The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
The importance of repairing stalled replication forks
Abstract
The bacterial SOS response to unusual levels of DNA damage has been recognized and studied for several decades. Pathways for re-establishing inactivated replication forks under normal growth conditions have received far less attention. In bacteria growing aerobically in the absence of SOS-inducing conditions, many replication forks encounter DNA damage, leading to inactivation. The pathways for fork reactivation involve the homologous recombination systems, are nonmutagenic, and integrate almost every aspect of DNA metabolism. On a frequency-of-use basis, these pathways represent the main function of bacterial DNA recombination systems, as well as the main function of a number of other enzymatic systems that are associated with replication and site-specific recombination.
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“Unrepaired fork gaps can become frank DSB [24, 61, 62].”
From NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites (2013) · cites this paper as [62]
Citations
Cites
Mammalian Telomeres End in a Large Duplex Loop
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An alternative pathway for yeast telomere maintenance rescues est1− senescence
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Recombinational Repair of DNA Damage in Escherichia coli and Bacteriophage λ
Kuzminov, A. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.4.751-813.1999 · Cited by 897
ISOLATION AND CHARACTERIZATION OF RECOMBINATION-DEFICIENT MUTANTS OF ESCHERICHIA COLI K12
Clark, A. J., & Margulies, A. D. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.53.2.451 · Cited by 835
MUTANTS OF ESCHERICHIA COLI K-12 DEFECTIVE IN DNA REPAIR AND IN GENETIC RECOMBINATION
Howard-Flanders, P., & Theriot, L. (1966) · Genetics · doi:10.1093/genetics/53.6.1137 · Cited by 629
RuvAB Acts at Arrested Replication Forks
Seigneur, M., Bidnenko, V., Ehrlich, S. D., & Michel, B. (1998) · Cell · doi:10.1016/s0092-8674(00)81772-9 · Cited by 538
UmuD′ 2 C is an error-prone DNA polymerase, Escherichia coli pol V
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The dinB Gene Encodes a Novel E. coli DNA Polymerase, DNA Pol IV, Involved in Mutagenesis
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DNA double‐strand breaks caused by replication arrest
Michel, B., Ehrlich, S. D., & Uzest, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.2.430 · Cited by 426
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Stochastic Gene Expression in a Single Cell
Elowitz, M. B., Levine, A. J., Siggia, E. D., & Swain, P. S. (2002) · Science · doi:10.1126/science.1070919 · Cited by 5,441
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317
Cellular roles of DNA topoisomerases: a molecular perspective
Wang, J. C. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm831 · Cited by 2,364
How antibiotics kill bacteria: from targets to networks
Kohanski, M. A., Dwyer, D. J., & Collins, J. J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2333 · Cited by 2,377
Cell cycle checkpoint signaling through the ATM and ATR kinases
Abraham, R. T. (2001) · Genes & Development · doi:10.1101/gad.914401 · Cited by 1,966
Metadata
- Authors
- Cox, M. M., Goodman, M. F., Kreuzer, K. N., Sherratt, D. J., Sandler, S. J., & Marians, K. J.
- Affiliations
- University of Wisconsin System (US)
- University of Southern California (US)
- Duke Medical Center (US)
- University of Oxford (GB)
- University of Massachusetts Amherst (US)
- Memorial Sloan Kettering Cancer Center (US)
- Venue
- Nature
- Published
- 2000-03
- Volume
- 404
- Issue
- 6773
- Pages
- 37-41
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1570361288
- Cited by
- 1,044
- References
- 63
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 13 · 2023: 14 · 2022: 26 · 2021: 27 · 2020: 21 · 2019: 22 · 2018: 26 · 2017: 22 · 2016: 36 · 2015: 34 · 2014: 49 · 2013: 43 · 2012: 39
- FWCI
- 28.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Institute of General Medical Sciences (R37GM034557)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Keywords
- stalled replication forks, bacterial DNA damage, SOS response, homologous recombination, DNA repair, site-specific recombination, DNA metabolism
- MeSH terms
- Bacteria, Bacterial Proteins, Chromosomes, Bacterial, DNA Replication, DNA, Bacterial, Escherichia coli, Recombination, Genetic, SOS Response, Genetics, Replication Origin
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