B. J. appl. Prob. 11, 437–444 (1974). · DOI · Paper page
Luria, S. E. Cold Spring Harb. Symp. quant. Biol. 16, 463–470 (1951). · DOI
Hadley, P. J. infect. Dis. 40, 1–312 (1927). · DOI
Ryan, F. J. Nature 169, 882–883 (1952). · DOI
Shapiro, J. A. Molec. Gen. Genet. 194, 79–90 (1984). · DOI
Reynolds, A. E., Felton, J. & Wright, A. Nature 293, 625–629 (1981). · DOI
Campbell, J. H., Lengyel, J. A. & Langridge, J. Proc. natn. Acad. Sci. U.S.A. 70, 1841–1845 (1973). · DOI
Hall, B. G. J. Bact. 129, 540–543 (1977). · DOI
Hall, B. G. & Zuzel, T. Proc. natn. Acad. Sci. U.S.A. 77, 3529–3533 (1980). · DOI
Reanney, D. C. Nature 307, 318–319 (1984). · DOI

Sorted by citations

Items 501–600 of 866

From enzymes to E = mc2: A reply to critics
Barham, J. (1992) · Journal of Social and Evolutionary Systems · doi:10.1016/1061-7361(92)90009-3 · Cited by 11
Constancy and Change in Bacterial Genomes
Riley, M. (1989) · Springer eBooks · doi:10.1007/978-1-4613-0803-4_7 · Cited by 11
Mutation and evolution: Conceptual possibilities
Livnat, A., & Love, A. C. (2024) · BioEssays · doi:10.1002/bies.202300025 · Cited by 14
Adaptive Resistance Mutations at Suprainhibitory Concentrations Independent of SOS Mutagenesis
Gutiérrez, R., Ram, Y., Berman, J. G., de Sousa, K. C. M., Nachum‐Biala, Y., Britzi, M., Elad, D., Glaser, G., Covo, S., & Harrus, S. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab196 · Cited by 16
“Cairns et al. (1988) showed that such a scenario is possible when cells are exposed to nonlethal stress conditions.”
Ecology, Evidence, and Objectivity: In Search of a Bias-Free Methodology
Brittan, G. G., & Bandyopadhyay, P. S. (2019) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2019.00399 · Cited by 12
“42See Cairns et al. (1988) for the initial clue re stress-induced mutation, and Houston (2014) for a multi-model approach to re-thinking the rejection of at least two classic population equilibrium hypotheses.”
Background
The Interplay between DNA Topology and Accessory Factors in Site-Specific Recombination in Bacteria and their Bacteriophages
Dorman, C., & Bogue, M. M. (2016) · Science in progress · doi:10.3184/003685016x14811202974921 · Cited by 9
Endogenous network states predict gain or loss of functions for genetic mutations in hepatocellular carcinoma
Wang, G., Su, H., Yu, H., Yuan, R., Zhu, X., & Ao, P. (2016) · Journal of The Royal Society Interface · doi:10.1098/rsif.2015.1115 · Cited by 10
“It was known that some random mutations in cancers were selected for and accumulated in response to phenotypic consequences [36–38].”
Background
Race Differences in Intelligence
Lynn, R. (2006) · doi:10.1093/oxfordjournals.jhered.a105282 · Cited by 9
“These results are corroborated by a further large-scale study of children carried out by Broman, Nichols, Shaughnessy, and Kennedy (1987). They examined and followed up approximately 17,000 European and 19,000 African children in the United States from conception to the age of 7 years.”
Result
The genotype-phenotype link
Rasmuson, M. (2002) · Hereditas · doi:10.1034/j.1601-5223.2002.1360101.x · Cited by 8
Heterologous Gene Expression in an Escherichia coli Population Under Starvation Stress Conditions
Fani, R., Gallo, R., Fancelli, S., Mori, E., Tamburini, E., & Lazcano, A. (1998) · Journal of Molecular Evolution · doi:10.1007/pl00013149 · Cited by 9
“Based on the enhancement of spontaneous mutation rates under strongly selective stress conditions (Cairns et al. 1988; Hall 1990; Foster 1993), Kasak et al.”
Background
Levels of the Vsr Endonuclease Do Not Regulate Stationary-Phase Reversion of a Lac − Frameshift Allele in Escherichia coli
Foster, P. L., & Rosche, W. A. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.7.1944-1946.1998 · Cited by 9
Catabolite repressors are potent antimutagens in Escherichia coli plate incorporation assays: experiments with glucose, glucose-6-phosphate and methyl-alpha-D-glucopyranoside.
Ambrose, M., & Macphee, D. (1998) · Mutation research · doi:10.1016/s0027-5107(97)00315-1 · Cited by 9
Selection or mutation: Which, if either, comes first?
Hall, B. G. (1994) · doi:10.1111/j.1574-6968.1994.tb06773.x · Cited by 9
The Role of Action in Evolution: Evolution By Process and the Ecological Approach To Perception
Ho, M. (1991) · doi:10.1177/092137409100400306 · Cited by 9
Different parental practices – Different sources of influence
Lytton, H. (1991) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00070436 · Cited by 8
Permafrost Bacteria in Biotechnology: Biomedical Applications
Brouchkov, A. V., Melnikov, V., Kalenova, L., Fursova, O. V., Pogorelko, G. V., Potapov, V. D., Константиновна, Ф. Н., Ignatov, S. G., Brenner, E., Bezrukov, V. V., et al. (2017) · Springer eBooks · doi:10.1007/978-3-319-57057-0_23 · Cited by 11
Spontaneous mutagenesis in exponentially growing and stationary-phase, umuDC-proficient and -deficient, Escherichia coli dnaQ49.
Nowosielska, A., Nieminuszczy, J., & Grzesiuk, E. (2004) · Acta Biochimica Polonica · doi:10.18388/abp.2004_3553 · Cited by 6
“Corresponding author: Elzbieta Grzesiuk, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, A. Pawinskiego 5A, 02-106 Warszawa, Poland; tel.: (48 22) 592 3337; fax: (48 22) 658 4636; e-mail: elag@ibb.waw.pl spontaneous growth-dependent mutations, which appear in the genome randomly before exposure t…”
Background
The Artistry of Bacterial Colonies and the Antibiotic Crisis
Golding, I., & Ben-Jacob, E. (2001) · Lecture notes in physics · doi:10.1007/3-540-44698-2_14 · Cited by 9
“A high level of antibiotics, like other forms of stress, seems to encourage the appearance of new mutations [47], so that many sectors emerge in the developing colony.”
Background
A Test of Hypotheses about Random Mutation: Using Classic Experiments To Teach Experimental Design.
Green, D. S., & Bozzone, D. (2001) · doi:10.2307/4451031 · Cited by 9
Complex Adaptive Systems Ecology
Molín, J., & Molin, S. (2000) · doi:10.1007/978-1-4615-4187-5_7 · Cited by 9
Reversion of argE3 ochre strain Escherichia coli AB1157 as a tool for studying the stationary-phase (adaptive) mutations.
Nowosielska, A., & Grzesiuk, E. (2000) · Acta Biochimica Polonica · doi:10.18388/abp.2000_4026 · Cited by 9
Adaptive mutation: a general phenomenon or special case?
Benson, S. A. (1997) · Bioessays · doi:10.1002/bies.950190104 · Cited by 9
Efficient, robust, and versatile fluctuation data analysis using MLE MUtation Rate calculator (mlemur)
Łazowski, K. (2023) · bioRxiv · doi:10.1101/2023.01.05.522850 · Cited by 8
“Mutations in carbon source metabolism-associated genes such as lacZ can occur after plating due to adaptive mutagenesis, because the selective agent does not immediately kill the non-mutant cells [18,19].”
Background
Adaptation prevents the extinction of Chlamydomonas reinhardtii under toxic beryllium
Baselga‐Cervera, B., Costas, E., Bustillo-Avendaño, E., & García‐Balboa, C. (2016) · PeerJ · doi:10.7717/peerj.1823 · Cited by 10
Toward Topological Descriptions of the Therapeutic Process: Part 3. Two New Metaphors Based on Quantum Superposition, Wave Function “Collapse,” and Conic Sections
Milgrom, L. R. (2014) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2013.0212 · Cited by 4
“26 Though hotly debated, adaptive mutations are thought to differ from standard mutations in that (1) they occur only in cells that are not dividing or divide only rarely, (2) they are time dependent not replication dependent, and (3) they appear only after the cell is exposed to some selective…”
State of Art in Genetic Algorithms for Agricultural Systems
Bolboaca, S. D., Jäntschi, L., Balan, M. C., Diudea, M. V., & SESTRAȘ, R. E. (2010) · Notulae Botanicae Horti Agrobotanici Cluj-Napoca · doi:10.15835/nbha3835455 · Cited by 7
“…since the precursors of modern genetics: • Random (De Veies, 1902); • Deliberate by exposure to certain conditions (Pat-terson, 1928; Auerbach et al. , 1947); • Under the pressure of environmental factors: (Cairns et al. , 1988); ■ Natural selection or “survival of the fittest” (Darwin, 1859).”
Background
Directed evolutionary algorithms
Berlik, S. (2007) · Technische Universität Dortmund Eldorado (Technische Universität Dortmund) · doi:10.17877/de290r-148 · Cited by 8
Heterochromatin and Complexity: A Theoretical Approach
Spinelli, G. (2003) · Nonlinear Dynamics Psychology and Life Sciences · doi:10.1023/a:1025980007520 · Cited by 5
“The discovery, for example, of adaptive mutations in bacteria ( Cairns, Overbaugh & Miller, 1988 ), has challenged the neodarwinistic view, indicating that randomness in mutations might not be the only way to ensure the genetic changes which are necessary in evolution to adapt to an environment in which continuous cha…”
Background
The growth and survivability of Streptococcus pneumoniae clinical isolates subjected to various environmental conditions
Mazzola, G. J., Mortensen, J. E., Miller, L. A., & Poupard, J. A. (2003) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(02)00526-6 · Cited by 5
Transient appearance of the mutator phenotype during carcinogenesis as a possible explanation for the lack of mini/microsatellite instability in many late stage tumors.
Stark, A. (1998) · Mutation research · doi:10.1016/s0027-5107(98)00209-7 · Cited by 8
Asymptotics of the Luria-Delbrück distribution
Goldie, C. (1995) · Journal of Applied Probability · doi:10.2307/3215135 · Cited by 8
“…the end of Kemp (1994), equivalent to (9) of Pakes (1993), that (5) lim n(n+ I)Pn=m. n--+oo As Kemp observes, (5) implies immediately that P, :=~f=nPj"'m/n as n---+oo, and 'This establishes mathematically the feature of the Luria-Delbruck distribution that was so important in Cairns et al. (1988).”
Background
A novel illegitimate recombination event: precise excision and reintegration with the Mu gem mutant prophage
Ghelardini, P., Liébart, J. C., Zenzo, G. D., Michell, G., D'Ari, R., & Paolozzi, L. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb00464.x · Cited by 8
Origin of mutants disputed
Cairns, J. (1988) · Nature · doi:10.1038/336527c0 · Cited by 8
Self-citation
Adaptive Mutation Controversy
Maisnier‐Patin, S., & Roth, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800049-6.00229-8 · Cited by 8
Mutation Spectrum in Carcinogenicity
Ramel, C. (1990) · doi:10.1007/978-1-4615-3808-0_1 · Cited by 8
Mutation-based mechanisms of antibiotic resistance
Misra, R. (2026) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00101-25 · Cited by 8
“Mutations also occur in non-dividing bacterial cells; these post-replicative mutations are generated by DNA repair or recombination reactions and are called adaptive or stress-induced mutations (22, 23).”
A Highly Glyphosate-Resistant EPSPS Mutant from Laboratory Evolution
Yuan, Y., Zhou, Z.-F., Zhan, Y.-H., Ke, X.-B., Yan, Y.-L., Lin, M., Li, P., Jiang, S.-J., Wang, J., & Lu, W. (2022) · Applied Sciences · doi:10.3390/app12115723 · Cited by 7
Selective Inbreeding: Genetic Crosses Drive Apparent Adaptive Mutation in the Cairns-Foster System of Escherichia coli
Nguyen, A., Maisnier‐Patin, S., Yamayoshi, I., Kofoid, E., & Roth, J. R. (2019) · Genetics · doi:10.1534/genetics.119.302754 · Cited by 7
Is Mutation Random or Targeted?: No Evidence for Hypermutability in Snail Toxin Genes.
Roy, S. (2016) · Molecular biology and evolution · doi:10.1093/molbev/msw140 · Cited by 7
Evolution of Cancer: A Quantum Mechanical Approach
Rahman, M. S. (2014) · European Journal of Biophysics · doi:10.11648/j.ejb.20140204.12 · Cited by 7
Stress-induced recombination and the mechanism of evolvability
Zhong, W., & Priest, N. K. (2010) · Behavioral Ecology and Sociobiology · doi:10.1007/s00265-010-1117-7 · Cited by 58
“There are several empirical studies which support genetic accommodation and adaptive mutation and recombination (Waddington 1953; Rutherford and Lindquist 1998; Cairns et al. 1988; Fischer and Schmid-Hempel 2005; for reviews, see Rosenberg 2001; Parsons 1988; Badyaev 2005).”
Background
Adaptation and Radiation-Induced Chromosomal Instability Studied by Statistical Modeling
Korogodina, V., Florko, B., & Osipova, L. (2010) · doi:10.2174/1874404401004010001 · Cited by 7
“In the 1990s it was found that such stresses are accompanied by time-dependent genetic instabilities, which include spatial intracellular [1-4] and intercellular [5-9] spreading of DNA damage.”
Background
From quasi-organism to protolife
Marinakis, Y. (2007) · Ecological Complexity · doi:10.1016/j.ecocom.2007.05.001 · Cited by 6
Safety assurance during food processing
Smulders, F., & Collins, J. (2004) · doi:10.3920/978-90-8686-522-2 · Cited by 7
Comparison of spontaneous and adaptive mutation spectra in yeast
Greene, C., & Jinks-Robertson, S. (1999) · Journal Genetika · doi:10.1007/bf02994703 · Cited by 7
“Cairns et al. (1988) first documented the accumulation of mutations in nondividing bacterial cells in an apparent response to a selective agent.”
Background
Life without KatG.
Zhang, Y. (1996) · Trends in Microbiology · doi:10.1016/0966-842x(96)30030-9 · Cited by 7
Short-patch reverse transcription in Escherichia coli.
Thaler, D. S., Tombline, G., & Zahn, K. (1995) · Genetics · doi:10.1093/genetics/140.3.909 · Cited by 6
Genetic information and the determination of functional organization in biological systems
Wills, P. (1989) · doi:10.1002/sres.3850060305 · Cited by 7
Fundamentals of Molecular Evolution
Choudhuri, S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-410471-6.00002-5 · Cited by 63
The origin of adaptive mutants: Random or nonrandom?
Sniegowski, P. (2004) · Journal of Molecular Evolution · doi:10.1007/bf00166600 · Cited by 7
“Mittler and Lenski (1990) replicated the observations of Shapiro (1984) and Cairns et al. (1988), but showed that Lac(Ara) + mutants also arise in starving cultures in solid and liquid media when no sugars are present.”
BackgroundInfluential
DNA Mismatch Repair
O'Driscoll, M., Humbert, O., & Karran, P. (1998) · doi:10.1007/978-3-642-48770-5_9 · Cited by 7
Looking backward on a century of mutation research
Drake, J. (1994) · Environmental and Molecular Mutagenesis · doi:10.1002/em.2850230605 · Cited by 7
Modeling stress-induced responses: plasticity in continuous state space and gradual clonal evolution
Bukkuri, A. (2024) · Theory in Biosciences · doi:10.1007/s12064-023-00410-3 · Cited by 6
“is that of directed mutagenesis in which useful mutations are induced preferentially (or at least that mutations 199 occur more frequently in genes that improve fitness if mutated) [13, 88].”
Evolutionary honing in and mutational replacement: how long-term directed mutational responses to specific environmental pressures are possible
Livnat, A., & Melamed, D. (2023) · Theory in Biosciences · doi:10.1007/s12064-023-00387-z · Cited by 8
“Another hypothetical possibility is that the HbS mutation originates as a Lamarckian, direct response to the immediate environment (Luria and Delbrück 1943; Cairns et al. 1988; Sarkar 1990).”
Background
L-Alanine Prototrophic Suppressors Emerge from L-Alanine Auxotroph through Stress-Induced Mutagenesis in Escherichia coli
Mishima, H., Watanabe, H., Uchigasaki, K., Shimoda, S., Seki, S., Kumagai, T., Nochi, T., Ando, T., & Yoneyama, H. (2021) · Microorganisms · doi:10.3390/microorganisms9030472 · Cited by 6
“However, this concept has been challenged by the 1988 Cairns study of adaptive mutagenesis [38], which posits that mutations emerge after cells encounter a growth-limiting environment (i.”
Background
Groundwater promotes emergence of asporogenic mutants of emetic Bacillus cereus
Rousset, L., Alpha‐Bazin, B., Château, A., Armengaud, J., Clavel, T., Berge, O., & Duport, C. (2020) · Environmental Microbiology · doi:10.1111/1462-2920.15203 · Cited by 10
Evidence for immortality and autonomy in animal cancer models is often not provided, which causes confusion on key issues of cancer biology
Dou, X., Tong, P., Huang, H., Zellmer, L., He, Y., Jia, Q., Zhang, D., Peng, J., Wang, C., Xu, N., et al. (2020) · Journal of Cancer · doi:10.7150/jca.41324 · Cited by 7
“This is partly because a lengthier course allows accumulation of more haphazardly-occurring mutations, including the one(s) required for immortality and autonomy, if we accept the notion that tumors, especially cancers, occur as repercussions of mutations that have cell-autonomous modes of action [29-31, 525, 526, 551…”
Background
Microbiological Procedures for Biodegradation Research
Focht, D. (2018) · SSSA Book Series · doi:10.2136/sssabookser5.2.c20 · Cited by 6
Implementation of a loss-of-function system to determine growth and stress-associated mutagenesis in Bacillus subtilis
Villegas-Negrete, N., Robleto, E., Obregón-Herrera, A., Yasbin, R., & Pedraza-Reyes, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179625 · Cited by 6
Mutational randomness as conditional independence and the experimental vindication of mutational Lamarckism
Razeto-Barry, P., & Vecchi, D. (2017) · Biological Reviews of The Cambridge Philosophical Society · doi:10.1111/brv.12249 · Cited by 6
“This experimental vindication of Lamarckism should propel, in our opinion, a reflection on the way in which the debate about directed mutation unfolded since the publication of Cairns et al. (1988).”
Background
Guest-Editorial Introduction: Converging Evolutionary Patterns in Life and Culture
Gontier, N. (2016) · Evolutionary Biology · doi:10.1007/s11692-016-9389-0 · Cited by 6
“…puts emphasis on the variation bias that intentional teaching brings forth); and also biologists debate whether or not genetic mutations (Cairns et al. 1988), lateral gene transfers (Popa et al. 2011), eco-evo-devo phenomena such as phenotypic plasticity (West-Eberhard 2003) and niche…”
Norms of Reaction: Do They Include Molecular Events?
Wallace, B. (2015) · Perspectives in biology and medicine · doi:10.1353/pbm.1990.0002 · Cited by 6
An Approximate Algorithm Combining P Systems and Active Evolutionary Algorithms for Traveling Salesman Problems
Song, X., & Wang, J. (2014) · International Journal of Computers Communications & Control · doi:10.15837/ijccc.2015.1.1567 · Cited by 6
Longevity and Plasticity of CFTR Provide an Argument for Noncanonical SNP Organization in Hominid DNA
Hill, A. E., Plyler, Z. E., Tiwari, H. K., Patki, A., Tully, J. P., McAtee, C. W., Moseley, L. A., & Sorscher, E. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109186 · Cited by 6
Adaptation of Organisms by Resonance of RNA Transcription with the Cellular Redox Cycle
Štolc, V., Shmygelska, A., & Griko, Y. V. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025270 · Cited by 6
A genetic algorithm for structure-activity relationships: software implementationPreprint
Jäntschi, L. (2009) · arXiv (Cornell University) · doi:10.48550/arxiv.0906.4846 · Cited by 6
“34, 35]; mutation, such as was observed beginning with modern genetics precursors to date (random [36], deliberate through exposing to certain conditions [37,38], or under environment factors stress [39]); and finally, the last but not the list, natural selection and survival of the fittest [40]. The obtaining of a go…”
Background
The optimal burst of mutation to create a phenotype
Bull, J. J. (2008) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2008.06.006 · Cited by 6
“This possibility harkens to the ”directed mutation” controversy (Cairns et al., 1988; McKenzie et al., 2001; McKenzie and Rosenberg, 2001; Andersson et al., 1998; Hendrickson et al., 2002), although in this instance, the mutations are not ”directed.””
Background
Stationary phase-induction of G → T mutations in Escherichia coli
Shu, J., Schellhorn, H. E., & Murphy, T. M. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.12.015 · Cited by 5
“Introduction27 Cairns et al.[1] noted that reversions ofEscherichia28 coli auxotrophs to prototrophy occurred more rapidly29 under selective conditions than in the absence of30 selection.”
Background
Going places: forced and natural molecular evolution.
Winson, M., & Kell, D. (1996) · Trends in Biotechnology · doi:10.1016/0167-7799(96)30013-9 · Cited by 6
Increased mutation rate in bacteria overexpressing a cloned foreign gene.
Lukacsovich, T., & Venetianer, P. (1991) · Mutation research · doi:10.1016/0165-7992(91)90041-2 · Cited by 6
On genes, environment, and experience
McGue, M. K., Bouchard, T. J., Lykken, D. T., & Finkel, D. (1991) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00070448 · Cited by 6
Causes of mutation and Mu excision
Mittler, J., & Lenski, R. (1990) · Nature · doi:10.1038/345213b0 · Cited by 6
Endogenous Molecular-Cellular Network Cancer Theory: A Systems Biology Approach
Wang, G., Yuan, R., Zhu, X., & Ao, P. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7456-6_11 · Cited by 9
Resuscitation of “Uncultured” Microorganisms
Kell, D. B., Mukamolova, G. V., Finan, C. L., Zhao, H., Goodacre, R., Kaprelyants, A. S., & Young, M. R. (2014) · ASM Press eBooks · doi:10.1128/9781555817770.ch10 · Cited by 6
The organisations of hereditary information
Paton, R. (1997) · Biosystems · doi:10.1016/s0303-2647(96)01652-8 · Cited by 7
The origin of His+ revertants of Salmonella typhimurium obtained on selective medium.
Gizatullin, F., & Lyozin, G. (1992) · Research in Microbiology · doi:10.1016/0923-2508(92)90066-w · Cited by 6
Directed Mutation in Escherichia Coli: Theory and Mechanisms
Foster, P. L. (1991) · Boston studies in the philosophy of science · doi:10.1007/978-94-011-3406-4_10 · Cited by 7
The origin of genetic and metabolic systems: Evolutionary structuralinsights
Deng, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14466 · Cited by 7
“In adaptive evolution, cells seem to be able to actively select useful mutations and give up useless mutations [237, 253].”
Background
Sources of evolutionary contingency: chance variation and genetic drift
Wong, T. Y. W. (2020) · Biology & Philosophy · doi:10.1007/s10539-020-09752-4 · Cited by 8
Let's Stop the Sloppy Use of “Lamarckian”
Speijer, D. (2019) · Bioessays · doi:10.1002/bies.201800258 · Cited by 5
Recombination Is Responsible for the Increased Recovery of Drug-Resistant Mutants with Hypermutated Genomes in Resting Yeast Diploids Expressing APOBEC Deaminases
Lada, A. G., Stepchenkova, E. I., Zhuk, A. S., Kliver, S. F., Rogozin, I. B., Polev, D. E., Dhar, A., & Pavlov, Y. I. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00202 · Cited by 4
“In the 1980s, this was developed further with the discovery of adaptive mutations (Shapiro, 1984; Cairns et al., 1988; Rosenberg, 2001).”
Background
Putative RNA-directed adaptive mutations in cancer evolution
Auboeuf, D. (2016) · Transcription · doi:10.1080/21541264.2016.1221491 · Cited by 4
“, a stress imposed to a cell) could induce a general increase in the cellular mutational rate.(20-24)”
Background
"Natural Site-Directed Mutagenesis" Might Exist in Eukaryotic Cells
Li, G.-D. (2016) · doi:10.4236/oalib.1102595 · Cited by 5
Control of Transposon-mediated Directed Mutation by the Escherichia coli Phosphoenolpyruvate:Sugar Phosphotransferase System
Saier, M., & Zhang, Z. (2015) · Journal of Molecular Microbiology and Biotechnology · doi:10.1159/000375375 · Cited by 5
“The Proposal of Directed Mutation John Cairns at Harvard University [Cairns et al., 1988] and Barry Hall at the University of Rochester [Hall, 1991] proposed and argued in favor of the concept of directed mutation.”
What history tells us XXXVI. Reverse transcriptase and Lamarckian scenarios of evolution
Morange, M. (2015) · Journal of Biosciences · doi:10.1007/s12038-015-9504-x · Cited by 4
“Reverse transcriptase and Lamarckian scenarios of evolution MICHEL MORANGE Centre Cavaillès, République des Savoirs: Lettres, Sciences, Philosophie USR 3608, Ecole Normale Supérieure, 29 Rue d’Ulm, 75230 Paris Cedex 05, France (Fax, 33-144-323941; Email, morange@biologie.ens.fr)”
BackgroundInfluential
Catabolite repression of SOS-dependent and SOS-independent spontaneous mutagenesis in stationary-phase Escherichia coli
MacPhee, D. G., & Ambrose, M. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.01.022 · Cited by 6
Genetic Control of Mitosis: Features of Anaphase Separation of Sister Chromatid Sets in Mutant Strain aarV158 in Drosophila melanogaster
Lebedeva, L., Trunova, S., Fedorova, S., & Omelyanchuk, L. (2003) · Russian Journal of Genetics · doi:10.1023/a:1025723117521 · Cited by 5
“Finally, an increase in tolerance of individual cells to the effect of the aarV158 mutation and their subsequent selection could occur during the so-called rapid adaptive mutagenesis (hyper mutagenesis), which has been described for prokaryotes [19, 20] and is assumed for eukaryotes [19].”
Background
Occurrence of leu+ revertants under starvation cultures in Escherichia coli is growth-dependent
Jin, J., Gao, P., & Mao, Y. (2002) · BMC Genetics · doi:10.1186/1471-2156-3-6 · Cited by 5
“According to the hypothesis of adaptive mutation by Cairns et al, the distribution of mutations under selection should follow Poisson pattern [1].”
Background
Selection and analysis of rare second-site suppressors of Drosophila RNA polymerase II mutations
Krasnoselskaya, I., Huang, J. N., Jones, T., Dezan, C., & Mortin, M. A. (1998) · Molecular and General Genetics MGG · doi:10.1007/s004380050756 · Cited by 5
“Adaptive mutation (also known as directed mutation) is de®ned as the preferential appearance of mutations that are advantageous under selective conditions (Cairns et al. 1988).”
Background
Fuzzy system identification through hybrid genetic algorithms
Tcholakian, A. B., Martins, A., Pacheco, R., & Barcia, R. (1997) · Annual Conference on the North American Fuzzy Information Processing Society · doi:10.1109/nafips.1997.624079 · Cited by 5
Preferential mutagenesis of lacZ integrated at unique sites in the Escherichia coli chromosome
LIu, S., Tseng, J.-N., Shiuan, D., & Hanawalt, P. (1997) · Molecular and General Genetics MGG · doi:10.1007/s004380050517 · Cited by 5
“Since the publication of the study by Cairns et al. (1988), the possible existence of so-called ``directed mutagenesis'' has been the subject of intensive debate.”
Background
Leakiness of genetic markers and susceptibility to post-plating mutagenesis inEscherichia coli
Jayaraman, R. (1995) · Journal Genetika · doi:10.1007/bf02932195 · Cited by 5
“The main claim of Cairns et al. (1988) was that when Lac- E. coli was under”
Background
A 25-kDa beta-lactam-induced outer membrane protein of Vibrio cholerae. Purification and characterization.
Deb, A., Bhattacharyya, D., & Das, J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.7.2914 · Cited by 5
Regulatory processes and the origins of spontaneous mutations.
Macphee, D. (1994) · Mutation research · doi:10.1016/0027-5107(94)90283-6 · Cited by 5
Enhancing Evolutionary Computation Using Analogues of Biological Mechanisms
Paton, R. (1994) · Evolutionary Computing, AISB Workshop · doi:10.1007/3-540-58483-8_5 · Cited by 5
Origin of mutants disputed
Holliday, R., & Rosenberger, R. (1988) · Nature · doi:10.1038/336526a0 · Cited by 5
Origin of mutants disputed
Grafen, A. (1988) · Nature · doi:10.1038/336525b0 · Cited by 5
Antimicrobial Metallodrugs
Simpson, D. H., & Scott, P. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803814-7.00007-1 · Cited by 9
Herpes simplex virus and the rheumatic diseases
Denman, A., Pelton, B., Hylton, W., Palmer, R., & Topper, R. (2004) · Rheumatology International · doi:10.1007/bf00271871 · Cited by 5
Obtaining Strains of Saccharomyces Tolerant to High Temperatures and Ethanol
Peres, M. F. S., de Sousa, S. R., & Laluce, C. (2001) · doi:10.1385/1-59259-029-2:355 · Cited by 5

Authors: Cairns, J., Overbaugh, J., & Miller, S.
Affiliations: Harvard University (US)
ORCID: Cairns, John
Overbaugh, Julie
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1988-09
Volume: 335
Issue: 6186
Pages: 142-145
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/335142a0
OpenAlex: W2043748488
Cited by: 1,025
References: 0
Citations by year: 2026: 8 · 2025: 6 · 2024: 12 · 2023: 13 · 2022: 14 · 2021: 10 · 2020: 22 · 2019: 20 · 2018: 30 · 2017: 19 · 2016: 23 · 2015: 14 · 2014: 29 · 2013: 23 · 2012: 29
FWCI: 25.69
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy of Biology and Scientific Explanation
Keywords: genetic mutations, bacterial variation, mutation rate, genetic variation, evolution
MeSH terms: Arabinose, Escherichia coli, Biological Evolution, Genes, Bacterial, Lactose, Models, Genetic, Mutation, Operon, Selection, Genetic, Genetic Variation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The origin of mutants

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks