Cited by 3,392Protein Kinase Regulation and GTPase SignalingReceptor Mechanisms and SignalingCellular transport and secretion

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The GTPase superfamily: conserved structure and molecular mechanism

Bourne, Henry R., Sanders, David A., McCormick, Frank·1991·Nature

DOI 10.1038/349117a0

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Abstract

GTPases are conserved molecular switches, built according to a common structural design. Rapidly accruing knowledge of individual GTPases--crystal structures, biochemical properties, or results of molecular genetic experiments--support and generate hypotheses relating structure to function in other members of the diverse family of GTPases.

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Authors: Bourne, H. R., Sanders, D. A., & McCormick, F.
Affiliations: University of California, San Francisco (US)
Whitehead Institute for Biomedical Research (US)
ORCID: Sanders, David A.
McCormick, Frank
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1991-01-10
Volume: 349
Issue: 6305
Pages: 117-127
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/349117a0
OpenAlex: W1977598234
Cited by: 3,392
References: 149
Citations by year: 2026: 24 · 2025: 44 · 2024: 51 · 2023: 52 · 2022: 37 · 2021: 55 · 2020: 62 · 2019: 50 · 2018: 48 · 2017: 44 · 2016: 58 · 2015: 56 · 2014: 63 · 2013: 61 · 2012: 69
FWCI: 30.15
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: GTPase, GTPase superfamily, molecular switches, structure-function relationship, molecular mechanisms, crystal structure, molecular genetics
MeSH terms: Amino Acid Sequence, Animals, Guanosine Diphosphate, Guanosine Triphosphate, Humans, Molecular Sequence Data, Peptide Elongation Factors, Peptide Initiation Factors, Protein Conformation, Protein Processing, Post-Translational, Signal Transduction, Proto-Oncogene Proteins p21(ras), GTP-Binding Proteins, GTP Phosphohydrolase-Linked Elongation Factors

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The GTPase superfamily: conserved structure and molecular mechanism

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