Cited by 1,025Evolution and Genetic DynamicsBacterial Genetics and BiotechnologyPhilosophy of Biology and Scientific Explanation

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

The origin of mutants

Cairns, John, Overbaugh, Julie, Miller, Stephan·1988·Nature

DOI 10.1038/335142a0

Open this paper in CoChat — free account

Abstract

Nucleic acids are replicated with conspicuous fidelity. Infrequently, however, they undergo changes in sequence, and this process of change (mutation) generates the variability that allows evolution. As the result of studies of bacterial variation, it is now widely believed that mutations arise continuously and without any consideration for their utility. In this paper, we briefly review the source of this idea and then describe some experiments suggesting that cells may have mechanisms for choosing which mutations will occur.

Integrity signals

Registry

Crossref · 10.1038/335142a0

Cites

0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The distribution of the numbers of mutants in bacterial populations
Lea, D. E., & Coulson, C. A. (1949) · Journal of Genetics · doi:10.1007/bf02986080 · Cited by 1,450

Flagged first, then by citations

Show all 0 references

Research works printed but not linked: 15

Luria, S. E. & Delbrück, M. Genetics 28, 491–511 (1943). · DOI · Paper page
Lederberg, J. & Lederberg, E. M. J. Bact. 63, 399–406 (1952). · DOI
Cavalli-Sforza, L. L. & Lederberg, J. Genetics 41, 367–381 (1956). · DOI
Hayes, W. The Genetics of Bacteria (Blackwell, Oxford, 1964).
Armitage, P. J. R. statist. Soc. B. 14, 1–40 (1952). · DOI · Paper page
Mandelbrot, B. J. appl. Prob. 11, 437–444 (1974). · DOI · Paper page
Luria, S. E. Cold Spring Harb. Symp. quant. Biol. 16, 463–470 (1951). · DOI
Hadley, P. J. infect. Dis. 40, 1–312 (1927). · DOI
Ryan, F. J. Nature 169, 882–883 (1952). · DOI
Shapiro, J. A. Molec. Gen. Genet. 194, 79–90 (1984). · DOI
Reynolds, A. E., Felton, J. & Wright, A. Nature 293, 625–629 (1981). · DOI
Campbell, J. H., Lengyel, J. A. & Langridge, J. Proc. natn. Acad. Sci. U.S.A. 70, 1841–1845 (1973). · DOI
Hall, B. G. J. Bact. 129, 540–543 (1977). · DOI
Hall, B. G. & Zuzel, T. Proc. natn. Acad. Sci. U.S.A. 77, 3529–3533 (1980). · DOI
Reanney, D. C. Nature 307, 318–319 (1984). · DOI

Sorted by citations

Items 101–200 of 866

Adaptive mutation and amplification in Escherichia coli: two pathways of genome adaptation under stress
Hersh, M. N., Ponder, R. G., Hastings, P. J., & Rosenberg, S. M. (2004) · Research in Microbiology · doi:10.1016/j.resmic.2004.01.020 · Cited by 121
The inheritance of acquired epigenetic variations.
Jablonka, E., & Lamb, M. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv020 · Cited by 123
On the origin of enzymatic species.
Petsko, G., Kenyon, G. L., Gerlt, J., Ringe, D., & Kozarich, J. (1993) · TIBS -Trends in Biochemical Sciences. Regular ed · doi:10.1016/0968-0004(93)90091-z · Cited by 122
Analysis of the Luria–Delbrück distribution using discrete convolution powers
Ma, W. T., Sandri, G. V., & Sarkar, S. (1992) · Journal of Applied Probability · doi:10.1017/s0021900200043023 · Cited by 146
“However, in 1988, Cairns et al. (1988) reported deviations from the Luria-Delbruck distribution for a mutation in a strain of bacteria from inability to ability to digest lactose.”
Background
Stationary-phase mutation in the bacterial chromosome: Recombination protein and DNA polymerase IV dependence
Bull, H. J., Lombardo, M., & Rosenberg, S. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151009798 · Cited by 116
Genome organization, natural genetic engineering and adaptive mutation.
Shapiro, J. A. (1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)01058-5 · Cited by 115
Promoter-creating mutations in Pseudomonas putida: a model system for the study of mutation in starving bacteria.
Kasak, L., Hõrak, R., & Kivisaar, M. (1997) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.94.7.3134 · Cited by 113
Roles of YqjH and YqjW, Homologs of the Escherichia coli UmuC/DinB or Y Superfamily of DNA Polymerases, in Stationary-Phase Mutagenesis and UV-Induced Mutagenesis of Bacillus subtilis
Sung, H., Yeamans, G., Ross, C. A., & Yasbin, R. E. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.7.2153-2160.2003 · Cited by 109
“The result of the mechanism(s) responsible for this phenomenon is the production of mutations that arise in nondividing or stationary-phase bacteria when the cells are subjected to nonlethal selective pressure, such as nutrient-limited environments (6, 10, 20, 36).”
Background
NahW, a Novel, Inducible Salicylate Hydroxylase Involved in Mineralization of Naphthalene by Pseudomonas stutzeri AN10
Bosch, R., Moore, E., García-Valdés, E., & Pieper, D. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.8.2315-2322.1999 · Cited by 111
“Gene amplification as a stress response provides a plausible mechanism whereby bacteria might appear to be able to direct mutability to base pairs whose alteration improves growth (5, 26).”
Background
Evolution of Evolvability a
Radman, M., Matic, I., & Taddei, F. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08874.x · Cited by 109
Yeast Spontaneous Mutation Rate and Spectrum Vary with Environment
Liu, H., & Zhang, J. (2019) · Current Biology · doi:10.1016/j.cub.2019.03.054 · Cited by 138
Reverse transcriptase associated with the biosynthesis of the branched RNA-linked msDNA in Myxococcus xanthus
Inouye, S., Hsu, M.-Y., Eagle, S., & Inouye, M. (1989) · Cell · doi:10.1016/0092-8674(89)90593-x · Cited by 119
“or if they are responsible for enhanced mutations in response to a particular environmental challenge as described by Cairns et al. (1988). There are many other in-”
Background
Cancer in Light of Experimental Evolution
Sprouffske, K., Merlo, L. M. F., Gerrish, P. J., Maley, C. C., & Sniegowski, P. (2012) · Current Biology · doi:10.1016/j.cub.2012.06.065 · Cited by 110
The generation of multiple co‐existing mal ‐regulatory mutations through polygenic evolution in glucose‐limited populations of Escherichia coli
Notley‐McRobb, L., & Ferenci, T. (1999) · Environmental Microbiology · doi:10.1046/j.1462-2920.1999.00003.x · Cited by 105
Evolution of cellular stress response mechanisms
Kültz, D. (2020) · Journal of Experimental Zoology Part A Ecological and Integrative Physiology · doi:10.1002/jez.2347 · Cited by 131
Bacteria in Nature
Herbert, R., Leadbetter, E., & Poindexter, J. (1989) · Bacteria in Nature · doi:10.1007/978-1-4613-0803-4 · Cited by 104
DNA Rearrangements in Response To Environmental Stress
Cullis, C. (1990) · Advances in genetics · doi:10.1016/s0065-2660(08)60524-6 · Cited by 103
Dynamics of IS-related genetic rearrangements in resting Escherichia coli K-12.
Naas, T., Blot, M., Fitch, W., & Arber, W. (1995) · Molecular biology and evolution · doi:10.1093/oxfordjournals.molbev.a040198 · Cited by 102
Mutation induced by DNA damage: a many protein affair
Echols, H., & Goodman, M. F. (1990) · Mutation Research/DNA Repair · doi:10.1016/0921-8777(90)90013-u · Cited by 114
Evolution of novel metabolic pathways for the degradation of chloroaromatic compounds
van der Meer, J. R. (1997) · Antonie van Leeuwenhoek · doi:10.1023/a:1000166400935 · Cited by 101
The magnitude of local adaptation under genotype‐dependent dispersal
Bolnick, D. I., & Otto, S. P. (2013) · Ecology and Evolution · doi:10.1002/ece3.850 · Cited by 110
“…adaptation to the environment (Harvey and Pagel 1991; Rose and Lauder 1996; Orzack and Sober 2001), other evolutionary processes, in particular nonran- dom dispersal (Edelaar and Bolnick 2012) but also nonrandom mutation (Cairns et al. 1988), potentially contribute to the adaptive process.”
Background
Accumulation of mutants in “aging” bacterial colonies is due to growth under selection, not stress-induced mutagenesis
Wrande, M., Roth, J., & Hughes, D. (2008) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0804739105 · Cited by 97
Adaptive Amplification and Point Mutation Are Independent Mechanisms: Evidence for Various Stress-Inducible Mutation Mechanisms
Hastings, P. J., Slack, A., Petrosino, J. F., & Rosenberg, S. M. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020399 · Cited by 85
“Adaptive mutation was first brought to wide attention by Cairns et al. (1988), and encompasses a collection of processes whereby cells adapt genetically in response to growth-limiting environments.”
Background
Adaptive mutation: General mutagenesis is not a programmed response to stress but results from rare coamplification of dinB with lac
Slechta, E. S., Bunny, K. L., Kugelberg, E., Kofoid, E., Andersson, D. I., & Roth, J. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1735464100 · Cited by 94
A Practical Guide to Measuring Mutation Rates in Antibiotic Resistance
Pope, C. F., O’Sullivan, D. M., McHugh, T. D., & Gillespie, S. H. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01152-07 · Cited by 86
“in their “directed-mutation” experiments with Lac, which allowed mutants arising postplating to grow (5).”
Background
Adenovirus serotype evolution is driven by illegitimate recombination in the hypervariable regions of the hexon protein.
Crawford-Miksza, L. K., & Schnurr, D. P. (1996) · Virology · doi:10.1006/viro.1996.0543 · Cited by 96
Spontaneous mutagenesis: Experimental, genetic and other factors
Smith, K. C. (1992) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(92)90002-q · Cited by 102
The unforeseen challenge: from genotype-to-phenotype in cell populations
Braun, E. (2015) · Reports on Progress in Physics · doi:10.1088/0034-4885/78/3/036602 · Cited by 94
New data on excisions of Mu from E. coli MCS2 cast doubt on directed mutation hypothesis
Mittler, J., & Lenski, R. (1990) · Nature · doi:10.1038/344173a0 · Cited by 95
Genetic and physiological relationships among the miaA gene, 2-methylthio-N6-(delta 2-isopentenyl)-adenosine tRNA modification, and spontaneous mutagenesis in Escherichia coli K-12
Connolly, D. M., & Winkler, M. E. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.6.3233-3246.1989 · Cited by 95
Natural genetic engineering in evolution
Shapiro, J. A. (1992) · Genetica · doi:10.1007/bf00133714 · Cited by 168
“(a) There have been numerous published and unpublished reports that prolonged incubation of bacteria under selective conditions triggers mutagenic processes ('directed mutation') that allow the formation of mutant clones capable of growth (Shapiro, 1984; Cairns et al., 1988; Hall, 1988).”
Background
Neutrophil elastase inhibitors for the treatment of (cardio)pulmonary diseases: Into clinical testing with pre-adaptive pharmacophores
von Nussbaum, F., & Li, V. M. ‐. (2015) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2015.08.049 · Cited by 99
Adaptive mutation in Escherichia coli: a role for conjugation
Jp, R., Pu, P., & Ms, F. (1995) · Science · doi:10.1126/science.7716545 · Cited by 94
The look-ahead effect of phenotypic mutations
Whitehead, D. J., Wilke, C. O., Vernazobres, D., & Bornberg-Bauer, E. (2008) · Biology Direct · doi:10.1186/1745-6150-3-18 · Cited by 84
“While the notion that cells can directly decide in which genomic regions to increase their mutation rate has been mostly abandoned [4,7], the original observations by [1] have been corroborated (see above reviews).”
BackgroundResult
Topological Data Analysis for Genomics and Evolution
Rabadán, R., & Blumberg, A. J. (2019) · Cambridge University Press eBooks · doi:10.1017/9781316671665 · Cited by 101
“For example, it has been shown that starving bacteria have dramatically increased evolutionary rates [72, 86].”
Non‐random mutation: The evolution of targeted hypermutation and hypomutation
Martincorena, I., & Luscombe, N. M. (2012) · BioEssays · doi:10.1002/bies.201200150 · Cited by 94
Error-Prone Polymerase, DNA Polymerase IV, Is Responsible for Transient Hypermutation during Adaptive Mutation in Escherichia coli
Tompkins, J. D., Nelson, J. L., Hazel, J. C., Leugers, S. L., Stumpf, J. D., & Foster, P. L. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.11.3469-3472.2003 · Cited by 85
“When populations of microorganisms are exposed to nonlethal selections, mutations that relieve the selective pressure arise (7), a phenomenon called adaptive mutation (6).”
Background
The evolution of genetic intelligence.
Thaler, D. S. (1994) · Science · doi:10.1126/science.8146652 · Cited by 86
Sources of spontaneous mutagenesis in bacteria
Schroeder, J. W., Yeesin, P., Simmons, L. A., & Wang, J. D. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2017.1394262 · Cited by 110
“Under conditions allowing post-selection mutagenesis, the total number of mutants observed in each culture is the sum of the number of mutants that arose spontaneously during growth in culture and the number that arose after selection was imposed (Figure 1(A)) (Cairns et al. 1988).”
Background
Mild environmental stress elicits mutations affecting fitness in Chlamydomonas
Goho, S., & Bell, G. (2000) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.2000.0976 · Cited by 85
Living is Information Processing: From Molecules to Global Systems
Farnsworth, K. D., Nelson, J., & Gershenson, C. (2013) · Acta Biotheoretica · doi:10.1007/s10441-013-9179-3 · Cited by 124
“This second signal typically initiates a complex sequence of interconnected changes which may alter the internal chemistry of the cell, change the response to other ﬁrst messengers, and even selectively alter gene expression (Cairns et al., 1988).”
Background
Stress-induced mutagenesis and complex adaptation
Ram, Y., & Hadany, L. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.1025 · Cited by 77
“Conclusions Stress-induced mutagenesis has been implicated as a driver of adaptive evolution for several decades [17,33,80].”
Background
Diversify or Die: Generation of Diversity in Response to Stress
Aertsen, A., & Michiels, C. W. (2005) · Critical Reviews in Microbiology · doi:10.1080/10408410590921718 · Cited by 74
“coli on a solid medium with lactose as sole energy source (Cairns et al. 1988; Cairns & Foster 1991).”
BackgroundMethod
Prokaryote and eukaryote evolvability
Poole, A. M., Phillips, M. J., & Penny, D. (2003) · Biosystems · doi:10.1016/s0303-2647(02)00131-4 · Cited by 76
“Cairns et al., 1988 ) then it is a specialised (and controversial) usage.”
Background
DNA computers in vitro and vivo
Smith, W. (1995) · DNA Based Computers · doi:10.1090/dimacs/027/07 · Cited by 82
Microbial genetics: The tinkerer's evolving tool-box
Moxon, E., & Thaler, D. S. (1997) · Nature · doi:10.1038/42607 · Cited by 81
Dynamic Metabolic Adjustments and Genome Plasticity Are Implicated in the Heat Shock Response of the Extremely Thermoacidophilic Archaeon Sulfolobus solfataricus
Tachdjian, S., & Kelly, R. (2006) · Journal of Bacteriology · doi:10.1128/jb.00080-06 · Cited by 80
Hypermutation in derepressed operons of Escherichia coli K12
Wright, B. E., Longacre, A., & Reimers, J. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5089 · Cited by 73
Evolutionary Biology of Transient Unstable Populations
Fontdevila, A. (1989) · Springer Berlin Heidelberg · doi:10.1007/978-3-642-74525-6 · Cited by 79
“Am Nat 126:642-661 Sene FM, Carson HL (1977) Genetic variation in Hawaiian Drosophila.”
Background
Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy
Pienta, K. J., Hammarlund, E. U., Austin, R. H., Axelrod, R., Brown, J. S., & Amend, S. R. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.11.016 · Cited by 80
Mechanisms of spontaneous mutation in DNA repair-proficient Escherichia coli.
Halliday, J., & Glickman, B. (1991) · Mutation research · doi:10.1016/0027-5107(91)90162-h · Cited by 78
Macroevolution and Retroviral ElementsInsertion of viral-like DNA segments may bring about rapid and dramatic changes in gene regulation and development
McDonald, J. (1990) · BioScience · doi:10.2307/1311363 · Cited by 78
Optimal control for a stochastic model of cancer chemotherapy.
Coldman, A., & Murray, J. M. (2000) · Mathematical Biosciences · doi:10.1016/s0025-5564(00)00045-6 · Cited by 76
“Experiments of the Luria±Delbruck [3] type have consistently implicated random mutational changes as being the origin of these genetic changes [4] although this may not be the exclusive mechanism [5].”
Background
Are radiation-induced effects hormetic?
Wolff, S. (1989) · Science · doi:10.1126/science.2762808 · Cited by 76
Resistance to glyphosate in the cyanobacterium Microcystis aeruginosa as result of pre-selective mutations
López-Rodas, V., Flores-Moya, A., Maneiro, E., Perdigones, N., Marvá, F., García, M., & Costas, E. (2007) · Evolutionary Ecology · doi:10.1007/s10682-006-9134-8 · Cited by 75
“However, recent evolutionary studies in bacteria have suggested that hypothetical ‘‘adaptive mutation’’ could be a process resembling Lamarckism which, in the absence of lethal selection, produces mutations that relieve selective pressure (Cairns et al. 1998; Foster 2000).”
Background
Mechanism for induction of adaptive mutations in Escherichia coli
Boe, L. (1990) · Molecular Microbiology · doi:10.1111/j.1365-2958.1990.tb00628.x · Cited by 74
Death and population dynamics affect mutation rate estimates and evolvability under stress in bacteria
Frénoy, A., & Bonhoeffer, S. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2005056 · Cited by 81
“One of the most puzzling and controversial microbial evolution experiments of the 20th century may be the one performed by Cairns and collaborators [8, 7] in which lac− cells are plated on lactose as the sole carbon source and therefore cannot grow.”
Background
Statistical and algorithmic methods for fluctuation analysis with SALVADOR as an implementation
Zheng, Q. (2002) · Mathematical Biosciences · doi:10.1016/s0025-5564(02)00087-1 · Cited by 70
Bacterial cooperative organization under antibiotic stress
Ben-Jacob, E., Cohen, I., Golding, I., Gutnick, D., Tcherpakov, M., Helbing, D., & Ron, I. G. (2000) · Physica A Statistical Mechanics and its Applications · doi:10.1016/s0378-4371(00)00093-5 · Cited by 72
“A high level of antibiotics, like other forms of stress, seems to encourage the appearance of new mutations [60], so that many sectors emerge in the developing colony.”
Background
Environmental signaling and evolutionary change: can exposure of pregnant mammals to environmental estrogens lead to epigenetically induced evolutionary changes in embryos?
Guerrero‐Bosagna, C., Sabat, P., & Valladares, L. (2005) · Evolution & Development · doi:10.1111/j.1525-142x.2005.05033.x · Cited by 70
“focus of epigenetic studies in a variety of organisms, including Drosophila (Rutherford and Lindquist 1998), bacteria ( Cairns et al. 1988 ), and yeast (Steele and Jinks-Robertson 1992).”
Background
Resistance of microalgae to modern water contaminants as the result of rare spontaneous mutations
López-Rodas, V., Agrelo, M., Carrillo, E., Ferrero, L. M., Larrauri, A., Martín-Otero, L., & Costas, E. (2001) · European Journal of Phycology · doi:10.1080/09670260110001735328 · Cited by 70
Mutation for survival.
Rosenberg, S. M. (1997) · Current Opinion in Genetics and Development · doi:10.1016/s0959-437x(97)80047-0 · Cited by 70
DNA precursor asymmetries, replication fidelity, and variable genome evolution
Mathews, C. K., & Ji, J. (1992) · BioEssays · doi:10.1002/bies.950140502 · Cited by 69
The Role of Mutation Bias in Adaptive Evolution
SVENSSON, E. I., & Berger, D. (2019) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2019.01.015 · Cited by 97
Nature and nurture
Plomin, R. J., & Bergeman, C. S. (1991) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00070588 · Cited by 50
Multiple mutations in human cancers.
Loeb, L., & Christians, F. (1996) · Mutation research · doi:10.1016/0027-5107(95)00117-4 · Cited by 68
Studies of diabetic twins
Lo, S. S. S., Tun, R. Y. M., Hawa, M. I., & Leslie, R. D. G. (1991) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610070403 · Cited by 54
Mission scheduling optimization of SAR satellite constellation for minimizing system response time
Kim, H., & Chang, Y.-K. (2014) · Aerospace Science and Technology · doi:10.1016/j.ast.2014.10.006 · Cited by 72
Bacterial wisdom, Gödel's theorem and creative genomic webs
Ben‐Jacob, E. (1998) · Physica A Statistical Mechanics and its Applications · doi:10.1016/s0378-4371(97)00529-3 · Cited by 60
“[23] showed the speci ty of those mutation events.”
Background
Schiff base metallodrugs in antimicrobial and anticancer chemotherapy applications: a comprehensive review
Shekhar, S., Khan, A., Sharma, S., Sharma, B., & Sarkar, A. (2021) · Emergent Materials · doi:10.1007/s42247-021-00234-1 · Cited by 67
An Insertion Sequence Prepares Pseudomonas putida S12 for Severe Solvent Stress
Wery, J., Hidayat, B., Kieboom, J., & de Bont, J. A. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007687200 · Cited by 58
Isolation and Characterization of Bacteria from Ancient Siberian Permafrost Sediment
Zhang, D.-C., Brouchkov, A. V., Грива, Г. И., Schinner, F., & Margesin, R. (2013) · Biology · doi:10.3390/biology2010085 · Cited by 68
What is mutation? A chapter in the series: How microbes “jeopardize” the modern synthesis
Fitzgerald, D. M., & Rosenberg, S. M. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1007995 · Cited by 92
Error-Prone DNA Polymerase IV Is Regulated by the Heat Shock Chaperone GroE in Escherichia coli
Layton, J. C., & Foster, P. L. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.2.449-457.2005 · Cited by 58
“When populations of microorganisms are placed under certain nonlethal selective conditions, mutations that relieve the selective pressure arise, a process called adaptive mutation (7, 16).”
Background
Mutation of algae from sensitivity to resistance against environmental selective agents: the ecological genetics of Dictyosphaerium chlorelloides (Chlorophyceae) under lethal doses of 3-(3,4-dichlorophenyl)-1, 1-dimethylurea herbicide
Costas, E., Carrillo, E., Ferrero, L. M., Agrelo, M., García-Villada, L., Juste, J., & López-Rodas, V. (2001) · doi:10.2216/i0031-8884-40-5-391.1 · Cited by 65
Evolution-driving genes.
Radman, M., Taddei, F., & Matic, I. (2000) · Research in Microbiology · doi:10.1016/s0923-2508(00)00122-4 · Cited by 65
Evolution of chlorocatechol catabolic pathways
Schlömann, M. (1994) · Biodegradation · doi:10.1007/bf00696467 · Cited by 65
Hypermutation in bacteria and other cellular systems
Bridges, B. A. (2001) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0745 · Cited by 71
“In many of the early experiments of this type the fact that mutations were not found at loci that did not confer the ability to grow led to the idea that bacteria possessed the ability to mutate only at those loci that carried a potential selective advantage (Cairns et al. 1988; Hall 1990).”
Background
The evolution of ecological tolerance in prokaryotes
Knoll, A. H., & Bauld, J. (1989) · Earth and Environmental Science Transactions of the Royal Society of Edinburgh · doi:10.1017/s0263593300028650 · Cited by 67
Phenomenon of life: Between equilibrium and non-linearity. Origin and principles of evolution
Галимов, Э. М. (2006) · Geochemistry International · doi:10.1134/s0016702906130015 · Cited by 65
Adaptive Mutation inSaccharomyces cerevisiae
Heidenreich, E. (2007) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230701507773 · Cited by 62
“Spurred by the revival of the adaptive mutation field in E. coli, which was stimulated by the controversial paper by Cairns et al. (1988), reports on adaptive mutation in S. cerevisiae as the first eukaryotic organism followed 4 years later (Hall, 1992; Steele and JinksRobertson, 1992).”
Background
Mutation rates: estimating phase variation rates when fitness differences are present and their impact on population structure
Saunders, N. J. S. G., Moxon, E. R., & Gravenor, M. B. (2003) · Microbiology · doi:10.1099/mic.0.25807-0 · Cited by 54
“…to the Luria & Delbrück method are not concordant with the experimental conditions (which is often the case) then divergence from their predicted distribution is to be expected, and does not necessarily indicate the action of 'directed' mutation (Cairns et al., 1988; Mittler & Lenski, 1992).”
Directed mutation: between unicorns and goats
Foster, P. L. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.6.1711-1716.1992 · Cited by 61
Homologous Recombination—Enzymes and Pathways
Michel, B., & Leach, D. R. F. (2012) · EcoSal Plus · doi:10.1128/ecosalplus.7.2.7 · Cited by 65
Transgenic Animal Models for Detection of In Vivo Mutations
Mirsalis, J. C., Monforte, J., & Winegar, R. A. (1995) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.35.040195.001045 · Cited by 56
The role of DNA damage in stationary phase (`adaptive') mutation
Bridges, B. A. (1998) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(98)00008-1 · Cited by 46
Transcription-Associated Mutation in Bacillus subtilis Cells under Stress
Pybus, C. A., Pedraza-Reyes, M., Ross, C. A., Martin, H., Ona, K., Yasbin, R., & Robleto, E. (2010) · Journal of Bacteriology · doi:10.1128/jb.00354-10 · Cited by 57
“coli cells unable to use the lactose provided as the sole carbon source in a minimal medium (6).”
Background
EVOLUTION OF MICROALGAE IN HIGHLY STRESSING ENVIRONMENTS: AN EXPERIMENTAL MODEL ANALYZING THE RAPID ADAPTATION OF DICTYOSPHAERIUM CHLORELLOIDES (CHLOROPHYCEAE) FROM SENSITIVITY TO RESISTANCE AGAINST 2,4,6‐TRINITROTOLUENE BY RARE PRESELECTIVE MUTATIONS1
Garcı́a-Villada, L., López‐Rodas, V., Bañares‐España, E., Flores‐Moya, A., Agrelo, M., Martín‐Otero, L., & Costas, E. (2002) · Journal of Phycology · doi:10.1046/j.1529-8817.2002.01128.x · Cited by 57
Genetic Antagonism and Hypermutability inMycobacterium smegmatis
Karunakaran, P., & Davies, J. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.12.3331-3335.2000 · Cited by 57
Adaptive mutagenesis: a process that generates almost exclusively beneficial mutations
Hall, B. G. (2004) · Genetica · doi:10.1023/a:1017015815643 · Cited by 57
“Cairns, Overbaugh, and Miller (1988) first reported that (uvrB-bio) increased the adaptive reversion of a lacZ allele by about 3-5 fold; however the increase could obviously not be attributed specifically to the lesion in uvrB.”
BackgroundInfluential
An evolutionary relationship between genetic variation and phenotypic fluctuation.
Kaneko, K., & Furusawa, C. (2006) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2005.08.029 · Cited by 56
“Such dependence of evolution speed on environment may shed a new light on the controversy on the so-called adaptive mutation (Cairns et al., 1988; Shapiro, 1995).”
Background
Adaptive Point Mutation and Adaptive Amplification Pathways in the Escherichia coli Lac System: Stress Responses Producing Genetic Change
Rosenberg, S. M., & Hastings, P. J. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.15.4838-4843.2004 · Cited by 52
Variation in assimilating functions occurs in spontaneous Candida albicans mutants having chromosomal alterations.
Rustchenko, E., Howard, D., & Sherman, F. (1997) · Microbiology · doi:10.1099/00221287-143-5-1765 · Cited by 55
The efficiency of antibody affinity maturation: can the rate of B-cell division be limiting?
Manser, T. (1990) · Immunology today (Amsterdam. Regular ed.) · doi:10.1016/0167-5699(90)90124-r · Cited by 55
Short-term adaptation of microalgae in highly stressful environments: an experimental model analysing the resistance ofScenedesmus intermedius(Chlorophyceae) to the heavy metals mixture from the Aznalcóllar mine spill
Baos, R., Garcı́a-Villada, L., Agrelo, M., López‐Rodas, V., Hiraldo, F., & Costas, E. (2002) · European Journal of Phycology · doi:10.1017/s096702620200392x · Cited by 56
“Although it has long been assumed that only pre-adaptive spontaneous mutations occur, Cairns et al. (1988) and Hall (1988) have proven the occurrence of adaptive mutation.”
BackgroundMethod
Evolution of new gene functions: simulation and analysis of the amplification model
Pettersson, M. E., Sun, S., Andersson, D., & Berg, O. (2009) · Genetica · doi:10.1007/s10709-008-9289-z · Cited by 53
“In addition, there is experimental evidence from the Cairns system ( Cairns et al. 1988; Cairns and Foster 1991) that directly supports adaptive amplifications.”
Background
A quantum-theoretical approach to the phenomenon of directed mutations in bacteria (hypothesis)
Ogryzko, V. V. (1997) · Biosystems · doi:10.1016/s0303-2647(97)00030-0 · Cited by 47
“Based on this analogy, the capacity of cell to grow in particular conditions is considered an observable of the cell; the plating experiments are interpreted as measurement of this observable.”
Background
Adaptive mutation: who's really in the garden?
Shapiro, J. A. (1995) · Science · doi:10.1126/science.7716540 · Cited by 53
The significance of biological heterogeneity
Rubin, H. (1990) · Cancer Metastasis Review · doi:10.1007/bf00047585 · Cited by 53
“However, this technique, known as fluctuation analysis, has many problems, some of which have recently been pointed out [40, 41].”
Background
Ecological population genetics: the interface between genes and the environment.
Hoffmann, A., Sgrò, C., & Lawler, S. (1995) · Annual Review of Genetics · doi:10.1146/annurev.ge.29.120195.002025 · Cited by 53

Authors: Cairns, J., Overbaugh, J., & Miller, S.
Affiliations: Harvard University (US)
ORCID: Cairns, John
Overbaugh, Julie
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1988-09
Volume: 335
Issue: 6186
Pages: 142-145
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/335142a0
OpenAlex: W2043748488
Cited by: 1,025
References: 0
Citations by year: 2026: 8 · 2025: 6 · 2024: 12 · 2023: 13 · 2022: 14 · 2021: 10 · 2020: 22 · 2019: 20 · 2018: 30 · 2017: 19 · 2016: 23 · 2015: 14 · 2014: 29 · 2013: 23 · 2012: 29
FWCI: 25.69
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy of Biology and Scientific Explanation
Keywords: genetic mutations, bacterial variation, mutation rate, genetic variation, evolution
MeSH terms: Arabinose, Escherichia coli, Biological Evolution, Genes, Bacterial, Lactose, Models, Genetic, Mutation, Operon, Selection, Genetic, Genetic Variation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The origin of mutants

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Metadata

Record

About these checks