Cited by 9,413Genetics, Aging, and Longevity in Model OrganismsRedox biology and oxidative stressAntioxidant Activity and Oxidative Stress

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Oxidants, oxidative stress and the biology of ageing

Finkel, Toren, Holbrook, Nikki J.·2000·Nature

DOI 10.1038/35041687

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Abstract

Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.

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A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants
Taub, J. J., Lau, J. F., Ma, C., Hahn, J. H., Hoque, R., Rothblatt, J. A., & Chalfie, M. (1999) · Nature · doi:10.1038/20208 · Cited by 243
Retracted
Superoxide Dismutase
McCord, J. M., & Fridovich, I. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)63504-5 · Cited by 12,952
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218 · cited 1×
“The role of oxidants in cellular senescence was further underscored by recent observations that overexpression of an activated Ras gene can also induce a senescence-like state in human diploid fibroblast”
Background
The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879
Oxidative Stress, Caloric Restriction, and Aging
Sohal, R. S., & Weindruch, R. H. (1996) · Science · doi:10.1126/science.273.5271.59 · Cited by 3,133
Protein Oxidation and Aging
Stadtman, E. R. (1992) · Science · doi:10.1126/science.1355616 · Cited by 2,701

Flagged first, then by citations

Show all 104 references

Research works printed but not linked: 2

Golubev, A. G. The other side of metabolism: a review. Biochemistry 61, 1443–1460 (1996).
Richardson, A. & Holbrook, N. J. in Cellular Aging and Cell Death (eds Holbrook, N. J., Martin, G. R. & Lockshin, R. A.) 67–89 (Wiley, New York, 1996).

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Trinei, M., Giorgio, M., Cicalese, A., Barozzi, S., Ventura, A., Migliaccio, E., Milia, E., Padura, I. M., Raker, V. A., Maccarana, M., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205513 · Cited by 436
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Oxidative stress and its effects during dehydration
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Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2022) · Inflammation Research · doi:10.1007/s00011-022-01598-8 · Cited by 432
Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF‐16
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Innate sensing of oxidation-specific epitopes in health and disease
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Peroxiredoxin III, a Mitochondrion-specific Peroxidase, Regulates Apoptotic Signaling by Mitochondria
Chang, T.-S., Cho, C.-S., Park, S., Yu, S., Kang, S. W., & Rhee, S. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407707200 · Cited by 388
Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage
Haendeler, J., Dröse, S., Büchner, N., Jakob, S., Altschmied, J., Goy, C., Spyridopoulos, I., Zeiher, A. M., Brandt, U., & Dimmeler, S. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.185546 · Cited by 375
Clusterin in Alzheimer’s Disease: Mechanisms, Genetics, and Lessons From Other Pathologies
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Thiol-based redox switches in eukaryotic proteins
Brandes, N., Schmitt, S., & Jakob, U. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2285 · Cited by 373
Nucleotide Excision Repair
Reardon, J. T., & Sancar, A. (2005) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(04)79004-2 · Cited by 350
Aging and Immune Function: Molecular Mechanisms to Interventions
Ponnappan, S., & Ponnappan, U. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3228 · Cited by 339
The power of exercise: buffering the effect of chronic stress on telomere length
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Authors: Finkel, T., & Holbrook, N. J.
Affiliations: National Institutes of Health (US)
Corresponding author: Finkel, Toren
Holbrook, Nikki J.
ORCID: Finkel, Toren
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2000-11
Volume: 408
Issue: 6809
Pages: 239-247
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35041687
OpenAlex: W2101861123
Cited by: 9,413
References: 104
Citations by year: 2026: 194 · 2025: 337 · 2024: 330 · 2023: 384 · 2022: 413 · 2021: 447 · 2020: 488 · 2019: 502 · 2018: 487 · 2017: 510 · 2016: 464 · 2015: 428 · 2014: 475 · 2013: 457 · 2012: 478
FWCI: 10.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: oxidizing agents, oxidative stress, aging, reactive oxygen species, lifespan, oxygen metabolism, cellular detoxification
MeSH terms: Aging, Animals, Energy Intake, Humans, Longevity, Signal Transduction, Oxidants, Cellular Senescence, Reactive Oxygen Species, Oxidative Stress

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