Cited by 896Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanismsWnt/β-catenin signaling in development and cancer

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

Thomas, Kirk R., Capecchi, Mario R.·1990·Nature

DOI 10.1038/346847a0

Open this paper in CoChat — free account

Abstract

The int-1 proto-oncogene was first identified as a gene activated in virally induced mouse mammary tumours. Expression studies, however, suggest that the normal function of this gene may be in spermatogenesis and in the development of the central nervous system. Genes sharing sequence similarity with int-1 have been found throughout the animal kingdom. For example, int-1 has 54% amino-acid identity to the Drosophila segment polarity gene wingless (wg). Both the int-1 and wg gene products seem to be secreted proteins, presumably involved in cell-cell signalling. We have now explored the function of int-1 in the mouse by disrupting one of the two int-1 alleles in mouse embryo-derived stem cells using positive-negative selection. This cell line was used to generate a chimaeric mouse that transmitted the mutant allele to its progeny. Mice heterozygous for the int-1 null mutation are normal and fertile, whereas mice homozygous for the mutation may exhibit a range of phenotypes from death before birth to survival with severe ataxia. The latter pathology in mice and humans is often associated with defects in the cerebellum. Examination of int-1-/int-1- mice at several stages of embryogenesis revealed severe abnormalities in the development of the mesencephalon and metencephalon indicating a prominent role for the int-1 protein is in the induction of the mesencephalon and cerebellum.

Integrity signals

Registry

Crossref · 10.1038/346847a0

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355
Self-citation
Altering the Genome by Homologous Recombination
Capecchi, M. R. (1989) · Science · doi:10.1126/science.2660260 · Cited by 2,037
Self-citation
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genome
Nusse, R., & VARMUS, H. E. (1982) · Cell · doi:10.1016/0092-8674(82)90409-3 · Cited by 1,864
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
Mansour, S. L., Thomas, K. R., & Capecchi, M. R. (1988) · Nature · doi:10.1038/336348a0 · Cited by 1,683
Self-citation
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting
DeChiara, T. M., Efstratiadis, A., & Robertsen, E. J. (1990) · Nature · doi:10.1038/345078a0 · Cited by 1,663
Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
Bradley, A., Evans, M. J., Kaufman, M. H., & Robertson, E. J. (1984) · Nature · doi:10.1038/309255a0 · Cited by 1,524
β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells
Zijlstra, M., Bix, M., Simister, N. E., Loring, J. M., Raulet, D. H., & Jaenisch, R. (1990) · Nature · doi:10.1038/344742a0 · Cited by 1,009
The Drosophila homology of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless
Rijsewijk, F. A. M., Schuermann, M., Wagenaar, E., Parren, P. W. H. I., Weigel, D., & Nusse, R. (1987) · Cell · doi:10.1016/0092-8674(87)90038-9 · Cited by 931
Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
Koller, B. H., Marrack, P., Kappler, J. W., & Smithies, O. (1990) · Science · doi:10.1126/science.2112266 · Cited by 884
The new mouse genetics: Altering the genome by gene targeting
Capecchi, M. R. (1989) · Trends in Genetics · doi:10.1016/0168-9525(89)90029-2 · Cited by 611
Self-citation

Flagged first, then by citations

Show all 30 references

Research works printed but not linked: 1

Mansour, S. L., Thomas, K. R., Deng, C. & Capecchi, M. R. Proc. natn. Acad. Sci. U.S.A. (in the press).

Sorted by citations

Items 301–400 of 896

An Efficient Method for the Derivation of Mouse Embryonic Stem Cells
Bryja, V., Bonilla, S., Čajánek, L., Parish, C. L., Schwartz, C. M., Luo, Y., Rao, M. S., & Arenas, E. (2005) · Stem Cells · doi:10.1634/stemcells.2005-0444 · Cited by 89
Cerebellar granule cells: Insights into proliferation, differentiation, and role in medulloblastoma pathogenesis
Behesti, H., & Marino, S. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.06.017 · Cited by 89
Expression of a dominant negative inhibitor of intercellular communication in the early Xenopus embryo causes delamination and extrusion of cells
Paul, D. L., Yu, K., Bruzzone, R., Gimlich, R. L., & Goodenough, D. A. (1995) · Development · doi:10.1242/dev.121.2.371 · Cited by 89
The wnt-frizzled cascade in cardiovascular disease
van Gijn, M. E. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00221-3 · Cited by 91
Wnt/β‐catenin signaling during early vertebrate neural development
Brafman, D. A., & Willert, K. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22517 · Cited by 95
Postulated boundaries and differential fate in the developing rostral hindbrain
Aroca, P., & Puelles, L. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.12.031 · Cited by 88
Zebrafish wnt11: pattern and regulation of the expression by the yolk cell and No tail activity
Makita, R., Mizuno, T., Koshida, S., Kuroiwa, A., & Takeda, H. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00013-6 · Cited by 88
Wnt/β-Catenin-Dependent Transcription in Autism Spectrum Disorders
Caracci, M. O., Ávila, M. E., Espinoza-Cavieres, F. A., López, H. R., Ugarte, G. D., & Ferrari, G. V. D. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.764756 · Cited by 86
Once a killer, always a killer: from cytotoxic T cell to memory cell
Lefrançois, L., & Obar, J. J. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2010.00895.x · Cited by 89
Knowing your neighbors: Cell interactions determine intrasegmental patterning in Drosophila
Peifer, M. A., & Bejsovec, A. (1992) · Trends in Genetics · doi:10.1016/0168-9525(92)90394-j · Cited by 86
Specification of the meso-isthmo-cerebellar region: The Otx2/Gbx2 boundary
Hidalgo‐Sánchez, M., Millet, S., Bloch‐Gallego, E., & Alvarado‐Mallart, R. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.01.010 · Cited by 85
Targeting of the creating kinase M gene in embryonic stem cells using isogenic and nonisogenic vectors
van Deursen, J., & Wieringa, B. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.15.3815 · Cited by 85
Fate and potentialities of the avian mesencephalic/metencephalic neuroepithelium
Alvarado‐Mallart, R. (1993) · Journal of Neurobiology · doi:10.1002/neu.480241007 · Cited by 85
Genetic Determination of Drosophila Heart Development
Bodmer, R., & Frasch, M. (1999) · Elsevier eBooks · doi:10.1016/b978-012329860-7/50007-6 · Cited by 85
TheXenopus laevis homeo☐ geneXgbx-2 is an early marker of anteroposterior patterning in the ectoderm
von Bubnoff, A., Schmidt, J. E., & Kimelman, D. (1996) · Mechanisms of Development · doi:10.1016/0925-4773(95)00468-8 · Cited by 83
Fgf8 signaling for development of the midbrain and hindbrain
Harada, H., Sato, T., & Nakamura, H. (2016) · Development Growth & Differentiation · doi:10.1111/dgd.12293 · Cited by 82
WNT3 Inhibits Cerebellar Granule Neuron Progenitor Proliferation and Medulloblastoma Formation via MAPK Activation
Anne, S. L., Govek, E., Ayrault, O., Kim, J. H., Zhu, X., Murphy, D. A., Aelst, L. V., Roussel, M. F., & Hatten, M. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081769 · Cited by 82
Human Dishevelled Genes Constitute a DHR-Containing Multigene Family
Semënov, M. V., & Snyder, M. P. (1997) · Genomics · doi:10.1006/geno.1997.4713 · Cited by 81
The isthmic neuroepithelium is essential for cerebellar midline fusion
Louvi, A., Alexandre, P., Métin, C., Wurst, W., & Wassef, M. (2003) · Development · doi:10.1242/dev.00736 · Cited by 81
A Soluble Form of Wnt-1 Protein with Mitogenic Activity on Mammary Epithelial Cells
Bradley, R. S., & Brown, A. M. C. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.8.4616 · Cited by 80
Wnt signaling and neural stem cells: caught in the Wnt web
Michaelidis, T. M., & Lie, D. C. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0476-5 · Cited by 84
Isolation of cDNAs partially encoding four Xenopus - proteins and characterization of their transient expression during embryonic development
Christian, J. L., Gavin, B. J., McMahon, A. P., & Moon, R. T. (1991) · Developmental Biology · doi:10.1016/0012-1606(91)90073-c · Cited by 80
Of fin and fur: mutational analysis of vertebrate embryonic development.Preprint
Rossant, J., & Hopkins, N. H. (1992) · Genes & Development · doi:10.1101/gad.6.1.1 · Cited by 79
Cre‐mediated recombination in rhombic lip derivatives
Fünfschilling, U., & Reichardt, L. F. (2002) · genesis · doi:10.1002/gene.10104 · Cited by 78
Newer Gene Editing Technologies toward HIV Gene Therapy
Manjunath, N., Yi, G., Dang, Y., & Shankar, P. (2013) · Viruses · doi:10.3390/v5112748 · Cited by 77
Contributions of Mammalian Chimeras to Pluripotent Stem Cell Research
Mascetti, V. L., & Pedersen, R. A. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.07.018 · Cited by 78
Wnt2 Regulates Progenitor Proliferation in the Developing Ventral Midbrain
Sousa, K. M., Villaescusa, C., Čajánek, L., Ondr, J. K., Castelo‐Branco, G., Hofstra, W. A., Bryja, V., Palmberg, C., Bergman, T., Wainwright, B. J., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.079822 · Cited by 77
Wnt-1 promotes neuronal differentiation and inhibits gliogenesis in P19 cells
Tang, K., Yang, J., Gao, X., Wang, C., Liu, L., Kitani, H., Atsumi, T., & Jing, N. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00215-2 · Cited by 77
Precise genome-editing in human diseases: mechanisms, strategies and applications
Zheng, Y., Li, Y., Zhou, K., Li, T., VanDusen, N. J., & Hua, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01750-2 · Cited by 91
The canonical Wnt pathway directly regulates NRSF/REST expression in chick spinal cord
Nishihara, S., Tsuda, L., & Ogura, T. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.158 · Cited by 76
Roles of Armadillo, a Drosophila catenin, during central nervous system development.
Loureiro, J., & Peifer, M. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70249-0 · Cited by 81
Structure and expression of Wnt13, a novel mouse Wnt2 related gene
Zakin, L., Mazan, S., Maury, M., Martín-Martín, N., Guénet, J., & Brûlet, P. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00040-9 · Cited by 74
Wingless Signaling: A Genetic Journey from Morphogenesis to Metastasis
Bejsovec, A. (2018) · Genetics · doi:10.1534/genetics.117.300157 · Cited by 74
Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeres
Salinas, P. C., & Nusse, R. (1992) · Mechanisms of Development · doi:10.1016/0925-4773(92)90042-i · Cited by 74
Identification of an evolutionarily conserved 110 base-pair cis-acting regulatory sequence that governs Wnt-1 expression in the murine neural plate
Rowitch, D. H., Echelard, Y., Danielian, P. S., Gellner, K., Brenner, S., & McMahon, A. P. (1998) · Development · doi:10.1242/dev.125.14.2735 · Cited by 74
Estrogen regulation of Dkk1 and Wnt/β-Catenin signaling in neurodegenerative disease
Scott, E. L., & Brann, D. W. (2012) · Brain Research · doi:10.1016/j.brainres.2012.12.015 · Cited by 73
Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae
Chen, F., Greer, J. M., & Capecchi, M. R. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00126-9 · Cited by 73
Self-citation
TGF-β S ignaling and its F unctional S ignificance in R egulating the F ate of C ranial N eural C rest C ells
Chai, Y., Ito, Y., & Han, J. (2003) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130301400202 · Cited by 74
Targeted Disruption of Hoxd9 and Hoxd10 Alters Locomotor Behavior, Vertebral Identity, and Peripheral Nervous System Development
de la Cruz, C. C., Der‐Avakian, A., Spyropoulos, D. D., Tieu, D. D., & Carpenter, E. M. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9528 · Cited by 72
Wntless in Wnt secretion: molecular, cellular and genetic aspects
Das, S., Yu, S., Sakamori, R., Stypulkowski, E., & Gao, N. (2012) · Frontiers in Biology · doi:10.1007/s11515-012-1200-8 · Cited by 71
Axogenesis in the embryonic brain of the grasshopper Schistocerca gregaria: an identified cell analysis of early brain development
Boyan, G., Therianos, S., Williams, J. L. D., & Reichert, H. (1995) · Development · doi:10.1242/dev.121.1.75 · Cited by 71
Mapping genes in the mouse using single-strand conformation polymorphism analysis of recombinant inbred strains and interspecific crosses.
Beier, D. R., Dushkin, H., & Sussman, D. J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9102 · Cited by 71
Dysregulated Wnt Signalling in the Alzheimer’s Brain
Aghaizu, N. D., Jin, H., & Whiting, P. J. (2020) · Brain Sciences · doi:10.3390/brainsci10120902 · Cited by 70
Wnt/β-Catenin Signaling Blockade Promotes Neuronal Induction and Dopaminergic Differentiation in Embryonic Stem Cells
Čajánek, L., Ribeiro, D., Liste, I., Parish, C. L., Bryja, V., & Arenas, E. (2009) · Stem Cells · doi:10.1002/stem.210 · Cited by 70
Overlapping and distinct functions provided by fgf17 , a new zebrafish member of the Fgf8/17/18 subgroup of Fgfs
Reifers, F., Adams, J., Mason, I. J., Schulte‐Merker, S., & Brand, M. (2000) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00475-5 · Cited by 70
The Dynamic Expression Pattern of frzb-1 Suggests Multiple Roles in Chick Development
Baranski, M., Berdougo, E., Sandler, J. S., Darnell, D. K., & Burrus, L. W. (2000) · Developmental Biology · doi:10.1006/dbio.1999.9516 · Cited by 70
Fkh5 -deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body
Wehr, R., Mansouri, A., de Maeyer, T., & Gruß, P. (1997) · Development · doi:10.1242/dev.124.22.4447 · Cited by 70
Expression of four zebrafish wnt -related genes during embryogenesis
Krauss, S. J. K., Korzh, V. P., Fjose, A., & Johansen, T. (1992) · Development · doi:10.1242/dev.116.1.249 · Cited by 70
Midbrain-Hindbrain Boundary Morphogenesis: At the Intersection of Wnt and Fgf Signaling
Gibbs, H. C., Chang-Gonzalez, A. C., Hwang, W., Yeh, A. T., & Lekven, A. C. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00064 · Cited by 72
The extracellular matrix component WIF-1 is expressed during, and can modulate, retinal development
Hunter, D. D., Zhang, M., Ferguson, J. W., Koch, M., & Brunken, W. J. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.08.003 · Cited by 69
Aquaporin 4 expression in the mammalian inner ear and its role in hearing
Mhatre, A. N., Stern, R. E., Li, J., & Lalwani, A. K. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02296-9 · Cited by 69
Identification and characterization of Zic4, a new member of the mouse Zic gene family
Aruga, J., Yozu, A., Hayashizaki, Y., Okazaki, Y., Chapman, V. M., & Mikoshiba, K. (1996) · Gene · doi:10.1016/0378-1119(96)00111-4 · Cited by 68
Efficacious Production of Viable Germ‐Line Chimeras between Embryonic Stem (ES) Cells and 8‐Cell Stage Embryos
Tokunaga, T., & Tsunoda, Y. (1992) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.1992.00561.x · Cited by 68
Migratory routes and fates of cells transcribing the Wnt‐1 gene in the murine hindbrain
Nichols, D. H., & Bruce, L. L. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20611 · Cited by 67
Cre-Lox Neurogenetics: 20 Years of Versatile Applications in Brain Research and Counting…
Tsien, J. Z. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00019 · Cited by 72
DWnt-4, a novel Drosophila Wnt gene acts downstream of homeotic complex genes in the visceral mesoderm
Graba, Y., Gieseler, K., Aragnol, D., Laurenti, P., Mariol, M., Bérenger, H., Sagnier, T., & Pradel, J. (1995) · Development · doi:10.1242/dev.121.1.209 · Cited by 67
Pluripotency of cultured rabbit inner cell mass cells detected by isozyme analysis and eye pigmentation of fetuses following injection into blastocysts or morulae
Giles, J. R., Yang, X., Mark, W. H., & Foote, R. H. (1993) · Molecular Reproduction and Development · doi:10.1002/mrd.1080360203 · Cited by 66
Ectopic Engrailed 1 expression in the dorsal midline causes cell death, abnormal differentiation of circumventricular organs and errors in axonal pathfinding
Louvi, A., & Wassef, M. (2000) · Development · doi:10.1242/dev.127.18.4061 · Cited by 66
The armadillo homologs β-catenin and plakoglobin are differentially expressed during early development of Xenopus laevis
DeMarais, A. A., & Moon, R. T. (1992) · Developmental Biology · doi:10.1016/0012-1606(92)90118-z · Cited by 66
The Gin recombinase of phage Mu can catalyse site-specific recombination in plant protoplasts
Maeser, S., & Kahmann, R. (1991) · Molecular and General Genetics MGG · doi:10.1007/bf00290665 · Cited by 66
Expression of Xfz3, a Xenopus frizzled family member, is restricted to the early nervous system
Shi, D., Goisset, C., & Boucaut, J. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00166-4 · Cited by 66
Escaping the mouse trap: the selection of new Evo-Devo model species.
Milinkovitch, M., & Tzika, A. C. (2007) · Journal of Experimental Zoology Part B: Molecular and Developmental Evolution · doi:10.1002/jez.b.21180 · Cited by 59
The zebrafishzic2a-zic5gene pair acts downstream of canonical Wnt signaling to control cell proliferation in the developing tectum
Nyholm, M. K., Wu, S., Dorsky, R. I., & Grinblat, Y. (2007) · Development · doi:10.1242/dev.02756 · Cited by 65
Function of Wnts in Dopaminergic Neuron Development
Castelo‐Branco, G., & Arenas, E. (2006) · Neurodegenerative Diseases · doi:10.1159/000092086 · Cited by 64
A new intellectual disability syndrome caused by CTNNB1 haploinsufficiency
Dubruc, E., Putoux, A., Labalme, A., Rougeot, C., Sanlaville, D., & Edery, P. (2014) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36484 · Cited by 66
Targeted methylation sequencing reveals dysregulated Wnt signaling in Parkinson disease
Zhang, L., Deng, J., Pan, Q., Zhan, Y., Fan, J., Zhang, K., & Zhang, Z. (2016) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2016.05.002 · Cited by 64
Involvement of Wnt1 and Pax2 in the formation of the midbrain‐hindbrain boundary in the zebrafish gastrula
Kelly, G. M., & Moon, R. T. (1995) · Developmental Genetics · doi:10.1002/dvg.1020170205 · Cited by 64
Isthmus organizer for mesencephalon and metencephalon
Nakamura, H., Sato, T., & Suzuki‐Hirano, A. (2008) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2008.00995.x · Cited by 63
Early development of the neural plate: New roles for apoptosis and for one of its main effectors caspase‐3
Juraver-Geslin, H. A., & Durand, B. (2015) · genesis · doi:10.1002/dvg.22844 · Cited by 65
gbx2 Homeobox gene is required for the maintenance of the isthmic region in the zebrafish embryonic brain
Kikuta, H., Kanai, M., Ito, Y., & Yamasu, K. (2003) · Developmental Dynamics · doi:10.1002/dvdy.10409 · Cited by 63
Hh and Wnt signaling regulate formation of olig2+ neurons in the zebrafish cerebellum.
McFarland, K. A., Topczewska, J. M., Weidinger, G., Dorsky, R., & Appel, B. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.03.016 · Cited by 61
Combined Deletion of CD8 Locus cis-Regulatory Elements Affects Initiation but Not Maintenance of CD8 Expression
Ellmeier, W., Sunshine, M. J., Maschek, R., & Littman, D. R. (2002) · Immunity · doi:10.1016/s1074-7613(02)00309-6 · Cited by 63
Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer
Echevarrı́a, D., Martı́nez, S., Marques, S., Teixeira, V., & Belo, J. A. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.09.011 · Cited by 63
Fritz: a secreted frizzled-related protein that inhibits Wnt activity
Mayr, T., Deutsch, U., Kühl, M., Drexler, H. C. A., Lottspeich, F., Deutzmann, R., Wedlich, D., & Risau, W. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00035-x · Cited by 63
Medulloblastoma stem cells: where development and cancer cross pathways
Manoranjan, B., Venugopal, C., McFarlane, N. M., Doble, B. W., Dunn, S. E., Scheinemann, K., & Singh, S. K. (2012) · Pediatric Research · doi:10.1038/pr.2011.62 · Cited by 62
Maintenance of Wnt-3 expression in Purkinje cells of the mouse cerebellum depends on interactions with granule cells
Salinas, P. C., Fletcher, C., Copeland, N. G., Jenkins, N. A., & Nusse, R. (1994) · Development · doi:10.1242/dev.120.5.1277 · Cited by 62
Pet-1 Switches Transcriptional Targets Postnatally to Regulate Maturation of Serotonin Neuron Excitability
Wyler, S. C., Spencer, W. C., Green, N. H., Rood, B. D., Crawford, L. K., Craige, C. P., Gresch, P. J., McMahon, D. G., Beck, S. G., & Deneris, E. S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3798-15.2016 · Cited by 61
Isolation and expression of two novel Wnt/wingless gene homologues in Drosophila
Russell, J., Gennissen, A. M. C., & Nusse, R. (1992) · Development · doi:10.1242/dev.115.2.475 · Cited by 61
Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain
Fischer, T. H., Guimerá, J., Wurst, W., & Prakash, N. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.04.060 · Cited by 61
Molecular Genetic Studies of Wnt Signaling in the Mouse
Uusitalo, M., Heikkilä, M. M., & Vainio, S. J. (1999) · Experimental Cell Research · doi:10.1006/excr.1999.4710 · Cited by 61
WNT-Frizzled signalling and the many paths to neural development and adult brain homeostasis
Malaterre, J. (2006) · Frontiers in bioscience · doi:10.2741/2077 · Cited by 59
FGF Signaling Mediates Regeneration of the Differentiating Cerebellum through Repatterning of the Anterior Hindbrain and Reinitiation of Neuronal Migration
Köster, R. W., & Fraser, S. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0095-06.2006 · Cited by 60
Intrinsic connections of the rat amygdaloid complex: Projections originating in the accessory basal nucleus
Savander, V., Go, C.-G., LeDoux, J. E., & Pitk�nen, A. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19961014)374:2 · Cited by 79
Development of midbrain and anterior hindbrain ocular motoneurons in normal and Wnt‐1 knockout mice
Fritzsch, B., Nichols, D. H., Echelard, Y., & McMahon, A. P. (1995) · Journal of Neurobiology · doi:10.1002/neu.480270403 · Cited by 60
Gene targeting and gene trap screens using embryonic stem cells: New approaches to mammalian development
Joyner, A. L. (1991) · BioEssays · doi:10.1002/bies.950131206 · Cited by 60
Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages
Dietrich, P., Shanmugasundaram, R., Scavenius Karina, E., & Dragatsis, I. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn324 · Cited by 59
Regulated expression of Wnt family members during proliferation of C57mg mammary cells.
Olson, D. J., & Papkoff, J. S. (1994) · PubMed · Cited by 59
Targeted homologous recombination in mammalian cells
Waldman, A. S. (1992) · Critical Reviews in Oncology/Hematology · doi:10.1016/1040-8428(92)90064-w · Cited by 59
The role of Wnt genes in vertebrate development
Dickinson, M. E., & McMahon, A. P. (1992) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(05)80172-8 · Cited by 59
Physiological basis for xenotransplantation from genetically modified pigs to humans
Peterson, L., Yacoub, M. H., Ayares, D., Yamada, K., Eisenson, D. L., Griffith, B. P., Mohiuddin, M. M., Eyestone, W. H., Venter, J. C., Smolenski, R. T., et al. (2024) · Physiological Reviews · doi:10.1152/physrev.00041.2023 · Cited by 64
Wnt4 is essential to normal mammalian lung development
Caprioli, A., Villasenor, A., Wylie, L. A., Braitsch, C. M., Marty‐Santos, L., Barry, D., Karner, C. M., Fu, S., Meadows, S. M., Carroll, T. J., et al. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.08.017 · Cited by 58
QTL mapping in outbred populations: successes and challenges
Woods, L. C. S. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00127.2013 · Cited by 59
Ocular and Cerebellar Defects in Zebrafish Induced by Overexpression of the LIM Domains of the Islet-3 LIM/Homeodomain Protein
Kikuchi, Y., Segawa, H., Tokumoto, M., Tsubokawa, T., Hotta, Y., Uyemura, K., & Okamoto, H. (1997) · Neuron · doi:10.1016/s0896-6273(00)81239-8 · Cited by 58
Redundant functions of the genes knirps and knirps-related for the establishment of anterior Drosophila head structures.
González‐Gaitán, M., Rothe, M., Wimmer, E. A., Taubert, H., & Jäckle, H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.18.8567 · Cited by 58
The Molecular Genetic Basis of Positional Information in Insect Segments
Hooper, J. E., & Scott, M. P. (1992) · Results and problems in cell differentiation · doi:10.1007/978-3-540-47191-2_1 · Cited by 58
SFRP1 and SFRP2 Dose‐Dependently Regulate Midbrain Dopamine Neuron Development In Vivo and in Embryonic Stem Cells
Kele, J., Andersson, E. R., Villaescusa, C., Čajánek, L., Parish, C. L., Bonilla, S., Toledo, E. M., Bryja, V., Rubin, J. S., Shimono, A., et al. (2012) · Stem Cells · doi:10.1002/stem.1049 · Cited by 57
Electroporation of Murine Embryonic Stem Cells: A Step‐by‐Step Guide
Tompers, D. M., & Labosky, P. A. (2004) · Stem Cells · doi:10.1634/stemcells.22-3-243 · Cited by 57
Technical Assessment of the First 20 Years of Research Using Mouse Embryonic Stem Cell Lines
Downing, G. J., & Battey, J. F. (2004) · Stem Cells · doi:10.1634/stemcells.2004-0101 · Cited by 57
Neurogenetics of the Cerebellar System
Millen, K. J., Millonig, J. H., Wingate, R. J. T., Alder, J., & Hatten, M. E. (1999) · Journal of Child Neurology · doi:10.1177/088307389901400905 · Cited by 57
FGF regulated gene-expression and neuronal differentiation in the developing midbrain–hindbrain region
Jukkola, T., Lahti, L., Naserke, T., Wurst, W., & Partanen, J. M. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.05.002 · Cited by 56

Authors: Thomas, K. R., & Capecchi, M. R.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Capecchi, Mario R.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1990-08
Volume: 346
Issue: 6287
Pages: 847-850
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/346847a0
OpenAlex: W2033291406
Cited by: 896
References: 30
Citations by year: 2026: 3 · 2025: 8 · 2024: 8 · 2023: 14 · 2022: 10 · 2021: 13 · 2020: 19 · 2019: 9 · 2018: 6 · 2017: 18 · 2016: 20 · 2015: 20 · 2014: 12 · 2013: 35 · 2012: 26
FWCI: 23.82
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Keywords: cerebellar development, midbrain development, metencephalon, ataxia, cell-to-cell communication, chimeric mice, embryonic stem cells, spermatogenesis
MeSH terms: Proto-Oncogene Mas, Animals, Blastocyst, Cell Line, Cerebellum, Chimera, DNA, Female, Genotype, Heterozygote, Homozygote, Male, Mesencephalon, Mice, Inbred C57BL, Motor Activity, Mutation, Nucleic Acid Hybridization, Proto-Oncogene Proteins, Stem Cells, Transfection, Zebrafish Proteins, Wnt Proteins, Wnt1 Protein, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks