Cited by 9,413Genetics, Aging, and Longevity in Model OrganismsRedox biology and oxidative stressAntioxidant Activity and Oxidative Stress

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Oxidants, oxidative stress and the biology of ageing

Finkel, Toren, Holbrook, Nikki J.·2000·Nature

DOI 10.1038/35041687

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Abstract

Living in an oxygenated environment has required the evolution of effective cellular strategies to detect and detoxify metabolites of molecular oxygen known as reactive oxygen species. Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span.

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Authors: Finkel, T., & Holbrook, N. J.
Affiliations: National Institutes of Health (US)
Corresponding author: Finkel, Toren
Holbrook, Nikki J.
ORCID: Finkel, Toren
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2000-11
Volume: 408
Issue: 6809
Pages: 239-247
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/35041687
OpenAlex: W2101861123
Cited by: 9,413
References: 104
Citations by year: 2026: 194 · 2025: 337 · 2024: 330 · 2023: 384 · 2022: 413 · 2021: 447 · 2020: 488 · 2019: 502 · 2018: 487 · 2017: 510 · 2016: 464 · 2015: 428 · 2014: 475 · 2013: 457 · 2012: 478
FWCI: 10.25
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: oxidizing agents, oxidative stress, aging, reactive oxygen species, lifespan, oxygen metabolism, cellular detoxification
MeSH terms: Aging, Animals, Energy Intake, Humans, Longevity, Signal Transduction, Oxidants, Cellular Senescence, Reactive Oxygen Species, Oxidative Stress

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Oxidants, oxidative stress and the biology of ageing

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