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Cited by 219Microtubule and mitosis dynamicsDNA Repair MechanismsGenomics and Chromatin Dynamics

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores

Chan, G. K. T., Jablonski, S. A., Starr, D. A., Goldberg, M. L., Yen, T. J.·2000·Nature Cell Biology
DOI 10.1038/35046598
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Abstract

Here we show that human Zeste White 10 (Zw10) and Rough deal (Rod) are new components of the mitotic checkpoint, as cells lacking these proteins at kinetochores fail to arrest in mitosis when exposed to microtubule inhibitors. Checkpoint failure and premature mitotic exit may explain why cells defective for hZw10 and hRod divide with lagging chromosomes. As Zw10 and Rod are not conserved in yeast, our data, combined with an accompanying study of Drosophila Zw10 and Rod, indicate that metazoans may require an elaborate spindle checkpoint to monitor complex kinetochore functions.

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Crossref · 10.1038/35046598

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Metadata

Authors
Chan, G. K. T., Jablonski, S. A., Starr, D. A., Goldberg, M. L., & Yen, T. J.
Affiliations
  • Fox Chase Cancer Center (US)
  • University of Colorado Boulder (US)
  • Cornell University (US)
Corresponding author
Yen, T. J.
ORCID
Venue
Nature Cell Biology
Publisher
Springer Science and Business Media LLC
Published
2000-11-14
Volume
2
Issue
12
Pages
944-947
ISSN
  • 1465-7392 (ISSN-L)
  • 1476-4679
DOI
10.1038/35046598
OpenAlex
W1540858422
Cited by
217
References
31
Citations by year
2026: 5 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 2 · 2020: 10 · 2019: 5 · 2018: 8 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 8 · 2012: 2
FWCI
5.28
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Cancer Institute (P30CA006927, CA06927)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
ZW10, rods, spindle assembly checkpoint, kinetochore, microtubule inhibitors, mitotic arrest, lagging chromosomes, chromosome segregation, Drosophila, animal evolution
MeSH terms
Binding Sites, Chromosomal Proteins, Non-Histone, HeLa Cells, Humans, Microscopy, Fluorescence, Microtubules, Mitosis, Spindle Apparatus, Protein Binding, Nocodazole, Kinetochores, Cell Cycle Proteins

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