Cited by 519Evolution and Genetic DynamicsLanguage and cultural evolutionPhilosophy of Biology and Scientific Explanation

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The population genetics of ecological specialization in evolving Escherichia coli populations

Cooper, Vaughn S., Lenski, Richard E.·2000·Nature

DOI 10.1038/35037572

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Abstract

When organisms adapt genetically to one environment, they may lose fitness in other environments. Two distinct population genetic processes can produce ecological specialization-mutation accumulation and antagonistic pleiotropy. In mutation accumulation, mutations become fixed by genetic drift in genes that are not maintained by selection; adaptation to one environment and loss of adaptation to another are caused by different mutations. Antagonistic pleiotropy arises from trade-offs, such that the same mutations that are beneficial in one environment are detrimental in another. In general, it is difficult to distinguish between these processes. We analysed the decay of unused catabolic functions in 12 lines of Escherichia coli propagated on glucose for 20,000 generations. During that time, several lines evolved high mutation rates. If mutation accumulation is important, their unused functions should decay more than the other lines, but no significant difference was observed. Moreover, most catabolic losses occurred early in the experiment when beneficial mutations were being rapidly fixed, a pattern predicted by antagonistic pleiotropy. Thus, antagonistic pleiotropy appears more important than mutation accumulation for the decay of unused catabolic functions in these populations.

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Authors: Cooper, V. S., & Lenski, R. E.
Affiliations: Michigan State University (US)
Corresponding author: Cooper, Vaughn S.
ORCID: Cooper, Vaughn S.
Lenski, Richard E.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2000-10
Volume: 407
Issue: 6805
Pages: 736-739
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35037572
OpenAlex: W1480307447
Cited by: 519
References: 23
Citations by year: 2026: 11 · 2025: 18 · 2024: 8 · 2023: 23 · 2022: 20 · 2021: 20 · 2020: 22 · 2019: 19 · 2018: 13 · 2017: 20 · 2016: 16 · 2015: 17 · 2014: 29 · 2013: 27 · 2012: 32
FWCI: 8.36
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Natural Science Foundation of China
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Social Sciences › Cultural Studies › Language and cultural evolution
Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy of Biology and Scientific Explanation
Keywords: ecological specialization, antagonistic pleiotropy, mutation accumulation, Escherichia coli, fitness trade-offs, mutation rate evolution, genetic drift
MeSH terms: Adaptation, Physiological, Ecology, Escherichia coli, Genes, Bacterial, Glucose, Models, Biological, Mutation, Evolution, Molecular

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The population genetics of ecological specialization in evolving Escherichia coli populations

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