The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Oxidants, oxidative stress and the biology of ageing
Abstract
Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.
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In the citing paper
“During aging and neurodegeneration, there is a decrease in normal antioxidant and anti-inflammatory defense mechanisms, making the brain more susceptible to the detrimental effects of oxidative stress [44,45,46].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [45]
In the citing paper
“Indeed, most neurological disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), inflammatory injuries and senility are the result of age-linked inflammation and/or oxidative stress increase [44,45].”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [45]
In the citing paper
“There is considerably strong evidence to clarify that inflammation and oxidative stress play a fundamental role in the onset and progression of neurodegenerative diseases [45],”
From Beneficial Effects of Spirulina Consumption on Brain Health (2022) · cites this paper as [45]
In the citing paper
“A complex antioxidant defense system, including both endogenous and exogenous antioxidants, protect cells from ROS-induced toxicity (Finkel and Holbrook 2000).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Finkel and Holbrook 2000
In the citing paper
“One of the hallmarks of aging is elevated oxidative stress and inflammation (Finkel and Holbrook, 2000).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Finkel and Holbrook, 2000
Citations
Cites
1 retracted
A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants
Taub, J. J., Lau, J. F., Ma, C., Hahn, J. H., Hoque, R., Rothblatt, J. A., & Chalfie, M. (1999) · Nature · doi:10.1038/20208 · Cited by 243
RetractedMcCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218 · cited 1×
“The role of oxidants in cellular senescence was further underscored by recent observations that overexpression of an activated Ras gene can also induce a senescence-like state in human diploid fibroblast”
Background(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879
Oxidative Stress, Caloric Restriction, and Aging
Sohal, R. S., & Weindruch, R. H. (1996) · Science · doi:10.1126/science.273.5271.59 · Cited by 3,133
Stadtman, E. R. (1992) · Science · doi:10.1126/science.1355616 · Cited by 2,701
Research works printed but not linked: 2
- Golubev, A. G. The other side of metabolism: a review. Biochemistry 61, 1443–1460 (1996).
- Richardson, A. & Holbrook, N. J. in Cellular Aging and Cell Death (eds Holbrook, N. J., Martin, G. R. & Lockshin, R. A.) 67–89 (Wiley, New York, 1996).
Cited by
Sorted by citations
Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Genome maintenance mechanisms for preventing cancer
Hoeijmakers, J. H. J. (2001) · Nature · doi:10.1038/35077232 · Cited by 3,939
Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases
Phaniendra, A., Jestadi, D. B., & Periyasamy, L. (2015) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-014-0446-0 · Cited by 2,886
Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638
Metadata
- Authors
- Finkel, T., & Holbrook, N. J.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Finkel, Toren
- Holbrook, Nikki J.
- ORCID
- Finkel, Toren
- Venue
- Nature
- Published
- 2000-11
- Volume
- 408
- Issue
- 6809
- Pages
- 239-247
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2101861123
- Cited by
- 9,413
- References
- 104
- Citations by year
- 2026: 194 · 2025: 337 · 2024: 330 · 2023: 384 · 2022: 413 · 2021: 447 · 2020: 488 · 2019: 502 · 2018: 487 · 2017: 510 · 2016: 464 · 2015: 428 · 2014: 475 · 2013: 457 · 2012: 478
- FWCI
- 10.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- oxidizing agents, oxidative stress, aging, reactive oxygen species, lifespan, oxygen metabolism, cellular detoxification
- MeSH terms
- Aging, Animals, Energy Intake, Humans, Longevity, Signal Transduction, Oxidants, Cellular Senescence, Reactive Oxygen Species, Oxidative Stress
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