The GTPase superfamily: conserved structure and molecular mechanism

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

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ras GENES

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The GTPase superfamily: a conserved switch for diverse cell functions

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GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

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Refined crystal structure of the triphosphate conformation of H‐ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

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Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

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Two G Protein Oncogenes in Human Endocrine Tumors

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Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

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G Proteins: A Family of Signal Transducers

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Mechanism of cholera toxin action: Covalent modification of the guanyl nucleotide-binding protein of the adenylate cyclase system

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Aberrant function of the Ras signal transduction pathway in human breast cancer

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Garrotes, Springs, Ratchets, and Whips: Putting Dynamin Models to the Test

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An evolutionarily conserved U5 snRNP‐specific protein is a GTP‐binding factor closely related to the ribosomal translocase EF‐2

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Cdc42p GTPase is involved in controlling polarized cell growth in Schizosaccharomyces pombe.

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ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.

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Crystal structure of the NG domain from the signal-recognition particle receptor FtsY.

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The Universally Conserved Prokaryotic GTPases

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The requirement for cobalt in vitamin B12: A paradigm for protein metalation

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Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae.

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RhoE Regulates Actin Cytoskeleton Organization and Cell Migration

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GTP-binding proteins in plants: new members of an old family

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The Rho GTPase Rho3 Has a Direct Role in Exocytosis That Is Distinct from Its Role in Actin Polarity

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Two Families of GTPases Dominate the Complex Cellular Response to IFN-γ

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A Posttermination Ribosomal Complex Is the Guanine Nucleotide Exchange Factor for Peptide Release Factor RF3

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Lipid modifications of G proteins

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The Spg1p GTPase is an essential, dosage-dependent inducer of septum formation in Schizosaccharomyces pombe.Preprint

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GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation inSaccharomyces cerevisiaePreprint

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Role of heterotrimeric G proteins in membrane traffic.

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The Highly Conserved LepA Is a Ribosomal Elongation Factor that Back-Translocates the Ribosome

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Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras·GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins

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Mitochondrial Dynamics in Stem Cells and Differentiation

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Regulation of cadherin-mediated cell–cell adhesion by the Rho family GTPases

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A new family of G-protein regulators — the RGS proteins

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Drug-metabolizing enzymes in ligand-modulated transcription

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Cloning of a Rab3 isotype predominantly expressed in adipocytes.

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Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases

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A constituent of the chloroplast import complex represents a new type of GTP‐binding protein

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Intraflagellar Transport Protein 27 Is a Small G Protein Involved in Cell-Cycle Control

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miR-204-5p Inhibits Proliferation and Invasion and Enhances Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating RAB22A

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Plant Rac-Like GTPases Are Activated by Auxin and Mediate Auxin-Responsive Gene Expression

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ROP GTPases Structure-Function and Signaling Pathways

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GDI1 encodes a GDP dissociation inhibitor that plays an essential role in the yeast secretory pathway.

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The Role of GTP-Binding Proteins in Transport Along the Exocytic Pathway

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Interactions between Two Catalytically Distinct MCM Subgroups Are Essential for Coordinated ATP Hydrolysis and DNA Replication

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Receptor and βγ Binding Sites in the α Subunit of the Retinal G Protein Transducin

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Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility.

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Nucleotide binding and autophosphorylation of the clock protein KaiC as a circadian timing process of cyanobacteria

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C-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophils

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Genes and their organization in the replication origin region of the bacterial chromosome

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Evidence for G-Protein Regulation of Inward K + Channel Current in Guard Cells of Fava Bean

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Mitochondrial fusion proteins: Dual regulators of morphology and metabolism

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Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.

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G-protein diseases furnish a model for the turn-on switch

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Nucleocytoplasmic transport of macromolecules

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RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML)

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Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis.

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Eph receptor–ephrin bidirectional signals that target Ras and Rho proteins

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A dynamin-like protein (ADL2b), rather than FtsZ, is involved in Arabidopsis mitochondrial division

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A single amino acid change in Raf-1 inhibits Ras binding and alters Raf-1 function.

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Cell wall integrity modulates RHO1 activity via the exchange factor ROM2

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Rho3 ofSaccharomyces cerevisiae, Which Regulates the Actin Cytoskeleton and Exocytosis, Is a GTPase Which Interacts with Myo2 and Exo70

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Powering through ribosome assembly

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Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C

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Oxidized Human Neuroglobin Acts as a Heterotrimeric Gα Protein Guanine Nucleotide Dissociation Inhibitor

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Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity

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Structure of the Guanine Nucleotide Exchange Factor Sec7 Domain of Human Arno and Analysis of the Interaction with ARF GTPase

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The product of the hypB gene, which is required for nickel incorporation into hydrogenases, is a novel guanine nucleotide-binding protein

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The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein.

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Identification of effector-activating residues of Gsα

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Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity

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TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of RhoG

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KRAS G12C Game of Thrones, which direct KRAS inhibitor will claim the iron throne?

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Homoleptic Phosphoraneiminato Complexes of Rare Earth Elements as Initiators for Ring-Opening Polymerization of Lactones

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Roles of plant homologs of Rab1p and Rab7p in the biogenesis of the peribacteroid membrane, a subcellular compartment formed de novo during root nodule symbiosis.

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Induction of Cyclooxygenase-2 by Activated Ha-rasOncogene in Rat-1 Fibroblasts and the Role of Mitogen-activated Protein Kinase Pathway

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Antagonism between Goalpha and Gqalpha in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for Goalpha signaling and regulates Gqalpha activityPreprint

Hajdu-Cronin, Y. M., Chen, W. J., Patikoglou, G. A., Koelle, M. R., & Sternberg, P. W. (1999) · Genes & Development · doi:10.1101/gad.13.14.1780 · Cited by 185

The Ras Superfamily of Small GTPases: The Unlocked Secrets

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The Yeast TEM1 Gene, Which Encodes a GTP-Binding Protein, Is Involved in Termination of Μ Phase

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GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation

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Rho GTPases in platelet function

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Six GTP-binding proteins of the Era/Obg family are essential for cell growth in Bacillus subtilis b bThe primer sequences used for PCR in this study are shown as supplementary data on Microbiology Online (http://mic.sgmjournals.org).

Morimoto, T., Loh, P. C., Hirai, T., Asai, K., Kobayashi, K., Moriya, S., & Ogasawara, N. (2002) · Microbiology · doi:10.1099/00221287-148-11-3539 · Cited by 191

Increasing Complexity of Ras Signal Transduction: Involvement of Rho Family Proteins

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Clinical and electrophysiologic features of CMT2A with mutations in the mitofusin 2 gene

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Nog2p, a putative GTPase associated with pre‐60S subunits and required for late 60S maturation steps

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Rho 1 GTPase activates the (1–3)beta‐D‐glucan synthase and is involved in Schizosaccharomyces pombe morphogenesis.

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Ras Activation by Insulin and Epidermal Growth Factor through Enhanced Exchange of Guanine Nucleotides on p21ras

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The three faces of profilin

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A functional GTP-binding motif is necessary for antiviral activity of Mx proteins

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GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins

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Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily.

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Multiple trimeric G‐proteins on the trans‐Golgi network exert stimulatory and inhibitory effects on secretory vesicle formation.

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Activation of neutrophil leukocytes: chemoattractant receptors and respiratory burst 1

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The biochemistry of ras p21

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Effect of precise mechanical loading on fibroblast populated collagen lattices: Morphological changes

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An α to β conformational switch in EF-Tu

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Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex.

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Dexamethasone Rapidly Induces a Novel Ras Superfamily Member-related Gene in AtT-20 Cells

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Phospholipase C β and Membrane Action of Calcitriol and Estradiol

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The Ras-related Protein Rheb Is Farnesylated and Antagonizes Ras Signaling and Transformation

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A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells.

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Control of Ribosomal Subunit Rotation by Elongation Factor G

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