The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
The population genetics of ecological specialization in evolving Escherichia coli populations
Abstract
When organisms adapt genetically to one environment, they may lose fitness in other environments. Two distinct population genetic processes can produce ecological specialization-mutation accumulation and antagonistic pleiotropy. In mutation accumulation, mutations become fixed by genetic drift in genes that are not maintained by selection; adaptation to one environment and loss of adaptation to another are caused by different mutations. Antagonistic pleiotropy arises from trade-offs, such that the same mutations that are beneficial in one environment are detrimental in another. In general, it is difficult to distinguish between these processes. We analysed the decay of unused catabolic functions in 12 lines of Escherichia coli propagated on glucose for 20,000 generations. During that time, several lines evolved high mutation rates. If mutation accumulation is important, their unused functions should decay more than the other lines, but no significant difference was observed. Moreover, most catabolic losses occurred early in the experiment when beneficial mutations were being rapidly fixed, a pattern predicted by antagonistic pleiotropy. Thus, antagonistic pleiotropy appears more important than mutation accumulation for the decay of unused catabolic functions in these populations.
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“Moreover, due to rather new technologies, including transcriptional profiling [30] and massive next-generation DNA sequencing (NGS) [31,32], phenotype-genotype correlations can be easily obtained by whole genome re-sequencing (WGS).”
From Adaptive laboratory evolution—Principles and applications for biotechnology (2013) · cites this paper as [31]
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“The specificity of this pattern of gene loss suggests a footprint of selection through an antagonistic pleiotropy mechanism of adaptation [57] during the very peculiar Shigella intracellular life style.”
Background
Metadata
- Authors
- Cooper, V. S., & Lenski, R. E.
- Affiliations
- Michigan State University (US)
- Corresponding author
- Cooper, Vaughn S.
- Venue
- Nature
- Published
- 2000-10
- Volume
- 407
- Issue
- 6805
- Pages
- 736-739
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1480307447
- Cited by
- 519
- References
- 23
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 8 · 2023: 23 · 2022: 20 · 2021: 20 · 2020: 22 · 2019: 19 · 2018: 13 · 2017: 20 · 2016: 16 · 2015: 17 · 2014: 29 · 2013: 27 · 2012: 32
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Social Sciences › Cultural Studies › Language and cultural evolution
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy of Biology and Scientific Explanation
- Keywords
- ecological specialization, antagonistic pleiotropy, mutation accumulation, Escherichia coli, fitness trade-offs, mutation rate evolution, genetic drift
- MeSH terms
- Adaptation, Physiological, Ecology, Escherichia coli, Genes, Bacterial, Glucose, Models, Biological, Mutation, Evolution, Molecular
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